Skip to main content
SpringerLink
Log in

Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: a literature survey

  • Original Research Papers
  • Published:
Plant Cell, Tissue and Organ Culture Aims and scope Submit manuscript

Abstract

The literature concerning the tissue culture of Taxus sp. as an alternative source for taxoid production is reviewed. The aim of this review is to summarize and discuss the progress achieved with the approaches and methods used for the establishment of various Taxus culture systems, the methods used for the evaluation of taxoid production, the multiple factors which control taxoid production and the feasibility of the in vitro production of taxoids on a commercial scale.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Amos RR & McCown BH (1981) Micropropagation of members of the coniferae. HortScience 16: 453

    Google Scholar 

  • Appendino G (1993) Taxol (paelitaxel): historical and ecological aspects. Fitoterapia. LXIV: 5–25

    Google Scholar 

  • Arteca RN & Wiekremesinhe E (1993) Cultured Taxus tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds. WO Patent N° 93/23555

  • Barnes L (1983) Micropropagation of endangered native conifers, Torreya taxifolia and Taxus floridana. HortScience 18: 617

    Google Scholar 

  • Bourgin JP & Nitsch JP (1967) Obtention de Nicotiana haploïdes à partir d'étamines cultivées in vitro. Ann. Physiol. Vég. 9: 377–382

    Google Scholar 

  • Bringi V & Kadkade PG (1993) Enhanced production of taxol and taxanes by cell cultures of Taxus species. WO Patent No 93/17121

  • CardelinaII JH (1991) HPLC separation of taxol and cephalomannine. J. Liq. chromatogr. 14: 659–665

    Google Scholar 

  • Castor TP & Tyler TA (1993) Determination of taxol in Taxus x media needles in the presence of interfering components. J. Liq. Chromatogr. 16: 723–731

    Google Scholar 

  • Cerdeira RM, Mc Chesney JD & Burandt CJr (1994) Microcuttings of Taxus x media cv. Hicksii. In vitro Cell. & Dev. Biol. 30: 77

    Google Scholar 

  • Chan KC, Alvarado AB, McGuire MT, Muschik GM, Issaq HJ & Snader KM (1994) High performance liquid chromatography and micellar electrokinetic chromatography of taxol and related taxanes from bark and needles extracts of Taxus species. J. Chromatogr. 657: 301–306

    Google Scholar 

  • Chee PP (1994) In vitro culture of zygotic embryos of Taxus species. HortScience 29: 695–697

    Google Scholar 

  • Chee PP (1995) Organogenesis in Taxus brevifolia tissue cultures. Plant Cell Rep. 14: 560–565

    Google Scholar 

  • Christen AA, Bland J & Gibson DM (1989) Cell culture as a means to produce taxol. (Abstract) Proc. Am. Assoc. Cancer Res. 30: A2252

  • Christen AA, Gibson DM & Bland J (1991) Production of taxol or taxol-like compounds in cell culture. US Patent No 5,019,504

  • Cino PM, Schwarz SR & Cazzulino DL (1993) Callus cell induction and the preparation of taxanes. European Patent No 0 568 821 A1

  • Commerçon A. (1995) Semi-synthèse et propriétés biologiques d'analogues du docetaxel. Proceeding ler Symposium ICSN: Taxoids. Institut de Chimie des substances Naturelles, CNRS, Gif-sur-Yvette, France. May 11–12 1995 (p.7)

    Google Scholar 

  • Concetti A, Ripani E, Barboni L, Torregiani E, Bombardelli E, Gariboldi P & Venanzi FM (1994) Immunorecognition of ring skeleton of taxanes by chicken egg yolk antibodies. Biol. Chem. Hopppe-Seyler 375: 419–423

    Google Scholar 

  • Cragg JM & Snader KM (1991) Taxol: the supply issue. Cancer Cells 3: 233–235

    Google Scholar 

  • Cragg GM, Schepartz SA & Suffness M & Grever MR (1993) The taxol supply crisis. New NCI policies for handling the largescale production of novel natural product anticancer and anti-HIV agents. J. Nat. Prod. 56: 1657–1668

    Google Scholar 

  • David A & Plastira V (1974) Histophysiologie végétale. Réalisation de cultures de tissus d'If (Taxus baccata L.) à partir de fragments de pousses âgés d'un an; obtention d'une culture indéfinie. C. R. Acad. Sc. Paris 279: 1757–1759

    Google Scholar 

  • David A (1977) La culture des tissus de deux gymnospermes Pinus pinaster Sol. et Taxus baccata L. In: Gautheret G (ed) La Culture des Tissus et des Cellules des Végétaux (pp 9: 3–99). Masson, Paris, New York, Barcelona, Milan

    Google Scholar 

  • David A & Plastira V (1976) Histophysiologie végétale. Comportement en culture in vitro de cellules isolées de deux gymnospermes: Taxus baccata L. et Pinus pinaster Sol. C. R. Acad. Sc. Paris 282: 1159–1162

    Google Scholar 

  • Denis JN, Greene AE, Guénard D, Guéritte-Voegelein F, Mangatal L & Potier P (1988) A highly efficient,practical approach to natural taxol. J. Am. Chem. Soc. 110: 5917–5919

    Google Scholar 

  • Donovan TA (1995) The paelitaxel dilerna. Taxane Journal 1: 28–41

    Google Scholar 

  • Durzan DJ & Ventimiglia F (1994) Free taxanes and the release of bound compounds having taxane antibody reactivity by xylanase in female, haploid-derived cell suspension cultures of Taxus brevifolia. In vitro Cell. Dev. Biol. 30: 219–227

    Google Scholar 

  • Ellis DD (1994) Taxol. The production of an anti-cancer drug from trees. Proc. Second International Symposium on the Applications of Biotechnology to the Tree Culture, Protection, and Utilization. Bloomington, Minnesota, Oct. 2–6, 198–202

  • Ellis DD, Zeldin E, Russin W, Brodhagen M, Evert R & McCown B (1993) Taxane production in shoot cultures of Taxus sp. and the immunological localization of taxanes in Taxus tissues. Paper presented at the International Yew Resources Conference Berkeley, CA March 12–13

  • Ellis DD, Zeldin EL, Brodhagen M, Russin WA, Mocek U, Flemming PE, Floss HG & McCown BH (1994) Taxol production, localization, and biotransformation of precursors in Taxus shoot and nodule cultures. In vitro Cell. Dev. Biol. 30: 229

    Google Scholar 

  • ElSohly HA, Croom ED, Kopycki WJ, Joshi AS, ElSohly MA & McChesney JD (1995) Concentration of taxol and related taxanes in the needles of different Taxus cultivars. Phytochemical Analysts 6: 149–156

    Google Scholar 

  • Ettouati L, Ahond A, Convert O, Poupat C & Potier P (1988) Plantes de Nouvelle-Calédonie. 114. Taxanes isolés des feuilles d'Austrotatus spicata Compton (Taxacées). Bull. Soc. Chim. Fr. 4: 749–755

    Google Scholar 

  • Ettouati L, Ahond A, Convert O, Poupat C & Potier P (1989) Plants of New Caledonia. 124. Taxanes from the trunk bark of Austrotaxus spicata Compton (Taxaceae). Bull. Soc. Chim. Fr. 687–694

  • Fett-Neto AG & DiCosmo F (1992) Distribution and amounts of taxol in different shoot parts of Taxus cuspidata. Planta Med. 58: 464–466

    Google Scholar 

  • Fett-Neto AG, DiCosmo F, Reynolds WF & Sakata K (1992) Cell culture of Taxus as a source of the antineoplastic drug taxol and related taxanes. Bio/Technology 10: 1572–1575

    Google Scholar 

  • Fett-Neto AG, Melanson SJ, Sakata K & DiCosmo F (1993a) Improved growth and taxol yield in developing calli of Taxus cuspidata by medium composition modification. Bio/Technology 11: 731–734

    Google Scholar 

  • Fett-Neto AG, Melanson SJ, Pennington JJ & DiCosmo F (1993b) Effect of precursor feeding on taxol side chain biosynthesis in callus cultures of Taxus cuspidata. Plant Physiol. 102: 97

    Google Scholar 

  • Fett-Neto AG, Melanson SJ, Nicholson SA, Pennington JJ & DiCosmo F (1994a) Improved taxol yield by aromatic carboxylic acid and amino acid feeding to cell cultures of Taxus cuspidata. Biotech. Bioeng. 44: 967–971

    Google Scholar 

  • Fett-Neto AG, Zhang WY & DiCosmo F (1994b) Kinetics of taxol production, growth, and nutrient uptake in cell suspensions of Taxus cuspidata. Biotechnology and Bioengineering 44: 205–210

    Google Scholar 

  • Fett-Neto AG, Pennington JJ & DiCosmo F (1995) Effect of white light on taxol and baccatin III accumulation in cell cultures of Taxus cuspidata Sieb and Zucc. J. Plant Physiol. 146: 584–590

    Google Scholar 

  • Fleming PE, Mocek U & Floss HG (1993) Biosynthesis of taxoids. Mode of formation of the side chain. J. Am. Chem. Soc. 115: 805–807

    Google Scholar 

  • Flores HE & Sgrinoli PJ (1991) In vitro culture and precocious germination of Taxus embryos. In Vitro Cell. Dev. Biol. 27: 139–142

    Google Scholar 

  • Flores T, Wagner LJ & Flores HE (1993) Embryo culture and taxane production in Taxus spp. In Vitro Cell. Dev. Biol. 29: 160–165

    Google Scholar 

  • Floss HG (1995) Biosynthesis of taxol. Presented at 1st Symposium ICSN, Taxoids. Gifsur-Yvette, France, May 11–12

  • Furmanowa M, Gowniak K, Zobel A, Guzewska J, Zgorka G, Rapczewska L & Jozefezyk A (1995) Taxol in Taxus baceata L. var. elegantissima organs and in tissue culture. Med. Fac. Landbouww. Univ. Gent 60: 2115–2118

    Google Scholar 

  • Furuya T, Yoshikawa T, Ishii T & Kajii K (1983) Regulation of saponin production in callus cultures of Panax ginseng. Planta Med. 47: 200–203

    Google Scholar 

  • Gamborg OL, Miller RA & Ojima K (1968) Nutrient requirements of suspension cultures of soybean root cell. Expt. Cell Res. 50: 151–158

    Google Scholar 

  • Gibson DM, Ketchum REB, Vance NC & Christen AA (1993) Initiation and growth of cell lines of Taxus brevifolia (Pacific yew). Plant Cell Rep. 12: 479–482

    Google Scholar 

  • Gibson DM, Ketchum REB, Hirasuna TJ & Shuler ML (1995) Potential of plant cell culture for taxane production. In: Suffness M (ed) Taxol Science and Applications (pp 71–95). CRC Press, Boca Raton, New York, London, Tokyo

    Google Scholar 

  • Grothaus PG, Raybould TJG, Bignami GS, Lazo CB & Byrnes JB (1993) An enzyme immunoassay for the determination of taxol and taxanes in Taxus sp. tissues and human plasma. Journal of Immunological Methods 158: 5–15

    Google Scholar 

  • Grothaus PG, Bignami GS, O'Malley S, Harada KE, Byrnes JB, Waller DF & Raybould TJG (1995) Taxane-specific monoclonal antibodies: measurement of taxol, baccatin III, and ‘total taxanes’ in Taxus brevifolia extracts by enzyme immunoassay. J. Nat. Prod. 58: 1003–1014

    Google Scholar 

  • Guo Y (1995) The combination of phytochemical and biochemical methods: a new concept to the identification of bioactive constituents from plants; application to the study of taxoids from Taxus baccata L. and Torreya nucifera Sieb. & Zucc. Thesis Free University of Brussels

  • Guo YW, Jaziri M, Diallo B, Vanhaelen_Fastré R, Zhiri A, Vanhaelen M Homès J & Bombardelli E (1994) Immunological detection and quantitation of 10-deacetylbaccatin III in Taxus sp. plant and tissue cultures. Biol. Chem. Hoppe-Seyler 375: 281–287

    Google Scholar 

  • Guo YW, Vanhaelen-Fastré R, Diallo B, Vanhaelen M, Jaziri M, Homès J & Ottinger R (1985) Immunoenzymatic methods applied to the search for bioactive taxoids from Taxus baccata. J. Nat. Prod. 58: 1015–1023.

    Google Scholar 

  • Guo YW, Diallo B, Jaziri M, Vanhaelen-Fastré R, Vanhaelen M & Ottinger R (1996a) Immunological detection and isolation of a new taxoid from the stem bark of Taxus baccata L. cv.stricta. J. Nat. Prod. (in press)

  • Guo YW, Diallo B, Jaziri M, Vanhaelen-Fastré R, Vanhaelen M & Ottinger R (1996b) Two new taxoids from the stem bark of Taxus baccata. J. Nat. Prod. (in press)

  • Han KH, Fleming P, Walker K, Loper M, Chilton WS, Mocek U, Gordon MP & Floss HG (1994) Genetic transformation of mature Taxus: an approach to genetically control the in vitro production of the anticancer drug, taxol. Plant Science 95: 187–196

    Google Scholar 

  • Hirasuma TJ, Pestchanker LJ, Srinivasan V & Shuler ML (1996) Taxol production in suspension cultures of Taxus baccata. Plant Cell Tiss. Org. Cult. 44: 95–102

    Google Scholar 

  • Holmes FA, Walters RS & Theriault RL (1991) Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst. 83: 1795–1805

    Google Scholar 

  • Holton R A, Somoza C, Kim HB, Liang F, Biediger RJ, Boatman PD, Shindo MS, Mith CC & Kim SC (1994a) First total synthesis of taxol. 1. J. Am. Chem. Soc. 116: 1597–1598

    Google Scholar 

  • Holton RA, Kim HB, Somoza C, Liang F, Biediger RJ, Boatman PD, Shindo MS, Mith CC & Kim SC (1994b) Frist total synthesis of taxol. 2. Completion of the C and D rings. J. Am. Chem. Soc. 116: 1599–1600

    Google Scholar 

  • Hu C-Y, Wang L & Wu B (1992) In vitro culture of immature Taxus embryos. HortScience 27: 698

    Google Scholar 

  • Jaziri M, Diallo B, Vanhaelen M, Vanhaelen-Fastré R, Zhiri A, Beau A & Homès J (1991) Enzyme-linked immunosorbent assay for the detection and the semi-quantitative determination of taxane diterpenoids related to taxol in Taxus sp. and tissue cultures. J. Pharm. Belg. 46: 93–99

    Google Scholar 

  • Jaziri M, Vanhaelen-Fastré R, Diallo B, Guo YW, Homès J & Vanhaelen M 1994 Combined chromatographic and immunoenzymatic methods for the detection and the isolation of bioactive taxoids from Taxus baccata. Pharmacy World & Science Suppl. 16 (p. 10)

  • Ketchum REB & Gibson DM (1993) Rapid isocratic reverse phase HPLC of taxanes on new columns developped specifically for taxol analysis. J. Liq. Chromatogr. 16: 2519–2530

    Google Scholar 

  • Ketchum REB, Gibson DM & Gallo LG (1995) Media optimization for maximum biomass production in cell cultures of pacific yew. Plant Cell Tiss. Org. Cult. 42: 185–193

    Google Scholar 

  • Ketchum REB & Gibson DM (1996) Paclitaxel production in suspension cell cultures of Taxus. Plant Cell Tiss. Org. Cult. (in press)

  • Kim JH, Yun JH, Hwang YS, Byun SY & Kim DI (1995) Production of taxol and related taxanes in Taxus brevifolia cell cultures: effect of sugar. Biotech. Lett. 17: 101–106

    Google Scholar 

  • Kingston DGI (1991) The chemistry of taxol. Pharm. Ther. 52: 1–34

    Google Scholar 

  • Kuda Kasseril GJ, Lam L & Staba EJ (1987) Effect of sterol inhibitors on the incorporation of 14C-isopentyl pyrophosphate into artemisinin by a cell-free system from Artemisia annua tissue cultures and plant. Planta Med. 3: 280–284.

    Google Scholar 

  • Larue CD (1953) Studies on growth and regeneration in gametophytes arid sporophytes of Gymnosperms. In: Abnormal and pathological plant growth. Report of symposium held August 3–5, 1953. Brookhaven National Laboratory, Upton, New York (pp: 187–208)

    Google Scholar 

  • Lavelle F, Guéritte-Voegelein F & Guénard D (1993) Le taxotère: des aiguilles d'if à la clinique. Bull. Cancer 80: 326–338

    Google Scholar 

  • Lee BS & Son SH (1995) A method for producing taxol and taxanes from embryo cultures of Taxus species. WO Patent No 95/02063

  • LePage-Degivry MT (1970) Physiologie végétale. Acide abscissique et dormance chez les embryons de Taxus baccata L. C. R. Acad. Sc. Paris 271: 482–484

    Google Scholar 

  • LePage-Degivry MT & Garello G (1973) La dormance embryonnaire chez Taxus baccata Influence de la composition du milieu liquide sur l'induction de la germination. Physiol. Plant 29: 204–207

    Google Scholar 

  • LePage-Degivry MT (1973a) Influence de l'acide absicissique sur le développement des embryons de Taxus baccata L. cultivés in vitro. Zeitschrift für Pflanzenphysiologie 70: 406–413

    Google Scholar 

  • LePage-Degivry MT (1973b) Physiologie végétale. Intervention d'un inhibiteur lié dans la dormance embryonnaire de Taxus baccata L. C. R. Acad. Sc. Paris 77: 177–180

    Google Scholar 

  • Leu JG, Chen BX, Schiff PB & Erlanger BF (1993a) Characterization of polyclonal and Monoclonal anti-taxol antibodies and measurement of taxol in serum. Cancer Research 53: 1388–1391

    Google Scholar 

  • Leu JG, Jech KS, Wheeler NC, Chen BX & Erlanger BF (1993b) Immunoassay of taxol and taxol-like compounds in plant extracts. Life Sciences 53: 183–187

    Google Scholar 

  • Lloyd G & McCown BM (1981) Commercially-feasible microprop-agation of mountain laurel Kalmia latfolia by use of shoot tip culture. Inter. Plant. Prop. Soc. 30: 421–427

    Google Scholar 

  • Lucas H (1856) Ueber ein den blattern von Taxus baccata L. enthaltenes alkaloid (das taxin). Arch. Pharm. 85: 145–149.

    Google Scholar 

  • Luo SD, Ning BM, Ruan DC & Wang HY (1994) HPLC analysis of taxol and related compounds from Taxus and its related plants. J. Plant Resour. and Environ 3: 31–33

    Google Scholar 

  • Ma W, Park GL, Gomez GA, Nieder MH, Adams TL, Aynsley JS, Sahai OP, Smith RJ, Stahlhut RW & Hlands PJ (1994) New bioactive taxoids from cell cultures of Taxus baccata. J. Nat. Prod. 57: 116–122

    Google Scholar 

  • McGuire WP, Rowinsky EK, Rosenshein NB, Grumbine FC, Ettinger DS & Armstrong DK (1989) Taxol: a unique antineo-plastic agent significant activity in advanced ovarian epithelial neoplasmas. Ann. Intern. Med. 111: 273–279

    Google Scholar 

  • Miller RW, Powell RG & Smith CR (1981) Antileukemic alkaloids from Taxus wallichiana Zucc. J. Org. Chem. 46: 1469–1474

    Google Scholar 

  • Mirjalili N & Linden JC (1995) Gas phase composition effects on suspension cultures of Taxus cuspidata. Biotechnology and Bioengineering 48: 123–132

    Google Scholar 

  • Murashige T & Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15: 473–497

    Google Scholar 

  • Nicolaou KC, Dai WM & Guy RK (1994a) Chemistry and biology of Taxol. Angew. Chem. Int. Ed. Engl. 33: 15–44

    Google Scholar 

  • Nicolaou KC, Yang Z, Liu JJ, Ueno H, Natermet PG, Guy RK, Clalborne CF, Renaud J, Couladouros EA, Paulvannan K & Sorensen EJ (1994b) Total synthesis of taxol. Nature 367: 630–634

    Google Scholar 

  • Plaut-Carcasson Y (1994) Plant tissue culture method for taxol production. WO Patent N° 94/20606

  • Richheimer SL, Tinnersnerier DM & Timmons DW (1992) High performance liquid chromatographic assay of Taxol. Anal Chem. 64: 2323–2326

    Google Scholar 

  • Rohr R (1973a) Production de cals par les gamétophytes mâles de Taxus baccata L. cultivés sur un milieu artificiel. Etude en microscopie photonique et électronique. Caryologia 25: 177–189

    Google Scholar 

  • Rohr R (1973b) Cytologie végétale. Ultrastructure des spermatozoïdes de Taxus baccata L. obtenus à partir de cultures aseptiques de microspores sur un milieu artificiel. C. R, Acad. Sc. Paris 277: 1869–1871

    Google Scholar 

  • Rohr R (1982) Activation et prolifération des cellules du mégagamétophyte de Taxus cultivé in vitro. Can. J. Bot. 60: 1583–1589

    Google Scholar 

  • Russin WA, Ellis DD, Gottwald JR, Zelden EL, Brodhagen M & Evert F (1995) Immunocytochemical localization of taxol in Taxus cuspidata. Int. J. Plant Sci 156: 668–678

    Google Scholar 

  • Russin WA, Ellis DD, Zeldin EL & Evert RF (1992) Cytological and immunochemical analysis of Taxus tissues. (Abstract). Second National Cancer Institute Workshop on Taxol and Taxus. Alexandria VA Sept. 23–24

  • Saito K, Ohashi H, Hibi M & Tahara M (1994) Process for producing taxol by cell culture of Taxus species. US Patent N° 5.312,740

  • Salandy A, Granfton L, Uddin MR & Shafi MI (1993) Establishing an embryogenic cell suspension culture system in Florida yew (Taxus floridana). In vitro Cell. Dev. Biol. 29: 75A

  • Schiff PB, Fant J & Horwitz SB (1979) Promotion of microtubule assembly in vitro by taxol. Nature 277: 665–667

    Google Scholar 

  • Shuler ML, Hirasuna TJ & Willard DM (1992) Kinetics of taxol production by tissue culture. In: Proc. Natl. Cancer Institute Workshop on Taxol and Taxus

  • Smith RJ (1994) Synthesis of taxanes in culture using pseudocallus cells. US Patent No 5,344,775

  • Song JI & Dumais MR (1991) From yew to us: the curious development of taxol. Jama 266: 1281

    Google Scholar 

  • Srinivasan V, Pestchanker L, Moser S, Hirasuna TJ, Taticek RA & Shuler ML (1995) Taxol-production in bioreactors: kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata. Biotechnology and Bioengi-neering 47: 666–676

    Google Scholar 

  • Steinfeld D (1992) Early lessons from propagating Pacific yew. Rocky Mountain Forest & Range. Expt. Sta. Tech. Res. Rept. 221

  • Stierle A, Strobel G & Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of pacific yew. Science 260: 214–216

    Google Scholar 

  • Stierle GA, Strobel G, Stierle D, Grothaus P & Bignami G (1995) The search for a taxol producing microorganism among the endophytic fungus of the Pacifc yew, Taxus brevifolia. J. Nat. Prod. 58: 1315–1324

    Google Scholar 

  • Strobel GA, Stierle A & Hess WM (1994) The stimulation of taxol production in Taxus brevifolia by various growth retardants. Plant Science 101: 115–124

    Google Scholar 

  • Strobel GA, Stierle A & vanKuijk FJGM (1992) Factors influencing the in vitro production of radiolabeled taxol by Pacific yew, Taxus brevifolia. Plant Science 84: 65–74

    Google Scholar 

  • Suffness M & Cordell GA (1985) In: Brossi A (ed) The alkaloids Vol 25 (pp 1–369). Academic Press

  • Suffness M & Wall ME (1995) Discovery and development of taxol. In: Suffness M (ed) Taxol: science and applications (pp 3–25). CRC, Boca Raton, FI

    Google Scholar 

  • Tubbing HJMM & McDowell B (1995) The yew story: past, present and future of an extraordinary tree. Taxane Journal 1: 14–20

    Google Scholar 

  • Tuleke W (1959) The pollen cultures of C.D. Larue: A tissue from the pollen of Taxus. Bull. Torrey Bot. Club 86: 283–289

    Google Scholar 

  • Vanhaelen-Fastré R, Diallo B, Jaziri M, Faes M-L, Homès J & Vanhaelen M (1992) High-speed countercurrent chromatography separation of taxol and related diterpenoids from Taxus baccata. J. Liq. Chromatogr. 15: 697–706

    Google Scholar 

  • Vidensek N, Lim P, Campbell A & Carlson C (1990) Taxol content in bark wood, root, leaf, twig and seedling from several Taxus species. J. Nat. Prod. 53: 1609–1610

    Google Scholar 

  • Wani MC, Taylor HL, Wall ME, Coggon P & McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. American Chem. Soc. 93: 2325–2327

    Google Scholar 

  • Wann SR & Goldner WR (1994) Induction of somatic embryogenesis in Taxus, and the production of taxane-ring containing alkaloids therefrom. WO Patent No 93/19585

  • Weerdenburg C, Falconer MM, Setterfield G & Seagull RW (1986) Effects of taxol on microtubule arrays in cultured higher plant cells. Cell Motil Cytoskeleton 6: 469–478

    Google Scholar 

  • Wheeler NC, Jech K, Masters S, Brobst SW, Alvarado AB, Hoover AJ & Snader KM (1992) Effects of genetic, epigenetic and environmental factors on taxol content: in Taxus brevifolia and related species. J. Nat. Prod. 55: 432–440

    Google Scholar 

  • Wickremesinhe ERM & Arteca RN (1991) Habituated callus culture of Taxus media cv. Hicksii as a source of taxol. Plant Physiol. 96: 96

    Google Scholar 

  • Wickremesinhe ERM & Arteca RN (1993a) Methodology for the identification and purification of taxol and cephalomannine from Taxus callus culture. J. Liq. Chromatogr. 16: 3263–3274

    Google Scholar 

  • Wickremesinhe ERM & Arteca RN (1993b) Taxus callus cultures: initiation, growth optimization, characterization and taxol production. Plant Cell Tiss. Org. Cult. 35: 181–193

    Google Scholar 

  • Wickremesinhe ERM & Arteca RN (1994) Taxus cell suspension cultures: optimizing growth and production of taxol. J. Plant. Physiol. 44: 183–188

    Google Scholar 

  • Witherup KM, Look SA, Stasko MW, McCloud TG, Issaq HJ & Muchik GM (1989) HPLC separation of taxol and related compounds from Taxus brevifolia. J. Liq. Chromatogr. 12: 2117–2132

    Google Scholar 

  • Witherup KM, Look SA, Stasko MW, Ghiorzi TJ & Muschik GM (1990) Taxus spp. needles contain amount of taxol comparable to the bark of Taxus brevifolia: analysis and isolation. J. Nat. Prod. 53: 1249–1255

    Google Scholar 

  • Yukimune Y, Hara Y, Higashi Y, Ohnishi N, Tabata H,Suga C & Matsubara K (1995) Process for producing taxane diterpene and method of harvesting cultured cell capable of producing taxane diterpene in high yield. WO Patent No 95/1410.3

  • Zamir LO, Nedea ME & Gazneau FX (1992) Biosynthetic building blocks of Taxus canadensis taxanes. Tetrahedron Lett. 33: 5235–5236

    Google Scholar 

  • Zhiri, Jaziri M, Homès J, Vanhaelen M & Shimomura K (1994) Factors affecting the in vitro rapid germination of Taxus embryos and the evaluation of taxol content in the plantlets. Plant Cell Tiss. Org. Cult. 39: 261–263

    Google Scholar 

  • Zhiri A, Maciejewska K, Jaziri M, Homès J & Vanhaelen M (1995a) Establishment of Taxus baccata callus cultures and evaluation of taxoid production. Med. Fac. Lanbouww. Univ. Gent 60: 2111–2114

    Google Scholar 

  • Zhiri A, Jaziri M, Guo YW, Vanhaelen-Fastré R, Vanhaelen M, Homés J, Kayo Y & Shimomura K (1995b) Tissue cultures of Taxus baccata as a source of 10- deacetylbaceatin III, a precursor for the hemisynthesis of taxol. Biol. Chem. Hoppe-Soyler 376: 583–586

    Google Scholar 

  • Zhiri A, Jaziri M, Guo YW, Homès J & Vanhaelen M (1995c) Occurrence of 10- deacetylbaccatin III in Taxus callus cultures. Pharmacy World & Science 17: N14

Download references

Author information

Authors and Affiliations

  1. Laboratory of Plant Morphology, Université Libre de Bruxelles, Chaussée de Wavre 1850, B-1160, Brussels, Belgium

    Mondher Jaziri, Abdesslam Zhiri, Jean-Pierre Dupont & Jacques Homès

  2. Laboratory of Pharmacognosy and Bromatology, Université Libre de Bruxelles, Campus Plaine CP205/4, Bld. Triomphe, B-1150, Brussels, Belgium

    Yan-Wen Guo & Maurice Vanhaelen

  3. Tsukuba medicinal Plant Research Station, National Institute of Health Sciences, 1 Hachimandai, 305, Tsukuba, Ibaraki, Japan

    Koichiro Shimomura

  4. Department of Applied Science, Okayama University of Science, 1-1 Radai-cho, 700, Okayama, Japan

    Hiroki Hamada

Authors
  1. Mondher Jaziri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abdesslam Zhiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yan-Wen Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jean-Pierre Dupont
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Koichiro Shimomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroki Hamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maurice Vanhaelen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jacques Homès
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jaziri, M., Zhiri, A., Guo, YW. et al. Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: a literature survey. Plant Cell Tiss Organ Cult 46, 59–75 (1996). https://doi.org/10.1007/BF00039697

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00039697

Key words

Search

Navigation