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Polymers as Biomaterials for Tissue Engineering and Controlled Drug Delivery

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Tissue Engineering I

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 102))

Abstract

The advent of biodegradable polymers has significantly influenced the development and rapid growth of various technologies in modern medicine. Biodegradable polymers are mainly used where the transient existence of materials is required and they find applications as sutures, scaffolds for tissue regeneration, tissue adhesives, hemostats, and transient barriers for tissue adhesion, as well as drug delivery systems. Each of these applications demands materials with unique physical, chemical, biological, and biomechanical properties to provide efficient therapy. Consequently, a wide range of degradable polymers, both natural and synthetic, have been investigated for these applications. Furthermore, recent advances in molecular and cellular biology, coupled with the development of novel biotechnological drugs, necessitate the modification of existing polymers or synthesis of novel polymers for specific applications. This review highlights various biodegradable polymeric materials currently investigated for use in two key medical applications: drug delivery and tissue engineering.

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References

  1. Williams DF (1999) The Williams dictionary of biomaterials. Liverpool University Press, Liverpool

    Google Scholar 

  2. Barbucci R (ed) (2002) Integrated biomaterial science. Kluwer=Plenum, New York

    Google Scholar 

  3. Castner DG, Ratner BD (2002) Surf Sci 500:28

    CAS  Google Scholar 

  4. Okada M (2002) Prog Polym Sci 27:87

    CAS  Google Scholar 

  5. Kulkarni RK, Moore EG, Hegyeli AF, Leonard F (1971) J Biomed Mater Res 5:169

    CAS  Google Scholar 

  6. Kricheldorf HR, Kreiser-Sauders (1990) J Macromol Chem 191:1057

    CAS  Google Scholar 

  7. Jedlinski Z, Walach W, Kurcok P, Adamus G (1991) Macromol Chem 192:2051

    CAS  Google Scholar 

  8. Kricheldorf HR (2001) Chemosphere 43:49

    CAS  Google Scholar 

  9. Bhaw-Luximon A, Jhurry D, Spassky N, Pensec S, Belleney J (2001) Polymer 42:9651

    CAS  Google Scholar 

  10. Kricheldorf HR, Langanke D (2002) Polymer 43:1973

    CAS  Google Scholar 

  11. Middleton JC, Tipton AJ (2000) Biomaterials 21:2335

    CAS  Google Scholar 

  12. Katz AR, Tumer RJ (1970) Surg Gynecol Obstet 131:701

    CAS  Google Scholar 

  13. Ueda H, Tabata Y (2003) Adv Drug Deliv Rev 55:501

    CAS  Google Scholar 

  14. Griffith LG (2000) Acta Mater 48:263

    CAS  Google Scholar 

  15. Lewis OG, Gabisial W (1997) Sutures. In: Kirk–Othmer encyclopedia of chemical technology, 4th edn. Wiley, New York

    Google Scholar 

  16. Cao X, Schoichet MS (1999) Biomaterials 20:329

    CAS  Google Scholar 

  17. Zhu G, Mallery SR, Schwendeman SP (2000) Nat Biotechnol 18:52

    CAS  Google Scholar 

  18. Sabino MA, Gonzalez S, Marquez L, Feijoo JL (2000) Polym Degrad Stab 69:209

    CAS  Google Scholar 

  19. Cai Q, Bei J, Wang S (2002) Polymer 43:3585

    CAS  Google Scholar 

  20. Jeong JH, Lim DW, Han DK, Park TG (2000) Colloids Surf B Biointerfaces 18:371

    CAS  Google Scholar 

  21. Radder AM, Leenders H, van Blitterswijk CA (1996) J Biomed Mater Res 30:341

    CAS  Google Scholar 

  22. Bezemer JM, Grijpma DW, Dijkstra PJ, van Blitterswijk CA, Feijen J (2000) J Control Release 66:307

    CAS  Google Scholar 

  23. Schappacher M, Fabre T, Mingotaud AF, Soum A (2001) Biomaterials 22:2849

    CAS  Google Scholar 

  24. Arvanitoyannis I, Nakayama A, Kawasaki N, Yamamoto N (1994) Angew Makromol Chem 222:111

    CAS  Google Scholar 

  25. Barrows TH (1994) In: Shalaby SE (ed) Biomedical polymers designed to degrade systems. Hanser, Munich, pp 97–116

    Google Scholar 

  26. Edlund U, ALbertsson AC (2003) Adv Drug Deliv Rev 55:585

    CAS  Google Scholar 

  27. Ho LH, Huang SJ (1992) Polymer Prepr 33:94

    CAS  Google Scholar 

  28. Story RF, Hickey TP (1994) Polymer 35:830

    Google Scholar 

  29. Saad B, Hirt TD, Welti M, Uhlscgmid GK, Neuenschwander P, Suter UW (1997) J Biomed Mater Res 36:65

    CAS  Google Scholar 

  30. Timmer MD, Ambrose CG, Mikos AG (2003) Biomaterials 24:571

    CAS  Google Scholar 

  31. Payne RG, McGonigle JS, Yaszemski MJ, Yasko AW, Mikos AG (2002) Biomaterials 23:4381

    CAS  Google Scholar 

  32. Heller J, Barr J, Ng SY, Abdellauoi KS, Gurny R (2002) Adv Drug Deliv Rev 54:1015

    CAS  Google Scholar 

  33. Heller J, Barr J, Ng SY, Shen HR, Schwach-Abdellaou K, Emmah S, Rothen-Weinhold A, Gurny R (2000) Eur J Pharm Biopharm 50:121

    CAS  Google Scholar 

  34. Heller J, Penhale DWH, Helwing RF (1980) J Polym Sci Polym Lett 18:82

    Google Scholar 

  35. Ng SY, Vandamme T, Taylor MS, Heller J (1997) Macromolecules 30:770

    CAS  Google Scholar 

  36. Bucher JE, Slade WC (1909) J Am Chem Soc 31:1319

    Google Scholar 

  37. Hill JW, Carothers HW (1932) J Am Chem Soc 54:5169

    Google Scholar 

  38. Conix A (1958) J Polym Sci A 29:343

    CAS  Google Scholar 

  39. Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R (1983) Biomaterials 4:131

    CAS  Google Scholar 

  40. Kumar N, Langer RS, Domb AJ (2002) Adv Drug Deliv Rev 54:889

    CAS  Google Scholar 

  41. Gopferich A, Tessmar J (2002) Adv Drug Deliv Rev 54:911

    CAS  Google Scholar 

  42. Laurencin CT, Domb A, Morris C, Brown V, Chasin M, McConnell R, Lange N, Langer R (1990) J Biomed Mater Res 24:1463

    CAS  Google Scholar 

  43. Uhrich KE, Ibim SEM, Larrier DR, Langer R, Laurencin CT (1998) Biomaterials 19:2045

    CAS  Google Scholar 

  44. Attawia MA, Uhrich KE, Botchwey E, Langer R, Laurencin CT (1996) J Orthop Res 14:445

    CAS  Google Scholar 

  45. Attawia MA, Uhrich KE, Botchwey E, Fan M, Langer R, Laurencin CT (1995) J Biomed Mater Res 29:1233

    CAS  Google Scholar 

  46. Jiang HL, Zhu KJ (2001) Biomaterials 22:211

    CAS  Google Scholar 

  47. Lherm C, Moiler RH, Puizieux F, Couvreur P (1992) Int J Pharm 84:13

    CAS  Google Scholar 

  48. Harmia T, Kreuter J, Speiser P, Boye T, Gurny R, Kubi A (1986) Int J Pharm 33:187

    CAS  Google Scholar 

  49. Spotnitz WD, Burks S, Mercer D (2002) Clinical indications for surgical tissue adhesives. In: Lewandrowski K-U et al. (eds) Tissue engineering and biodegradable equivalents: scientific and clinical applications. Marcel Dekker, New York, p 651

    Google Scholar 

  50. Anderson JM, Spilizewski KL, Hiltner K (1985) Poly(α-amino acids as biomedical polymers. In: Williams DF (ed) Biocompatibility of tissue analogs, vol I. CRC, Boca Raton, p 55

    Google Scholar 

  51. Bourke SL, Kohn J (2003) Adv Drug Deliv Rev 55:447

    CAS  Google Scholar 

  52. Kohn J, Langer R (1984) A new approach to the development of bioerodible polymers for controlled release applications employing naturally occurring amino acids. In: Polymeric materials, science and engineering, vol 51. American Chemical Society, Washington, DC, pp 119–121

    Google Scholar 

  53. Ertel SI, Kohn J (1994) J Biomed Mater Res 28:919

    CAS  Google Scholar 

  54. James K, Levene H, Parsons JR, Kohn J (1999) Biomaterials 20:2203

    CAS  Google Scholar 

  55. Choueka J Charvet JL, Koval KJ, Alexander H, James KS, Hooper KA, Kohn J (1996) J Biomed Mater Res 31:35

    CAS  Google Scholar 

  56. Pulapura S, Li C, Kohn J (1990) Biomaterials 11:666

    CAS  Google Scholar 

  57. Allcock HR, Kugel RL (1965) J Am Chem Soc 87:4216

    CAS  Google Scholar 

  58. Allcock HR, Connolly MS, Sisko JT, Al-Shali S (1988) Macromolecules 21:323

    CAS  Google Scholar 

  59. Scopelianos AG (1994) Polyphosphazenes as new biomaterials. In: Shalaby SW (ed) Biomedical polymers designed-to-degrade systems. Hanser, New York p 153

    Google Scholar 

  60. Laurencin CT, Norman ME, Elgendy HM, El-Amin SF, Allcock HR, Puscher SR, Ambrosio AA (1993) J Biomed Mater Res 27:963

    CAS  Google Scholar 

  61. Laurenicin CT, Ambrosio AMA, Bauer TW, Allcock HR, Attawia MA, Borden MD, Gorum WJ, Frank D (1998) The biocompatibility of polyphophazenes: evaluation in bone. Society for Biomaterials, 24th annual meeting in conjuction with 30th international symposium, April 22–26 1998, San Diego

    Google Scholar 

  62. Laurencin CT, El-Amin SF, Ibim SE, Willoughby DA, Attawia M, Allcock HR, Ambrosio AA (1996) J Biomed Mater Res 30:133

    CAS  Google Scholar 

  63. Langone F, Lora S, Veronese FM, Calceti P, Parnigotto PP, Valenti F, Palma G (1995) Biomaterials 16:347

    CAS  Google Scholar 

  64. Veronese FM, Marsilio F, Lora S, Caliceti P, Passi P, Orsolini P (1999) Biomaterials 20:91

    CAS  Google Scholar 

  65. Andrianov AK, Payne LG (1998) Adv Drug Deliv Rev 31:185

    CAS  Google Scholar 

  66. Lakshmi S, Katti DS, Laurencin CT (2003) Adv Drug Deliv Rev 55:467

    CAS  Google Scholar 

  67. Penczek S, Dida K, Kaluzynski G, Lapienis A, Nyk R, Szymanski R (1993) Makromol Chem Makromol Symp 73:91

    CAS  Google Scholar 

  68. Mao HQ, Shipanova-Kadiyaia I, Zhao Z, Dang W, Leong KW (1999) Biodegradable polymers: polyphosphoesters. In: Mathiowitz E (ed) Encyclopaedia of controlled drug delivery. Wiley, New York, p 45

    Google Scholar 

  69. Zhao Z, Wang J, Mao H, Leong KW (2003) Adv Drug Deliv Rev 55:483

    CAS  Google Scholar 

  70. Baeyer H, Lajous-Petter A, Debrandt W, Hampl H, Kochinke F, Herbst R (1988) J Membrane Sci 36:215

    Google Scholar 

  71. Hou KC, Zaniewski R, Roy S (1991) Biotechnol Appl Biochem 13:257

    CAS  Google Scholar 

  72. Swarbrick J, Boyan HC (1991) Gels and jellies. In: Encyclopedia of pharmaceutical technology, vol 6. Marcel Dekker, New York, p 415

    Google Scholar 

  73. Marques AP, Reis RL, Hunt JA (2002) Biomaterials 23:1471

    CAS  Google Scholar 

  74. Illum L, Fisher AN, Jabbal-Gill I, Davis SS (2001) Int J Pharm 222:109

    CAS  Google Scholar 

  75. Salgado AJ, Gomes ME, Chou A, Coutinho OP, Reis RL, Hutmacher DW (2002) Mater Sci Eng C 20:27

    Google Scholar 

  76. Horncastle J (1995) Med Device Technol 6:30

    CAS  Google Scholar 

  77. Mumper RJ, Huffman AS, Puolakkainen PA, Bouchard LS, Gombotz WR (1994) J Control Release 30:241

    CAS  Google Scholar 

  78. Gaserod O, Smidsrod O, Skjak-Braek G (1998) Biomaterials 19:1815

    CAS  Google Scholar 

  79. Awad HA, Erickson GR, Guilak F (2002) Material selection for engineering cartilage. In: Lewandrowski K-U et al. (eds) Tissue engineering and biodegradable equivalents: scientific and clinical applications. Marcel Dekker, New York, p 195

    Google Scholar 

  80. Lloyd LL, Kennedy JF, Methacanon P, Paterson M, Knill CJ (1998) Carbohydrate Polym 37:315

    CAS  Google Scholar 

  81. Williams D (1997) Med Device Technol 8:8

    Google Scholar 

  82. Khor E, Lim LY (2003) Biomaterials 24:2339

    CAS  Google Scholar 

  83. Ishihara M, Nakanishi K, Ono K, Sato M, Kikuchi M, Saito Y, Yura H, Mutsui T, Hattori H, Uenoyama M, Kurita A (2002) Biomaterials 23:833

    CAS  Google Scholar 

  84. Mi FW, Wu YB, Shyu SS, Schoung JY, Huang YB, Tsai YH, Hao JY (2002) J Biomed Mater Res 59:438

    CAS  Google Scholar 

  85. Lahiji A, Sohrabi A, Hungerford DS, Frondoza CG (2000) J Biomed Mater Res 51:486

    Google Scholar 

  86. Friess W (1998) Eur J Pharm Biopharm 45:113

    CAS  Google Scholar 

  87. Othman MO, Quassem W, Shahalam AP (1996) Med Eng Phys 18:584

    CAS  Google Scholar 

  88. Kaufman HE, Steinemann TL, Lehman E, Thomposon HW, Varnell ED, Jacob-Labarre T, Gebhardt BM (1994) J Ocul Pharmacol 10:17

    CAS  Google Scholar 

  89. Nimni ME, Harkness RD (1988) Molecular structures and functions of collagen. In: Nimni ME (ed) Collagen vol I: biochemistry. CRC, Boca Raton p 1

    Google Scholar 

  90. Burke J, Yannas I, Quinby W, Bondoc C, Jung W (1981) Ann Surg 194:413

    CAS  Google Scholar 

  91. Royce PM, Kato T, Ohsaki K, Miura A (1995) J Dermatol Sci 10:42

    CAS  Google Scholar 

  92. Sung HW, Huang DM, Chang WH, Huang LL, Tsai CC, Liang IL (1999) J Biomater Sci Polym Ed 10:751

    CAS  Google Scholar 

  93. Tabata Y, Ikada Y (1998) Adv Drug Deliv Rev 31:287

    CAS  Google Scholar 

  94. Tabata Y, Nagano A, Ikada Y (1999) Tissue Eng 5:127

    CAS  Google Scholar 

  95. Merodio M, Irache JM, Valamanesh F, Mirshahi M (2002) Biomaterials 23:1587

    CAS  Google Scholar 

  96. Reddy CSK, Ghai R, Rashmi Kalia VC (2003) Bioresour Technol 87:137

    CAS  Google Scholar 

  97. Madison LL, Huisman GW (1999) Microbiol Mol Biol Rev 63:21

    CAS  Google Scholar 

  98. Kassab AC, Xu K, Denkbas EB, Dou Y, Zhao S, Piskin E (1997) J Biomater Sci Polym Ed 8:947

    CAS  Google Scholar 

  99. Li C, Yu DF, Newman A, Cabral F, Stephens C, Hunter N, Milas L, Wallace S (1998) Cancer Res 58:2404

    CAS  Google Scholar 

  100. Otani Y, Tabata Y, Ikada Y (1998) Biomaterials 19:2167

    CAS  Google Scholar 

  101. Otani Y, Tabata Y, Ikada Y (1998) Biomaterials 19:2091

    CAS  Google Scholar 

  102. Choi HJ, Yang R, Kunioka M (1995) J Appl Polym Sci 58:807

    CAS  Google Scholar 

  103. Fuchs JR, Nasseri BA, Vacanti JP (2001) Ann Thorac Surg 72:577

    CAS  Google Scholar 

  104. Laurencin CT, Ambrosio AMA, Borden MD, Cooper JA (1999) Annu Rev Biomed Eng 1:9

    Google Scholar 

  105. Widmer MS, Mikos AG (1998) Fabrication of biodegradable polymer scaffolds for tissue engineering. In: Patrick CW, Mikos AG, Mcintire LV (eds) Frontiers in tissue engineering. Pergamon, Oxford, p 107

    Google Scholar 

  106. Katti DS, Laurencin CT (2003) Synthetic biomedical polymers for tissue engineering and drug delivery. In: Shonaike GO, Advani SG (eds) Advanced polymeric biomaterials. CRC, Boca Raton, p 479

    Google Scholar 

  107. Leong KF, Cheah CM, Chua CK (2003) Biomaterials 24:2363

    CAS  Google Scholar 

  108. Meyer U, Runte C, Dirksen D, Stamm T, Fillies T, Joos U, Wiesmann HP (2003) Int Congr Ser 1256:726

    Google Scholar 

  109. Holbrook KA, Wolff K (1993) The structure and development of skin. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds) Dermatology in general medicine. McGraw-Hill, New York, p 97

    Google Scholar 

  110. Lanza RP, Langer R, Vacanti J (2000) Principles of tissue engineering. Academic, New York

    Google Scholar 

  111. Falanga V, Margolis D, Alvarez O, Auletta M, Maggiacomo F, Altman M, Jensen J, Sabolinski M, Hardin-Young J (1998) Arch Dermatol 134:293

    CAS  Google Scholar 

  112. Langone F, Lora S, Veronese FM, Caliceti P, Parnigotto PP, Valenti F, Palma G (1995) Biomaterials 16:347

    CAS  Google Scholar 

  113. Yannas EV, Orgill DP, Silver J, Norregaard TV, Zervas NT, Schoene WC (1985) Trans Soc Biomater 11:146

    Google Scholar 

  114. Yu X, George P, Dillon GP, Bellamkonda RV (1999) Tissue Eng 5:291

    CAS  Google Scholar 

  115. Beaty CE, Saltzman M (1993) J Control Release 24:15

    CAS  Google Scholar 

  116. Plevris JN, Schina M, Haynes PC (1998) Aliment Pharmacol Ther 12:405

    CAS  Google Scholar 

  117. Langer R, Vacanti JP (1993) Science 260:920

    CAS  Google Scholar 

  118. Takeshita K, Bowen WC, Michalopoulos GK (1998) In Vitro Cell Dev Biol Anim 34:482

    CAS  Google Scholar 

  119. Gutomard C, Rialland L, Fremond B, Chesne C, Guillouzo A (1996) Toxicol Appl Pharmacol 141:349

    Google Scholar 

  120. Kawase M, Michibayashi N, Nakashima Y, Kurikawa N, Yagi K, Mizoguchi T (1997) Biol Pharm Bull 20:708

    CAS  Google Scholar 

  121. Griffith LG, Wu B, Cima MJ, Powers MJ, Chaignaur B, Vacanti JP (1997) Ann N Y Acad Sci 831:382

    CAS  Google Scholar 

  122. Takeda T, Kim TH, Lee SK, Langer R, Vacanti JP (1995) Transplant Proc 27:635

    CAS  Google Scholar 

  123. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG Langer R (1993) J Biomed Mater Res 27:11

    CAS  Google Scholar 

  124. Rorrer N, Aigner J, Naumann A, Planck H, Hammer C, Burmester G, Sittinger M (1998) J Biomed Mater Res 42:347

    Google Scholar 

  125. Niederauer GG, Slivka MA, Leatherbury NC, Korvick DL, Harroff HH, Ehler WC, Dunnn CJ, Kieswetter K (2000) Biomaterials 21:2561

    CAS  Google Scholar 

  126. Sims CD, Butler PE, Casanova R, Lee BT, Randolph MA, Lee WP, Vacanti CA, Yaremchuk MJ (1996) Plast Reconstruct Surg 98:843

    CAS  Google Scholar 

  127. Nehrer S, Breinan HA, Ramappa A, Hsu HP, Minas T, Shortkroff S, Sledge CB, Yannas IV, Spectro M (1998) Biomaterials 19:2313

    CAS  Google Scholar 

  128. Fragonas E, Valente M, Pozzi-Mucelli M, Toffanin R, Rizzo R, Silvestri F, Vittur F (2000) Biomaterials 21:795

    CAS  Google Scholar 

  129. Rahfoth B, Weisser J, Sternkopf F, Aigner T, von der Mark K, Brauer R (1998) Osteoarthr Cartil 6:50

    CAS  Google Scholar 

  130. Radice M, Brun P, Cortivo R, Scapinelli R, Battaliard C, Abatangelo G (2000) J Biomed Mater Res 50:101

    CAS  Google Scholar 

  131. Kokubo T, Kim HM, Kawashita M (2003) Biomaterials 24:2161

    CAS  Google Scholar 

  132. Elgendy HM, Norman ME, Keaton AR, Laurencin CT (1993) Biomaterials 14:263

    CAS  Google Scholar 

  133. Devin JE, Attawia MA, Laurencin CT (1996) J Biomater Sci Polym 7:661

    CAS  Google Scholar 

  134. Laurencin CT, Attawia MA, Elgendy HE, Herbert KM (1996) Bone 19:93S

    CAS  Google Scholar 

  135. Mooney DJ, Organ G, Vacanti JP, Langer R (1994) Cell Transplant 3:203

    CAS  Google Scholar 

  136. Borden M, Attawia M, Laurencin CT (2002) J Biomed Mater Res 61:421

    CAS  Google Scholar 

  137. Vozzi G, Flaim C, Ahluwalia A, Bhatia S (2003) Biomaterials 24:2533

    CAS  Google Scholar 

  138. Laurencin CT, Attawia MA, Lu LQ, Borden MD, Lu HH, Gorum WJ, Lieberman JR (2001) Biomaterials 22:1271

    CAS  Google Scholar 

  139. Ciapetti G, Ambrosio L, Savarino L, Granchi D, Cenni E, Baldini N, Pagani S, Guizzardi S, Causa F, Giunti A (2003) Biomaterials 24:3815

    CAS  Google Scholar 

  140. Anseth KS, Sastri VR, Langer R (1999) Nat Biotech 17:156

    CAS  Google Scholar 

  141. Staubli A, Mathiowitz E, Langer R (1991) Macromolecules 24:2291

    CAS  Google Scholar 

  142. Staubli A, Mathiowitz E, Lucarelli M, Langer R (1991) Macromolecules 24:2283

    CAS  Google Scholar 

  143. Attawia MA, Uhrich KE, Botchwey E, Fan M, Langer R, Laurencin CT (1995) J Biomed Mater Res 29:1233

    CAS  Google Scholar 

  144. Attawia MA, Herbert KM, Uhrich KE, Langer R, Laurencin CT (1999) J Biomed Mater Res B Appl Biomater 48:322

    CAS  Google Scholar 

  145. Attawia MA, Uhrich KE, Botchwey E, Langer R (1996) J Orthop Res 14:445

    CAS  Google Scholar 

  146. Ibim SE, Uhrich KE, Attawia M, Shastri VR, El-Amin SF, Bronson R, Langer R, Laurencin CT (1998) J Biomed Mater Res 43:374

    CAS  Google Scholar 

  147. Leong KW, Langer R (1987) Adv Drug Deliv Rev 1:199

    Google Scholar 

  148. Langer R (1998) Nature 392:5

    CAS  Google Scholar 

  149. Nimni ME (1997) Biomaterials 18:1201

    CAS  Google Scholar 

  150. Robinson JR, Lee VHL (eds) Controlled drug delivery: fundamentals and applications, 2nd edn. Marcel Dekker, New York

    Google Scholar 

  151. Qiu Y, Park K (2001) Adv Drug Deliv Rev 53:321

    CAS  Google Scholar 

  152. Kikuchi A, Okano T (2002) Adv Drug Deliv Rev 54:53

    CAS  Google Scholar 

  153. Santini JT, Cima MJ, Langer R (1999) Nature 397:335

    CAS  Google Scholar 

  154. Domb AJ (ed) (1994) Polymeric site-specific pharmacotherapy. Wiley, Chichester

    Google Scholar 

  155. Leong KW, Langer R (1987) Adv Drug Deliv Rev 1:199

    Google Scholar 

  156. Dash AK, Cudworth GC (1998) J Pharmacol Toxicol Methods 40:1

    CAS  Google Scholar 

  157. Mathiowitz E (ed) (1999) Encyclopedia of controlled drug delivery, vols I & II. Wiley, New York

    Google Scholar 

  158. Bae YH, Kim SW (1998) Drug delivery. In: Patrick CW, Mikos AG, Mcintire LV (eds) Frontiers in tissue engineering. Pergamon, Oxford, p 261

    Google Scholar 

  159. Langer R (1983) Pharmacol Ther 21:35

    CAS  Google Scholar 

  160. Vert M, Schwach G, Engel R, Coudane J (1998) J Control Release 53:85

    CAS  Google Scholar 

  161. Yolles S, Eldridge JE, Wodland JHR (1970) Polymer News 1:9

    Google Scholar 

  162. Lewis DH (1990) Controlled release of bioactive agents from lactide=glycolide polymers. In: Chasin M, Langer R (eds) Biodegradable polymers as drug delivery systems. Marcel Dekker, New York, pp 1–42

    Google Scholar 

  163. Arshady R (ed) (1999) Microspheres, microcapsules and liposomes, vol I. Preparation and chemical applications. Citrus, London

    Google Scholar 

  164. O'Donnell PB, McGinity JW (1997) Adv Drug Deliv Rev 28:25

    Google Scholar 

  165. Grattard N, Pernin M, Marty B, Roudaut G, Champion D, Le Meste M (2002) J Control Release 84:125

    CAS  Google Scholar 

  166. Caliceti P, Veronese FM, Lora S (2000) Int J Pharm 211:57

    CAS  Google Scholar 

  167. Jalil R, Nixon JR (1990) J Microencapsul 7:297

    CAS  Google Scholar 

  168. Iwata M, McGinity JW (1992) J Microencapsul 9:201

    CAS  Google Scholar 

  169. Arshady R (ed) (1999) Microspheres, microcapsules and liposomes, vol II. Medical and biotechnology applications. Citrus, London

    Google Scholar 

  170. Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S (1989) Int J Pharm 55:R1

    CAS  Google Scholar 

  171. Lu Z, Jianzhong B, Wang S (1999) J Control Release 61:107

    CAS  Google Scholar 

  172. Panyam J, Labhasetwar V (2003) Adv Drug Deliv Rev 55:329

    CAS  Google Scholar 

  173. Blanco MD, Bernardo MV, Sastre RL, Olmo R, Muniz E, Teijon JM (2003) Eur J Pharm Biopharm 55:229

    CAS  Google Scholar 

  174. Heller J, Barr J, Ng S, Shen HR, Gurny R, Schwach-Abdelaouo K, Rothen-Weinhold A, van de Weert M (2002) J Control Release 78:133

    CAS  Google Scholar 

  175. Heller J, Barr J, Ng SY, Schwach-Abdelaouo K, Gurny R, Vivien-Castioni N, Loup PJ, Baehni P, Momb A (2002) Biomaterials 23:4397

    CAS  Google Scholar 

  176. Mathiowitz E, Langer R (1987) J Control Release 5:13

    CAS  Google Scholar 

  177. Attawia MA, Borden MD, Herbert KM, Katti DS, Asrari F, Uhrich KE, Laurencin CT (2001) J Control Release 71:193

    CAS  Google Scholar 

  178. Li LC, Deng J, Stephens D (2002) Adv Drug Deliv Rev 54:963

    Google Scholar 

  179. Vauthier C, Dubernet C, Fattal E, Pinto-Alphandary H, Couvreur P (2003) Adv Drug Deliv Rev 55:519

    CAS  Google Scholar 

  180. Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Eur J Pharm Biopharm 50:27

    CAS  Google Scholar 

  181. Gibbs DA, Merrill EW, Smith KA, Balazs EA (1968) Biopolymers 6:777

    CAS  Google Scholar 

  182. Zhao L, Mitomo H, Nagasawa N, Yoshii F, Kume A (2003) Carbohydrate Polym 51:169

    CAS  Google Scholar 

  183. Park YD, Tirelli N, Hubbell JA (2003) Biomaterials 24:893

    CAS  Google Scholar 

  184. Forse RA, Mass B (1995) US Patent 005,403,590

    Google Scholar 

  185. Qiu LY, Zhu KJ (2001) Int J Pharm 219:151

    CAS  Google Scholar 

  186. Peppas NA (1991) J Bioact Compat Polym 6:241

    CAS  Google Scholar 

  187. Scranton AB, Rangarajan B, Klier J (1995) Adv Polym Sci 120:1

    Google Scholar 

  188. Ohmine I, Tanaka T (1992) J Chem Phys 77:5725

    Google Scholar 

  189. Jeong B, Bae YH, Kim SW (1999) Macromolecules 32:7064

    CAS  Google Scholar 

  190. Song S, Lee SB, Jin J, Sohn YS (1999) Macromolecules 32:2188

    CAS  Google Scholar 

  191. Kodzwa MG, Staben ME, Rethwisch DG (1999) J Membrane Sci 158:85

    CAS  Google Scholar 

  192. Zrynyi M, Szabo D, Killian HG (1998) Polym Gels Networks 6:441

    Google Scholar 

  193. Lavon I, Kost J (1998) J Control Release 54:1

    CAS  Google Scholar 

  194. Hsu CS, Block LH (1996) Pharm Res 13:1865

    CAS  Google Scholar 

  195. Goldbart R, Kost J (1999) Pharm Res 16:1483

    CAS  Google Scholar 

  196. Makino K, Mack EJ, Okano T, Kim SW (1990) J Control Release 12:235

    CAS  Google Scholar 

  197. Yui N, Nihira J, Okano T, Sakurai Y (1993) J Control Release 25:133

    CAS  Google Scholar 

  198. Miyata T, Asami N, Uragami T (1999) Nature 399:766

    CAS  Google Scholar 

  199. Tanihara M, Suzuki Y, Nishimura Y, Suzuki K, Kakimaru Y, Fukunishi Y (1999) J Pharm Sci 88:510

    CAS  Google Scholar 

  200. Kaetsu I, Uchida K, Shindo H, Gomi S, Sutani K (1999) Radiat Phys Chem 55:193

    CAS  Google Scholar 

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Acknowledgments

The authors acknowledge NIH (Grant #46560) for financial assistance.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, College of Medicine, University of Virginia, 22903, Charlottesville, VA, USA

    Lakshmi S. Nair

  2. Department of Biomedical Engineering, University of Virginia, 22908, Charlottesville, VA, USA

    Cato T. Laurencin

  3. Department of Chemical Engineering, University of Virginia, 22904, Charlottesville, VA, USA

    Cato T. Laurencin

  4. The University of Virginia, 400 Ray C. Hunt Drive, Suite 330, 22903, Charlottesville, VA, USA

    Cato T. Laurencin

Authors
  1. Lakshmi S. Nair
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  2. Cato T. Laurencin
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Correspondence to Cato T. Laurencin .

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Kyongbum Lee David Kaplan

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© 2005 Springer-Verlag Berlin Heidelberg

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Nair, L.S., Laurencin, C.T. (2005). Polymers as Biomaterials for Tissue Engineering and Controlled Drug Delivery. In: Lee, K., Kaplan, D. (eds) Tissue Engineering I. Advances in Biochemical Engineering/Biotechnology, vol 102. Springer, Berlin, Heidelberg . https://doi.org/10.1007/b137240

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