Abstract
In this chapter, we focus on one of the most important applications of graphene-based nanomaterials—cancer diagnosis. Recently, there have been a lot of interest on how to use these nanomaterials and explore their properties—majorly optical properties in visualization and sensing of tumor cells. We start with a discussion about the origin of fluorescence in these quantum dots and how they are being engineered for our biological application. We further explore various modalities—contrast and Raman imaging—that are being used along with the optical properties to enhance the diagnosis with more sensitivity.
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References
Ajayan, P. M., et al. (2000). Single-walled carbon nanotube–polymer composites: Strength and weakness. Advanced Materials, 12(10), 750–753. https://doi.org/10.1002/(SICI)1521-4095(200005)12:10%3c750::AID-ADMA750%3e3.0.CO;2-6. (John Wiley & Sons, Ltd).
Ajayan, P. M., & Zhou, O. Z. (2001). Applications of carbon nanotubes. In M. S. Dresselhaus, G. Dresselhaus, & P. Avouris (Eds.) Carbon nanotubes: synthesis, structure, properties, and applications (pp. 391–425). Berlin, Heidelberg: Springer. https://doi.org/10.1007/3-540-39947-x_14.
Bartelmess, J., Quinn, S. J., & Giordani, S. (2015). Carbon nanomaterials: Multi-functional agents for biomedical fluorescence and Raman imaging. Chemical Society Reviews. https://doi.org/10.1039/C4CS00306C. (Royal Society of Chemistry).
Bhori, M., et al. (2020). Potential of graphene nano-dots in cellular imaging and Raman mapping. Nano. https://doi.org/10.1142/s1793292020500988. (World Scientific Publishing Co.).
Bolskar, R. D., et al. (2003). First soluble M@C60 derivatives provide enhanced access to metallofullerenes and permit in vivo evaluation of Gd@C60[C(COOH)2]10 as a MRI contrast agent. Journal of the American Chemical Society, 125(18), 5471–5478. https://doi.org/10.1021/ja0340984. (American Chemical Society).
Brooks, R. A., Moiny, F., & Gillis, P. (2001). On T2-shortening by weakly magnetized particles: The chemical exchange model. Magnetic Resonance in Medicine, 45(6), 1014–1020. https://doi.org/10.1002/mrm.1135.
Caravan, P., et al. (1999). Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications. Chemical Reviews, 99(9), 2293–2352. https://doi.org/10.1021/cr980440x. (American Chemical Society).
Chang, I. P., Hwang, K. C., & Chiang, C.-S. (2008). Preparation of fluorescent magnetic nanodiamonds and cellular imaging. Journal of the American Chemical Society, 130(46), 15476–15481. https://doi.org/10.1021/ja804253y. (American Chemical Society).
Chatterjee, N., Eom, H.-J., & Choi, J. (2014). A systems toxicology approach to the surface functionality control of graphene–cell interactions. Biomaterials, 35(4), 1109–1127. https://doi.org/10.1016/J.BIOMATERIALS.2013.09.108. (Elsevier).
Chaudhary, R. P., et al. (2017). Fe core-carbon shell nanoparticles as advanced MRI contrast enhancer. Journal of functional biomaterials, 8(4), 46. https://doi.org/10.3390/jfb8040046. (MDPI).
Chen, R. J., et al. (2003). Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proceedings of the National Academy of Sciences, 100(9), 4984–4989. https://doi.org/10.1073/pnas.0837064100.
Chen, H., et al. (2010). Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer. Nano Research, 3(12), 852–862. https://doi.org/10.1007/s12274-010-0056-y.
Chen, W., et al. (2011). Composites of Aminodextran-coated Fe3O4 nanoparticles and graphene oxide for cellular magnetic resonance imaging. ACS Applied Materials & Interfaces, 3(10), 4085–4091. https://doi.org/10.1021/am2009647. (American Chemical Society).
Chen, D., et al. (2017). In vivo targeting and positron emission tomography imaging of tumor with intrinsically radioactive metal-organic frameworks nanomaterials. ACS Nano, 11(4), 4315–4327. https://doi.org/10.1021/acsnano.7b01530. (American Chemical Society).
Cioffi, C. T., et al. (2009). A Carbon nano-onion-ferrocene donor-acceptor system: Synthesis, characterization and properties. Chemistry—A European Journal, 15, 4419–4427. https://doi.org/10.1002/chem.200801818.
Cong, H.-P., et al. (2010). Water-soluble magnetic-functionalized reduced graphene oxide sheets: In situ synthesis and magnetic resonance imaging applications. Small, 6(2), 169–173. https://doi.org/10.1002/smll.200901360. (John Wiley & Sons Ltd.).
Delhaye, M., & Dhamelincourt, P. (1975). Raman microprobe and microscope with laser excitation. Journal of Raman Spectroscopy, 3(1), 33–43. https://doi.org/10.1002/jrs.1250030105. (John Wiley & Sons Ltd.).
Du, F., et al. (2014). Economical and green synthesis of bagasse-derived fluorescent carbon dots for biomedical applications. Nanotechnology, 25, 315702. https://doi.org/10.1088/0957-4484/25/31/315702. (IOP Publishing).
Eatemadi, A., et al. (2014). Carbon nanotubes: Properties, synthesis, purification, and medical applications. Nanoscale Research Letters, 9(1), 393. https://doi.org/10.1186/1556-276X-9-393.
Ebbesen, T. W., & Ajayan, P. M. (1992). Large-scale synthesis of carbon nanotubes. Nature, 358(6383), 220–222. https://doi.org/10.1038/358220a0.
Ember, K. J. I., et al. (2017). Raman spectroscopy and regenerative medicine: A review. NPJ Regenerative Medicine, 2(1), 12. https://doi.org/10.1038/s41536-017-0014-3.
Ferrari, A. C., et al. (2006). Raman spectrum of graphene and graphene layers. Physical Review Letters, 97(18), 187401. https://doi.org/10.1103/PhysRevLett.97.187401. (American Physical Society).
Fred, H. L. (2004). Drawbacks and limitations of computed tomography: Views from a medical educator. Texas Heart Institute Journal, 31(4), 345–348. Available at: https://pubmed.ncbi.nlm.nih.gov/15745283.
Frisoli, J. K., & Ph, D. (no date). High-dose gadolinium.
Frush, D., & Ogden, K. (2008). Update course: Diagnostic radiology physics—From invisible to visible: The science and practice of X-ray imaging and radiation dose optimization.
Goldman, L. W. (2007). Principles of CT and CT technology. Journal of Nuclear Medicine Technology, 35(3), 115–128. https://doi.org/10.2967/jnmt.107.042978.
Haka, A. S., et al. (2005). Diagnosing breast cancer by using Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 102(35), 12371–12376. https://doi.org/10.1073/pnas.0501390102.
Haka, A. S., et al. (2006). In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy. Cancer Research, 66(6), 3317–3322. https://doi.org/10.1158/0008-5472.can-05-2815.
He, H., et al. (2013). Carbon NANOTUBES: Applications in Pharmacy and Medicine. In T. Noda (Ed.) BioMed Research International, Hindawi Publishing Corporation, p. 578290. https://doi.org/10.1155/2013/578290.
Hou, J., et al. (2013). A novel one-pot route for large-scale preparation of highly photoluminescent carbon quantum dots powders. Nanoscale, 5, 9558–9561. https://doi.org/10.1039/c3nr03444e.
Huda, W. (2014a). Kerma-Area Product in Diagnostic Radiology. American Roentgen Ray Society, 203(6), W565–W569. https://doi.org/10.2214/AJR.14.12513. (American Journal of Roentgenology).
Huda, W. (2014b). Understanding (and explaining) imaging performance metrics. American Journal of Roentgenology, 203(1), W1–W2. https://doi.org/10.2214/AJR.13.10827. (American Roentgen Ray Society).
Huda, W., & Abrahams, R. B. (2015). Radiographic techniques, contrast, and noise in X-ray imaging, pp. 126–131 (February). https://doi.org/10.2214/ajr.14.13116.
Iijima, S. (1991). Helical microtubules of graphitic carbon. Nature, 354(6348), 56–58. https://doi.org/10.1038/354056a0.
Jasonoff, A. (2006). Special feature—New technology for bioimaging with MRI. Asia-Pacific Biotech News, 10(06), 298–300. https://doi.org/10.1142/S021903030600036X. (World Scientific Publishing Co.).
Kato, H., et al. (2003). Lanthanoid endohedral metallofullerenols for MRI contrast agents. Journal of the American Chemical Society, 125(14), 4391–4397. https://doi.org/10.1021/ja027555+. (American Chemical Society).
Kerr, L. T., et al. (2016). Methodologies for bladder cancer detection with Raman based urine cytology. Analytical Methods, 8(25), 4991–5000. https://doi.org/10.1039/C5AY03300D. (The Royal Society of Chemistry).
Kim, D., et al. (2018). Recent development of inorganic nanoparticles for biomedical imaging. ACS Central Science. American Chemical Society, 4(3), 324–336. https://doi.org/10.1021/acscentsci.7b00574.
Krueger, A. (2008). New carbon materials: Biological applications of functionalized nanodiamond materials. Chemistry—A European Journal, 14, 1382–1390. https://doi.org/10.1002/chem.200700987.
Kumawat, M. K., Thakur, M., et al. (2017a). ‘Graphene quantum dots for cell proliferation, nucleus imaging, and photoluminescent sensing applications. Scientific Reports, 7(1), 15858. https://doi.org/10.1038/s41598-017-16025-w. (Springer, US).
Kumawat, M. K., Srivastava, R., et al. (2017b). Graphene quantum dots from mangifera indica: Application in near-infrared bioimaging and intracellular nanothermometry. ACS Sustainable Chemistry and Engineering, 5(2), 1382–1391. https://doi.org/10.1021/acssuschemeng.6b01893.
Lalwani, G., et al. (2014). Synthesis, characterization, in vitro phantom imaging, and cytotoxicity of a novel graphene-based multimodal magnetic resonance imaging—X-ray computed tomography contrast agent. Journal of materials chemistry. B, 2(22), 3519–3530. https://doi.org/10.1039/C4TB00326H.
Lee, N., Choi, S. H., & Hyeon, T. (2013). Nano-sized CT contrast agents. Advanced Materials, 25(19), 2641–2660. https://doi.org/10.1002/adma.201300081.
Lee, T., et al. (2017). Spatially resolved Raman spectroscopy of defects, strains, and strain fluctuations in domain structures of monolayer graphene. Scientific Reports, 7(1), 16681. https://doi.org/10.1038/s41598-017-16969-z.
Li, H., et al. (2012). Carbon nanodots: Synthesis, properties and applications. Journal of Materials Chemistry, 22(46). https://doi.org/10.1039/c2jm34690g.
Li, S., et al. (2015). Characterization and noninvasive diagnosis of bladder cancer with serum surface enhanced Raman spectroscopy and genetic algorithms. Scientific Reports, 5(1), 9582. https://doi.org/10.1038/srep09582.
Li, Q., Chen, B., & Xing, B. (2017). Aggregation kinetics and self-assembly mechanisms of graphene quantum dots in aqueous solutions: Cooperative effects of pH and electrolytes. Environmental Science & Technology, 51(3), 1364–1376. https://doi.org/10.1021/acs.est.6b04178. (American Chemical Society).
Lien, Z.-Y., et al. (2012). Cancer cell labeling and tracking using fluorescent and magnetic nanodiamond. Biomaterials, 33(26), 6172–6185. https://doi.org/10.1016/j.biomaterials.2012.05.009.
Luo, P. G., et al. (2013). Carbon “quantum” dots for optical bioimaging. Journal of Materials Chemistry B, 1(16), 2116–2127. https://doi.org/10.1039/c3tb00018d.
Ma, X., et al. (2012). A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging. Nano Research, 5(3), 199–212. https://doi.org/10.1007/s12274-012-0200-y.
Mahasin Alam, S.K., et al. (2014). Revealing the tunable photoluminescence properties of graphene quantum dots. Journal of Materials Chemistry C, 2(34), 6954–6960. https://doi.org/10.1039/c4tc01191k. (The Royal Society of Chemistry).
Manus, L. M., et al. (2010). Gd(III)-nanodiamond conjugates for MRI contrast enhancement. Nano Letters, 10(2), 484–489. https://doi.org/10.1021/nl903264h. (American Chemical Society).
McDonough, J., & Gogotsi, Y. (2013). Carbon onions: Synthesis and electrochemical applications. Electrochemical Society Interface, 22, 61–66.
McGregor, H. C., et al. (2017). Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection. Journal of Biophotonics, 10(1), 98–110. https://doi.org/10.1002/jbio.201500204. (John Wiley & Sons Ltd).
Mornet, S., et al. (2004). Magnetic nanoparticle design for medical diagnosis and therapy. Journal of Materials Chemistry, 14(14), 2161–2175. https://doi.org/10.1039/B402025A. (The Royal Society of Chemistry).
Mu, Q., et al. (2012). Size-dependent cell uptake of protein-coated graphene oxide nanosheets. ACS Applied Materials and Interfaces, 4(4), 2259–2266. https://doi.org/10.1021/am300253c. (American Chemical Society).
Oza, G., Oza, K., Pandey, S., Shinde, S., Mewada, A., Thakur, M., Sharon, M., & Sharon, M. (2015). A green route towards highly photoluminescent and cytocompatible carbon dot synthesis and its separation using sucrose density gradient centrifugation. Journal of Fluorescence, 25(1), 9–14. https://doi.org/10.1007/s10895-014-1477-x.
Padalkar, M. V., & Pleshko, N. (2015). Wavelength-dependent penetration depth of near infrared radiation into cartilage. The Analyst, 140(7), 2093–2100. https://doi.org/10.1039/c4an01987c.
Pan, B. D., et al. (2010). Hydrothermal route for cutting graphene sheets into blue-luminescent graphene quantum dots (pp. 734–738). https://doi.org/10.1002/adma.200902825.
Pan, J., et al. (2018). Gd3+ -doped MoSe2 nanosheets used as a theranostic agent for bimodal imaging and highly efficient photothermal cancer therapy. Biomaterials Science, 6(2), 372–387. https://doi.org/10.1039/C7BM00894E. (The Royal Society of Chemistry).
Pandey, S., et al. (2014). Synthesis of mesoporous silica oxide/C-dot complex (meso-SiO 2/C-dots) using pyrolysed rice husk and its application in bioimaging. RSC Advances, 4(3). https://doi.org/10.1039/c3ra45227a.
Pandey, S., Thakur, M., et al. (2013). Carbon dots functionalized gold nanorod mediated delivery of doxorubicin: Tri-functional nano-worms for drug delivery, photothermal therapy and bioimaging. Journal of Materials Chemistry B. https://doi.org/10.1039/c3tb20761g. (The Royal Society of Chemistry).
Pandey, S., Mewada, A., et al. (2013). Cysteamine hydrochloride protected carbon dots as a vehicle for the efficient release of the anti-schizophrenic drug haloperidol. RSC Advances, 3(48), 26290. https://doi.org/10.1039/c3ra42139b.
Puvvada, N., et al. (2012). Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications. Science and Technology of Advanced Materials, 13, 045008. https://doi.org/10.1088/1468-6996/13/4/045008.
Sandborg, M., et al. (1995). The physical performance of different X-ray contrast agents: Calculations using a Monte Carlo model of the imaging chain. Physics in Medicine and Biology, 40(7), 1209–1224. https://doi.org/10.1088/0031-9155/40/7/005. (IOP Publishing).
Servant, A., et al. (2016). Gadolinium-functionalised multi-walled carbon nanotubes as a T1 contrast agent for MRI cell labelling and tracking. Carbon, 97, 126–133. https://doi.org/10.1016/j.carbon.2015.08.051.
Shi, X., et al. (2013). Graphene-based magnetic plasmonic nanocomposite for dual bioimaging and photothermal therapy. Biomaterials, 34(20), 4786–4793. https://doi.org/10.1016/j.biomaterials.2013.03.023.
Shi, J., et al. (2014). A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging. Biomaterials, 35(22), 5847–5861. https://doi.org/10.1016/j.biomaterials.2014.03.042.
Shokrollahi, H. (2013). Contrast agents for MRI. Materials Science & Engineering C, 33(8), 4485–4497. https://doi.org/10.1016/j.msec.2013.07.012. (Elsevier B.V.).
Sinharay, S., & Pagel, M. D. (2016). Advances in magnetic resonance imaging contrast agents for biomarker detection. Annual Review of Analytical Chemistry. Annual Reviews, 9(1), 95–115. https://doi.org/10.1146/annurev-anchem-071015-041514.
Sitharaman, B., & Wilson, L. J. (2006). Gadonanotubes as new high-performance MRI contrast agents. International journal of nanomedicine. 1(3), 291–295. Available at: https://pubmed.ncbi.nlm.nih.gov/17717970. (Dove Medical Press).
Sonkar, S. K., et al. (2012). Water soluble carbon nano-onions from wood wool as growth promoters for gram plants. Nanoscale, 7670–7675. https://doi.org/10.1039/c2nr32408c.
Sun, H., et al. (2013a). The effects of composition and surface chemistry on the toxicity of quantum dots. Journal of Materials Chemistry B, 1, 6485–6494. https://doi.org/10.1039/C3TB21151G.
Sun, Y., et al. (2013b). Highly efficient enrichment of radionuclides on graphene oxide-supported polyaniline. Environmental Science & Technology, 47(17), 9904–9910. https://doi.org/10.1021/es401174n. (American Chemical Society).
Sun, B., Cui, R., Huang, H., & Guo, X. (2015). Novel Carbon Nanohybrids As Highly Efficient Magnetic Resonance Imaging Contrast Agents. (2015). ECS Meeting Abstracts. The Electrochemical Society. https://doi.org/10.1149/ma2015-01/7/816.
Sun, B., et al. (2017). In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy. Nano Research, 10(1), 37–48. https://doi.org/10.1007/s12274-016-1264-x.
Talapatra, S., et al. (2005). Irradiation-induced magnetism in carbon nanostructures. Physical Review Letters, 95(9), 97201. https://doi.org/10.1103/PhysRevLett.95.097201. (American Physical Society).
Tao, H., et al. (2012). In vivo NIR fluorescence imaging, biodistribution, and toxicology of photoluminescent carbon dots produced from carbon nanotubes and graphite. Small, 8(2), 281–290. https://doi.org/10.1002/smll.201101706. (Weinheim an der Bergstrasse, Germany).
Thakur, M., et al. (2014). Antibiotic conjugated fluorescent carbon dots as a theranostic agent for controlled drug release, bioimaging, and enhanced antimicrobial activity. Journal of drug delivery, 282193. https://doi.org/10.1155/2014/282193.
Thakur, M., et al. (2016). Milk-derived multi-fluorescent graphene quantum dot-based cancer theranostic system. Materials Science and Engineering C, 67. https://doi.org/10.1016/j.msec.2016.05.007.
Thomsen, H. S. (2007). ESUR guideline: gadolinium-based contrast media and nephrogenic systemic fibrosis. European Radiology, 17(10), 2692–2696. Available at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17977076.
Tian, P., et al. (2018). Graphene quantum dots from chemistry to applications. Materials Today Chemistry, 10, 221–258. https://doi.org/10.1016/J.MTCHEM.2018.09.007. Elsevier.
Tripathi, S. K., et al. (2013). Functionalized graphene oxide mediated nucleic acid delivery. Carbon, 51(1), 224–235. https://doi.org/10.1016/j.carbon.2012.08.047. Elsevier Ltd.
Wang, Y. ying, et al. (2008). Raman studies of monolayer graphene: The substrate effect. The Journal of Physical Chemistry C, 112(29), 10637–10640. https://doi.org/10.1021/jp8008404. (American Chemical Society).
Wang, X., et al. (2010). Bandgap-like strong fluorescence in functionalized carbon nanoparticles. Angewandte Chemie—International Edition, 49, 5310–5314. https://doi.org/10.1002/anie.201000982.
Xie, W., et al. (2018). Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics. Theranostics, 8(12), 3284–3307. https://doi.org/10.7150/thno.25220. (Ivyspring International Publisher).
Xu, X. et al. (2004). Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments (pp. 12736–12737).
Yan, Y., et al. (2019). Recent advances on graphene quantum dots: From chemistry and physics to applications. Advanced Materials, 31(21), 1808283. https://doi.org/10.1002/adma.201808283. (John Wiley & Sons Ltd).
Yang, K., et al. (2012). Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Advanced Materials, 24(14), 1868–1872. https://doi.org/10.1002/adma.201104964. (John Wiley & Sons Ltd).
Ye, R., et al. (2013). Coal as an abundant source of graphene quantum dots. Nature communications, 4, 2943. https://doi.org/10.1038/ncomms3943.
Yu, S.-B., & Watson, A. D. (1999). Metal-based x-ray contrast media. Chemical Reviews, 99(9), 2353–2378. https://doi.org/10.1021/cr980441p. (American Chemical Society).
Zhang, M., et al. (2013). Graphene oxide based theranostic platform for T1-weighted magnetic resonance imaging and drug delivery. ACS Applied Materials & Interfaces, 5(24), 13325–13332. https://doi.org/10.1021/am404292e. (American Chemical Society).
Zhang, H., et al. (2015). Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials, 42, 66–77. https://doi.org/10.1016/j.biomaterials.2014.11.055.
Zhang, B., et al. (2016). Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights. Advanced Drug Delivery Reviews, 105, 145–162. https://doi.org/10.1016/J.ADDR.2016.08.009. (Elsevier).
Zhang, Yixue, et al. (2017). Hydrophilic graphene oxide/bismuth selenide nanocomposites for CT imaging, photoacoustic imaging, and photothermal therapy. Journal of Materials Chemistry B, 5(9), 1846–1855. https://doi.org/10.1039/C6TB02137A. (The Royal Society of Chemistry).
Zhang, G., et al. (2018). A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy. Nanoscale, 10(1), 488–498. https://doi.org/10.1039/C7NR07957E. (The Royal Society of Chemistry).
Zhao, A., et al. (2015). Recent advances in bioapplications of C-dots. Carbon, 85, 309–327. https://doi.org/10.1016/j.carbon.2014.12.045. (Elsevier Ltd).
Zheng, X. T., et al. (2015). Glowing graphene quantum dots and carbon dots: Properties, syntheses, and biological applications. Small, 1620–1636. https://doi.org/10.1002/smll.201402648.
Zhou, J., et al. (2012). Facile synthesis of fluorescent carbon dots using watermelon peel as a carbon source. Materials Letters, 66(1), 222–224. https://doi.org/10.1016/j.matlet.2011.08.081. (Elsevier B.V.).
Zhou, C., Wang, J., & Szpunar, J. A. (2014). X-ray chemical imaging and the electronic structure of a single nanoplatelet Ni/graphene composite. Chemical Communications, 50(18), 2282–2285. https://doi.org/10.1039/C3CC47008C. (The Royal Society of Chemistry).
Zhu, S., et al. (2015). The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective. Nano Research, 8, 355–381. https://doi.org/10.1007/s12274-014-0644-3.
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Srivastava, R., Thakur, M., Kumawat, M.K., Bahadur, R. (2021). Graphene Nanomaterials for Multi-modal Bioimaging and Diagnosis of Cancer. In: Next Generation Graphene Nanomaterials for Cancer Theranostic Applications . Springer, Singapore. https://doi.org/10.1007/978-981-33-6303-8_4
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