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Genetic Architecture of Depression: Where Do We Stand Now?

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Major Depressive Disorder

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1305))

Abstract

The research of depression genetics has been occupied by historical candidate genes which were tested by candidate gene association studies. However, these studies were mostly not replicable. Thus, genetics of depression have remained elusive for a long time. As research moves from candidate gene association studies to GWAS, the hypothesis-free non-candidate gene association studies in genome-wide level, this trend will likely change. Despite the fact that the earlier GWAS of depression were not successful, the recent GWAS suggest robust findings for depression genetics. These altogether will catalyze a new wave of multidisciplinary research to pin down the neurobiology of depression.

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Abbreviations

5-HTTLPR:

Serotonin-transporter-linked polymorphic region

BDNF:

Brain-derived neurotrophic factor

COMT:

Catechol-O-methyltransferase

DSM-5:

Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition

GWAS:

Genome-wide association studies

LD:

Linkage disequilibrium

MAF:

Minor allele frequency

MD:

Major depression

PRS:

Polygenic risk score

RDoc:

research domain criteria

SNP:

Single-nucleotide polymorphism

TDT:

Transmission disequilibrium test

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Authors and Affiliations

  1. Psychology Program, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    Pinar Unal-Aydin & Orkun Aydin

  2. School of Advanced Studies, University of Tyumen, Tyumen, Russia

    Ayla Arslan

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Correspondence to Ayla Arslan .

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  1. Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Ansan, Korea (Republic of)

    Yong-Ku Kim

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Unal-Aydin, P., Aydin, O., Arslan, A. (2021). Genetic Architecture of Depression: Where Do We Stand Now?. In: Kim, YK. (eds) Major Depressive Disorder. Advances in Experimental Medicine and Biology, vol 1305. Springer, Singapore. https://doi.org/10.1007/978-981-33-6044-0_12

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