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Role of Co-stimulatory Molecules in T Helper Cell Differentiation

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Co-signal Molecules in T Cell Activation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1189))

Abstract

CD4+ T cells play a central role in orchestrating the immune response to a variety of pathogens but also regulate autoimmune responses, asthma, allergic responses, as well as tumor immunity. To cover this broad spectrum of responses, naïve CD4+ T cells differentiate into one of several lineages of T helper cells, including Th1, Th2, Th17, and TFH, as defined by their cytokine pattern and function. The fate decision of T helper cell differentiation integrates signals delivered through the T cell receptor, cytokine receptors, and the pattern of co-stimulatory signals received. In this review, we summarize the contribution of co-stimulatory and co-inhibitory receptors to the differentiation and maintenance of T helper cell responses.

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Acknowledgments

This work was supported by the Swiss National Science Foundation (PP00P3_150663 and PP00P3_ 181037 to N.J.), the European Research Council (677200 to N.J.), the Zuercher Universitaetsverein (ZUNIV-FAN to N.J.), the Olga Mayenfisch Stiftung (to N.J.), and the Novartis Foundation for medical-biological research (17A027 to N.J.).

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Authors and Affiliations

  1. Institute for Experimental Immunology, University of Zurich, Zurich, Switzerland

    Michelle Schorer & Nicole Joller

  2. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham & Women’s Hospital, Boston, MA, USA

    Vijay K. Kuchroo

  3. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Vijay K. Kuchroo

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  1. Michelle Schorer
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  2. Vijay K. Kuchroo
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  3. Nicole Joller
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Correspondence to Nicole Joller .

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Editors and Affiliations

  1. Department of Molecular Immunology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Miyuki Azuma

  2. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

    Hideo Yagita

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Schorer, M., Kuchroo, V.K., Joller, N. (2019). Role of Co-stimulatory Molecules in T Helper Cell Differentiation. In: Azuma, M., Yagita, H. (eds) Co-signal Molecules in T Cell Activation. Advances in Experimental Medicine and Biology, vol 1189. Springer, Singapore. https://doi.org/10.1007/978-981-32-9717-3_6

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