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Electrochemical DNA Biosensors Based on Carbon Nanomaterials

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Carbon Related Materials

Abstract

Nowadays, it has become clear that the critical demands of biosensor development can only be achieved with advanced nanoscale materials. The unique electronic and structural properties of carbon nanomaterials (CNs) and the recent advances in their design and synthesis methodology have enabled new high-performance electrochemical sensing platforms. Furthermore, the progress made towards the functionalization of these nanomaterials led to successful interfacing of biomolecules, such as DNA, and thus to an extensive development of CNs-based electrochemical DNA sensors. The transduction of DNA hybridization events into electrical signals has facilitated the development of rapid, highly sensitive, and highly specific sensing devices employed in important fields such as medical diagnosis, food analysis, and environmental monitoring. A broad range of CNs such as two-dimensional graphene, one-dimensional carbon nanotubes, and zero-dimensional graphene or carbon quantum dots are being explored for designing high-performance DNA-sensing devices. This chapter provides a comprehensive overview of the recent strategies for CNs incorporation into novel DNA-sensing schemes for medical, food, and environmental applications. Likewise, the issues required for an extensive implementation of CNs-based electrochemical DNA sensors in POC technology are critically presented.

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Acknowledgements

This work was supported by a grant of Ministry of Research and Innovation, CNCS—UEFISCDI, project number PN-III-P4-ID-PCE-2016-0629, within PNCDI III.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University “Politehnica” of Bucharest, 1-7 Polizu St, 011061, Bucharest, Romania

    Luisa Pilan

  2. “Costin Nenitzescu” Department of Organic Chemistry, University “Politehnica” of Bucharest, 1-7 Polizu St, 011061, Bucharest, Romania

    Matei Raicopol

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  1. Luisa Pilan
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Correspondence to Luisa Pilan or Matei Raicopol .

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Editors and Affiliations

  1. Kanagawa Institute of Industrial Science and Technology, Ebina, Kanagawa, Japan

    Satoru Kaneko

  2. Department of Electrical and Electronics Engineering, Kagoshima University, Kagoshima, Japan

    Masami Aono

  3. Center for Surface Science and Nanotechnology, University Politehnica of Bucharest, București, Romania

    Alina Pruna

  4. Department of Physics, Faculty of Science, Istanbul University, Istanbul, Turkey

    Musa Can

  5. Shibaura Institute of Technology, Tokyo, Japan

    Paolo Mele

  6. Faculty of Engineering, Ataturk University, Erzurum, Turkey

    Mehmet Ertugrul

  7. Japan Advanced Chemicals, Atsugi, Kanagawa, Japan

    Tamio Endo

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Pilan, L., Raicopol, M. (2021). Electrochemical DNA Biosensors Based on Carbon Nanomaterials. In: Kaneko, S., et al. Carbon Related Materials. Springer, Singapore. https://doi.org/10.1007/978-981-15-7610-2_10

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