Abstract
Phenolic compounds are a widespread group of phytochemicals derived from the secondary metabolism of herbs and plants. Phytochemicals are mainly produced as a plant response to biotic and abiotic stresses to overcome/adapt these adverse conditions. The study of abiotic stress response of plants has led to numerous discoveries regarding flavonoids and phenolic acids biosynthetic pathways. Since phenolic compounds such as flavonoids and phenolic acids have been related to numerous bioactive health effects, it is of interest to enhance the content of these compounds in plants and herbs. One of the most studied abiotic stresses on herbs is manipulation of light, whether through use of different light colors, light intensity, and/or sunlight. One of the most active groups of compounds elicited in response of light stress is flavones, flavonols, and some phenolic acids. These groups of compounds have been related to health benefits to humans such as antioxidant, cardiovascular disease, and against metabolic syndrome. This chapter aims to comprehensive review recent works on this field.
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References
Anand David AV, Arulmoli R, Parasuraman S (2016) Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev 10(20):84–89. https://doi.org/10.4103/0973-7847.194044
Begas E, Tsioutsiouliti A, Kouvaras E, Haroutounian SA, Kasiotis KM, Kouretas D et al (2017) Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers. Food Chem Toxicol 100:80–89
Bower AM, Real Hernandez LM, Berhow MA, de Mejia EG (2014) Bioactive compounds from culinary herbs inhibit a molecular target for type 2 diabetes management, dipeptidyl peptidase IV. J Agric Food Chem 62(26):6147–6158. https://doi.org/10.1021/jf500639f
Brahmachari G, Gorai D (2006) Progress in the research on naturally occurring flavones and flavonols: an overview. Curr Org Chem 10(8):873–898. https://doi.org/10.2174/138527206776894438
Bray EA, Bailey-Serres J, Weretilnyk E (2015) Responses to abiotic stresses. In: Buchanan B, Gruissem W, Jones R (eds) Biochemistry & molecular biology of plants, 2nd edn. American Society of Plants, Rockville, pp 1158–1203
Chen I-GJ, Lee M-S, Lin M-K, Ko C-Y, Chang W-T (2018) Blue light decreases tanshinone IIA content in Salvia miltiorrhiza hairy roots via genes regulation. J Photochem Photobiol B Biol 183:164–171
Conéjéro G, Noirot M, Talamond P, Verdeil J-L (2014) Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees. Front Plant Sci 5(39). https://doi.org/10.3389/fpls.2014.00039
Corradini E, Foglia P, Giansanti P, Gubbiotti R, Samperi R, Laganà A (2011) Flavonoids: chemical properties and analytical methodologies of identification and quantitation in foods and plants. Nat Prod Res 25(5):469–495. https://doi.org/10.1080/14786419.2010.482054
Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26(8):1001. https://doi.org/10.1039/b802662a
Csepregi K, Coffey A, Cunningham N, Prinsen E, Hideg É, Jansen MAK (2017) Developmental age and UV-B exposure co-determine antioxidant capacity and flavonol accumulation in Arabidopsis leaves. Environ Exp Bot 140:19–25. https://doi.org/10.1016/j.envexpbot.2017.05.009
Dludla PV, Muller CJF, Louw J, Joubert E, Salie R, Opoku AR et al (2014) The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats. Phytomedicine 21(5):595–601. https://doi.org/10.1016/j.phymed.2013.10.029
Embuscado ME (2015) Spices and herbs: natural sources of antioxidants – a mini review. J Funct Foods 18:811–819. https://doi.org/10.1016/j.jff.2015.03.005
Falcone Ferreyra ML, Rius S, Emiliani J, Pourcel L, Feller A, Morohashi K et al (2010) Cloning and characterization of a UV-B-inducible maize flavonol synthase. Plant J 62(1):77–91. https://doi.org/10.1111/j.1365-313X.2010.04133.x
Feliciano RP, Pritzel S, Heiss C, Rodriguez-Mateos A (2015) Flavonoid intake and cardiovascular disease risk. Curr Opin Food Sci 2:92–99
Figueroa-Pérez MG, Rocha-Guzmán NE, Pérez-Ramírez IF, Mercado-Silva E, Reynoso-Camacho R (2014) Metabolite profile, antioxidant capacity, and inhibition of digestive enzymes in infusions of peppermint (Mentha piperita) grown under drought stress. J Agric Food Chem 62(49):12027–12033. https://doi.org/10.1021/jf503628c
Förstermann U, Sessa WC (2011) Nitric oxide synthases: regulation and function. Eur Heart J 33(7):829–837. https://doi.org/10.1093/eurheartj/ehr304
Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Bruel A et al (2012) Flavonoids purified from parsley inhibit human blood platelet aggregation and adhesion to collagen under flow. J Complem Integr Med 9
Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N (2015) Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis. Apoptosis 20(12):1531–1562. https://doi.org/10.1007/s10495-015-1169-2
García-Bores AM, Espinosa-González AM, Reyna-Campos A, Cruz-Toscano S, Benítez-Flores JC, Hernández-Delgado CT et al (2017) Lippia graveolens photochemopreventive effect against UVB radiation-induced skin carcinogenesis. J Photochem Photobiol B Biol 167:72–81. https://doi.org/10.1016/j.jphotobiol.2016.12.014
García-Pérez E, Noratto GD, García-Lara S, Gutiérrez-Uribe JA, Mertens-Talcott SU (2013) Micropropagation effect on the anti-carcinogenic activity of polyphenolics from Mexican Oregano (Poliomintha glabrescens Gray) in human colon cancer cells HT-29. Plant Foods Hum Nutr 68(2):155–162. https://doi.org/10.1007/s11130-013-0344-2
Ghasemzadeh A, Ashkani S, Baghdadi A, Pazoki A, Jaafar HZE, Rahmat A (2016) Improvement in flavonoids and phenolic acids production and pharmaceutical quality of sweet basil (Ocimum basilicum L.) by ultraviolet-B irradiation. Molecules 21(9):15. https://doi.org/10.3390/molecules21091203
Grundy SM (2016) Metabolic syndrome update. Trends Cardiovasc Med 26(4):364–373. https://doi.org/10.1016/j.tcm.2015.10.004
Guimarães R, Barros L, Dueñas M, Calhelha RC, Carvalho AM, Santos-Buelga C et al (2013) Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations. Food Chem 136(2):718–725. https://doi.org/10.1016/j.foodchem.2012.08.025
Gutiérrez-Grijalva EP, Antunes-Ricardo M, Acosta-Estrada BA, Gutiérrez-Uribe JA, Basilio HJ (2019) Cellular antioxidant activity and in vitro inhibition of α-glucosidase, α-amylase and pancreatic lipase of oregano polyphenols under simulated gastrointestinal digestion. Food Res Int 116:676. https://doi.org/10.1016/j.foodres.2018.08.096
Haidari F, Keshavarz SA, Mohammad Shahi M, Mahboob S-A, Rashidi M-R (2011) Effects of parsley (Petroselinum crispum) and its flavonol constituents, kaempferol and quercetin, on serum uric acid levels, biomarkers of oxidative stress and liver xanthine oxidoreductase activity inOxonate-induced hyperuricemic rats. Iran J Pharm Res IJPR 10(4):811–819
Hegazy AM, Abdel-Azeem AS, Zeidan HM, Ibrahim KS, Sayed EME (2017) Hypolipidemic and hepatoprotective activities of rosemary and thyme in gentamicin-treated rats. Hum Exp Toxicol 37(4):420–430. https://doi.org/10.1177/0960327117710534
Jang HJ, Lee SJ, Kim CY, Hwang JT, Choi JH, Park JH et al (2017) Effect of sunlight radiation on the growth and chemical constituents of Salvia plebeia R. Br. Molecules 22(8):16. https://doi.org/10.3390/molecules22081279
Kogiannou DAA, Kalogeropoulos N, Kefalas P, Polissiou MG, Kaliora AC (2013) Herbal infusions; their phenolic profile, antioxidant and anti-inflammatory effects in HT29 and PC3 cells. Food Chem Toxicol 61:152–159. https://doi.org/10.1016/j.fct.2013.05.027
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. TheScientificWorldJournal 2013:162750. https://doi.org/10.1155/2013/162750
Kutchan TM, Gershenzon J, Møller BL, Gang DR (2015) Natural products. In: Buchanan BB, Gruissem W, Jones RL (eds) Biochemistry & molecular biology of plants. American Society of Plants, Rockville, pp 1250–1318
León-Chan RG, López-Meyer M, Osuna-Enciso T, Sañudo-Barajas JA, Heredia JB, León-Félix J (2017) Low temperature and ultraviolet-B radiation affect chlorophyll content and induce the accumulation of UV-B-absorbing and antioxidant compounds in bell pepper (Capsicum annuum) plants. Environ Exp Bot 139:143–151. https://doi.org/10.1016/j.envexpbot.2017.05.006
Leyva-López N, Nair V, Bang WY, Cisneros-Zevallos L, Heredia JB (2016) Protective role of terpenes and polyphenols from three species of Oregano (Lippia graveolens, Lippia palmeri and Hedeoma patens) on the suppression of lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells. J Ethnopharmacol 187:302–312. https://doi.org/10.1016/j.jep.2016.04.051
Lobiuc A, Vasilache V, Pintilie O, Stoleru T, Burducea M, Oroian M et al (2017) Blue and red LED illumination improves growth and bioactive compounds contents in acyanic and cyanic Ocimum basilicum L. microgreens. Molecules 22(12):14. https://doi.org/10.3390/molecules22122111
López-Alarcón C, Denicola A (2013) Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays. Anal Chim Acta 763:1–10. https://doi.org/10.1016/j.aca.2012.11.051
Ma P, Liu J, Zhang C, Liang Z (2013) Regulation of water-soluble phenolic acid biosynthesis in Salvia miltiorrhiza Bunge. Appl Biochem Biotechnol 170(6):1253–1262. https://doi.org/10.1007/s12010-013-0265-4
Manju K, Jat RK, Anju G (2017) A review on medicinal plants used as a source of anticancer agents. Int J Drug Res Technol 2(2)
Manukyan A (2013) Effects of PAR and UV-B radiation on herbal yield, bioactive compounds and their antioxidant capacity of some medicinal plants under controlled environmental conditions. Photochem Photobiol 89(2):406–414. https://doi.org/10.1111/j.1751-1097.2012.01242.x
Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G et al (2015) Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci 16(1). https://doi.org/10.3390/ijms16010378
Martens S, Mithöfer A (2005) Flavones and flavone synthases. Phytochemistry 66(20):2399–2407. https://doi.org/10.1016/j.phytochem.2005.07.013
Nadeem M, Abbasi BH, Younas M, Ahmad W, Zahir A, Hano C (2019) LED-enhanced biosynthesis of biologically active ingredients in callus cultures of Ocimum basilicum. J Photochem Photobiol B Biol 190:172–178. https://doi.org/10.1016/j.jphotobiol.2018.09.011
Nadia Z, Rachid M (2013) Antioxidant and antibacterial activities of Thymus vulgaris L. Med Aromat Plant Res J 1(1):5–11
Nickavar B, Abolhasani L (2013) Bioactivity-guided separation of an α-amylase inhibitor flavonoid from Salvia virgata. Iran J Pharm Res IJPR 12(1):57–61
Nijveldt RJ, Van Nood E, Van Hoorn DE, Boelens PG, Van Norren K, Van Leeuwen PA (2001) Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74(4):418–425
Opara IE, Chohan M (2014) Culinary herbs and spices: their bioactive properties, the contribution of polyphenols and the challenges in deducing their true health benefits. Int J Mol Sci 15(10). https://doi.org/10.3390/ijms151019183
Pantsi WG, Marnewick JL, Esterhuyse AJ, Rautenbach F, van Rooyen J (2011) Rooibos (Aspalathus linearis) offers cardiac protection against ischaemia/reperfusion in the isolated perfused rat heart. Phytomedicine 18(14):1220–1228. https://doi.org/10.1016/j.phymed.2011.09.069
Peng M, Shahzad R, Gul A, Subthain H, Shen S, Lei L et al (2017) Differentially evolved glucosyltransferases determine natural variation of rice flavone accumulation and UV-tolerance. Nat Commun 8(1):1975. https://doi.org/10.1038/s41467-017-02168-x
Pisoschi AM, Pop A (2015) The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Med Chem 97:55–74. https://doi.org/10.1016/j.ejmech.2015.04.040
Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V et al (2017) Oxidative stress: harms and benefits for human health. Oxidative Med Cell Longev 2017:13. https://doi.org/10.1155/2017/8416763
Procházková D, Boušová I, Wilhelmová N (2011) Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82(4):513–523. https://doi.org/10.1016/j.fitote.2011.01.018
Radyukina NL, Toaima VIM, Zaripova NR (2012) The involvement of low-molecular antioxidants in cross-adaptation of medicine plants to successive action of UV-B radiation and salinity. Russ J Plant Physiol 59(1):71–78. https://doi.org/10.1134/s1021443712010165
Ralston RA, Schwartz SJ, Hostetler GL (2017) Flavones: food sources, bioavailability, metabolism, and bioactivity. Adv Nutr 8(3):423–435. https://doi.org/10.3945/an.116.012948
Rubió L, Motilva M-J, Romero M-P (2013) Recent advances in biologically active compounds in herbs and spices: a review of the Most effective antioxidant and anti-inflammatory active principles. Crit Rev Food Sci Nutr 53(9):943–953. https://doi.org/10.1080/10408398.2011.574802
Sesso HD, Lee IM, Blumberg JB, Buring JE, Zhang SM, Wang L (2009) Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. Am J Clin Nutr 89(3):905–912. https://doi.org/10.3945/ajcn.2008.26913
Singh M, Kaur M, Silakari O (2014) Flavones: an important scaffold for medicinal chemistry. Eur J Med Chem 84:206–239. https://doi.org/10.1016/j.ejmech.2014.07.013
Smith C, Swart A (2018) Aspalathus linearis (Rooibos) – a functional food targeting cardiovascular disease. Food Funct 9(10):5041–5058. https://doi.org/10.1039/C8FO01010B
Stagnari F, Di Mattia C, Galieni A, Santarelli V, D’Egidio S, Pagnani G et al (2018) Light quantity and quality supplies sharply affect growth, morphological, physiological and quality traits of basil. Ind Crop Prod 122:277–289. https://doi.org/10.1016/j.indcrop.2018.05.073
Stewart AJ, Bozonnet S, Mullen W, Jenkins GI, Lean MEJ, Crozier A (2000) Occurrence of flavonols in tomatoes and tomato-based products. J Agric Food Chem 48(7):2663–2669. https://doi.org/10.1021/jf000070p
Szymańska R, Ślesak I, Orzechowska A, Kruk J (2017) Physiological and biochemical responses to high light and temperature stress in plants. Environ Exp Bot 139:165–177. https://doi.org/10.1016/j.envexpbot.2017.05.002
Tattini M, Galardi C, Pinelli P, Massai R, Remorini D, Agati G (2004) Differential accumulation of flavonoids and hydroxycinnamates in leaves of Ligustrum vulgare under excess light and drought stress. New Phytol 163(3):547–561. https://doi.org/10.1111/j.1469-8137.2004.01126.x
Taulavuori K, Pyysalo A, Taulavuori E, Julkunen-Tiitto R (2018) Responses of phenolic acid and flavonoid synthesis to blue and blue-violet light depends on plant species. Environ Exp Bot 150:183–187. https://doi.org/10.1016/j.envexpbot.2018.03.016
Tian Y, Sun L-M, Liu X-Q, Li B, Wang Q, Dong J-X (2010) Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. Fitoterapia 81(7):799–802. https://doi.org/10.1016/j.fitote.2010.04.012
Torres-Contreras AM, Senés-Guerrero C, Pacheco A, González-Agüero M, Ramos-Parra PA, Cisneros-Zevallos L et al (2018) Genes differentially expressed in broccoli as an early and late response to wounding stress. Postharvest Biol Technol 145:172–182. https://doi.org/10.1016/j.postharvbio.2018.07.010
Trivellini A, Lucchesini M, Maggini R, Mosadegh H, Villamarin TSS, Vernieri P et al (2016) Lamiaceae phenols as multifaceted compounds: bioactivity, industrial prospects and role of “positive-stress”. Ind Crop Prod 83:241–254. https://doi.org/10.1016/j.indcrop.2015.12.039
Tsao R (2010) Chemistry and biochemistry of dietary polyphenols. Nutrients 2(12):1231–1246. https://doi.org/10.3390/nu2121231
Wang T-y, Li Q, K-s B (2018) Bioactive flavonoids in medicinal plants: structure, activity and biological fate. Asian J Pharm Sci 13(1):12–23. https://doi.org/10.1016/j.ajps.2017.08.004
Zaman SB, Hussain MA, Nye R, Mehta V, Mamun KT, Hossain N (2017) A review on antibiotic resistance: alarm bells are ringing. Cureus 9(6):e1403-e. https://doi.org/10.7759/cureus.1403
Zhou Z, Schenke D, Miao Y, Cai D (2017) Investigation of the crosstalk between the flg22 and the UV-B-induced flavonol pathway in Arabidopsis thaliana seedlings. Plant Cell Environ 40(3):453–458. https://doi.org/10.1111/pce.12869
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Gutiérrez-Grijalva, E.P., Santos-Zea, L., Ambriz-Pérez, D.L., López-Martínez, L.X., Heredia, J.B. (2020). Flavones and Flavonols: Bioactivities and Responses Under Light Stress in Herbs. In: Lone, R., Shuab, R., Kamili, A. (eds) Plant Phenolics in Sustainable Agriculture . Springer, Singapore. https://doi.org/10.1007/978-981-15-4890-1_4
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