Abstract
Fungi the primitive eukaryotes are emerging as life-threatening pathogens of public health. Over a decade and ago, the frequency of fungal infections has been enormous, with an increased range of mortality and morbidity in immunocompromised patients. The risk of fungal infections is aggravated by random use of broad-spectrum antibacterial drugs, immunosuppressive agents, and various cancer chemotherapies. Most of the well-known fungal disease and the pathogenic fungi are Aspergillus, Blastomycosis, Candidiasis, Coccidioidomycosis, Cryptococcus, and Dermatophytes. The resistance to antifungal medicines might be characteristic, acquired, or clinical. The comprehension of the mechanism of the clinical resistance effect is significant, unlike alternating treatment. In this chapter, after a concise overview of antifungal resistance, the molecular transport mechanism and mechanism of drugs will be detailed. It emerges that the main systems of resistance are necessarily appropriate to the deregulation of antifungal resistance effector genes. This deregulation in transcriptional regulators of the genes is due to the occurrence of point mutations. The study of antifungal its pathogenicity and resistance to drugs is essential for a better understanding of the human pathogenic fungal biology.
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Pola, S., Vijayaramya, A., Sanapala, P., Deepthi, V.A.I. (2020). Pathogenesis of Fungal Infections and Drug-Resistance Phenomenon. In: Siddhardha, B., Dyavaiah, M., Syed, A. (eds) Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-1695-5_17
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