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Circulating Non-coding RNAs and Cardiovascular Diseases

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Non-coding RNAs in Cardiovascular Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1229))

Abstract

The discovery of noncoding RNAs (ncRNAs) including short microRNAs, long ncRNAs and circular RNAs has broaden our knowledge about mammalian genomes and transcriptomes. A growing number of evidence on aberrantly regulated ncRNAs in cardiovascular diseases has indicated that ncRNAs are critical contributors to cardiovascular pathophysiology. Moreover, multiple recent studies have reported that ncRNAs can be detected in the bloodstream that differs between health subjects and diseased patients and some of them are remarkably stable. Although our knowledge about the origin and function of the circulating ncRNAs is still limited, these molecules have been regarded as promising noninvasive biomarker for risk stratification, diagnosis and prognosis of various cardiovascular diseases. In this chapter, we have described biological characteristics of circulating ncRNAs and discussed current trends and future prospects for the usage of circulating ncRNAs as biomarkers for common cardiovascular diseases.

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Acknowledgements

This work was supported by the grants from National Natural Science Foundation of China.

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The authors declare no competing financial interests.

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Authors and Affiliations

  1. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China

    Chenglin Zhao, Yicheng Lv, Yi Duan & Zhongrong Zhang

  2. Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Guoping Li

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  1. Chenglin Zhao
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  2. Yicheng Lv
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  4. Guoping Li
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  5. Zhongrong Zhang
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  1. Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Zhao, C., Lv, Y., Duan, Y., Li, G., Zhang, Z. (2020). Circulating Non-coding RNAs and Cardiovascular Diseases. In: Xiao, J. (eds) Non-coding RNAs in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 1229. Springer, Singapore. https://doi.org/10.1007/978-981-15-1671-9_22

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