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Vitamin E-Based Nanomedicines for Anticancer Drug Delivery

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Nanomedicine for Bioactives

Abstract

Cancer is one of the leading causes of death throughout the world. It is defined as abnormal cell growth with the potential to invade or spread to other parts of the body [1]. Today, cancer is known as a dreadful disease with a death of 8.2 million people in cancer and 14.1 million diagnoses of new cancer cases worldwide in 2012. It is expected that the number of new cancer cases will reach 21.7 million in 2030. According to the food and nutrition report in 2003, in 30–40% cases, cancer is directly related to nutrition. Therefore, the use of chemopreventive agents such as vitamin E from nutritional source is an acceptable method to reduce the rate of cancer [2]. In most cases, conventional treatment methods, including chemo/surgical/radiation treatments, fail to target and treat the disease adequately. Recent progress in the field of tumor-directed nanotechnologies provides hope of treatment for cancer patients. Nanoparticle (NP)-based therapeutics can significantly improve the treatment outcomes of oncological diseases by increasing the tumor delivery of drugs and limiting off-target uptake [1, 3]. Nanomedicines are defined by the European Science Foundation as follow: “nanometer size scale complex systems, consisting of at least two components, one of which being the active ingredient.” Nanomedicines can increase drug function including efficacy, specificity, tolerability, and therapeutic index [4]. In other words, the loading of drugs into nanocarriers can make some advantages:

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Notes

  1. 1.

    Taxol is a name for paclitaxel that is used clinically.

  2. 2.

    Taxol is a brand name of paclitaxel (PTX).

  3. 3.

    Drug-loading content

  4. 4.

    The concentration of drug needed to kill half amount of the cells

  5. 5.

    TC was used in this study as an abbreviation for α-tocopheryl succinate.

  6. 6.

    Poly(lactic-co-glycolic acid) nanoparticles

  7. 7.

    The poly(lactide)–vitamin E TPGS nanoparticles

  8. 8.

    Poly(lactic-co-glycolic acid)–montmorillonite nanoparticles

  9. 9.

    Taxotere is the trade name for docetaxel.

  10. 10.

    Folate decorated

Abbreviations

ABC:

ATPγ

AMF:

Alternative magnetic field

Ap:

Apigenin

AUC:

Area under the concentration−time curve

BBB:

Blood–brain barrier

BCT:

Breast conservation treatment

BMM:

Bone marrow derived macrophages

BTB:

Blood–tumor barrier

CA:

Chitosan

CA:

Cholic acid

CEHC:

Carboxyethylhydroxychromans

CLSM:

Confocal laser scanning microscopy

CMC:

Critical micelle concentration

CPT:

Camptothecin

Cremophor-EL:

Polyoxyethylated castor oil

CSO:

Chitosan oligosaccharide

DMAP:

4-dimethylamioprydine

DNPs:

Docetaxel loaded polymeric nanoparticles

DOPE:

Dioleoyl phosphatidyl ethanolamine

DOX:

Doxorobicin

DTX:

Docetaxel

DTX:

Marketed formulation of Docetaxel

EDC:

(1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride

EE:

Drug encapsulation efficiency

EGFR:

Epidermal growth factor receptor

EPR:

Enhanced permeability and retention effect

ER:

Estrogen

FDA:

Food and Drug Administration

GAR:

Garcinol

GI:

Gastrointestinal

GMO:

Glyceryl monooleate

GSH:

Glutathione

HCPT:

10-Hydroxycamptothecin

IOs:

Nano-sized iron oxides

LC:

Drug-loading content

LUT:

Luteolin

MDR:

Multidrug resistance

MNPs:

Magnetic nanoparticles

MPS:

Mononuclear phagocyte system

MRP1:

Multidrug resistance protein 1

mTHPC:

Temoporfin

NIR:

Near-infrared

NLC:

Nanostructured lipid carriers

NO:

Nitric oxide

NONOates:

N-diazeniumdiolates

NP:

Nanoparticle

PAA:

Poly acrylic acid

PAMAM:

Poly (amidoamine)

PBS:

Phosphate-buffered saline

PCL:

Poly (ε-caprolactone)

PDT:

Photodynamic therapy

PEG:

Poly (ethylene glycol)

PF-TOS micelles:

TOS modified pluronic micelles

P-gp:

P-Glycoprotein

PLA:

Poly (lactide)

PLA–TPGS:

Poly (l-lactide)-vitamin E TPGS

PLGA:

Poly (lactide co-glycolide)

PR:

Progesterone

PTX:

Paclitaxel

QDs:

Quantum dots

RES:

Reticuloendothelial system

ROS :

Reactive oxygen species

RSNOs:

S-nitrosothiols

RT:

Radiation treatment

SA:

Succinic anhydride

SC:

Solvent casting

SESD:

Spontaneous emulsification solvent-diffusion method

Taxotere®:

Clinical DTX formulation

TC:

Terephthaloyl chloride

TCOsomes:

α-Tocopherol-oligochitosan-based oligomersomes

THP:

Pirarubicin

TNBC:

Triple negative breast cancer

TOC:

Tocopherols

TPGS:

α-Tocopherol polyethylene glycol 1000 succinate

TPNs:

TPGS-functionalized PLGA nanoparticles

TQR:

Tariquidar

TT:

Tocotrienols

VE:

Vitamin E

VES:

Vitamin E succinate

VES-g-CSO:

TPGS and VES-grafted CSO

α-Fmoc:

α-Fluorenylmethoxycarbonyl

α-TOS:

α-Tocopheryl succinate

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Authors and Affiliations

  1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

    Roya Karimi Alavijeh & Kamran Akhbari

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  1. Roya Karimi Alavijeh
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  2. Kamran Akhbari
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Correspondence to Kamran Akhbari .

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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, SHUATS, Allahabad, Uttar Pradesh, India

    Mahfoozur Rahman

  2. Nanomedicine Research Lab, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India

    Sarwar Beg

  3. Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, SHUATS, Allahabad, Uttar Pradesh, India

    Vikas Kumar

  4. Nanomedicine Research Lab, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India

    Farhan Jalees Ahmad

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Karimi Alavijeh, R., Akhbari, K. (2020). Vitamin E-Based Nanomedicines for Anticancer Drug Delivery. In: Rahman, M., Beg, S., Kumar, V., Ahmad, F. (eds) Nanomedicine for Bioactives . Springer, Singapore. https://doi.org/10.1007/978-981-15-1664-1_2

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