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Interpenetrating Polymer Network (IPN) Nanoparticles for Drug Delivery Applications

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Book cover Interpenetrating Polymer Network: Biomedical Applications

Abstract

Recent studies emphasize the interpenetrating polymer network (IPN) as a combination of two or more polymers in the form of network where covalent bond is unlikely to be formed when at least one of the polymers is synthesized or cross-linked in the presence of the other during formation of IPN. One of the most IPN hydrogel applications is the formation of stimuli-sensitive delivery system. Researchers have used them alone or in combination with synthetic polymers to fabricate IPN hydrogels with desired properties. Those polymers include polysaccharides such as chitosan, cellulose, dextran and xyloglucan, and proteins such as gelatin as well as synthetic polymers such as poloxamer. The IPN nanoparticle-based hydrogels have the ability to form aqueous solutions with high colloidal stability in vivo and entrap of macromolecules, such as proteins and peptides, target, and control the drug release, feasibility of surface modifications by various types of site-specific ligands in order to improve targeted delivery in the body in addition to feasibility for administration through different pathways, such as oral, parenteral, nasal, pulmonary, and ocular routes.

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Authors and Affiliations

  1. Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

    Rania M. Abou El-Ela, May S. Freag, Kadria A. Elkhodairy & Ahmed O. Elzoghby

  2. Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

    Rania M. Abou El-Ela, Kadria A. Elkhodairy & Ahmed O. Elzoghby

  3. Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

    May S. Freag

  4. Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    May S. Freag & Ahmed O. Elzoghby

  5. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA

    May S. Freag & Ahmed O. Elzoghby

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  1. Rania M. Abou El-Ela
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  2. May S. Freag
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  3. Kadria A. Elkhodairy
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  4. Ahmed O. Elzoghby
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Correspondence to Ahmed O. Elzoghby .

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  1. Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India, Department of Health and Family Welfare, Directorate of Health Services, Kolkata, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Abou El-Ela, R.M., Freag, M.S., Elkhodairy, K.A., Elzoghby, A.O. (2020). Interpenetrating Polymer Network (IPN) Nanoparticles for Drug Delivery Applications. In: Jana, S., Jana, S. (eds) Interpenetrating Polymer Network: Biomedical Applications. Springer, Singapore. https://doi.org/10.1007/978-981-15-0283-5_2

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