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The Application of Chitooligosaccharides on Biomaterials

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Oligosaccharides of Chitin and Chitosan

Abstract

Biomaterials are natural or synthetic materials that are suitable for introduction into human body. Chitooligosaccharides has many functions such as bone repair, wound healing, anti-inflammatory and nerve repair. It also has advantages of biocompatibility, biodegradability and no-toxicity. Thus, it widely applied on biomaterials preparation. Although chitooligosaccharides’s molecular weight is low compared with chitosan that limited its application on biomaterials, it also has unique advantages such as better solubility. All these are helpful in biomaterials preparation. Chitooligosaccharides has been used in preparation nanoparticles and nanofibers, and further applied in drug and gene delivery, nutrition fortification and wound dress. Hence, we will review the development and preparation of biomaterials based on chitooligosaccharides as well as their applications in different fields in this chapter.

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References

  • Akhlaghi SP, Berry RC, Tam KC (2013) Surface modification of cellulose nanocrystal with chitosan oligosaccharide for drug delivery applications. Cellulose 20(4):1747–1764

    Article  CAS  Google Scholar 

  • Andrievski RA, Glezer AM (2001) Size effects in properties of nanomaterials. Scr Mater 44(8):1621–1624

    Article  CAS  Google Scholar 

  • Barry E, Alvarez JA, Scully RE, Miller TL, Lipshultz SE (2007) Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management. Expert Opin Pharmaco 8(8):1039–1058

    Article  CAS  Google Scholar 

  • Borchard G (2001) Chitosans for gene delivery. Adv Drug Deliv Rev 52(2):145–150

    Article  CAS  PubMed  Google Scholar 

  • Calvo P, Remuñán-López C, Vila-Jato JL, Alonso MJ (1997) Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci 63(1):125–132

    Article  CAS  Google Scholar 

  • Chae SY, Son S, Lee M, Jang M-K, Nah J-W (2005) Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier. J Control Release 109(1–3):330–344

    Article  CAS  PubMed  Google Scholar 

  • Chi XF, Ding XM, Peng X, Li XC, Fang J (2017) Effects of chitosan oligosaccharides supplementation on the cell cycle of immune organs in broilers. Kafkas Univ Veteriner Fakultesi Derg 23(6):1003–1006

    Google Scholar 

  • Choi H, Lee JP, Ko SJ, Jung JW, Park H, Yoo S, Park O, Jeong JR, Park S, Kim JY (2013) Multipositional silica-coated silver nanoparticles for high-performance polymer solar cells. Nano Lett 13(5):2204

    Article  CAS  PubMed  Google Scholar 

  • Choi C, Nam J-P, Nah J-W (2016) Application of chitosan and chitosan derivatives as biomaterials. J Ind Eng Chem 33:1–10

    Article  CAS  Google Scholar 

  • Chokradjaroen C, Theeramunkong S, Yui H, Saito N, Rujiravanit R (2018) Cytotoxicity against cancer cells of chitosan oligosaccharides prepared from chitosan powder degraded by electrical discharge plasma. Carbohydr Polym 201:20–30

    Article  CAS  PubMed  Google Scholar 

  • Chuyen HV, Eun JB (2015) Marine carotenoids: bioactivities and potential benefits to human health. C R C Crit Rev Food Technol 57(12):2600–2610

    Article  CAS  Google Scholar 

  • Das S, Ghosh S, De AK, Bera T (2017) Oral delivery of ursolic acid-loaded nanostructured lipid carrier coated with chitosan oligosaccharides: development, characterization, in vitro and in vivo assessment for the therapy of leishmaniasis. Int J Biol Macromol 102:996–1008

    Article  CAS  PubMed  Google Scholar 

  • Delavary BM, van der Veer WM, van Egmond M, Niessen FB, Beelen RHJ (2011) Macrophages in skin injury and repair. Immunobiology 216(7):753–762

    Article  CAS  Google Scholar 

  • Delgado D, del Pozo-Rodríguez A, Angeles Solinís M, Bartkowiak A, Rodríguez-Gascón A (2013) New gene delivery system based on oligochitosan and solid lipid nanoparticles: ‘in vitro’ and ‘in vivo’ evaluation. Eur J Pharm Sci 50(3):484–491

    Article  CAS  PubMed  Google Scholar 

  • Ding S-J, Shie M-Y, Hoshiba T, Kawazoe N, Chen G, Chang H-C (2010) Osteogenic differentiation and immune response of human bone-marrow-derived mesenchymal stem cells on injectable calcium-silicate-based bone grafts. Tissue Eng A 16(7):2343–2354

    Article  CAS  Google Scholar 

  • Du Y-Z, Wang L, Yuan H, Wei X-H, Hu F-Q (2009) Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin. Colloids Surf B: Biointerfaces 69(2):257–263

    Article  CAS  PubMed  Google Scholar 

  • Du Y-Z, Wang L, Dong Y, Yuan H, Hu F-Q (2010a) Characteristics of paclitaxel-loaded chitosan oligosaccharide nanoparticles and their preparation by interfacial polyaddition in O/W miniemulsion system. Carbohydr Polym 79(4):1034–1039

    Article  CAS  Google Scholar 

  • Du Y-Z, Ying X-Y, Wang L, Zhai Y, Yuan H, Yu R-S, Hu F-Q (2010b) Sustained release of ATP encapsulated in chitosan oligosaccharide nanoparticles. Int J Pharm 392(1-2):164–169

    Article  CAS  PubMed  Google Scholar 

  • Duy Nguyen H, Dzung Nguyen T, Hai Nguyen D, Nguyen PT (2014) Magnetic properties of Cr doped Fe3O4 porous nanoparticles prepared through a co-precipitation method using surfactant. Adv Nat Sci Nanosci Nanotechnol 5(3):035017

    Article  CAS  Google Scholar 

  • El-Sayed NS, Sharma M, Aliabadi HM, El-Meligy MG, El-Zaity AK, Nageib ZA, Tiwari RK (2018) Synthesis, characterization, and in vitro cytotoxicity of fatty acyl-CGKRK-chitosan oligosaccharides conjugates for siRNA delivery. Int J Biol Macromol 112:694–702

    Article  CAS  PubMed  Google Scholar 

  • Fernández-Díaz C, Coste O, Malta E-j (2017) Polymer chitosan nanoparticles functionalized with Ulva ohnoi extracts boost in vitro ulvan immunostimulant effect in Solea senegalensis macrophages. Algal Res 26:135–142

    Article  Google Scholar 

  • Gregorio-Jauregui KM, Pineda MG, Rivera-Salinas JE, Hurtado G, Saade H, Ilyina A (2012) One-step method for preparation of magnetic nanoparticles coated with chitosan. J Nanomater.,2012,(2012-6-27) 2012(2):4

    Google Scholar 

  • Guesnet P, Alessandri J-M (2011) Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) – implications for dietary recommendations. Biochimie 93(1):7–12

    Article  CAS  PubMed  Google Scholar 

  • Gwak SJ, Jung JK, An SS, Kim HJ, Oh JS, Pennant WA, Lee HY, Kong MH, Kim KN, Yoon DH (2012a) Chitosan/TPP-hyaluronic acid nanoparticles: a new vehicle for gene delivery to the spinal cord. J Biomater Sci Polym Ed 23(11):1437–1450

    CAS  PubMed  Google Scholar 

  • Gwak SJ, Jung JK, An SS, Kim HJ, Oh JS, Pennant WA, Lee HY, Kong MH, Kim KN, Yoon DH, Ha Y (2012b) Chitosan/TPP-hyaluronic acid nanoparticles: a new vehicle for gene delivery to the spinal cord. J Biomater Sci Polym Ed 23(11):1437–1450

    CAS  PubMed  Google Scholar 

  • Ha HK, Jin WK, Han KS, Yun SS, Lee MR, Lee WJ (2017) Development and characterization of a hydrolyzed goat milk protein/Chitosan Oligosaccharide nano-delivery system. Biotechnol 35(3):208–214

    Google Scholar 

  • Ha H-K, Lee M-R, Lee W-J (2018) Oxidative stability of DHA in beta-lactoglobulin/oleic acid-modified chitosan oligosaccharide nanoparticles during storage in skim milk. LWT-Food Sci Technol 90:440–447

    Article  CAS  Google Scholar 

  • Heidarisasan S, Ziamajidi N, Karimi J, Abbasalipourkabir R (2018) Effects of insulin-loaded chitosan-alginate nanoparticle on RAGE expression and oxidative stress status in the kidney tissue of rats with type 1 diabetes. Iran J Basic Med Sci 21(10):1035–1042

    PubMed  PubMed Central  Google Scholar 

  • Hu F-Q, Wu X-L, Du Y-Z, You J, Yuan H (2008) Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. Eur J Pharm Biopharm 69(1):117–125

    Article  CAS  PubMed  Google Scholar 

  • Hu FQ, Jiang XH, Huang X, Wu XL, Yuan H, Wei XH, Du YZ (2009a) Enhanced cellular uptake of chlorine e6 mediated by stearic acid-grafted chitosan oligosaccharide micelles. J Drug Target 17(5):384–391

    Article  CAS  PubMed  Google Scholar 

  • Hu F-Q, Liu L-N, Du Y-Z, Yuan H (2009b) Synthesis and antitumor activity of doxorubicin conjugated stearic acid-g-chitosan oligosaccharide polymeric micelles. Biomaterials 30(36):6955–6963

    Article  CAS  PubMed  Google Scholar 

  • Hu F, Du Y, Yuan H, Meng P (2013) Pegylated and fatty acid grafted chitosan oligosaccharide, synthesis method and application for drug delivery system

    Google Scholar 

  • Huo M, Zhang Y, Zhou J, Zou A, Yu D, Wu Y, Li J, Li H (2010) Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug. Int J Pharm 394(1):162–173

    Article  CAS  PubMed  Google Scholar 

  • Ismail A, Bannenberg G, Rice HB, Schutt E, Mackay D (2016) Oxidation in EPA- and DHA-rich oils: an overview. Lipid Technol 28(3–4):55–59

    Article  CAS  Google Scholar 

  • Jia J, Gao X, Hao M, Tang L (2017) Comparison of binding interaction between β-lactoglobulin and three common polyphenols using multi-spectroscopy and modeling methods. Food Chem 228:143–151

    Article  CAS  PubMed  Google Scholar 

  • Jiang S, Chen Y, Duan G, Mei C, Greiner A, Agarwal S (2018) Electrospun nanofiber reinforced composites: a review. Polym Chem 9(20):2685–2720

    Article  CAS  Google Scholar 

  • Khalid N, Shu G, Kobayashi I, Nakajima M, Barrow CJ (2017) Formulation and characterization of monodisperse O/W emulsions encapsulating astaxanthin extracts using microchannel emulsification: insights of formulation and stability evaluation. Colloids Surf B: Biointerfaces 157:355–365

    Article  CAS  PubMed  Google Scholar 

  • Kim SK, Park PJ, Yang HP, Han SS (2001) Subacute toxicity of chitosan oligosaccharide in Sprague-Dawley rats. Arzneimittelforschung 51(9):769–774

    CAS  PubMed  Google Scholar 

  • Kumar S, Maiti SK, Kumar N, Samsuzzama MM, Ravindran NA, Balwada AK, Mathew DD (1999) Effect of medical grade chitosan powder in full thickness skin wound healing in rat model. Adv Anim Vet Sci 2(5):270–276

    Google Scholar 

  • Kumar PTS, Lakshmanan V-K, Biswas R, Nair SV, Jayakumar R (2012) Synthesis and biological evaluation of chitin hydrogel/nano ZnO composite bandage as antibacterial wound dressing. J Biomed Nanotechnol 8(6):891–900

    Article  CAS  PubMed  Google Scholar 

  • Lee KY, Ha WS, Park WH (1995) Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials 16(16):1211–1216

    Article  CAS  PubMed  Google Scholar 

  • Li F, Liao H-D, Liu X (2013) Preparation of 5-fluorouracil-chitosan oligosaccharide/selenium nano-microspheres co-carrying anti-tumor drug and sensitizer and their anti-tumor activity. J Control Release 172(1):e24

    Article  CAS  Google Scholar 

  • Li J, Liu D, Tan G, Zhao Z, Yang X, Pan W (2016a) A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier for ophthalmic delivery of curcumin. Carbohydr Polym 146:435–444

    Article  CAS  PubMed  Google Scholar 

  • Li C-W, Wang Q, Li J, Hu M, Shi S-J, Li Z-W, Wu G-L, Cui H-H, Li Y-Y, Zhang Q, Yu X-H, Lu L-C (2016b) Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGF beta 1/Smad signaling pathway. Int J Nanomedicine 11:373–387

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li Y, Yu Z, Men Y, Chen X, Wang B (2018) Laminin-chitosan-PLGA conduit co-transplanted with Schwann and neural stem cells to repair the injured recurrent laryngeal nerve. Exp Ther Med 16(2):1250–1258

    PubMed  PubMed Central  Google Scholar 

  • Liu C, Tan Y, Liu C, Chen X, Yu L (2007) Preparations, characterizations and applications of chitosan-based nanoparticles. J Ocean Univ China 6(3):237–243

    Article  CAS  Google Scholar 

  • Liu C, Liu Z, Sun X, Zhang S, Wang S, Feng F, Wang D, Xu Y (2018a) Fabrication and characterization of beta-Lactoglobulin-based nanocomplexes composed of chitosan oligosaccharides as vehicles for delivery of Astaxanthin. J Agric Food Chem 66(26):6717–6726

    Article  CAS  PubMed  Google Scholar 

  • Liu X, Xia W, Jiang Q, Yu P, Yue L (2018b) Chitosan oligosaccharide-N-chlorokojic acid mannich base polymer as a potential antibacterial material. Carbohydr Polym 182:225–234

    Article  CAS  PubMed  Google Scholar 

  • Lu W, Xu H, Zhang B, Ma M, Guo Y (2016) The preparation of chitosan oligosaccharide/alginate sodium/gelatin nanofibers by spiral-electrospinning. J Nanosci Nanotechnol 16(3):2360–2364

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Zhao J, Zhang X, Pan W (2011) Nanostructured lipid carrier (NLC) coated with chitosan oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm 403(1):185–191

    Article  CAS  PubMed  Google Scholar 

  • Maeda H (2001) SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv Drug Deliv Rev 46(1):169–185

    Article  CAS  PubMed  Google Scholar 

  • Mao S, Sun W, Kissel T (2010) Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 62(1):12–27

    Article  CAS  PubMed  Google Scholar 

  • Materials, C. M., Physics,, & Council, N (1999) Condensed-matter and materials physics: basic research for tomorrow’s technology. Eur J Phys 21(2):197–202

    Google Scholar 

  • Mcnaught AD, Wilkinson A (2006) IUPAC compendium of chemical terminology. Encyclopedic dictionary of polymers

    Google Scholar 

  • Moghadam NH, Salehzadeh S, Rakhtshah J, Tanzadehpanah H, Moghadam AH, Hajibabaei F, Sharifinia S, Asl SS, Saidijam M (2018) Improving antiproliferative effect of the nevirapine on Hela cells by loading onto chitosan coated magnetic nanoparticles as a fully biocompatible nano drug carrier. Int J Biol Macromol 118(Pt A):1220–1228

    Article  CAS  PubMed  Google Scholar 

  • Nascimento MLF, Araujo ES, Cordeiro ER, de Oliveira AHP, de Oliveira HP (2015) A literature investigation about electrospinning and nanofibers: historical trends, current status and future challenges. Recent Pat Nanotechnol 9(2):76–85

    Article  CAS  PubMed  Google Scholar 

  • Oryan A, Alemzadeh E, Tashkhourian J, Ana SFN (2018) Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: a preclinical study. Carbohydr Polym 200:82–92

    Article  CAS  PubMed  Google Scholar 

  • Pham DC, Nguyen TH, Ngoc UTP, Le NTT, Tran TV, Nguyen DH (2018) Preparation, characterization and antifungal properties of chitosan-silver nanoparticles synergize fungicide against Pyricularia oryzae. J Nanosci Nanotechnol 18(8):5299–5305

    Article  CAS  PubMed  Google Scholar 

  • Puras G, Zarate J, Aceves M, Murua A, Díaz AR, Avilés-Triguero M, Fernández E, Pedraz JL (2013) Low molecular weight oligochitosans for non-viral retinal gene therapy. Eur J Pharm Biopharm 83(2):131–140

    Article  CAS  PubMed  Google Scholar 

  • Rabbani MM, Yang SB, Park S-J, Oh W, Yeum JH (2016) Characterization of pullulan/chitosan oligosaccharide/montmorillonite nanofibers prepared by electrospinning technique. J Nanosci Nanotechnol 16(6):6486–6493

    Article  CAS  PubMed  Google Scholar 

  • Rahmouni N, Tahri W, Sbihi HM, Nehdi IA, Desbrieres J, Besbes-Hentati S (2018) Improvement of chitosan solubility and bactericidity by synthesis of N-benzimidazole-O-acetyl-chitosan and its electrodeposition. Int J Biol Macromol 113:623–630

    Article  CAS  PubMed  Google Scholar 

  • Reneker DH, Chun I (1999) Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 7(3):216–223

    Article  Google Scholar 

  • Rezaei B, Jamei HR, Ensafi AA (2018) An ultrasensitive and selective electrochemical aptasensor based on rGO-MWCNTs/chitosan/carbon quantum dot for the detection of lysozyme. Biosens Bioelectron 115:37–44

    Article  CAS  PubMed  Google Scholar 

  • Richardson SCW, Kolbe HJV, Duncan R (1999) Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int J Pharm 178(2):231–243

    Article  CAS  PubMed  Google Scholar 

  • Sacco P, Cok M, Asaro F, Paoletti S, Donati I (2018) The role played by the molecular weight and acetylation degree in modulating the stiffness and elasticity of chitosan gels. Carbohydr Polym 196:405–413

    Article  CAS  PubMed  Google Scholar 

  • Safari J, Javadian L (2014) Chitosan decorated Fe3O4 nanoparticles as a magnetic catalyst in the synthesis of phenytoin derivatives. RSC Adv 4(90):48973–48979

    Article  CAS  Google Scholar 

  • Sandri G, Aguzzi C, Rossi S, Bonferoni MC, Bruni G, Boselli C, Cornaglia AI, Riva F, Viseras C, Caramella C, Ferrari F (2017) Halloysite and chitosan oligosaccharide nanocomposite for wound healing. Acta Biomater 57:216–224

    Article  CAS  PubMed  Google Scholar 

  • Saranya N, Moorthi A, Saravanan S, Devi MP, Selvamurugan N (2011) Chitosan and its derivatives for gene delivery. Int J Biol Macromol 48(2):234–238

    Article  CAS  PubMed  Google Scholar 

  • Sauthier G, Segura JJ, Fraxedas J, Verdaguer A (2014) Hydrophobic coating of mica by stearic acid vapor deposition. Colloids Surf A-Physicochem Eng Asp 443:331–337

    Article  CAS  Google Scholar 

  • Schild HG, Tirrell DA (1991) Microheterogeneous solutions of amphiphilic copolymers of N-isopropylacrylamide. An investigation via fluorescence methods. Langmuir 7(7):1319–1324

    Article  CAS  Google Scholar 

  • Tahvilian R, Tajani B, Sadrjavadi K, Fattahi A (2016) Preparation and characterization of pH-sensitive Camptothecin-Cis-Aconityl grafted Chitosan oligosaccharide nanomicelles. Int J Biol Macromol 92:795–802

    Article  CAS  PubMed  Google Scholar 

  • Tashkhourian J, Nami-Ana SF, Shamsipur M (2018) Designing a modified electrode based on graphene quantum dot-chitosan application to electrochemical detection of epinephrine. J Mol Liq 266:548–556

    Article  CAS  Google Scholar 

  • Thao Nguyen Le T, Thi Hiep N, Dong Quy H, Tuong Vi T, Ngoc Thuy N, Dai Hai N (2017) Development of new magnetic nanoparticles: Oligochitosan obtained by gamma-rays and -coated Fe3O4 nanoparticles. Appl Surf Sci 422:863–868

    Article  CAS  Google Scholar 

  • Tokumitsu H, Ichikawa H, Fukumori Y (1999) Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization. Pharm Res 16(12):1830–1835

    Article  CAS  PubMed  Google Scholar 

  • Tucker N, Stanger JJ, Staiger MP, Razzaq H, Hofman K (2012) The history of the science and Technology of Electrospinning from 1600 to 1995. J Eng Fibers Fabr 7:63–73

    CAS  Google Scholar 

  • Wang FH, Liu J, Tang DY, Xue CG, Tong CY, Wu XY, Liu XM (2009) Chitosan nanoparticle as gene vehicle mediated by particle bombardment in onion cell transformation. J Hunan Univ 36(5):67–70

    Google Scholar 

  • Wang J, Lu Z, Wientjes MG, Au JL (2010) Delivery of siRNA therapeutics: barriers and carriers. AAPS J 12(4):492–503

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang T, Hu Y, Leach MK, Zhang L, Yang W, Jiang L, Feng Z-Q, He N (2012) Erythropoietin-loaded oligochitosan nanoparticles for treatment of periventricular leukomalacia. Int J Pharm 422(1):462–471

    Article  CAS  PubMed  Google Scholar 

  • Wang D, Zhang Y, Hong Z (2014) Novel fast-setting chitosan/β-dicalcium silicate bone cements with high compressive strength and bioactivity. Ceram Int 40(7, Part A):9799–9808

    Article  CAS  Google Scholar 

  • Wang N, Chen C, Hu X (2017) Chitosan oligosaccharide/Pluronic polymers nano-aggregates as a potential oral drug delivery system. J Control Release 259:e147–e148

    Article  Google Scholar 

  • Wu Z, Tang Y, Fang H, Su Z, Xu B, Lin Y, Zhang P, Wei X (2015) Decellularized scaffolds containing hyaluronic acid and EGF for promoting the recovery of skin wounds. J Mater Sci-Mater Med 26(1)

    Google Scholar 

  • Xu T, Zhang Z, Zhao J, Xue Q (1996) Study on the structure of surface-modified MoS2 nanoparticles. Mater Res Bull 31(4):345–349

    Article  CAS  Google Scholar 

  • Yang Y, Liu M, Lin S, Ding F, Gu X (2007) Effect of chitooligosaccharide on neuronal differentiation of neurospheres. Med J Commun 55(7):429–436

    Google Scholar 

  • Yang L, Guo C, Jia L, Liang X, Liu C, Liu H (2010) Dual responsive copolymer micelles for drug controlled release. J Colloid Interface Sci 350(1):22–29

    Article  CAS  PubMed  Google Scholar 

  • Yu S-Y, Kwon Y-I, Lee C, Apostolidis E, Kim Y-C (2017) Antidiabetic effect of chitosan oligosaccharide (GO2KA1) is mediated via inhibition of intestinal alpha-glucosidase and glucose transporters and PPAR expression. Biofactors 43(1):90–99

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Jiang T, Li Y, Wang T, Wang S (2009) Evaluation of Chitosan Oligosaccharide nanoparticles prepared by A novel microemulsion-coacervation method. In: International symposium on crystal engineering and drug delivery system 2009)

    Google Scholar 

  • Zhou Y-Y, Du Y-Z, Wang L, Yuan H, Zhou J-P, Hu F-Q (2010) Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-hydroxycamptothecin. Int J Pharm 393(1):144–152

    Article  CAS  Google Scholar 

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Chen, Q., Zhao, L. (2019). The Application of Chitooligosaccharides on Biomaterials. In: Zhao, L. (eds) Oligosaccharides of Chitin and Chitosan. Springer, Singapore. https://doi.org/10.1007/978-981-13-9402-7_9

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