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Modulation of Oxidative Stress in Heart Disease pp 215–235Cite as

Heat Shock Proteins and Their Associated Oxidative Stress-Induced Heart Disease

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Abstract

Heat shock proteins, apart from having a strong impactful function as molecular chaperones, are involved in a variety of diseases including cardiovascular diseases. Various studies have reported that there is an elevation of concentration gradients of circulating heat shock protein antibodies. These HSP antibodies have a strong alliance in case of extremity and advancement of cardiovascular diseases. A major stress factor, such as oxidative stress, contributes largely to endothelial dysfunction through several mechanisms, hence leading to the development of associated cardiovascular diseases. During this time, the heart accumulates misfolded proteins and chaperones/co-chaperone network function for preventing misfolding, refolding denatured proteins, and targeting them for further degradation. In this review, the cardioprotective roles of these chaperones, co-chaperones, and heat shock factors (HSF) will be discussed in correlation with oxidative stress, inflammatory cytokines, and others which are said to be acquainted with the evolution and advancement of cardiovascular diseases.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sangeeta Mitra, Rakhi Dasgupta & Angshuman Bagchi

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  1. Sangeeta Mitra
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  2. Rakhi Dasgupta
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  3. Angshuman Bagchi
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Science, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada

    Naranjan S. Dhalla

  3. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Madhu Dikshit

  4. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Nirmal K. Ganguly

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Mitra, S., Dasgupta, R., Bagchi, A. (2019). Heat Shock Proteins and Their Associated Oxidative Stress-Induced Heart Disease. In: Chakraborti, S., Dhalla, N., Dikshit, M., Ganguly, N. (eds) Modulation of Oxidative Stress in Heart Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-8946-7_9

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