Abstract
Tissue homeostasis and the response to injury require a tight regulation of the balance between self-renewal and differentiation of adult stem/progenitor cells. Recent evidence obtained in several tissues suggests that this balance is regulated, at least in part, by the cellular redox status via the control of reactive oxygen species (ROS) levels and cellular metabolism. In this chapter, we consider the main sources and the relevance of oxidative stress in adult stem turnover and the key signaling pathways involved, with a particular focus on cardiac progenitor cell turnover. While it is generally accepted that the mammalian heart has high physiological levels of ROS and an oxidative metabolism, few studies have explored the importance of redox signaling in cardiac progenitor cells. We propose that low-ROS areas in the heart are permissive niches for adult cardiac progenitor cells. Accordingly, manipulation of ROS-related signaling pathways in the adult heart might open new horizons for stem cell therapy by enhancing their heretofore limited cardiac regenerative potential.
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Herrero, D. et al. (2019). Oxidative Stress as a Critical Determinant of Adult Cardiac Progenitor Cell-Fate Decisions. In: Chakraborti, S., Dhalla, N., Dikshit, M., Ganguly, N. (eds) Modulation of Oxidative Stress in Heart Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-8946-7_13
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