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Endophytic Fungi As the Alternate Source of High-Value Plant Secondary Metabolites

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Book cover Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications

Abstract

Endophytic fungi are associated with plants and reside inside it without causing any harm to the host plants. These fungi are considered as one of the natural sources for getting diverse high-value compounds. Natural compounds which are primarily produced by the host plants including Taxol, camptothecin, podophyllotoxin, vinblastine, vincristine, and huperzine A are also produced by these fungi. Therefore, these endophytic fungi can be considered as an alternate source of high-value natural compounds. The medicinally important plant metabolites isolated from endophytic fungi, their biological properties, and the challenges associated with it are presented in this chapter. Various methods used to optimize the culture conditions, including one strain many compounds (OSMAC), response surface method (RSM), and the genetic tools along with other techniques like cocultivation and epigenetic modification to overcome the problem of attenuation of metabolite synthesis, are also discussed.

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Acknowledgments

The authors are thankful to Alok Adholeya, Senior Director, Sustainable Agriculture Division, The Energy and Resources Institute (India), for continuous support.

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  1. TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), New Delhi, Delhi, India

    Sunil K. Deshmukh, Manish K. Gupta & Sangram K. Lenka

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  1. Sunil K. Deshmukh
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  1. Division of Biological Sciences and Engineering, Netaji Subhas University of Technology (NSUT), New Delhi, Delhi, India

    Tulasi Satyanarayana

  2. Division of Molecular Microbiology, Institute of Life Sciences, Bhubaneshwar, Odisha, India

    Subrata Kumar Das

  3. Department of Biotechnology, Barkatullah University, Bhopal, Madhya Pradesh, India

    Bhavdish Narain Johri

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Deshmukh, S.K., Gupta, M.K., Lenka, S.K. (2019). Endophytic Fungi As the Alternate Source of High-Value Plant Secondary Metabolites. In: Satyanarayana, T., Das, S., Johri, B. (eds) Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications. Springer, Singapore. https://doi.org/10.1007/978-981-13-8487-5_19

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