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Sleep Loss and Neuronal Stress

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Sleep, Memory and Synaptic Plasticity

Abstract

Sleep loss and insufficient sleep are increasingly prevalent in most societies these days. Besides the well-known effects of sleep loss such as motor vehicle and workplace accidents, studies have shown a myriad of physiological consequences including increased risk for type 2 diabetes, obesity, and cardiovascular disease. Sleep loss is known to impair cognition and affect learning and memory. More recent studies have demonstrated a link between sleep loss, neuronal stress, injury, and degeneration. Both acute and chronic sleep loss as well as sleep fragmentation have been shown to impact neurons at a molecular level and lead to injury and sometimes death. Mechanisms and pathways involved will be discussed in this chapter.

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Acknowledgments

NIH grants P01 AG17628 and GM123783. Thanks to Sarah Ly for assistance with figures.

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Authors and Affiliations

  1. Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Nirinjini Naidoo

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  1. Nirinjini Naidoo
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Correspondence to Nirinjini Naidoo .

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Editors and Affiliations

  1. Sleep Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Sushil K. Jha

  2. Sleep Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Vibha M. Jha

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Naidoo, N. (2019). Sleep Loss and Neuronal Stress. In: Jha, S., Jha, V. (eds) Sleep, Memory and Synaptic Plasticity. Springer, Singapore. https://doi.org/10.1007/978-981-13-2814-5_3

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