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Biodegradable Polymeric Nanocarrier-Based Immunotherapy in Hepatitis Vaccination

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Cutting-Edge Enabling Technologies for Regenerative Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1078))

Abstract

Various commercial vaccines are used for immunization against hepatitis B. However, these immunotherapeutic vaccines require invasive administration, which can induce side effects, and require multiple shots to elicit an immune response, limiting their efficacy. Compared to traditional hepatitis B vaccines, polymer nanoparticles have more advantageous inherent properties as vaccine delivery carriers, providing increased stability of encapsulated antigen, the possibility of single-shot immunotherapy, and the capability of mucosal administration, which allows various routes of vaccination. In this review, we present up-to-date information on the potential of a biodegradable nanoparticle-based delivery system in treating hepatitis B. We also discuss the application of nanoparticles in various vaccines and highlighted strategies for eliciting an appropriate immune response.

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Acknowledgements

This work was supported by the Seoul National University (SNU) Research Grant, Creative-Pioneering Research Program through Seoul National University (SNU), and National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (2015-R1A2A2A03004448).

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Authors and Affiliations

  1. Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, South Korea

    Seo Jin Hong, Min Hye Ahn, Yong Woo Lee & Rohidas B. Arote

  2. Wastewater Technology Division, CSIR-National Environmental Engineering Research Institute, Nagpur, Maharashtra, India

    Sukdeb Pal

  3. Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India

    Jaiprakash Sangshetti

  4. Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea

    Rohidas B. Arote

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  1. Seo Jin Hong
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Correspondence to Rohidas B. Arote .

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  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Hallym University, Gangwon-do, Korea (Republic of)

    Chan Hum Park

  3. Kyung Hee University, Seoul, Korea (Republic of)

    Il Keun Kwon

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Hong, S.J., Ahn, M.H., Lee, Y.W., Pal, S., Sangshetti, J., Arote, R.B. (2018). Biodegradable Polymeric Nanocarrier-Based Immunotherapy in Hepatitis Vaccination. In: Chun, H., Park, C., Kwon, I., Khang, G. (eds) Cutting-Edge Enabling Technologies for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1078. Springer, Singapore. https://doi.org/10.1007/978-981-13-0950-2_16

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