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The Role of Natural-Based Biomaterials in Advanced Therapies for Autoimmune Diseases

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Novel Biomaterials for Regenerative Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1077))

Abstract

Autoimmune diseases (ADs) constitute a heterogeneous group of more than 100 pathophysiological conditions in which an immune response against the self is observed. The incidence and prevalence of these chronic diseases are increasing with inherently high social and economic impacts. The currently available therapies generally focus on reducing the activity of the immune system and, therefore, can present severe side effects such as enhanced patient susceptibility to opportunistic infections. Advanced therapies emerged as promising treatments and with real curative potential for ADs. Additionally, the use of natural polymers to engineer gene therapies, cell therapies and/or tissue-engineered medicinal products presents specific advantages. Natural polymers present higher affinity with biological systems than synthetic polymers, and frequently have a chemical structure and motifs similar to those existing in the extracellular matrix of the tissues. They also have good biological performance, making them very strong candidates for advanced therapy medicinal products. This review discusses the therapeutic advances and provides demonstrative examples of the role of natural-based biomaterials for the development of advanced therapies for ADs.

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Acknowledgements

The authors wish to acknowledge the Programa Operacional Norte 2020 under the research project FROnTHERA (NORTE-01-0145-FEDER-000023) and the Fundação para a Ciência e Tecnologia do Ministério da Ciência e Tecnologia (FCT, Portugal) under the research project SPARTAN (PTDC/CTM-BIO/4388/2014).

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  1. *Author contributed equally with all other contributors.Helena Ferreira and Joana F. Fangueiro.

Authors and Affiliations

  1. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal

    Helena Ferreira, Joana F. Fangueiro & Nuno M. Neves

  2. ICVS/3B’s – PT Government Associate Laboratory, Braga, Portugal

    Helena Ferreira, Joana F. Fangueiro & Nuno M. Neves

  3. The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark 4805-017 Barco, Guimarães, Portugal

    Nuno M. Neves

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  1. Helena Ferreira
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Correspondence to Helena Ferreira .

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  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Korea Institute of Science and Technology, Seoul, Korea (Republic of)

    Kwideok Park

  3. Korea Institute of Radiological and Medical Sciences, Seoul, Korea (Republic of)

    Chun-Ho Kim

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Ferreira, H., Fangueiro, J.F., Neves, N.M. (2018). The Role of Natural-Based Biomaterials in Advanced Therapies for Autoimmune Diseases. In: Chun, H., Park, K., Kim, CH., Khang, G. (eds) Novel Biomaterials for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1077. Springer, Singapore. https://doi.org/10.1007/978-981-13-0947-2_8

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