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Silk Fibroin-Based Scaffold for Bone Tissue Engineering

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Novel Biomaterials for Regenerative Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1077))

Abstract

Regeneration of diseased or damaged skeletal tissues is one of the challenge that needs to be solved. Although there have been many bone tissue engineering developed, scaffold-based tissue engineering complement the conventional treatment for large bone by completing biological and functional environment. Among many materials, silk fibroin (SF) is one of the favorable material for applications in bone tissue engineering scaffolding. SF is a fibrous protein mainly extracted from Bombyx mori. and spiders. SF has been used as a biomaterial for bone graft by its unique mechanical properties, controllable biodegradation rate and high biocompatibility. Moreover, SF can be processed using conventional and advanced biofabrication methods to form various scaffold types such as sponges, mats, hydrogels and films. This review discusses about recent application and advancement of SF as a biomaterial.

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Abbreviations

ALP:

Alkaline phosphatase

ASCs:

Adipose-derived stem cells

BK:

Broussonetia kazinoki

BMSCs:

Bone marrow derived mesenchymal stem cells

BMP-2:

Bone morphogenic protein-2

DBM:

Demineralized bone matrix

3D:

3 dimensional

ECM:

Extracellular matrix

FDA:

Food and Drug Administration

HFIP:

Hexafluoro-2-propanol

hMSCs:

Human mesenchymal stem cells

HAp:

Hydroxyapatite

MSCs:

Mesenchymal stem cells

micro-CT:

Micro computed tomography

PLGA:

Poly(lactide-co-glycolide)

PCL:

Polycarprolactam

PGA:

Polyglycolide

PEG:

Polyethylene glycole

PLA:

Polylactide

SF:

Silk fibroin

TCP:

Tricalcium phosphate

TE:

Tissue Engineering

VEGF:

Vascular endothelial growth factor

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Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1A2B3010270) and Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &Welfare, South Korea (HI15C2996).

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Authors and Affiliations

  1. Department of BIN Convergence Technology, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea

    Joo Hee Choi, Do Kyung Kim, Jeong Eun Song & Gilson Khang

  2. Department of PolymerNano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea

    Joaquim Miguel Oliveira & Rui Luis Reis

  3. ICVS/3B’s – PT Government Associated Laboratory, Braga/Guimarães, Portugal

    Joaquim Miguel Oliveira & Rui Luis Reis

  4. The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Guimarães, Portugal

    Joaquim Miguel Oliveira & Rui Luis Reis

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  1. Joo Hee Choi
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  2. Do Kyung Kim
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  3. Jeong Eun Song
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  4. Joaquim Miguel Oliveira
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  5. Rui Luis Reis
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  6. Gilson Khang
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Correspondence to Gilson Khang .

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Editors and Affiliations

  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Korea Institute of Science and Technology, Seoul, Korea (Republic of)

    Kwideok Park

  3. Korea Institute of Radiological and Medical Sciences, Seoul, Korea (Republic of)

    Chun-Ho Kim

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Choi, J.H., Kim, D.K., Song, J.E., Oliveira, J.M., Reis, R.L., Khang, G. (2018). Silk Fibroin-Based Scaffold for Bone Tissue Engineering. In: Chun, H., Park, K., Kim, CH., Khang, G. (eds) Novel Biomaterials for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1077. Springer, Singapore. https://doi.org/10.1007/978-981-13-0947-2_20

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