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New Treatment Modalities for the Management of Peritoneal Metastases

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Management of Peritoneal Metastases- Cytoreductive Surgery, HIPEC and Beyond

Abstract

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a therapeutic option for a small subset of patients with peritoneal metastases arising from various primary sites. Locoregional therapies for effective management of patients who are not candidates for this procedure are needed. Recurrence after CRS and HIPEC is common. Strategies for improving the efficacy of CRS and HIPEC are being studied. New treatments that overcome the limitations of CRS and HIPEC are being evaluated in clinical and preclinical studies. New drugs for intraperitoneal use and new intraperitoneal therapies have been developed and investigated in both experimental and clinical studies. The results of some of these studies are encouraging, and these therapies may find a place in routine clinical practice in the future. An overview of the rationale, methodology, and preliminary results of experimental and clinical studies evaluating these new locoregional therapies for the management of PM is provided here.

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  1. Department of Surgical Oncology, Fortis Hospital, Bangalore, India

    Aditi Bhatt

  2. Peritoneal Malignancy Institute, Basingstoke & North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK

    Akash Mehta

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    Aditi Bhatt

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Bhatt, A., Mehta, A. (2018). New Treatment Modalities for the Management of Peritoneal Metastases. In: Bhatt, A. (eds) Management of Peritoneal Metastases- Cytoreductive Surgery, HIPEC and Beyond. Springer, Singapore. https://doi.org/10.1007/978-981-10-7053-2_20

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