Skip to main content
SpringerLink
Log in

Clinical Manifestation: Adult-Type Atopic Dermatitis

  • Chapter
  • First Online:
Book cover Evolution of Atopic Dermatitis in the 21st Century

  • 933 Accesses

Abstract

Most of the patients with atopic dermatitis (AD) get better before about 10 years old. Although some patients get better and flare up once again after adolescence, some never get better and symptoms remain from childhood through to adulthood, and some have an onset after adolescence. and dirty neck are common among any type of AD of adolescent and adult, and other typical manifestations are also found.

Scratching the itchy spot for a long time and inappropriate treatment induce intractable chronic eczema. In the adolescent and adult patients of AD, the life and job environment directly affect the condition of their eruption. In addition, decreased perspiration in AD is one of the causes of skin dryness and decreased skin barrier function, so it is susceptible to complications like skin infectious disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  1. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92:44–7.

    Google Scholar 

  2. The Japanese Dermatological Association. Definition and diagnostic criteria for atopic dermatitis. Jpn J Dermatol. 1994;104:1210. (in Japanese)

    Google Scholar 

  3. Saeki H, Nakahara T, Tanaka A, et al. Clinical practice guidelines for the management of atopic dermatitis 2016. J Dermatol. 2016;43:1117–45.

    Article  PubMed  Google Scholar 

  4. Lewis WH, Marion BS, et al. Evolution of atopic dermatitis. Arch Derm Syphilol. 1935;32:451–63.

    Article  Google Scholar 

  5. Werner Y, Lindberg M. Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol. 1985;65(2):102–5.

    CAS  PubMed  Google Scholar 

  6. Takahashi A, Tani S, Murota H, et al. Histamine modulates sweating and affects clinical manifestations of atopic dermatitis. Kerger Curr Probl Dermatol. 2016;51:50–6.

    Article  Google Scholar 

  7. Hajar T, Leshem YA, Hanifin JM, et al. A systematic review of topical corticosteroid withdrawal (“steroid addiction”) in patients with atopic dermatitis and other dermatoses. J Am Acad Dermatol. 2015;72(3):541–9.

    Article  CAS  PubMed  Google Scholar 

  8. Oh SH, Bae BG, Park CO, et al. Association of stress with symptoms of atopic dermatitis. Acta Derm Venereol. 2010;90:582–8.

    Article  PubMed  Google Scholar 

  9. Nilsson EJ, Knutsson A. Atopic dermatitis, nickel sensitivity and xerosis as risk factors for hand eczema in women. Contact Dermatitis. 1995;33:401–6.

    Article  CAS  PubMed  Google Scholar 

  10. Arase N, Murakami Y, Takahashi A, et al. Analysis of work productivity and activity impairment (WPAI), quality of life (QOL) and healthcare costs for Japanese patients with hand eczema. J Environ Dermatol Cutan Allergol. 2013;7(2):87–92.

    Google Scholar 

  11. Hashimoto T, Satoh T, Yokozeki H. Protective role of STAT6 in basophil-dependent prurigo-like allergic skin inflammation. J Immunol. 2015;194(10):4631–40.

    Article  CAS  PubMed  Google Scholar 

  12. Mukai H, Nishioka K, Kamimura K, et al. Poikiloderma-like lesions on the neck in atopic dermatitis: a histopathological study. J Dermatol. 1990;17(2):85–91.

    Article  CAS  PubMed  Google Scholar 

  13. Schram ME, Leeflang MM, DEN Ottolander JP, et al. Validation and refinement of the Millennium Criteria for atopic dermatitis. J Dermatol. 2011;38(9):850–8.

    PubMed  Google Scholar 

  14. Uehara M. Infraorbital fold in atopic dermatitis. Arch Dermatol. 1981;117(10):627–9.

    Article  CAS  PubMed  Google Scholar 

  15. Wong CK, Lin CS. Friction amyloidosis. Int J Dermatol. 1988;27(5):302–7.

    Article  CAS  PubMed  Google Scholar 

  16. Smith FJD, Irvine AD, Terron-Kwiatkowski A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;38:337–42.

    Article  CAS  PubMed  Google Scholar 

  17. Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, et al. FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema. Br J Dermatol. 2009;161(6):1387–90.

    Article  CAS  PubMed  Google Scholar 

  18. Novak N, Baurecht H, Schafer T, et al. Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. J Invest Dermatol. 2008;128:1430–5.

    Article  CAS  PubMed  Google Scholar 

  19. Sergeant A, Campbell LE, Hull PR, et al. Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly. J Invest Dermatol. 2009;129:1042–5.

    Article  CAS  PubMed  Google Scholar 

  20. Brown SJ, Relton CL, Liao H, et al. Filaggrin null mutations and childhood atopic eczema: a population-based case–control study. J Allergy Clin Immunol. 2008;121:940–6.

    Article  CAS  PubMed  Google Scholar 

  21. Brown SJ, Relton CL, Liao H, et al. Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children. Br J Dermatol. 2009;161(4):884–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan, 5650871

    Aya Takahashi, Hiroyuki Murota & Ichiro Katayama

Authors
  1. Aya Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroyuki Murota
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ichiro Katayama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aya Takahashi .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Ichiro Katayama

  2. Department of Dermatology, Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

    Hiroyuki Murota

  3. Department of Dermatology, National Defense Medical College, Tokorosazawa, Saitama, Japan

    Takahiro Satoh

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Cite this chapter

Takahashi, A., Murota, H., Katayama, I. (2018). Clinical Manifestation: Adult-Type Atopic Dermatitis. In: Katayama, I., Murota, H., Satoh, T. (eds) Evolution of Atopic Dermatitis in the 21st Century. Springer, Singapore. https://doi.org/10.1007/978-981-10-5541-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-5541-6_17

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5540-9

  • Online ISBN: 978-981-10-5541-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation