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Channelopathies: Application of Natural Products Using Nanotechnology

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Calcium Signaling: From Physiology to Diseases

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Abstract

Ca2+ channels have fundamental role in numerous physiological functions, by regulating intracellular Ca2+ homeostasis, in all organs and tissues including the heart, muscle and brain. There are different types of Ca2+channels, which mediate specific cellular functions in these tissues depending on their sensitivity to Ca2+ gradient. They have critical role in many pathological conditions such as hypertension, neurodegenerative diseases, pain, muscle dysfunctions, etc. Thus, targeting Ca2+channels gives great relief from many disorders. There are many naturally available Ca2+ blockers/agonists, which have been demonstrated for their effectiveness in experimental system, and some of them have been under clinical trial for various pathological conditions. However, their clinical effectiveness is mainly hindered by poor pharmacokinetics and low bioavailability at target sites. Nanotechnology-based delivery systems offer a promising solution for the above-mentioned problems. The Food and Drug Administration (FDA) has approved several nanomedicines to use them as a first line of therapeutics, and many of them are under consideration. The nanosystem-based therapeutic strategies could help to improve the efficiency of drugs in treating channelopathies, and it strengthens the efforts of the translation of natural products to utilize them in clinical application.

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Authors and Affiliations

  1. Department of Biochemistry, Rayalaseema University, Kurnool, AP, India

    Senthilkumar Rajagopal

  2. Center for Developmental Cardiology, Institute of Translational Medicine, Qingdao University, Qingdao, Shandong, China

    Murugavel Ponnusamy

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  1. Senthilkumar Rajagopal
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  2. Murugavel Ponnusamy
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Rajagopal, S., Ponnusamy, M. (2017). Channelopathies: Application of Natural Products Using Nanotechnology. In: Calcium Signaling: From Physiology to Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-5160-9_6

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