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Lipid Carriers: Role and Applications in Nano Drug Delivery

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Particulate Technology for Delivery of Therapeutics

Abstract

The ability of lipid carriers to enhance solubility, absorption and thereby the bioavailability of poorly soluble molecules by selective mechanism makes these systems a unique delivery option for certain classes of drugs. Different types of delivery systems that include liposome, solid lipid nanoparticles, nanostructured lipid carriers, lipid–polymer hybrid nanoparticles, lipoplexes, and phytosomes can be produced depending on the lipids/excipients used and the formulation technique employed. In this chapter, focus will be on different lipid-based carrier systems, their role in nano delivery and the advantages offered in improvement of solubility, absorption, and bioavailability with relevant case studies. Manufacturing methods of different carrier systems will be elaborated with a brief overview of scale up feasibility. Gene delivery with the use of charged lipids and delivery of herbal actives and neutraceuticals by phytosomes will be presented. Commercial products based on the lipid technology and recent patents in this area will be discussed.

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Abbreviations

BCS:

Biopharmaceutics classification system

GI:

Gastrointestinal

GRAS:

Generally regarded as safe

HPH:

High-pressure homogenization

LPHNs:

Lipid polymer hybrid nanoparticles

LUV:

Large unilamellar vesicles

MLV:

Multilamellar vesicles

NLC:

Nanostructured lipid carriers

PEG:

Polyethylene glycol

PLs:

Phospholipids

RES:

Reticuloendothelial system

SCF:

Supercritical fluid

SFEE:

Supercritical fluid extraction of emulsions

SLNs:

Solid lipid nanoparticles

SUV:

Small unilamellar vesicles

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  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, Telangana, India

    Naveen Chella & Nalini R. Shastri

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  1. Naveen Chella
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  2. Nalini R. Shastri
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Correspondence to Nalini R. Shastri .

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  1. Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Chella, N., Shastri, N.R. (2017). Lipid Carriers: Role and Applications in Nano Drug Delivery. In: Jana, S., Jana, S. (eds) Particulate Technology for Delivery of Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-10-3647-7_8

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