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Cells Transplantation for the Repair of Peripheral Nerve Injuries

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Advanced Trauma and Surgery

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Abstract

Peripheral nerve injury , resulted from different trauma and diseases, is quite popular in clinic and frequently leading to life-long disability. Although the peripheral nerve system has a more suitable environment for axon regeneration than the central nerve system, the treatment for the nerve injury is still a practical problem in clinic. Particularly, it is more difficult to repair the nerve defects with a greater gap, which needs to be bridged with different grafts. Autografts are considered as “gold standard” for surgical repair, but have many limitations. Therefore, the cells transplantation for the repair of peripheral nerve injury is a current interesting field in order to replace autografts. Generally, the donor cells derived from different tissue and ages, such as stem cells, mesenchymal stem cells , olfactory ensheathing cells and Schwann cells , are filled into the lumen of the synthetic and natural conduits to form artificial nerve for repairing the peripheral nerve defect, but the outcomes are various in the current literatures due to different donor cells , nerve conduits and animal injury model. The firearm nerve injuries are more special for surgical treatment as their wound features, so the research about it should be enhanced in the future.

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Abbreviations

AchR:

Acetylcholine receptors

ADSCs:

Adipose derived stem cells

AFDSCs:

Amniotic fluid derived stem cells

CAP1:

Cyclase-associated protein 1

BDNF:

Brain-derived neurotrophic factor

bFGF:

Basic fibroblast growth factor

BMSCs:

Bone marrow derived stem cells

CNS:

Central nervous system

CNTF:

Ciliary neurotrophic factor

CSPGs:

Chondroitin sulphate proteoglycan

DPSCs:

Dental pulp stem cells

DRG:

Dorsal root ganglia

ECM:

Extracellular matrix

EGF:

Endothelial growth factor

ERK1/2:

Extracellular regulated protein kinases

ESCs:

Embryonic stem cells

FGF:

Fibroblast growth factor

FOX:

Forkhead box

FSCs:

Fetal derived stem cells

GDNF:

Glial cell derived neurotrophic factor

GFP:

Green fluorescent protein

HGF:

Hepatocyte growth factor

IFN-γ:

Interferon-γ

IL:

Interleukin

MSCs:

Mesenchymal stem cells

NGF:

Nerve growth factor

NSCs:

Nerve stem cells

NT-3:

Neurotrophin-3

OB-OECs:

Olfactory-ensheathing cells from the olfactory bulb

OECs:

Olfactory-ensheathing cells

OM-OECs:

Olfactory-ensheathing cells from the olfactory mucosa

PCL:

Polyester poly(E-caprolactone)

PFTBA:

Perfluorotributylamine

PGA:

Polyglycolic acid

PLLA:

Poly(l-lactide)

PLGA:

Poly(lactic-co-glycolic acid)

PNI:

Peripheral nerve injury

PNS:

Peripheral nervous system

SCs:

Schwann cells

SFS:

Silk fibroin scaffolds

SFI:

Sciatic function index

SKPs:

Skin derived precursors

SKPSCs:

Schwann cells derived from skin-derived Schwann cell precursors

TNF-α:

Tumor necrotic factor-α

VEGF:

Vascular endothelial growth factor

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Acknowledgments

This paper was supported by National Basic Reseach Program of China/973 (2012CB518106), Major Project of PLA Logistcs Research Program (AWS14C003-5) and Program of State Key Laboratory of Trauma, Burn and Combined Injury (SKLZZ201003).

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Authors and Affiliations

  1. State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China

    Bingcang Li

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Editors and Affiliations

  1. Key Laboratory of Wound Repair and Regenerative Medicine of PLA, The first Affiliated Hospital of PLA General Hospital, Beijing, Beijing, China

    Xiaobing Fu

  2. Key Laboratory of Wound Repair and Regenerative Medicine of PLA, Daping Hospital, Chongqing, Chong Qing, China

    Liangming Liu

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Li, B. (2017). Cells Transplantation for the Repair of Peripheral Nerve Injuries. In: Fu, X., Liu, L. (eds) Advanced Trauma and Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-2425-2_22

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  • DOI: https://doi.org/10.1007/978-981-10-2425-2_22

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