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NADH Oxidase: A Multifunctional Ectoprotein of the Eukaryotic Cell Surface

  • Chapter
Plasma Membrane Redox Systems and their Role in Biological Stress and Disease

Abstract

The hormone-responsive external plasma membrane NADH oxidase (NOX) was first described for right side-out vesicles of plasma membranes isolated from dark-grown seedlings of soybean (Morré et al., 1986) in response to the auxin regulator of plant growth, 2,4-dichlorophenoxyacetic acid (2,4-D). A comparable hormone- and growth factor responsive NADH oxidase was subsequently described for isolated plasma membranes of rat liver. When hepatoma plasma membranes were examined, an NADH oxidase activity was observed but the activity was constitutively activated and no longer growth factor responsive (Bruno et al., 1992). Subsequent work has focused largely on the growth factor-insensitive activity of transformed cells grown in culture (Morré et al., 1995a). The latter has now been extensively characterized and is distinguished from that of non-transformed cells and tissues by being inhibited by both thiol reagents and several antitumor or potential antitumor drugs.

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  1. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, South University Av., IN, 47907, West Lafayette, USA

    D. James Morré

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  1. University of Antwerp (RUCA), Antwerp, Belgium

    Han Asard  & Roland J. Caubergs  & 

  2. Institute of Biophysics, Hungarian Academy of Sciences, Szeged, Hungary

    Alajos Bérczi

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Morré, D.J. (1998). NADH Oxidase: A Multifunctional Ectoprotein of the Eukaryotic Cell Surface. In: Asard, H., Bérczi, A., Caubergs, R.J. (eds) Plasma Membrane Redox Systems and their Role in Biological Stress and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2695-5_5

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  • DOI: https://doi.org/10.1007/978-94-017-2695-5_5

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