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The Platinum—Pyrimidine Blues

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Book cover Transition Metal Complexes as Drugs and Chemotherapeutic Agents

Part of the book series: Catalysis by Metal Complexes ((CMCO,volume 11))

Abstract

The platinum—pyrimidine blues, derived from cisplatin, are an interesting class of complexes with antitumour activity. They were first discovered as a result of studies on the interaction of cis-[PtCl2(NH3)2] and its aquated products with pyrimidines. The identification of DNA as the target for platinum attack naturally led to a systematic study of the reactions of the complex with nucleic acid constituents. The observation that with polyuridine no immediate reaction took place but that a blue color slowly developed in solution, from which a blue solid could be isolated, led to the preparation of a series of complexes containing substituted uracils and thymines.

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  1. The University of Vermont, Burlington, Vermont, USA

    Nicholas Farrell

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© 1989 Kluwer Academic Publishers

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Farrell, N. (1989). The Platinum—Pyrimidine Blues. In: Transition Metal Complexes as Drugs and Chemotherapeutic Agents. Catalysis by Metal Complexes, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7568-5_6

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  • DOI: https://doi.org/10.1007/978-94-011-7568-5_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7570-8

  • Online ISBN: 978-94-011-7568-5

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