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Transition Metal Complexes as Drugs and Chemotherapeutic Agents

  • Book
  • © 1989

Overview

Authors:
  1. Nicholas Farrell

    1. The University of Vermont, Burlington, USA

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Part of the book series: Catalysis by Metal Complexes (CMCO, volume 11)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    • Nicholas Farrell
    Pages 1-7

  3. Interaction of Metal Complexes with DNA

    • Nicholas Farrell
    Pages 8-45

  4. Platinum—Amine Complexes as Anticancer Agents

    • Nicholas Farrell
    Pages 46-66

  5. Structure—Activity Relationships of Platinum—Amine Complexes

    • Nicholas Farrell
    Pages 67-94

  6. Interactions of Platinum Complexes with DNA Components

    • Nicholas Farrell
    Pages 95-126

  7. The Platinum—Pyrimidine Blues

    • Nicholas Farrell
    Pages 127-141

  8. Antitumour Activity of Metal Complexes

    • Nicholas Farrell
    Pages 142-167

  9. Metal-Mediated Antibiotic Action

    • Nicholas Farrell
    Pages 168-182

  10. Metals, Metal Complexes, and Radiation

    • Nicholas Farrell
    Pages 183-207

  11. Antibacterial Effects of Metal Complexes

    • Nicholas Farrell
    Pages 208-221

  12. Antiviral and Antiparasitic Effects of Metal Complexes

    • Nicholas Farrell
    Pages 222-242

  13. Metal Complexes in Arthritis

    • Nicholas Farrell
    Pages 243-256

  14. Miscellaneous Uses of Metal Complexes

    • Nicholas Farrell
    Pages 257-265

  15. Back Matter

    Pages 266-291
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Keywords

About this book

When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate. This timeliness has not diminished during the gestation and final publica­ tion of the manuscript. The introduction contains an explanation of the layout and approach to the book, which I wrote as an overall survey of the wide variety of biological properties of metal complexes. Hopefully, the reader will see the parallels in mechanisms and behavior, even in different organisms. The writing was considerably helped by the enthusiasm and confidence (totally unearned on my part) in the project of Professor Brian James and lowe him my special thanks. I also owe a great debt of gratitude to my colleagues, and especially to Eucler Paniago, of the Universidade Federal de Minas Gerais, for their comprehension and for the initial leave of absence which allowed me to begin the project. To those who read some or all of the manuscript and made suggestions, Bernhard Lippert, Kirsten Skov, and Tom Tritton, as well as the editor's reviewer I am also grateful. As usual, the final responsibility for errors or otherwise rests with the author.

Reviews

`The book is well written, thoroughly documented and presents useful information to both scientists and clinicians.'
Oncology, 48:2
`The book is very readable, well referenced and there is a useful glossary for those baffled by pharmacological terms. The discovery of truly novel drugs in the future may well hinge on the application of the principles in inorganic chemistry - both metals and non-metals - to pharmacology. This book should therefore be welcome on all library shelves.'
Chemistry in Britain, 1990

Authors and Affiliations

  • The University of Vermont, Burlington, USA

    Nicholas Farrell

Bibliographic Information

  • Book Title: Transition Metal Complexes as Drugs and Chemotherapeutic Agents

  • Authors: Nicholas Farrell

  • Series Title: Catalysis by Metal Complexes

  • DOI: https://doi.org/10.1007/978-94-011-7568-5

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1989

  • Softcover ISBN: 978-94-011-7570-8Published: 15 March 2012

  • eBook ISBN: 978-94-011-7568-5Published: 06 December 2012

  • Series ISSN: 0920-4652

  • Series E-ISSN: 2215-180X

  • Edition Number: 1

  • Number of Pages: 304

  • Topics: Organometallic Chemistry, Pharmacy, Inorganic Chemistry, Oncology

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