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Cell death and the disease process. The role of calcium

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Cell death in biology and pathology

Abstract

The cellular processes involved in the death of the cell are of vital importance to biology and medicine: in biology because they occur as a normal part of the economy of every organism even during development and, of course, in its ultimate demise, and in medicine because cell death forms an important part of virtually every disease. We have been studying the events associated with cellular death for over 20 years and, in this chapter, will briefly review not only the knowledge that we have gained but also correlate it with data obtained from other laboratories. In addition, we will review our current working hypothesis concerning ion redistribution, particularly calcium, and their effects which lead to cell death.

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References

  • Ashraf, M., White, F. and Bloor, C. M. (1978), Ultrastructural influences of reperfusing dog myocardium with calcium-free blood after coronary artery occlusion. Am. J. Pathol, 90, 423–434.

    Google Scholar 

  • Baker, P. F (1972), Transport and metabolism of calcium ions in nerve. Prog. Biophys. Mol. Biol, 24, 177–223.

    Article  Google Scholar 

  • Barrett, L. A., McDowell, E. M., Harris, C. C. and Trump, B. F. (1977), Studies on the pathogenesis of ischemic cell injury. XV. Reversal of ischemic cell injury in hamster trachea and human bronchus by explant culture. Beitr. Pathol Bd, 161, 109–121.

    Article  Google Scholar 

  • Blaustein, M. P. (1974), The interrelationship between Na and Ca fluxes across the cell membranes. Rev. Physiol Biochem. Pharmacol, 70, 33 - 82.

    Article  Google Scholar 

  • Borle, A. B. and Studer, R. (1978), Effects of calcium ionophores on the transport and distribution of calcium in isolated cells in liver and kidney slices. J. Membr. Biol, 38, 51–72.

    Article  Google Scholar 

  • Brinley, F. J. Jr. (1978), Calcium-buffering in squid axons. Annu. Rev. Biophys. Bioeng, 7, 363 - 392.

    Article  Google Scholar 

  • Bulger, R. E. and Trump, B. F. (1969), Ca2+ and K+ ion effects on ultrastructure of isolated flounder kidney tubules. J. Ultrastruct. Res, 28, 301–319.

    Article  Google Scholar 

  • Bulkley, B., Nunnally, R. L. and Hollis, D. P. (1978), ‘Calcium paradox’ and the effect of varied temperature on its development: A phosphorous nuclear magnetic resonance and morphological study. Lab. Invest, 39, 133–140.

    Google Scholar 

  • Carafoli, E. (1979), The calcium cycle of mitochondria. Febs Lett, 104, 1–6.

    Article  Google Scholar 

  • Cheah, K. S. and Cheah, A. M. (1977), Inclusions in aged mitochondria. J. Bionerg. Biomembr, 9, 105–115.

    Article  Google Scholar 

  • Cheung, W. Y. (1970), Cyclic 3′, 5-nucleotide phosphodiesterases: Demonstration of an activator. Biochem. Biophys. Res. Commun, 33, 533–538.

    Article  Google Scholar 

  • Cheung, W. Y. (1980), Calmodulin plays pivotal role in cellular regulation. Science, 207, 19–27.

    Article  Google Scholar 

  • Chien, K. R., Abrams, J., Serroni, A., Martin, J. T. and Farber, J. L. (1978), Accelerated phospholipid degradation and associated membrane dysfunction in irreversible ischemia liver cell injury. J. Biol. Chem, 253, 4809–4817.

    Google Scholar 

  • Croker, B. P., Saladino, A. J. and Trump, B. F. (1970), Ion movements in cell injury: Relationships between energy metabolism and the pathogenesis of lethal injury in toad bladder. Am. J. Pathol, 59, 247–278.

    Google Scholar 

  • Crompton, M., Moser, R., Ludi, H. and Carafoli, E. (1978), The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues. Eur. J. Biochem, 82, 25–31.

    Article  Google Scholar 

  • Decker, R. S. and Wildenthal, K. (1980), Lysosomal alterations in hypoxic and reoxygenated hearts. I. Ulstrastructural and cytochemical changes. Am. J. Pathol, 98, 425–444.

    Google Scholar 

  • Dedman, J. R., Brinkley, B. R. and Means, A. R. (1979), Regulation of microfilaments and microtubules by calcium and cyclic AMP. Adv. Cyclic Nucleotide Res, 11, 131–174.

    Google Scholar 

  • De Duve, C. and Wattiaux, R. (1966), Function of lysosomes. Ann. Rev. Physiol, 28, 435–492.

    Article  Google Scholar 

  • Donohoe, J. F., Venkatachalam, M. A., Bernard, D. B. and Levinsky, N. G. (1978), Tubular leakage and obstruction after renal ischemia: Structural-functional correlations. Kidney Int, 13, 208–222.

    Article  Google Scholar 

  • French, S.W., Norum, H. L., Ihrig, T. J. and Todoroff, T. (1971), Effect of phospholipid hydrolysis on the structural and functional integrity of mitochrondria. Lab. Invest, 25, 427–434.

    Google Scholar 

  • Gan-Elepano, M. and Mead, J. F. (1978), The function of phospholipase A in the metabolism of membrane lipids. Biochem. Biophys. Res. Commun, 83, 247–251.

    Article  Google Scholar 

  • Ginn, F. L., Shelburne, J. D. and Trump, B. F. (1968), Disorders of cell volume regulation. I. Effects of inhibition of plasma membrane adenosine triphosphatase with ouabain. Am. J. Pathol, 53, 1041–1071.

    Google Scholar 

  • Glaumann, B., Glaumann, H., Berezesky, I. K. and Trump, B. F. (1975), Studies on the pathogenesis of ischemic cell injury. II. Morphological changes of the pars convoluta (Pi and P2) of the proximal tubule of the rat kidney made ischemic in vivo. Virch. Arch. B Cell Pathol, 19, 281–302.

    Google Scholar 

  • Glaumann, B., Glaumann, H., Berezesky, I. K. and Trump, B. F. (1977a), Studies on cellular recovery from injury. II. Ultrastructural studies on the recovery of the pars convoluta of the proximal tubule of the rat kidney from temporary ischemia. Virch. Arch. B Cell Pathol, 24, 1–18.

    Google Scholar 

  • Glaumann, B., Glaumann, H. and Trump, B. F. (1977b), Studies of cellular recovery from injury. III. Ultrastructural studies of the recovery of the pars recta of the proximal tubule (P3 segment) of the rat kidney from temporary ischemia. Virch. Arch. B Cell Pathol, 25, 281–308.

    Google Scholar 

  • Glaumann, B. and Trump, B. F. (1975), Studies on the pathogenesis of ischemic cell injury. III. Morphological changes of the proximal pars recta tubules (P3) of the rat kidney made ischemic in vivo. Virch. Arch. B Cell Pathol, 19, 303–323.

    Google Scholar 

  • Goracci, G., Porcellati, G. and Woelk, H. (1978), Subcellular localization and distribution of phospholipases A in liver and brain tissue. Adv. Prostaglandin Thromboxane Res, 3, 55–67.

    Google Scholar 

  • Goring, G. G. and Spieckermann, P. G. (1978), Ca2+ uptake and release phenomena from cardiac mitochondria under normal and ischemic conditions. Basic Res. Cardiol, 73, 126–132.

    Article  Google Scholar 

  • Gritzka, T. L. and Trump, B. F. (1968), Renal tubular lesions caused by mercuric chloride. Electron microscopic observations: Degeneration of the pars recta. Am. J. Pathol, 52, 1225–1277.

    Google Scholar 

  • Hanzlikova, V. and Schiaffino, S. (1977), Mitochondrial changes in ischemic skeletal muscle. J. Ultrastruct. Res, 60, 121–133.

    Article  Google Scholar 

  • Hawkins, H. K., Ericsson, J. L. E., Biberfeld, P. and Trump, B. F. (1972), Lysosome and phagosome stability in lethal cell injury. Am. J. Pathol, 68, 255–287.

    Google Scholar 

  • Hearse, D. J. (1977), Reperfusion of the ischemic myocardium. J. Mol. Cell Cardiol, 9, 605–616.

    Article  Google Scholar 

  • Jones, R. T., Garcia, J. H., Mergner, W. J., Pendergrass, R. E., Valigorsky, J. M. and Trump, B. F. (1975), Effects of shock on the pancreatic acinar cell. Cellular and subcellular effects in humans. Arch. Pathol, 99, 634–644.

    Google Scholar 

  • Kahng, M.W., Berezesky, I. K and Trump, B. F. (1978), Metabolic and ultrastructural response of rat kidney cortex to in vitro ischemia. Exp. Mol. Pathol, 29, 183–198.

    Article  Google Scholar 

  • Kakiuchi, S., Yamazaki, R. and Nakajima, H. (1970), Properties of a heat stable phosphodiesterase activating factor isolated from brain extract. Proc. Jpn. Acad, 46, 587–591.

    Google Scholar 

  • Karpati, G., Carpenter, S., Melmed, C. and Eisen, A.A. (1974), Experimental ischemic myopathy. J. Neurol Sci, 23, 129–161.

    Article  Google Scholar 

  • Kloner, R. A., Ganote, C. E., Whalen, D. A. and Jennings, R. B. (1974), Effect of transient period of ischemia on myocardial cells. II. Fine structure during the first few minutes of reflow. Am. J. Pathol, 74, 399–422.

    Google Scholar 

  • Kretsinger, R. H. (1976), Evolution and function of calcium-binding proteins. Int. Rev. Cytol, 46, 323–393.

    Article  Google Scholar 

  • Kunze, H., Nahas, N., Traynor, J. R. and Wurl, M. (1976), Effects of local anaesthetics on phospholipases. Biochim. Biophys. Acta, 441, 93–102.

    Google Scholar 

  • Laiho, K. U., Berezesky, I. K. and Trump, B. F. (1980), Studies on the modification of the cellular response to injury. VII. Effect of the ionophore A23187 on ATP and ion content of Ehrlich ascites tumour cells following anoxia. (In preparation)

    Google Scholar 

  • Laiho, K. U., Shelburne, J. D. and Trump, B. F. (1971), Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells: Effects of inhibiting energy production and function of the plasma membrane. Am. J. Pathol, 65, 203–230.

    Google Scholar 

  • Laiho, K. U. and Trump, B. F. (1974a), Relationship of ionic, water, and cell volume changes in cellular injury of Ehrlich ascites tumor cells. Lab. Invest, 31, 207–215.

    Google Scholar 

  • Laiho, K. U. and Trump, B. F. (1974b), The relationship between cell viability and changes in mitochondrial ultrastructure, cellular ATP, ion and water content following injury of Ehrlich ascites tumor cells. Virch. Arch. Abt. B Zellpathol, 15, 267–277.

    Google Scholar 

  • Laiho, K. U. and Trump, B. F. (1975), Mitochondrial changes, ion and water shifts in the cellular injury of Ehrlich ascites tumor cells. Beitr. Pathol Bd, 155, 237–247.

    Article  Google Scholar 

  • Lehninger, A. (1970), Proteins and their biological functions. In Biochemistry (ed. A. Lehninger ), Worth Publishers, Inc., New York, p. 59.

    Google Scholar 

  • Lochner, A., Kotze, J. C. N., Benade, A. J. and Gevers, W. (1978), Mitochondrial oxidative phosphorylation in low flow hypoxia: Role of free fatty acids. J. Mol. Cell Cardiol, 10, 857–875.

    Article  Google Scholar 

  • Luzikov, V. N. (1973), Stabilization of the enzymatic systems of the inner mitochondrial membrane and related problems. Sub-Cell. Biochem, 2, 1–31.

    Google Scholar 

  • Majno, G. Lagattuta, M. and Thompson, T. (1960), Cellular death and necrosis: Chemical, physical and morphological changes in rat liver. Virch. Arch. Pathol Anat, 333, 421–465.

    Google Scholar 

  • Means, A. R. and Dedman, J. R. (1980), Calmodulin — An intracellular calcium receptor. Nature (London), 285, 73–77.

    Google Scholar 

  • Mergner, W. J., Chang, S., H., Marzella, L., Kahng, M. W. and Trump, B. F. (1979), Studies on the pathogenesis of ischemic cell injury. VIII. ATPase of rat kidney mitochondria. Lab. Invest, 40, 686–694.

    Google Scholar 

  • Mergner, W. J., Smith, M. W., Sahaphong, S. and Trump, B. F. (1977), Studies on the pathogensis of ischemic cell injury. VI. Accumulation of calcium by isolated mitochondria of ischemic rat kidney cortex. Virch. Arch. B. Cell Pathol, 26, 1–16.

    Google Scholar 

  • Mergner, W. J., Smith, M. W. and Trump, B. F. (1972), Structural and functional

    Google Scholar 

  • effects of the negative stains silicotungstic acid, phosphotungstic acid, and ammonium molybdate on rat kidney mitochondria. Lab. Invest., 27, 372–383.

    Google Scholar 

  • Meyer, W. L., Fischer, W. H. and Krebs, E. G. (1964), Activation of skeletal muscle Phosphorylase b kinase by Ca2+. Biochemistry, 3, 1033–1039.

    Article  Google Scholar 

  • Nayler, W. G., Fassold, E. and Yepez, C. (1978), Pharmacological protection of mitochondrial function in hypoxic heart muscle: Effect of verapamil, propranolol, and methylprednisolone. Cardiovasc. Res, 12, 152–161.

    Article  Google Scholar 

  • Osornio, A. R., Berezesky, I.K., Mergner, W. J. and Trump, B. F. (1980), Mitochondrial membrane fusions in experimental myocardial infarction. Fed. Proc. Fed. Am. Soc. Exp. Biol, 39, 634.

    Google Scholar 

  • Osornio-Vargas, A. R., Berezesky, I. K. and Trump, B. F. (1980b), Mitochondrial membrane fusions: An early ultrastructural change in experimental rat myocardial infarction. (In preparation)

    Google Scholar 

  • Owens, K., Pang, D. C. and Weglicki, W. B. (1979), Production of lysophospholipids and free fatty acids by a sarcolemmal fraction from canine myocardium. Biochem. Biophys. Res. Commun, 89, 368–373.

    Article  Google Scholar 

  • Pappu, A. S., Fatterpaker, P. and Sreenivasan, A. (1978), Phospholipase A of rat liver mitochondria in vitamin E deficiency. Biochem. J, 172, 349–352.

    Google Scholar 

  • Parce, J. W., Cunningham, C. C. and Waite, M. (1978), Mitochondrial phospholipase A activity and mitochondrial aging. Biochemistry, 17, 1634–1639.

    Article  Google Scholar 

  • Paul, R. J., Bauer, M. and Prease, W. (1979), Vascular smooth muscle: Aerobic glycolysis linked to sodium and potassium transport processes. Science, 206, 1414–1416.

    Article  Google Scholar 

  • Penttila, A., Glaumann, H. and Trump, B. F. (1976), Studies on the modification of the cellular response to injury. IV. Protective effect of extracellular acidosis against anoxia, thermal, and p-chloromercuribenzene sulfonic acid treatment of isolated rat liver cells. Life Sci, 18, 1419–1930.

    Article  Google Scholar 

  • Penttila, A. and Trump, B. F. (1974), Extracellular acidosis protects Ehrlich ascites tumor cells and rat renal cortex against anoxic injury. Science, 135, 277–278.

    Article  Google Scholar 

  • Penttila, A. and Trump, B. F. (1975a), Studies on modifications of the cellular response to injury. I. Protective effect of acidosis on p-chloromercuribenzene sulfonic acid-induced injury of Ehrlich ascites tumor cells. Lab. Invest, 32, 690–695.

    Google Scholar 

  • Penttila, A. and Trump, B. F. (1975b), Studies on the modification of the cellular response to injury. II. Electron microscopic studies on the protective effect of acidosis on anoxic injury of Ehrlich ascites tumor cells. Virch. Arch. B Cell Pathol, 18, 1–16.

    Google Scholar 

  • Penttila, A. and Trump, B. F. (1975c), Studies on the modification of the cellular response to injury. III. Electron microscopic studies on the protective effect of acidosis on p-chloromercuribenzene sulfonic acid-(PCMBS) induced injury of Ehrlich ascites tumor cells. Virch. Arch. B Cell Pathol, 18, 1 7–34.

    Google Scholar 

  • Publicover, S. J., Duncan, C. J. and Smith, J. L. (1978), The use of A23187 to demonstrate the role of intracellular calcium in causing ultrastructural damage in mammalian muscle. J. Neuropathol. Exp. Neurol, 37, 554–557.

    Article  Google Scholar 

  • Rasmussen, H. and Goodman, D. B. (1977), Relationships between calcium and cyclic nucleotides in cell activation. Physiol. Rev, 57, 421–509.

    Google Scholar 

  • Rubin, R. P. (1974), Calcium and the secretory process. Plenum, New York.

    Google Scholar 

  • Russ,. J. C. (1978), Electron probe X-ray microanalysis-principles. In Electron Probe Microanalysis in Biology, (ed. D. A. Erasmus ), Chapman and Hall, London, pp. 5–36.

    Google Scholar 

  • Sahaphong, S. and Trump, B. F. (1971), Studies of cellular injury in isolated kidney tubules of the flounder. V. Effects of inhibiting sulfhydryl groups of plasma membrane with the organic mercurials PCMB (parachloromercuribenzoate and PCMBS (parachloromercuribenzenesulfonate). Am. J. Pathol, 63, 277–298.

    Google Scholar 

  • Saito, A., Smigel, M. and Fleisher, S. (1974), Membrane junctions in the inter- membrane space of mitochondria from mammalian tissues. J. Cell Biol, 60, 653–663.

    Article  Google Scholar 

  • Saladino, A. J., Bentley, P. J. and Trump, B. F. (1969), Ion movements in cell injury. Effect of amphotericin B on the ultrastructure and function of the epithelial cells of the toad bladder. Am. J. Pathol, 54, 421–466.

    Google Scholar 

  • Schanne, F. A. X., Kane, A.B., Young, E. E. and Farber, J. L. (1979), Calcium dependence of toxic cell death: A final common pathway. Science, 206, 700–702.

    Article  Google Scholar 

  • Schiaffino, S., Severin, E. and Hanzlikova, V. (1979), Intermembrane inclusions induced by anoxia in heart and skeletal muscle mitochondria. Virch. Arch. B Cell Pathol, 31, 169–179.

    Article  Google Scholar 

  • Schliwa, M. (1976), The role of divalent cations in the regulation of microtubule assembly. In vivo studies on microtubules of the heliozan axopodium using the ionophore A23187. J. Cell Biol, 70, 527–540.

    Google Scholar 

  • Scifulla, R. D., Onishchenko, N. H. and Artamonov, S. D. (1979), Stabilizing effect of the antioxidants alpha-tocopherol and sodium selenite following phos- pholipase damage in mitochondrial membranes in a model of anoxia. Farmakol. Toksikol, 42, 157–163.

    Google Scholar 

  • Shen, A.C. and Jennings, R. B. (1972), Myocardial calcium and magensium in acute ischemic injury. Am. J. Pathol, 67, 417–440.

    Google Scholar 

  • Smith, M.W., Collan, Y., Kahng, M. W. and Trump, B. F. (1980), Changes of fatty acids and phospholipids in ischemic rat kidney. Biochim. Biophys. Acta (in press).

    Google Scholar 

  • Somlyo, A. P., Somlyo, A. V. and Shuman, H. (1979), Electron probe analysis of vascular smooth muscle. Composition of mitochondria, nuclei and cytoplasm. J. Cell Biol, 81, 316–335.

    Article  Google Scholar 

  • Studer, R. K. and Borle, A. B. (1979), Effect of pH on the calcium metabolism of isolated rat kidney cells. J. Membr. Biol, 48, 325–341.

    Article  Google Scholar 

  • Sun, S. T., Day, E. P. and Ho, J. T. (1978), Temperature dependence of calcium- induced fusion of sonicated phosphatidylserine vesicles. Proc. Natl Acad. Sci. U.S.A, 75, 4325–4328.

    Article  Google Scholar 

  • Trump, B. F. and Arstila, A. U. (1975), Cell membranes and disease processes. In Pathobiology of Cell Membranes, Vol. I (eds. B. F. Trump and A. U. Arstial ), Academic Press, New York, pp. 1–52.

    Google Scholar 

  • Trump, B. F., Berezesky, I. K., Chang, S. H. and Bulger, R. E. (1976a), Detection of ion shifts in proximal tubule cells of the rat kidney using X-ray microanalysis. Virch. Arch. B Cell Pathol, 22, 1 11–120.

    Google Scholar 

  • Trump, B. F., Berezesky, I.K., Chang, S. H., Pendergrass, R. E. and Mergner, W. J. (1979a), The role of ion shifts in cell injury. In Scanning Electron MicroscopyJ IIf SEM Inc., AMF O’Hare, Illinois 60666, pp. 1 - 14.

    Google Scholar 

  • Trump, B.F., Berezesky, I.K., Collan, Y., Kahng, M.W. and Mergner, W. J. (1976b), Recent studies on the pathophysiology of ischemic cell injury. Beitr. Pathol Bd, 158, 363–388.

    Article  Google Scholar 

  • Trump, B.F., Berezesky, I. K., Laiho, K. U., Osornio, A. R., Mergner, W. J. and Smith, M. W. (1980), The role of calcium in cell injury. A review. In Scanning Electron Microscopy, SEM Inc., AMF O’Hare, Illinois 60666 (in press).

    Google Scholar 

  • Trump, B. F., Berezesky, I.K., Mergner, W. J. and Phelps, P.C. (1978a), The role of calcium in cell injury. Micron, 9, 5–6.

    Google Scholar 

  • Trump, B. F., Berezesky, I. K., Pendergrass, R. E., Chang, S. H., Bulger, R. E., and Mergner, W. J. (1978b), X-ray microanalysis of diffusible elements in scanning electron microscopy of biological thin sections. Studies of pathologically altered cells. In Scanning Electron Microscopy JII, SEM Inc., AMF O’Hare, Illinois 60666, pp. 1027–1039.

    Google Scholar 

  • Trump, B. F., Croker, B. P., Jr. and Mergner, W. J. (1971), The role of energy metabolism, ion, and water shifts in the pathogenesis of cell injury. In Cell Membranes: Biological and Pathological Aspects (eds. G. W. Richter and D. G. Scarpelli ), Williams and Wilkins Co., Baltimore, pp. 84–128.

    Google Scholar 

  • Trump, B. F. and Ginn, F. L. (1969), The pathogenesis of subcellular reaction to lethal injury. In Methods and Achievements in Experimental Pathology, vol. IV (eds. E. Bajusz and G. Jasmin), Karger, Basel, pp. 1–29.

    Google Scholar 

  • Trump, B. F., Jones, R. T., Berezesky, I. K., Phelps, P. C. and Laiho, K. U. (1978c), Role of calcium in cell injury. Fed. Proc. Fed. Am. Soc. Exp. Biol. y 37, 403.

    Google Scholar 

  • Trump, B. F. and Laiho, K. U. (1975), Studies of cellular recovery from injury. I. Recovery from anoxia in Ehrlich ascites tumor cells. Lab. Invest, 33, 706–711.

    Google Scholar 

  • Trump, B.F., Laiho, K. U., Mergner, W. J. and Arstila, A. U. (1974a), Studies on the subcellular pathophysiology of acute lethal cell injury. Beitr. Pathol. Bd, 152, 243–271.

    Article  Google Scholar 

  • Trump, B. F. and Mergner, W. J. (1974), Cell injury. In The Inflammatory Process, vol. 1, 2nd Ed. (eds. B.W. Zweifach, L. Grant and R. T. McClusky), Academic Press, New York, pp. 1 15–257.

    Google Scholar 

  • Trump, B. F., Mergner, W. J., Kahng, M. W. and Saladino, A. J. (1976c), Studies on the subcellular pathophysiology of ischemia. Circulation, 53, Suppl. I, 17–26.

    Google Scholar 

  • Trump, B. F., Penttila, A. and Berezesky, I. K. (1979b), Studies on cell surface conformation following injury. I. Scanning and transmission electron microscopy of cell surface changes following p-chloromercuribenzene sulfonic acid (PCMBS)-induced injury of Ehrlich ascites tumor cells. Virch. Arch. B Cell Pathol, 29, 281–296.

    Google Scholar 

  • Trump, B.F., Penttila, A. and Berezesky, I. K. (1979c), Studies on cell surface conformation following injury. II. Scanning and transmission electron microscopy of cell surface changes following anoxic injury in Ehrlich ascites tumor cells. Virch. Arch. B Cell Pathol, 29, 297–307.

    Google Scholar 

  • Trump, B. F., Phelps, P.C., Shamsuddin, A.M. and Harris, C. C. (1979d), Cell surface changes in premalignant and malignant lesions of the colon. Lab. Invest, 40, 289.

    Google Scholar 

  • Trump, B. F., Strum, J. M and Bulger, R. E. (1974b), Studies on the pathogenesis of ischemic cell injury. I. Relation between ion and water shifts and cell ultra- structure in rat kidney slices during swelling at 0-4°C. Virch. Arch. B. Cell Pathol 16, 1–34.

    Article  Google Scholar 

  • Vasdev, S. C., Kako, K. J. and Biro, G. P. (1979), Phospholipid composition of cardiac mitochondria and lysosomes in experimental myocardial ischemia in the dog. J. Mol. Cell. Cardiol, 11, 1195–1200.

    Article  Google Scholar 

  • Wildenthal, K. (1978), Lysosomal alterations in ischemic myocardium: Result or cause of myocellular damage. J. Mol. Cell. Cardiol, 10, 595–603.

    Article  Google Scholar 

  • Wolff, D. J. and Siegel, F. (1972), Purification of a calcium-binding phosphoprotein from pig brain. J. Biol Chem, 247, 4180–4185.

    Google Scholar 

  • Wrogemann, K. and Pena, S.D. J. (1976), Mitochondrial calcium overload: A general mechanism for cell necrosis in muscle diseases. Lancet, i, 672–674.

    Google Scholar 

  • Zimmerman, A.N.E., Daems, W., Hulsmann, W.C., Snijder, J., Wisse, E. and Dürrer, D. (1967), Morphological changes of heart muscle caused by successive perfusion with calcium-free and calcium-containing solutions (calcium paradox). Cardiovasc. Res, 1, 201–209.

    Article  Google Scholar 

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Authors
  1. Benjamin F. Trump
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  2. Irene K. Berezesky
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  3. Alvaro R. Osornio-Vargas
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Editor information

Editors and Affiliations

  1. Department of Zoology, University College, Cardiff, UK

    I. D. Bowen

  2. Department of Biological Sciences, St John’s University, New York, USA

    R. A. Lockshin

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Trump, B.F., Berezesky, I.K., Osornio-Vargas, A.R. (1981). Cell death and the disease process. The role of calcium. In: Bowen, I.D., Lockshin, R.A. (eds) Cell death in biology and pathology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6921-9_8

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  • DOI: https://doi.org/10.1007/978-94-011-6921-9_8

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