Abstract
Polymer colloids can be used either as models in academic research dealing with colloid phenomena or as dispersed material in a wide variety of industrial applications. One major reason for such a development is related to the basic understanding in the production of these latexes through an increasing number of free-radical heterogeneous polymerization processes as well as in their complete characterization in terms of molecular or colloidal properties. Two major reasons motived the attractive interest for such polymer colloids in biological, medical and pharmaceutical applications: i) their unique and versatile properties with regard to the control of the particle shape and morphology, size and size distribution, surface chemistry, polymer nature, etc., and ii) the huge progress in molecular biology during the last two decades resulting in a vast number of available biomolecules (monoclonal antibodies, peptides, DNA probes, enzymes, recombinant proteins etc.) and sophisticated methodologies (amplification techniques, protein engineering, capillary electrophoresis, etc.).
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References
Daniels, E.S., Sudol, E.D., El-Aasser, M.S. (eds.) (1992) Preparation, characterization and applications of polymer latexes, ACS Symp. Series, 492, Washington, D.C.
Singer, J.M., Plotz, C.M. (1996), The latex formation test.1-Application to the serological diagnosis of rheumatoid arthritis, Am. J. Med., 31, 888.
Singer, J.M. (1987) The use of polystyrene latexes in medicine, in M.S. El-Aasser, R.M. Fitch (eds.), Future Directions in Polymer Colloids, Martinus Nijhoff Publishers, Dordretch, pp. 372–394.
Van den Hul, H.J., Vanderhoff, J.W. (1971) “Clean monodisperse latexes as model colloids”, in R.M. Fitch (ed.) Polymer Colloids, Plenum Press, NY, 1–26.
Goodwin, A.R., Ottewill, R M, Pelton, R H, Vianello, G., Yates, D.E. (1978) Control of particle size in the formation of polystyrene latices, Br. Polym.J., 10, 173–180.
Arshady, R. (1993) Microspheres for biomedical applications: preparation of reactive and labelled microspheres, Biomaterial, 14, 5–15.
Rembaum, A., Margel S, (1978), Design of polymeric immunospheres for cell labeling and separation, Br. Polym. J, 10, 275–280.
Ugelstad, J., Berge, A., Ellingsen, T., Schmid, R., Nilson, T.N., Mork, P.C., Stenstad, P., Homes, E., Olswik, Ø.(1992) Preparation and applications of new monosized polymer particles, Prog. Polym., 17, 17.
Ugelstad, J., Stenstad, P., Kilaas, L., Prestvik, W.S., Rian, A., Nustad, K., Huge, R., Berge, A. (1996) Biochemical and biomedical applications of monodispersed polymer particles, Macromol. Symp., 101, 491–500.
El-Aasser, M.S., Methods of latex cleaning, in G.W. Poehlein, R.H. Ottewill, J.W. Goodwin (eds.) Science and Technology of Polymer Colloids, NATO ASI Series, E68, Ed. Nijhoff, The Hague, 1983, 422–448.
Blackley, D.C., (1983) Preparation of carboxylated latices by emulsion polymerization, in G.W. Poehlein, R.H. Goodwill, J.W. Goodwin (eds.), Science and Technology of Polymer Colloids, NATO ASI Series, E68, Nijhoff, The Hague, 203–219.
Delair, Th., Pichot, C., Mandrand, B. (1994) Synthesis and characterization of cationic latex particles bearing sulfhydryl groups and their use in the immobilization of Fab antibody fragments, Colloid Polym. Sci., 272, 72–81.
Delair, Th., Marguet, V., Pichot, C., and Mandrand, B. (1994) Synthesis and characterization of cationic amino functionalized latexes, Colloid Polym. Sci., 272, 962–970.
Ganachaud, F., Mouterde, G., Delair, Th., Elaïssari, A., and Pichot, C. (1994) Preparation and characterization of cationic polystyrene latex particles of different aminated surface charges, Polym. for Adv.Tech., 6, 480–488.
Sarobe J., and Forcada J. (1996) Synthesis of core-shell type polystyrene monodisperse particles with chloromethyl groups, Colloid Polym. Sci, 274, 8–13.
Kling, J.A., and Ploehn, H.J. (1995) Synthesis and characterization of epoxy-functional polystyrene particles, J. Polym. Sci. Part A: Polym. Chem., 33, 1107–1118.
Brouwer, W.M., Van Der Vegt, M., and Van Haaren, P. (1990) Particle surface characteristics of permanently charged poly(styrene-cationic monomer) latices, Europ. Polym. J., 26, 35–39.
Hassanein, M., Abdel-Hay, F.I., El-Hefnawy, T., and El-Esawy, A.(1994) Autooxidation of 2–6, di-tbutyl phenol catalyzed by Cobalt (II)-Schiff-base complex bound to cationic latexes, Europ. Polym. J., 30,335–337.
Ford, N.T., Yu, H., Lee, J.J., and El-Hamshary H. (1993) Synthesis of monodisperse cross-linked polystyrene latexes containing vinylbenzyl)trimethyl-ammoniumchloride units, Langmuir, 9, 1698–1703.
Vernier-Charleux, B., Graillat, C., Chevalier, Y., Pichot, C., Revillon, A. (1991) Synthesis and characterization of emulsifier-free quatemarized vinylbenzylchloride latexes, Colloid. Polym. Sci., 269,398–405.
Charleux, B., Fanget, P., Pichot, C. (1992) Radical-initiated copolymers of styrene and p-formylstyrene, 2) Preparation and characterization of emulsifier-free copolymer latices, Macromol. Chem. Phys., 193„205–220.
Charreyre, M.T., Razafindrakoto, V., Véron, L., Delair, Th., and Pichot, C. (1994) Radically-initiated copolymers of styrene with 4-vinylbenzylamine and its trifluoroacetaminde derivative, 2) Preparation of latex particles bearing amino groups, Macromol. Chem. Phys., 195, 2153–2167.
Tamai, H., Fuji, I., and Suzawa, T. (1987) Surface characterization of hydrophilic functional polymer latex particles, J. Colloid. Interface. Sci., 118, 176–181.
Yan, C., Zhang, X., and Sun, Z. (1990) Poly(styrene-co-acrolein) latex particles: copolymerization and characteristics, J. Appl.. Polym. Sci., 40, 89–98.
Basinska, T., Slomkowsky, S., and Delamar, M. (1993) Synthesis and characterization of polystyrene core/polyacrolein shell latexes, J. Bioactive Compatible Polymers, 8, 205–219.
Charreyre, M.T., Boullanger, P., Delair, Th., Mandrand, B., Llauro M.F and Pichot, C. (1993) Preparation and polymerization studies with an hexylmethacrylate cellobioside monomer, Macromol. Chem. Phys., 194., 117–130.
Vanderhoff, J.W., Van den Hul, H.J., Tausk, R.J.M, and Overbeck, J.T.G. (1970) Clean Surfaces: Their preparation and Characterization for interfacial surfaces, M. Dekker, New York.
Le Dissez, C., Wong, P.C., Mitchell, K.A.R., and Brooks, D.E. (1996) Analysis of surface aldehyde functions on surfactant-free polystyrene/polyacrolein latex, Macromolecules, 29, 953–959.
Davies, M.C., Lynn, R.A.P., Hearn, J., Paul, A.J., Vickerman, J.C.,and Watts, J.F. (1995) Surface chemical characterization using XPS and TOF-SIMS of latex particles prepared by the emulsion copolymerization of functional monomers with methyl methacrylate and 4-vinylpyridine, Langmuir, 11, 4313–4322.
Okubo, M., Azuma, I., Hattori, H. (1992) Preferential adsorption of bovine fibrinogen dimer onto polymer microspheres having heterogeneous surfaces consisting of hydrophobic and hydrophilic parts, J. Appl. Polym. Sci., 45, 245–251.
Ito, K. (1994), Polyethylene oxide macromonomers., in M.K. Mishra (ed.), Macromolecular Design: Concept and Practice.,PolymerFrontiers international Inc, 129–160.
Davies, R.C., Lynn, R.A.P., Davis, S.S., Hearn, J., Watts, J.F., Vickerman, J.C., Paul, A.J. (1993), Preparation of polymer latex particles with immobilized sugar residues and their surface characterization by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectroscopy, Langmuir, 9, 1637–1645.
Charreyre, M.T., Boullanger, P., Delair, Th., Mandrand, B., and Pichot, C. (1993) Preparation and characterization of polystyrene latexes bearing disaccharide surface groups, Colloid Polym. Sci., 271, 668–679.
Revilla, J., Elaïssari, A., Pichot, C., Gallot, B. (1995) Surface functionalization of polystyrene latex particles with a liposaccharide monomer, Polym. for Adv.Tech, 6, 455–464.
Demharter, S., Richtering, W. and Mulhaupt, R. (1995) Emulsion polymerization of styrene in the presence of carbohydrate-based amphiphiles, Polym. Bull., 34, 271–277.
Schild, H. G. (1992) Poly(N-isopropylacrylamide): experiment, theory and applicationProg, Polym. Sci.,17, 163–249.
Kawaguchi, H., Fujimoto, K., Mizuhara, Y. (1992) Hydrogel microspheres III. Temperature-dependent adsorption of proteins on poly-N-isopropylacrylamide hydrogel microspheres, Colloid Polym. Sci. 270, 53–57.
Pelton, R. H., Chibante, P. (1986) Preparation of aqueous lateces with N-isopropylacrylamide, Colloids Surfaces, 20, 247–257.
Wu, X., Pelton, R. H., Hamielec, A. E., Woods, D. R., McPhee, W. (1994) The kinetics of poly(Nisopropylacrylamide) microgel latex formation Colloid Polymer Science, 272, 467–477.
Meunier, F., Elaïssari, A., Pichot, C. (1995) Preparation and characterization of cationic poly(nisopropylacrylamide) copolymer latexes, Polym. for Adv.Tech, 6, 489–496.
Gamy, R. (1986) Controlled drug delivery with colloidal polymeric systems, NATO ASI Series E, Applied Sciences, 106, 195–211.
Lukowski, G., Müller, R.H., Müller, B.W., Dittgen, M. (1993) Acrylic acid copolymer nanoparticles for drug delivery. Part II characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants, Colloid. Polym. Sci., 271, 100–105.
Rolland, A., Gibassier, D., Saclo, P., Leverge, R. (1986) Purification et propriétés physicochimiques de suspensions de nanoparticules de polymères acryliques, J. Pharm. Belg., 41, 94–105.
Couvreur, P., Couarraze, G., Devissagnet, J.P., Puisieux, F. (1996) Nanoparticles: Preparation and Characterization in S. Benita (ed.) Microencapsulation,Methods and Industrial Applications, Marcel Dekker, New-York, 183–211.
Couvreur, P., Vautier, C. (1991) Polyalkylcryanoacrylate nanoparticles as drug carrier: present state and perpectives, J. Cont. Release, 17, 187–199.
Seijo, B., Fattal, E., Roblot-Treupel, L., Couvreur, P. (1990) Design of nanoparticles of less than 50nm diameter: preparation characterization and drug loading, Int. Jal. of Pharmaceutics, 62, 1–7.
Lescure, F., Zimmer, C., Roy, D., Couvreur, P. (1992) Optimisation of polyalkylcyanoacrylate nanoparticle preparation: influence of sulfur dioxide and pH on particle characteristics, J. Colloid Interface Sci., 254, 77–96.
Slomkowski, S. (1996) Controlled polymerization of e-caprolactone from macromolecules to microspheres, Macromol. Symp., 103, 213–228.
Couvreur, P., Dubemet, C., Puisieux, F. (1995) “Controlled drug delivery with nanoparticles: Current possiblity and future trends”, Eur. J. Pharm., 41 (1), 2–13.
Arshady, R. (1991) Preparation of biodegradable microspheres and microcapsules, J. Control. Release, 17, 1–21.
Stainmesse, S., Orecchioni, A.M., Nakache, E., Puisieux, F., Fessi, H. (1995) Formation and stabilization of a biodegradeble polymeric colloidal suspension of nanopaticles, Colloid. Polym. Sci., 273, 505–511
Diat, O., Roux, D., Nallet, F. (1993) Effect of shear an a lyotropic lamellar phase, J. Phys. II, 3, 1427–1452.
Kranz, H.J., Schwartz, A., Rohdewald, P. (1985) Polylactic and nanoparticles, a colloidal drug delivery system for lipophilic drugs, Int. J Pharm., 27, 145–155.
Chavany, C., Le Doan, T., Couvreur, P., Hélène, C. (1992) “Polyalkylcyanoacrylate nanopartcles as polymeric carriers for antisense oligonucleotides”, Pharm. Res., 9, 441.
Bangs, L.B. (1984), Uniform Latex Particles, Seragen Diagnostics Inc.
Tarcha, P.J., Misun, D., Finley, D., Wong, M., and Donovan, J.J. (1992) Synthesis, analysis, and immunodiagnostic applications of polypyrrole latex and its derivatives, in E.S. Daniels, E.D. Sudol, M.S. El-Aasser (eds.), Polymer Latexes - Preparation,Characterization, and Applications, ACS Symposium series, 492, 347–367.
Charreyre, M.T., Yekta, A., Winnik, M.A., Delair, T., and Pichot, C. (1995) Fluorescent energy transfert from fluorescein to tetramethylrhodamine covalently bound to the surface of polystyrene particles, Langmuir, 11, 2423–2428.
Cao, T., Weiping, Y., and Webber, S.E. (1994) Poly(2-vinylnaphtalene-alt-maleic acid)-graftpolystyrene as a photoactive polymer micelle and stabilizer for polystyrene latexes, Macromolecules, 27, 7459–7464.
Nilsson, S., Lager, C., Laurell, T., and Birnbaum, S. (1995) Thin-layer immunoaffinity chromatography with bar code quantitation of C-reactive protein, Analytical Chemistry, 67, 3051–3056.
Cheung, S.W. (1993) Methods for making fluorescent microspheres, United State Patent, 5, 194,300
Paulke, B.R., Hartig, W.,and Bruckner, G. (1992) Synthesis of nanoparticles for brain cell labelling in vivo, Acta Polymer., 43, 288–291.
Dickerhoff, R., and Von Ruecker, A. (1995) Enumeration of platelets by multiparameter flow cytometry using platelet-specific antibodies and fluorescent reference particles, Clinical and Laboratory Haematology 17, 163–172.
Advances in Biomagnetic Separation (1994) Uhlen,M., Hornes, M., and Olsvik, Ø. (eds), Eaton Publishing Co., Natik.
Rohr, T.E. (1995) United State Patent 5, 445, 971.
Andrade, J. D. (1985) Surface and Interfacial Aspects of Biomedical Polymers, Volume 2, Protein Adsorption, Plenum Press, New York.
Andrade, J. D., Hlady, V., Wei, A. P. (1992) Adsorption of complex proteins at interfaces, Pure and Appl. Chem., 64, 1777–1781.
Hondo, A., Higashitani, K. (1992) Adsorption model proteins with wide variation in molecular properties on colloidal particles,.J. Colloid and Interface Sci., 150, 344–351.
Belton, F., Theretz, A., Elaïssari, A., Pichot, C. (1993) Adsorption of bovine serum albumin onto amphiphilic acrylic acid copolymer-stabilized polystyrene latex particles, Colloids and Surfaces B: Biointerfaces, 1, 97–106.
Yoon, J.Y., Park, H. Y., Kim, J.H., Kim, W.S. (1996) Adsorption of BSA on highly carboxylatex microspheres-quantitative effect of surface functional groups and interaction forces, J. Colloid and Interface Sci. 177, 613–620.
Ball, V., Huetz, P., Elaïssari, A., Cazenave, J. P., Voegel, J. C., Schaaf, P. (1994) Kinetics of exchange processes in the adsorption of proteins on solid surfaces, Proc. Natl. Acad. Sci USA, 91, 7330–7334.
Norde, W., and Lyklema, J. (1979) Thermodynamics of protein adsorption: Theory with special reference the adsorption of human plasma albumin and bovine pancreas ribonuclease at polystytene surfaces, J. Colloid and Interface Sci. 71, 350–366.
Elgersma, A., Zsom, R. L., J., Norde, W., Lyklema, J. (1991) The adsorption of different types of monoclonal immunoglubin on positively and negatively charged polystyrene laticesColloids and Surfaces, 54, 89–101.
Elgersma, A., Zsom, R., L., J., Norde, W., Lyklema, J. (1990) The adsorption of bovine serum albumin on positively and negatively charged polystyrene laticesJ. Colloid and Interface Sci., 138, 145–156.
Aptel, J. D., Thomann, J. M., Schmitt, A., Bres, E. F. (1988) Adsorption of Human albumin onto hydroxyapatite. Static and dynamic studies, Colloids and Surfaces, 32, 159–171.
De Baillou, N., Voegel, J. C., Schmitt, A. (1985) Adsorption of human albumin and fibrinogen onto heparin-like materials. I. Adsorption isotherms, Colloids and Surfaces, 16, 271–288.
Suzawa, T., Shirahama, H. (1991) Adsorption of plasma proteins onto polymer latices, Advances in Colloid and Interface Science, 35, 139–172.
Martin, A., Puig, J., Galisteo, F., Serra, J., Hidalgo-Alvarez, R. (1992) Biocolloids and biosurfaces: On some aspects of the adsorption of immunoglobulin-g molecules on polystyrene microspheres, J. Dispersion Science and Tehnology, 13, 399–416.
Burns, N., Holmberg, K., Brink, C. (1996) Influence of surface charge on protein adsorption at an amphoteric surface: Effects of varying acid to base ratio, J. Colloid and Interface Sci., 178, 116–122.
Hidalgo-Alvarez, R., Galisteo-Gonzalez, F. (1995) The adsorption characteristics of immunoglobulins, Heterogeneous Chemistry Reviews, 2, 249–268.
Duinhoven, S., Poort, R., Van der Voet, G., Agterof, W. G. M., Norde, W., Lyklema, J. (1995) Driving forces for enzyme adsorption at solid-liquid interfaces: 1. The serine protease savinase, J. Colloid and Interface Sci., 170, 340–350.
Duinhoven, S., Poort, R., Van der Voet, G., Agterof, W. G. M., Norde, W., Lyklema, J. (1995) Driving forces for enzyme adsorption at solid-liquid interfaces: 2. The fungal lipase lipolase, J. Colloid and Interface Sci., 170, 351–357.
Kamei, S., Okubo, M., Matsumoto, T., Yamamoto, M. (1986) Adsorption of trypsin onto styrene-2hydroxyethyl methacrylate copolymer microspheres and its enzymatic activity, Colloid Polym. Sci., 264,743–747.
Walker, D. S., Garrison, M. D., Reichert, W. M. (1993) Protein adsorption to HEMA/EMA copolymers studied by integrated optical techniques, J. Colloid and Interface Science, 157, 41–49.
Revilla, J., Elaïssari, A., Carriere, O., Pichot, C. (1996) Adsorption of bovine serum Albumin onto polystyrene latex particles bearing saccharidic moieties, J. Colloid and Interface Sci., 180,405–412.
Charreyre, M. T., Revilla, J., Elaïssari, A., Pichot, C., Gallot, B. (1996) Surface-functionalized polystyrene latexes with liposaccharide monomers: preparation, characterization and applications, (in press). in R.J. Spontak (ed),ACS Meeting Advances in polysaccharides characterization and applications, M. Dekker.
Yoshioka, H., Mikami, M., Nakai, T., Mori, Y. (1994) Preparation of poly(N-isopropylacrylamide)-grafted silica gel and its temperature-dependent interaction with proteins, Polym. for Adv. Tech. 6, 418–420.
Kondo, A., Kaneko, T., Higashitani, K. (1994) Developement and application of thermo-sensitive immunomicrospheres for antibody purification, Biotechnology and Bioengineeiring, 44,1–6.
Yamaoka, K., Fukudome, K., Mukaiyama, N., Shirahama, H., Suzawa, T. (1990) Adsorption of deoxyribonucleic acid andpoly(cytidylic acid)-poly(inosinic acid) onto poly(styrene) latex, J. Colloid and Interface Sci., 136, 519–526.
Elaïssari, A., Cros, P., Laurent, V., Mandrand, B. (1994) Adsorption of oligonucleotides onto negatively and positively charged latex particles, Colloid and Surfaces A: Physicochemical and Engineering Aspect, 83, 25–31.
Elaïssari, A., Pichot, C., Delair, Th., Cros, Ph., Kürfurst, R. (1995) Adsorption and desorption studies of polyadenylic acid onto positively charged latex particles, Langmuir, 11, 1261–1267.
Ganachaud, F., Elaïssari, A., Laayoun, A., Pichot, C., Cros, P. (1997), Adsorption of single stranded DNA fragment onto aminated latex particles, (Langmuir, submitted).
Walker, H. W., Grant, S. B., (1995) Conformation of DNA block copolymer molecules adsorbed on latex particles as revealed by hydroxyl radical footprinting Langmuir, 11, 3772–3777.
B. Oenick, M.D.,and Warshawsky, A. (1991) Protein immobilization on surface modified latices bearing aldehyde groups, Colloid Polym. Sci., 269, 139–145.
Inomata, Y., Wada, T., Fujimoto, K., and Kawaguchi, H. (1994) Preparation of DNA-carrying affinity latex and purification of transcription factors with the latex, J. Biomater. Sci. Polymer Edn., 5, 293–302.
Basinska, T., Kowalczyk, D., Miska, B., and Slomkowsky, S. (1995) Interaction of proteins with polymeric latexes, Polym. Adv. Technol., 6, 526–533.
Pelton, R. (1990) Chemical reaction at the latex-solution interface, in F. Candau and R.H. Ottewill (eds.), Scientific Methods for the Study of Polymer Colloids and Their Applications, Kluwer Academic Publishers, Dordrecht, 493–516.
Wulff, G. (1991) in U.K. Pandit and F.C. Alderweurekt, (eds) Bioorganic Chemistry in Healthcare and Technology,NATO ASI Series A, 207, Plenum Press, 55–68.
Kempe, M., Glad, M., Mosbach, K. (1995) An approach towards surface imprinting using the Enzyme Ribonuclease A, J.of Molecular Recognition 8, 35–39.
Ferrier, R.J. (1972) Applications of phenylboronic acid in carbohydrate chemistry, in R.L. Whistler and J.N. BeMiller Methods in Carbohydrate Chemistry, Academic Predss, 419–426.
Tsukagoshi, K., Kawasaki, R., Maeda, M., Takagi, M. (1994) Preparation and sugar binding property of microspheres having surface-anchored phenylboronic acid groups, Chemistry Letters, 681–684.
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Pichot, C., Delair, T., Elaïssari, A. (1995). Polymer Colloids for Biomedical and Pharmaceutical Applications. In: Asua, J.M. (eds) Polymeric Dispersions: Principles and Applications. NATO ASI Series, vol 335. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5512-0_33
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