Skip to main content

Polymer Colloids for Biomedical and Pharmaceutical Applications

  • Chapter
  • 1012 Accesses

Part of the book series: NATO ASI Series ((NSSE,volume 335))

Abstract

Polymer colloids can be used either as models in academic research dealing with colloid phenomena or as dispersed material in a wide variety of industrial applications. One major reason for such a development is related to the basic understanding in the production of these latexes through an increasing number of free-radical heterogeneous polymerization processes as well as in their complete characterization in terms of molecular or colloidal properties. Two major reasons motived the attractive interest for such polymer colloids in biological, medical and pharmaceutical applications: i) their unique and versatile properties with regard to the control of the particle shape and morphology, size and size distribution, surface chemistry, polymer nature, etc., and ii) the huge progress in molecular biology during the last two decades resulting in a vast number of available biomolecules (monoclonal antibodies, peptides, DNA probes, enzymes, recombinant proteins etc.) and sophisticated methodologies (amplification techniques, protein engineering, capillary electrophoresis, etc.).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Daniels, E.S., Sudol, E.D., El-Aasser, M.S. (eds.) (1992) Preparation, characterization and applications of polymer latexes, ACS Symp. Series, 492, Washington, D.C.

    Google Scholar 

  2. Singer, J.M., Plotz, C.M. (1996), The latex formation test.1-Application to the serological diagnosis of rheumatoid arthritis, Am. J. Med., 31, 888.

    Google Scholar 

  3. Singer, J.M. (1987) The use of polystyrene latexes in medicine, in M.S. El-Aasser, R.M. Fitch (eds.), Future Directions in Polymer Colloids, Martinus Nijhoff Publishers, Dordretch, pp. 372–394.

    Google Scholar 

  4. Van den Hul, H.J., Vanderhoff, J.W. (1971) “Clean monodisperse latexes as model colloids”, in R.M. Fitch (ed.) Polymer Colloids, Plenum Press, NY, 1–26.

    Chapter  Google Scholar 

  5. Goodwin, A.R., Ottewill, R M, Pelton, R H, Vianello, G., Yates, D.E. (1978) Control of particle size in the formation of polystyrene latices, Br. Polym.J., 10, 173–180.

    Article  CAS  Google Scholar 

  6. Arshady, R. (1993) Microspheres for biomedical applications: preparation of reactive and labelled microspheres, Biomaterial, 14, 5–15.

    Article  CAS  Google Scholar 

  7. Rembaum, A., Margel S, (1978), Design of polymeric immunospheres for cell labeling and separation, Br. Polym. J, 10, 275–280.

    Article  CAS  Google Scholar 

  8. Ugelstad, J., Berge, A., Ellingsen, T., Schmid, R., Nilson, T.N., Mork, P.C., Stenstad, P., Homes, E., Olswik, Ø.(1992) Preparation and applications of new monosized polymer particles, Prog. Polym., 17, 17.

    Google Scholar 

  9. Ugelstad, J., Stenstad, P., Kilaas, L., Prestvik, W.S., Rian, A., Nustad, K., Huge, R., Berge, A. (1996) Biochemical and biomedical applications of monodispersed polymer particles, Macromol. Symp., 101, 491–500.

    Article  CAS  Google Scholar 

  10. El-Aasser, M.S., Methods of latex cleaning, in G.W. Poehlein, R.H. Ottewill, J.W. Goodwin (eds.) Science and Technology of Polymer Colloids, NATO ASI Series, E68, Ed. Nijhoff, The Hague, 1983, 422–448.

    Google Scholar 

  11. Blackley, D.C., (1983) Preparation of carboxylated latices by emulsion polymerization, in G.W. Poehlein, R.H. Goodwill, J.W. Goodwin (eds.), Science and Technology of Polymer Colloids, NATO ASI Series, E68, Nijhoff, The Hague, 203–219.

    Google Scholar 

  12. Delair, Th., Pichot, C., Mandrand, B. (1994) Synthesis and characterization of cationic latex particles bearing sulfhydryl groups and their use in the immobilization of Fab antibody fragments, Colloid Polym. Sci., 272, 72–81.

    Article  CAS  Google Scholar 

  13. Delair, Th., Marguet, V., Pichot, C., and Mandrand, B. (1994) Synthesis and characterization of cationic amino functionalized latexes, Colloid Polym. Sci., 272, 962–970.

    Article  CAS  Google Scholar 

  14. Ganachaud, F., Mouterde, G., Delair, Th., Elaïssari, A., and Pichot, C. (1994) Preparation and characterization of cationic polystyrene latex particles of different aminated surface charges, Polym. for Adv.Tech., 6, 480–488.

    Article  Google Scholar 

  15. Sarobe J., and Forcada J. (1996) Synthesis of core-shell type polystyrene monodisperse particles with chloromethyl groups, Colloid Polym. Sci, 274, 8–13.

    Article  CAS  Google Scholar 

  16. Kling, J.A., and Ploehn, H.J. (1995) Synthesis and characterization of epoxy-functional polystyrene particles, J. Polym. Sci. Part A: Polym. Chem., 33, 1107–1118.

    Article  CAS  Google Scholar 

  17. Brouwer, W.M., Van Der Vegt, M., and Van Haaren, P. (1990) Particle surface characteristics of permanently charged poly(styrene-cationic monomer) latices, Europ. Polym. J., 26, 35–39.

    Article  CAS  Google Scholar 

  18. Hassanein, M., Abdel-Hay, F.I., El-Hefnawy, T., and El-Esawy, A.(1994) Autooxidation of 2–6, di-tbutyl phenol catalyzed by Cobalt (II)-Schiff-base complex bound to cationic latexes, Europ. Polym. J., 30,335–337.

    Article  CAS  Google Scholar 

  19. Ford, N.T., Yu, H., Lee, J.J., and El-Hamshary H. (1993) Synthesis of monodisperse cross-linked polystyrene latexes containing vinylbenzyl)trimethyl-ammoniumchloride units, Langmuir, 9, 1698–1703.

    Article  CAS  Google Scholar 

  20. Vernier-Charleux, B., Graillat, C., Chevalier, Y., Pichot, C., Revillon, A. (1991) Synthesis and characterization of emulsifier-free quatemarized vinylbenzylchloride latexes, Colloid. Polym. Sci., 269,398–405.

    Article  Google Scholar 

  21. Charleux, B., Fanget, P., Pichot, C. (1992) Radical-initiated copolymers of styrene and p-formylstyrene, 2) Preparation and characterization of emulsifier-free copolymer latices, Macromol. Chem. Phys., 193„205–220.

    Article  CAS  Google Scholar 

  22. Charreyre, M.T., Razafindrakoto, V., Véron, L., Delair, Th., and Pichot, C. (1994) Radically-initiated copolymers of styrene with 4-vinylbenzylamine and its trifluoroacetaminde derivative, 2) Preparation of latex particles bearing amino groups, Macromol. Chem. Phys., 195, 2153–2167.

    Article  CAS  Google Scholar 

  23. Tamai, H., Fuji, I., and Suzawa, T. (1987) Surface characterization of hydrophilic functional polymer latex particles, J. Colloid. Interface. Sci., 118, 176–181.

    Article  CAS  Google Scholar 

  24. Yan, C., Zhang, X., and Sun, Z. (1990) Poly(styrene-co-acrolein) latex particles: copolymerization and characteristics, J. Appl.. Polym. Sci., 40, 89–98.

    Article  CAS  Google Scholar 

  25. Basinska, T., Slomkowsky, S., and Delamar, M. (1993) Synthesis and characterization of polystyrene core/polyacrolein shell latexes, J. Bioactive Compatible Polymers, 8, 205–219.

    Article  CAS  Google Scholar 

  26. Charreyre, M.T., Boullanger, P., Delair, Th., Mandrand, B., Llauro M.F and Pichot, C. (1993) Preparation and polymerization studies with an hexylmethacrylate cellobioside monomer, Macromol. Chem. Phys., 194., 117–130.

    Article  CAS  Google Scholar 

  27. Vanderhoff, J.W., Van den Hul, H.J., Tausk, R.J.M, and Overbeck, J.T.G. (1970) Clean Surfaces: Their preparation and Characterization for interfacial surfaces, M. Dekker, New York.

    Google Scholar 

  28. Le Dissez, C., Wong, P.C., Mitchell, K.A.R., and Brooks, D.E. (1996) Analysis of surface aldehyde functions on surfactant-free polystyrene/polyacrolein latex, Macromolecules, 29, 953–959.

    Article  Google Scholar 

  29. Davies, M.C., Lynn, R.A.P., Hearn, J., Paul, A.J., Vickerman, J.C.,and Watts, J.F. (1995) Surface chemical characterization using XPS and TOF-SIMS of latex particles prepared by the emulsion copolymerization of functional monomers with methyl methacrylate and 4-vinylpyridine, Langmuir, 11, 4313–4322.

    Article  CAS  Google Scholar 

  30. Okubo, M., Azuma, I., Hattori, H. (1992) Preferential adsorption of bovine fibrinogen dimer onto polymer microspheres having heterogeneous surfaces consisting of hydrophobic and hydrophilic parts, J. Appl. Polym. Sci., 45, 245–251.

    Article  CAS  Google Scholar 

  31. Ito, K. (1994), Polyethylene oxide macromonomers., in M.K. Mishra (ed.), Macromolecular Design: Concept and Practice.,PolymerFrontiers international Inc, 129–160.

    Google Scholar 

  32. Davies, R.C., Lynn, R.A.P., Davis, S.S., Hearn, J., Watts, J.F., Vickerman, J.C., Paul, A.J. (1993), Preparation of polymer latex particles with immobilized sugar residues and their surface characterization by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectroscopy, Langmuir, 9, 1637–1645.

    Article  CAS  Google Scholar 

  33. Charreyre, M.T., Boullanger, P., Delair, Th., Mandrand, B., and Pichot, C. (1993) Preparation and characterization of polystyrene latexes bearing disaccharide surface groups, Colloid Polym. Sci., 271, 668–679.

    Article  CAS  Google Scholar 

  34. Revilla, J., Elaïssari, A., Pichot, C., Gallot, B. (1995) Surface functionalization of polystyrene latex particles with a liposaccharide monomer, Polym. for Adv.Tech, 6, 455–464.

    Article  CAS  Google Scholar 

  35. Demharter, S., Richtering, W. and Mulhaupt, R. (1995) Emulsion polymerization of styrene in the presence of carbohydrate-based amphiphiles, Polym. Bull., 34, 271–277.

    Article  CAS  Google Scholar 

  36. Schild, H. G. (1992) Poly(N-isopropylacrylamide): experiment, theory and applicationProg, Polym. Sci.,17, 163–249.

    Article  CAS  Google Scholar 

  37. Kawaguchi, H., Fujimoto, K., Mizuhara, Y. (1992) Hydrogel microspheres III. Temperature-dependent adsorption of proteins on poly-N-isopropylacrylamide hydrogel microspheres, Colloid Polym. Sci. 270, 53–57.

    Article  CAS  Google Scholar 

  38. Pelton, R. H., Chibante, P. (1986) Preparation of aqueous lateces with N-isopropylacrylamide, Colloids Surfaces, 20, 247–257.

    Article  CAS  Google Scholar 

  39. Wu, X., Pelton, R. H., Hamielec, A. E., Woods, D. R., McPhee, W. (1994) The kinetics of poly(Nisopropylacrylamide) microgel latex formation Colloid Polymer Science, 272, 467–477.

    Article  CAS  Google Scholar 

  40. Meunier, F., Elaïssari, A., Pichot, C. (1995) Preparation and characterization of cationic poly(nisopropylacrylamide) copolymer latexes, Polym. for Adv.Tech, 6, 489–496.

    Article  CAS  Google Scholar 

  41. Gamy, R. (1986) Controlled drug delivery with colloidal polymeric systems, NATO ASI Series E, Applied Sciences, 106, 195–211.

    Google Scholar 

  42. Lukowski, G., Müller, R.H., Müller, B.W., Dittgen, M. (1993) Acrylic acid copolymer nanoparticles for drug delivery. Part II characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants, Colloid. Polym. Sci., 271, 100–105.

    Article  CAS  Google Scholar 

  43. Rolland, A., Gibassier, D., Saclo, P., Leverge, R. (1986) Purification et propriétés physicochimiques de suspensions de nanoparticules de polymères acryliques, J. Pharm. Belg., 41, 94–105.

    CAS  Google Scholar 

  44. Couvreur, P., Couarraze, G., Devissagnet, J.P., Puisieux, F. (1996) Nanoparticles: Preparation and Characterization in S. Benita (ed.) Microencapsulation,Methods and Industrial Applications, Marcel Dekker, New-York, 183–211.

    Google Scholar 

  45. Couvreur, P., Vautier, C. (1991) Polyalkylcryanoacrylate nanoparticles as drug carrier: present state and perpectives, J. Cont. Release, 17, 187–199.

    Article  CAS  Google Scholar 

  46. Seijo, B., Fattal, E., Roblot-Treupel, L., Couvreur, P. (1990) Design of nanoparticles of less than 50nm diameter: preparation characterization and drug loading, Int. Jal. of Pharmaceutics, 62, 1–7.

    Article  CAS  Google Scholar 

  47. Lescure, F., Zimmer, C., Roy, D., Couvreur, P. (1992) Optimisation of polyalkylcyanoacrylate nanoparticle preparation: influence of sulfur dioxide and pH on particle characteristics, J. Colloid Interface Sci., 254, 77–96.

    Article  Google Scholar 

  48. Slomkowski, S. (1996) Controlled polymerization of e-caprolactone from macromolecules to microspheres, Macromol. Symp., 103, 213–228.

    CAS  Google Scholar 

  49. Couvreur, P., Dubemet, C., Puisieux, F. (1995) “Controlled drug delivery with nanoparticles: Current possiblity and future trends”, Eur. J. Pharm., 41 (1), 2–13.

    CAS  Google Scholar 

  50. Arshady, R. (1991) Preparation of biodegradable microspheres and microcapsules, J. Control. Release, 17, 1–21.

    Article  CAS  Google Scholar 

  51. Stainmesse, S., Orecchioni, A.M., Nakache, E., Puisieux, F., Fessi, H. (1995) Formation and stabilization of a biodegradeble polymeric colloidal suspension of nanopaticles, Colloid. Polym. Sci., 273, 505–511

    Article  CAS  Google Scholar 

  52. Diat, O., Roux, D., Nallet, F. (1993) Effect of shear an a lyotropic lamellar phase, J. Phys. II, 3, 1427–1452.

    Article  CAS  Google Scholar 

  53. Kranz, H.J., Schwartz, A., Rohdewald, P. (1985) Polylactic and nanoparticles, a colloidal drug delivery system for lipophilic drugs, Int. J Pharm., 27, 145–155.

    Article  Google Scholar 

  54. Chavany, C., Le Doan, T., Couvreur, P., Hélène, C. (1992) “Polyalkylcyanoacrylate nanopartcles as polymeric carriers for antisense oligonucleotides”, Pharm. Res., 9, 441.

    Article  CAS  Google Scholar 

  55. Bangs, L.B. (1984), Uniform Latex Particles, Seragen Diagnostics Inc.

    Google Scholar 

  56. Tarcha, P.J., Misun, D., Finley, D., Wong, M., and Donovan, J.J. (1992) Synthesis, analysis, and immunodiagnostic applications of polypyrrole latex and its derivatives, in E.S. Daniels, E.D. Sudol, M.S. El-Aasser (eds.), Polymer Latexes - Preparation,Characterization, and Applications, ACS Symposium series, 492, 347–367.

    Chapter  Google Scholar 

  57. Charreyre, M.T., Yekta, A., Winnik, M.A., Delair, T., and Pichot, C. (1995) Fluorescent energy transfert from fluorescein to tetramethylrhodamine covalently bound to the surface of polystyrene particles, Langmuir, 11, 2423–2428.

    Article  CAS  Google Scholar 

  58. Cao, T., Weiping, Y., and Webber, S.E. (1994) Poly(2-vinylnaphtalene-alt-maleic acid)-graftpolystyrene as a photoactive polymer micelle and stabilizer for polystyrene latexes, Macromolecules, 27, 7459–7464.

    Article  CAS  Google Scholar 

  59. Nilsson, S., Lager, C., Laurell, T., and Birnbaum, S. (1995) Thin-layer immunoaffinity chromatography with bar code quantitation of C-reactive protein, Analytical Chemistry, 67, 3051–3056.

    Article  CAS  Google Scholar 

  60. Cheung, S.W. (1993) Methods for making fluorescent microspheres, United State Patent, 5, 194,300

    Google Scholar 

  61. Paulke, B.R., Hartig, W.,and Bruckner, G. (1992) Synthesis of nanoparticles for brain cell labelling in vivo, Acta Polymer., 43, 288–291.

    Article  CAS  Google Scholar 

  62. Dickerhoff, R., and Von Ruecker, A. (1995) Enumeration of platelets by multiparameter flow cytometry using platelet-specific antibodies and fluorescent reference particles, Clinical and Laboratory Haematology 17, 163–172.

    CAS  Google Scholar 

  63. Advances in Biomagnetic Separation (1994) Uhlen,M., Hornes, M., and Olsvik, Ø. (eds), Eaton Publishing Co., Natik.

    Google Scholar 

  64. Rohr, T.E. (1995) United State Patent 5, 445, 971.

    Google Scholar 

  65. Andrade, J. D. (1985) Surface and Interfacial Aspects of Biomedical Polymers, Volume 2, Protein Adsorption, Plenum Press, New York.

    Book  Google Scholar 

  66. Andrade, J. D., Hlady, V., Wei, A. P. (1992) Adsorption of complex proteins at interfaces, Pure and Appl. Chem., 64, 1777–1781.

    Article  CAS  Google Scholar 

  67. Hondo, A., Higashitani, K. (1992) Adsorption model proteins with wide variation in molecular properties on colloidal particles,.J. Colloid and Interface Sci., 150, 344–351.

    Article  Google Scholar 

  68. Belton, F., Theretz, A., Elaïssari, A., Pichot, C. (1993) Adsorption of bovine serum albumin onto amphiphilic acrylic acid copolymer-stabilized polystyrene latex particles, Colloids and Surfaces B: Biointerfaces, 1, 97–106.

    Article  Google Scholar 

  69. Yoon, J.Y., Park, H. Y., Kim, J.H., Kim, W.S. (1996) Adsorption of BSA on highly carboxylatex microspheres-quantitative effect of surface functional groups and interaction forces, J. Colloid and Interface Sci. 177, 613–620.

    Article  CAS  Google Scholar 

  70. Ball, V., Huetz, P., Elaïssari, A., Cazenave, J. P., Voegel, J. C., Schaaf, P. (1994) Kinetics of exchange processes in the adsorption of proteins on solid surfaces, Proc. Natl. Acad. Sci USA, 91, 7330–7334.

    Article  CAS  Google Scholar 

  71. Norde, W., and Lyklema, J. (1979) Thermodynamics of protein adsorption: Theory with special reference the adsorption of human plasma albumin and bovine pancreas ribonuclease at polystytene surfaces, J. Colloid and Interface Sci. 71, 350–366.

    Article  CAS  Google Scholar 

  72. Elgersma, A., Zsom, R. L., J., Norde, W., Lyklema, J. (1991) The adsorption of different types of monoclonal immunoglubin on positively and negatively charged polystyrene laticesColloids and Surfaces, 54, 89–101.

    Article  CAS  Google Scholar 

  73. Elgersma, A., Zsom, R., L., J., Norde, W., Lyklema, J. (1990) The adsorption of bovine serum albumin on positively and negatively charged polystyrene laticesJ. Colloid and Interface Sci., 138, 145–156.

    Article  CAS  Google Scholar 

  74. Aptel, J. D., Thomann, J. M., Schmitt, A., Bres, E. F. (1988) Adsorption of Human albumin onto hydroxyapatite. Static and dynamic studies, Colloids and Surfaces, 32, 159–171.

    Article  CAS  Google Scholar 

  75. De Baillou, N., Voegel, J. C., Schmitt, A. (1985) Adsorption of human albumin and fibrinogen onto heparin-like materials. I. Adsorption isotherms, Colloids and Surfaces, 16, 271–288.

    Article  Google Scholar 

  76. Suzawa, T., Shirahama, H. (1991) Adsorption of plasma proteins onto polymer latices, Advances in Colloid and Interface Science, 35, 139–172.

    Article  CAS  Google Scholar 

  77. Martin, A., Puig, J., Galisteo, F., Serra, J., Hidalgo-Alvarez, R. (1992) Biocolloids and biosurfaces: On some aspects of the adsorption of immunoglobulin-g molecules on polystyrene microspheres, J. Dispersion Science and Tehnology, 13, 399–416.

    Article  CAS  Google Scholar 

  78. Burns, N., Holmberg, K., Brink, C. (1996) Influence of surface charge on protein adsorption at an amphoteric surface: Effects of varying acid to base ratio, J. Colloid and Interface Sci., 178, 116–122.

    Article  CAS  Google Scholar 

  79. Hidalgo-Alvarez, R., Galisteo-Gonzalez, F. (1995) The adsorption characteristics of immunoglobulins, Heterogeneous Chemistry Reviews, 2, 249–268.

    CAS  Google Scholar 

  80. Duinhoven, S., Poort, R., Van der Voet, G., Agterof, W. G. M., Norde, W., Lyklema, J. (1995) Driving forces for enzyme adsorption at solid-liquid interfaces: 1. The serine protease savinase, J. Colloid and Interface Sci., 170, 340–350.

    Article  CAS  Google Scholar 

  81. Duinhoven, S., Poort, R., Van der Voet, G., Agterof, W. G. M., Norde, W., Lyklema, J. (1995) Driving forces for enzyme adsorption at solid-liquid interfaces: 2. The fungal lipase lipolase, J. Colloid and Interface Sci., 170, 351–357.

    Article  CAS  Google Scholar 

  82. Kamei, S., Okubo, M., Matsumoto, T., Yamamoto, M. (1986) Adsorption of trypsin onto styrene-2hydroxyethyl methacrylate copolymer microspheres and its enzymatic activity, Colloid Polym. Sci., 264,743–747.

    Article  CAS  Google Scholar 

  83. Walker, D. S., Garrison, M. D., Reichert, W. M. (1993) Protein adsorption to HEMA/EMA copolymers studied by integrated optical techniques, J. Colloid and Interface Science, 157, 41–49.

    Article  CAS  Google Scholar 

  84. Revilla, J., Elaïssari, A., Carriere, O., Pichot, C. (1996) Adsorption of bovine serum Albumin onto polystyrene latex particles bearing saccharidic moieties, J. Colloid and Interface Sci., 180,405–412.

    Article  CAS  Google Scholar 

  85. Charreyre, M. T., Revilla, J., Elaïssari, A., Pichot, C., Gallot, B. (1996) Surface-functionalized polystyrene latexes with liposaccharide monomers: preparation, characterization and applications, (in press). in R.J. Spontak (ed),ACS Meeting Advances in polysaccharides characterization and applications, M. Dekker.

    Google Scholar 

  86. Yoshioka, H., Mikami, M., Nakai, T., Mori, Y. (1994) Preparation of poly(N-isopropylacrylamide)-grafted silica gel and its temperature-dependent interaction with proteins, Polym. for Adv. Tech. 6, 418–420.

    Article  Google Scholar 

  87. Kondo, A., Kaneko, T., Higashitani, K. (1994) Developement and application of thermo-sensitive immunomicrospheres for antibody purification, Biotechnology and Bioengineeiring, 44,1–6.

    Article  CAS  Google Scholar 

  88. Yamaoka, K., Fukudome, K., Mukaiyama, N., Shirahama, H., Suzawa, T. (1990) Adsorption of deoxyribonucleic acid andpoly(cytidylic acid)-poly(inosinic acid) onto poly(styrene) latex, J. Colloid and Interface Sci., 136, 519–526.

    Article  CAS  Google Scholar 

  89. Elaïssari, A., Cros, P., Laurent, V., Mandrand, B. (1994) Adsorption of oligonucleotides onto negatively and positively charged latex particles, Colloid and Surfaces A: Physicochemical and Engineering Aspect, 83, 25–31.

    Article  Google Scholar 

  90. Elaïssari, A., Pichot, C., Delair, Th., Cros, Ph., Kürfurst, R. (1995) Adsorption and desorption studies of polyadenylic acid onto positively charged latex particles, Langmuir, 11, 1261–1267.

    Article  Google Scholar 

  91. Ganachaud, F., Elaïssari, A., Laayoun, A., Pichot, C., Cros, P. (1997), Adsorption of single stranded DNA fragment onto aminated latex particles, (Langmuir, submitted).

    Google Scholar 

  92. Walker, H. W., Grant, S. B., (1995) Conformation of DNA block copolymer molecules adsorbed on latex particles as revealed by hydroxyl radical footprinting Langmuir, 11, 3772–3777.

    Article  CAS  Google Scholar 

  93. B. Oenick, M.D.,and Warshawsky, A. (1991) Protein immobilization on surface modified latices bearing aldehyde groups, Colloid Polym. Sci., 269, 139–145.

    CAS  Google Scholar 

  94. Inomata, Y., Wada, T., Fujimoto, K., and Kawaguchi, H. (1994) Preparation of DNA-carrying affinity latex and purification of transcription factors with the latex, J. Biomater. Sci. Polymer Edn., 5, 293–302.

    Article  CAS  Google Scholar 

  95. Basinska, T., Kowalczyk, D., Miska, B., and Slomkowsky, S. (1995) Interaction of proteins with polymeric latexes, Polym. Adv. Technol., 6, 526–533.

    Article  CAS  Google Scholar 

  96. Pelton, R. (1990) Chemical reaction at the latex-solution interface, in F. Candau and R.H. Ottewill (eds.), Scientific Methods for the Study of Polymer Colloids and Their Applications, Kluwer Academic Publishers, Dordrecht, 493–516.

    Google Scholar 

  97. Wulff, G. (1991) in U.K. Pandit and F.C. Alderweurekt, (eds) Bioorganic Chemistry in Healthcare and Technology,NATO ASI Series A, 207, Plenum Press, 55–68.

    Chapter  Google Scholar 

  98. Kempe, M., Glad, M., Mosbach, K. (1995) An approach towards surface imprinting using the Enzyme Ribonuclease A, J.of Molecular Recognition 8, 35–39.

    Article  CAS  Google Scholar 

  99. Ferrier, R.J. (1972) Applications of phenylboronic acid in carbohydrate chemistry, in R.L. Whistler and J.N. BeMiller Methods in Carbohydrate Chemistry, Academic Predss, 419–426.

    Google Scholar 

  100. Tsukagoshi, K., Kawasaki, R., Maeda, M., Takagi, M. (1994) Preparation and sugar binding property of microspheres having surface-anchored phenylboronic acid groups, Chemistry Letters, 681–684.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Plenum Press, New York

About this chapter

Cite this chapter

Pichot, C., Delair, T., Elaïssari, A. (1995). Polymer Colloids for Biomedical and Pharmaceutical Applications. In: Asua, J.M. (eds) Polymeric Dispersions: Principles and Applications. NATO ASI Series, vol 335. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5512-0_33

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-5512-0_33

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6321-0

  • Online ISBN: 978-94-011-5512-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics