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Liver Growth and Repair pp 577–607Cite as

Hepatocyte transplantation: novel applications

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Abstract

Hepatocyte transplantation offers unexpected ways to analyze mechanisms of liver growth and repair. Survival of transplanted hepatocytes is particularly relevant for therapeutic purposes, such as ex vivo gene therapy or novel cell-based therapies for acute liver failure. In designing experiments to define fundamental biological mechanisms or investigating the therapeutic potential of hepatocytes, a number of considerations are important. Which site or sites might best support cell engraftment or survival? How might transplanted cells be localized in organs for unequivocal analysis of their fate? What strategies could be devised to analyze cell function or prolifera-tive capacity? Could pathophysiological insights into the organization of the liver lobule be surmised from analysis of isolated cell populations? Are satisfactory models available to define in controlled settings whether transplanted hepatocytes could replace deficient metabolic function or aid recovery from liver failure? Overall, recent progress has been particularly exciting in three major areas — potential sites have been defined where transplanted hepatocytes may engraft and survive, novel animal models have been developed to study mechanisms of liver re-population, and the therapeutic potential of hepatocyte transplantation has begun to be explored. The goal of this chapter is to describe the current status of hepatocyte transplantation in its various facets.

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  1. Marion Bessin Liver Research Center and Gastroenterology Division, Department of Medicine, Albert Einstein College of Medicine, New York, USA

    Sanjeev Gupta

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Gupta, S. (1998). Hepatocyte transplantation: novel applications. In: Strain, A., Diehl, A.M. (eds) Liver Growth and Repair. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4932-7_23

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