Abstract
The healthy eye is remarkably well protected from the common bacterial pathogens which are found around the lids and the conjunctival sac. The majority of serious intraoccular bacterial infections result either from a failure of these protective mechanisms or as a result of direct inoculation of microorganisms into the eye. The causes of intraocular infections such as corneal abscess and endophthalmitis are discussed.
An approach to the selection of antibacterial agents for the immediate and continuing treatment of such infections is presented including the routes of administration and the selection of supportive therapy, such as corticosteroids.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allen, H.F. & Mangiaracine, A.B. Bacterial endophthalmitis after cataract extraction: A study of 22 infections in 20,000 operations. Arch. Ophthal, 72, 454 (1964).
Allansmith, M.R., Ostler, H.B. & Butterworth, M. Concomitance of bacteria in various areas of the eye. Arch. Ophth. 82, 37 (1969).
Allansmith, M., Skaggs, C. & Kimura, S.J. Anterior chamber paracentesis. Arch. Ophth. 84, 745 (1970).
Aronson, S.B., Sussman. S.J., Moore. T.E. Jr., Williams, F.C. & Goodner, E.K. Corticosteroid therapy in metastatic endophthalmitis. Arch. Ophth. 85, 61 (1971).
Bellows, J.G. & Farmer, C.J. Streptomycin in ophthalmology. Amer. J. Ophth. 30, 1215 (1947).
Bloome, M.A., Golden, B. & Mckee, A.P. Antibiotic concentration in ocular tissues-penicillin G. and dihydrostreptomycin. Arch. Opthal. 83, 78 (1970).
Bohigan, G., Okumoto, M. & Valenton, M. Experimental Pseudomonas Keratitis: treatment with and evaluation of carbenicillin and gentamycin in combination. Arch. Ophthal 86, 432 (1971).
Burns, R.P. Post-operative infection in an ophthalmic hospital. Amer. J. Ophthal. 48, 579 (1959).
Fernandes, E., Zorab, E.C., Marshall, M.J. & Mills, P.M. Ocular use of Gentamycin and Cephaloridine, Pt. I. Intra-ocular penetration. Canad. J. Ophthal., 9, 170 (1974).
Freeman, M.I. & Gay, A.J. Systemic steroid therapy in postcataract endopthalmitis. In: Current Concepts in Opthalmology, St. Louis, C.V. Mosby 163–177 (1969).
Furguiele, F.P. Discussion in Ocular Inflammatory Disease Golden, B., Ed. Illinois, Charles Thomas 182 (1974).
Garrod, L.P. & O’Grady, F. Antibiotic and Chemotherapy 2nd Ed. London, E & S Livingstone (1968).
Golden, B. Discussion in Ocular Inflammatory Disease. Golden, B., Ed. Illinois, Charles C. Thomas 161–179 (1974).
Hattenhauer, J.M. & Lipsich, M.P. Late endophthalmitis after filtration surgery. Amer. J. Ophthal 72, 1097(1971).
Jones, D.B. Early diagnosis and therapy of bacterial corneal ulcers in External Ocular Diseases. Diagnosis and Current Therapy. International Ophthalmology Clinics 13 No. 4, Laibson, P.R. & Trobe. J.D. Eds. Boston, Little, Brown & Co. 1–37 (1973).
Jones, D.B. The early diagnosis and management of bacterial endophthalmitis in Ocular Inflammatory Disease. Golden, B., Ed. Illinois, Charles C. Thomas 161–179 (1974).
Kanski, J.J. Treatment of late endophthalmitis associated with filtering blebs. Arch. Ophthal. 91, 339 (1974) a.
Kanski, J.J. The prevention and management of post-operative bacterial endophthalmitis. Trans. Ophthal. Soc. U.K. 94, 19 (1974) b.
Langham, M.E. Factors affecting the penetration of antibiotics into the aqueous humour. Brit. J. Ophthal. 35, 614 (1951).
Leopold, I.H. Surgery of ocular trauma. Arch. Ophthal. 48, 738 (1952).
Leopold, I.H. Management of Intra-ocular infection. Doyne Memorial Lecture. Trans. Ophth. Soc. U.K. 91,577 (1971).
Leopold, I.H. & Apt, L. Postoperative intraocular infections. Amer.J. Ophthal 50, 1225 (1960).
Locatcher-Khorazo, D. & Gutierrez, E. Eye infections following cataract extraction with special reference to the role of Staphylococcus aureus. Am. J. Ophthal. 41, 981 (1956).
Maylath, F.R. & Leopold, I.H. Study of experimental intraocular infection. I. The recoverability of organisms inoculated into ocular tissue and fluids. II. The infleunce of antibiotics alone and combined on intraocular growth of these organisms. Amer. J. Ophthal. 40, 36 (1955).
Neveu, M. & Elliot, A.J. Prophylaxis and treatment of endophthalmitis. Amer. J. Ophthal. 48,368 (1959).
Norn, M.S. Localisation of bacteria on single eyelashes Acta. Ophth. 48, 237 (1970).
Peyman, G.A., Vastine, D.W., Crouch, E.R., Herbst, R.W. Jr. Clinical use of intravitreal antibiotics to treat bacterial endophthalmitis. Trans. Am. Acad. Ophthalmol. Otolaryngol. 78, 862 (1974).
Records, R.E. Intraocular penetration of cephaloridine. Arch. Ophthal. 81, 331 (1969).
Richards, A.B., Bron, A.J., Rice, N.S.C., Fells, P., Marshall, M.J., & Jones, B.R. Intraocular penetration of cephaloridine. Brit. J. Ophthal. 36, 531 (1972).
Sorsby, A. & Ungar, J. Neomycin in ophthalmology. Ann. Roy. Coll. Surg. Eng. 22, 107 (1958).
Theodore, F.H., Littman, M.L. & Almeda, E. The diagnosis and management of fungus endophthalmitis following cataract extraction. Arch. Ophthal. 66, 163 (1961).
Tucker, D.M., Meier, W.C. & Forster, R.K. Experimental osilation of intraocular bacteria via anterior chamber and vitreous aspiration. A.R.V.O. Meeting, Sarasota, April 1971 (Cited by D. JONES 1974).
Williamson, J. et al. Estimation of sodium fusidate levels in human serum, aqueous humor and vitreous body. Brit. J. Ophthal. 54, 126 (1970).
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1976 Dr W. Junk b. v. Publishers
About this chapter
Cite this chapter
Bron, A.J. (1976). The Treatment of Bacterial Infections of the Eye. In: Deutman, A.F. (eds) New Developments in Ophthalmology Nijmegen 16–18 October 1975. Documenta Ophthalmologica Proceedings Series, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1569-1_6
Download citation
DOI: https://doi.org/10.1007/978-94-010-1569-1_6
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-6193-147-8
Online ISBN: 978-94-010-1569-1
eBook Packages: Springer Book Archive