Abstract
Classification of antiarrhythmic drugs has always been a controversial subject. In recent years it has become increasingly so with so many new compounds appearing on the pharmacological horizon. Furthermore there is no complete understanding of either the electropharmacology of the antiarrhythmic agent or the mechanisms engendering various cardiac arrhythmias, despite the recent contributions by investigators using ultramicroelectrode and His bundle recording.
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References
Vaughan Williams EM: The classification of antiarrhythmic drugs. In: Symposium on cardiac arrhythmias, Sandol E, Fleusted-Jensen E, Olesen Kh. Sodertalje, Sweden: AB Astra 1970, p 449
Singh BN, Hauswirth O: Comparative mechanism of action of antiarrhythmic drugs. Am Heart J 87: 367, 1974
Dreifus LS, Ogawa S: Quality of the ideal antiarrhythmic drug. Am J Cardiol 39: 466, 1977
Ferrari M, Maragno I, Melacini P: Una classificazione dei farmaci antiaritmici quale indicazione alla terapia clinica. In: Le nuove frontiere delle aritmie, Furlanello F, Disertori M. Lanzetta L. Padua: Piccin, 1977, p 185
Touboul P, Attalah G, Gressard A, Michelon G, Chatelain MY, Delahaye JP: Effets électrophysiologiques des agents antiarythmiques chez l’homme. Tentative de classification. Arch Mal Coeur 72: 72, 1979
Hoffman BF: The action of quinidine and procaine amide on single fibers of dog ventricle and specialized conduction system. Ann Bras Ciencias 29: 365, 1957
West TC, Amory DW: Single fiber recording of the effects of quinidine at the atrial and pacemaker sites in the isolated right atrium of the rabbit. J Pharmacol Exp Ther 130: 183, 1960
Gettes LS, Surawicz B, Shive JC: Effect of high K, low K on QRS duration and ventricular action potential. Am J Physiol 203: 1135, 1962
Watanabe Y, Dreifus LS, Likoff WL: Electrophysiological antagonism and synergism of potassium and antiarrhythmic agents. Am J Cardiol 12: 702, 1963
Conn HI Jr, Luchi RJ: Some cellular and metabolic considerations relating to the action of quinidine as a prototype antiarrhythmic agent. Am J Med 37: 685, 1964
Wallace AG, Cline RE, Sealy WC, Young WG, Troyer WG: Electrophysiological effects of quinidine. Circ Res 19: 960, 1966
Wald RB, Vaxman MB, Downar E: The effect of antiarrhythmic drugs on depressed conduction and unidirectional block in sheep Purkinje fibers. Circ Res 46: 612, 1980
Heissenbuttel RH, Bigger JT Jr: The effects of oral quinidine on intraventricular conduction in man: correlation of plasma quinidine with changes in QRS duration. Am Heart J 80: 453, 1970
Moe GK, Abildskov JA: Antiarrhythmic drugs. In: The pharmacologic basis of therapeutics, 4th edn, Goodman LS, Gilman A. New York: Macmillan, 1970, p 709
Damato AN, Lau SH: The clinical value of the electrogram of the conduction system. Progr Cardiovasc Dis 13: 119, 1970
Josephson ME, Seides SF, Batsford WP, Wisfogel GM, Akhtar M, Caracta AR, Lau SH, Damato AN: The electrophysiological effects of intramuscular quinidine on the atrioventricular conducting system in man. Am Heart J 87: 55, 1974
Watanabe Y, Dreifus L: Interactions of quinidine and potassium on atrioventricular transmission. Circ Res 20: 434, 1967
Mirro MJ, Watanabe AM, Bailey JC: Electrophysiological effects of disopyramide and quinidine on guinea pig atria and canine cardiac Purkinje fibers. Dependence on underlying cholinergie tone. Circ Res 46: 660, 1980
Sokolow M, Perloff DB: The clinical pharmacology and use of quinidine in heart disease. Progr Cardiovasc Dis 3: 316, 1961
Marriott HJL: Rational approach to quinidine therapy. Mod Concepts Cardiovasc Dis 31: 745, 1962
Kock-Weser J: Antiarrhythmic prophylaxis in ambulatory patients with coronary heart disease. Arch Intern Med 129: 763, 1972
Giardina EGV, Heissenbuttel RH, Bigger JT Jr: Intermittent intravenous procaine amide to treat ventricular arrhythmias. Ann Intern Med 78: 183, 1973
Woske H, Belford J, Fasier FN: The effect of procainamide on excitability, refractoriness and conduction in the mammalian heart. J Pharmacol Exp Ther 107: 134, 1953
Weidman S: Effects of calcium ions and local anesthetic on electrical properties of Purkinje fibers. J Physiol 129: 568, 1955
Hoffman BF: The possible mode of action of antiarrhythmic agents. In: The myocardial cell, Briller S, Coon H. Philadelphia: University of Pennsylvania Press, 1966, p 251
Helfant RH, Scherlag BJ, Damato AN: The electrophysiological properties of diphenylhydantoin sodium as compared to procainamide in the normal and digitalis intoxicated dog. Circulation 36: 108, 1867
Rosen KM, Lisi KR, Berkowitz WS: The effect of procaineamide on atrioventricular and intraventricular conduction in man. Circulation (Abstr) 39: Suppl III: 111–173, 1969
Josephson ME, Caracta AR, Ricciutti MA, Lau SH, Damato AD: Electrophysiologic properties of procainamide in man. Am J Cardiol 33: 596, 1974
Reddy CP, Damato AN, Akatar M, Dhatt M, Gomes JAC, Calon AH: Effect of procainamide on reentry within the His-Purkinje system in man. Am J Cardiol 40: 957, 1977
Ogunkeiv JB, Damato AN, Akatar M, Reddy CP, Carata AR, Lau SH: Electro-physiologic effects of procainamide in subtherapeutic to therapeutic doses on human atrioventricular conduction system. Am J Cardiol 37: 724, 1976
Scheinman MM, Weiss AN, Shafton E, Benowitz N, Rowland M: Electrophysiologic effects of procaineamide in patients with intraventricular conduction delay. Circulation 49: 522, 1974
Wedd AM, Blair HA, Warner RS: The action of procaine amide on the heart. Am Heart J 42: 399, 1951
Siddiqui S, Siddiqui RH: The alkaloids of Rauwolfia serpentinaBenth. Part I. J Ind Chem Soc 9: 539, 1932
Arora RB, Madan BR: Antiarrhythmics VI. Ajmaline and serpentine in experimental cardiac arrhythmias. J Pharmacol Exp Ther 117: 62, 1956
Kleinsorge H: Klinische Untersuchungen über die Wirkungsweise des Rauwolfia-alkaloids Ajmaline bei Herzrhythmusstörungen insbesondere der Extrasistolie. Med Klin 54: 409, 1959
Puech P, Latour H, Hertault J, Grolleau R: L’ajmaline injectable dans les tachycardies paroxystiques et le syndrome WPW. Comparaison avec la procainamide. Arch Mal Coeur 57: 897, 1964
Bazika V, Lang TW, Pappelbaum S, Corday E: Ajmalin, a rauwolfia alkaloid for the treatment of digitoxis arrhythmias. Am J Cardiol 17: 227, 1966
Bianchi C, Beccari E: L’ajmalina nella terapia delle aritmie cardiache. Sperimentazione policentrica pianificata. Min Med 57: 1273, 1966
Farinelli A, Zanardi A, Degli Atti B, Longhini C, Alvisi A: Rilievi clinici sull’impiego dell’ajmalina in talune aritmie accessuali. Min Cardioangiol 16: 1047, 1968
Wellens HJJ, Durrer D: Effect of procaine amide, quinidine and ajmaline in the Wolff-Parkinson-White syndrome. Circulation 50: 114, 1974
Kleinsorge A. Gaida P: Quantities and rates of excretion of the Rauwolfiaalkaloid ajmaline following different methods of administration. Arzneim Forsch 11: 1100, 1961
Kleinsorge H. Gaida P: Behaviour of the serum level after intravenous injection of ajmaline. Klin Wschr 40: 149, 1962
Petter A, Zipf K: Zur antifibrillaren Herzwirkung von Ajmaline, Brom-Ajmalin, Chinidin und Novocainamid. Arch Exp Pharmacol 243: 519, 1962
Capra C: Sull’attività antiaritmica di alcuni derivati dell’ajmalina. Il Farmaco 19: 865, 1964
Vorgatti E, Pascucci E, Mavulis A, Magnani B: Risultati clinici preliminari sull’attività antiaritmica di un derivato acetilato dell’ajmalina: la dicloroacetilajmalina. Boll Soc Ital Card 8: 494, 1963
Botti G, Visioli O, Barbaresi F, Lazzari GB: Primi risultati sperimentali sull’attività antiaritmica di un derivato acetilato dell’ajmalina: la dicloroacetilajmalina. Boll Soc It Card 11: 135, 1966
Cocour V, Enesco R, Sirbulesco R, Pompilian P. La di-monocloroacetilajmalina nel trattamento delle alterazioni del ritmo cardiaco. Min Med 61: 16, 1970
Coumel P, Bouvrain Y: Pharmacodynamics and clinical results in 95 cases. In: Concepts on the mechanisms and treatment of arrhythmias, Gensini GG. New York: Futura, 1974, p 97
Pretolani E: Clinical studies on the antiarrhythmic properties of MCAA. In: Concepts on the mechanisms and treatment of arrhythmias, Gensini GG. New York: Futura, 1974, p 125
Ross P, Messina G, Giampaolo P, Cernigliaro C: Rapporto tra concentrazione plasmatica ed effetto antiaritmico della di-monocloroacetilajmalina. G Ital Cardiol 4: 444, 1974
Obayashi K, Mandel WJ: Electrophysiological effects of ajmaline in isolated cardiac tissue. Cardiovasc Res 10: 20, 1976
De Azevedo IM, Dreifus LS, Watanabe Y: Electrophysiologic effects of new ester of ajmaline 17-monochloroacetyl ajmaline hydrochloride (MCAA). Europ J Cardiol 2: 321, 1975
Piwonka RW, Canniff PC, Healey JF: Electrophysiological effects of a new antiarrhythmic agent in cardiac tissue. In: Concepts on the mechanisms and treatment of arrhythmias, Genzini GG. New York: Futura, 1974, p 219
Knippel M, Cadel A, Mazzini C, Figini A, Rovelli F: Effetti dell’ajmaline e della dimonocloroacetilajmalina sulla conduzione atrioventricolare ed intraventricolare nell’uomo. G Ital Cardiol 1: 321, 1971
Camerini F, Baldi N, Gori P, Martinoli E: L’ajmalina nello studio prognostico dei blocchi bifascicolari. E’ possibile valutare il rischio di evoluzione verso il blocco totale? G Ital Cardiol 3: 880, 1973
Jacovella G, Santini M, Dini P, Alliegro A, Floris B, Masini V: Effect of 17-monochloroacetylajmaline (MCAA) upon conduction and excitability of the human heart. In: Concepts on the mechanisms and treatment of arrhythmias, Gensini GG. New York: Futura, 1974, p 151
Meilhac B, Le Pailleur C, Heulin A, Vacheron A, Guise L, Di Matteo J: Intérêt de la stimulation auriculaire et des épreuves pharmaco-dynamiques dans le diagnostic des syncopes à électrocardiogramme normal. Arch Mal Coeur 67: 775, 1974
Morena H, Chaltiel G, Denis B, Rossignol B, Machecourt J, Martin Noel P: Effets dromotropes des associations médicamenteuses. Premiers resultats sur l’association deslanoside-ajmaline. Arch Mal Coeur 70: 749, 1977
Alboni P, Malacarne C, Pedroni P: Effetti elettrofisiologici dell’ajmalina sul sistema di conduzione nell’uomo. G Ital Cardiol 8: 752, 1978
Guerot CL, Valere PE, Castillo-Fenoy A, Coste A, Morice MC: Action comparée de l’ajmaline et du chloracetylajmaline sur la conduction auriculo-ventriculaire de l’homme. Coeur Med Int 14: 129, 1975
Seipel L, Both A, Breithardt G, Gleichman V, Loogen F: Action of antiarrhythmic drugs on His bundle electrocardiogram and sinus node function. Acta Cardiol (Suppl) 18: 251, 1974
Shigenobu K, Kasuya J, Ishiko J, Fukada J: The actions of N-propyl Ajmaline on experimental arrhythmias and electrophysiological properties of the heart. Chem i’harm Bull 22: 2329, 1974
Sekiya A, Vaughan Williams EM: A comparison of the antifibrillatory actions and effects on intracellular cardiac potentials of Pronethalol, Disopyramide and Quinidine. Br J Pharmacol 21: 473, 1963
Colonna D, Sorouche M, Tep T, Calisti G: Le traitement des troubles du rythme cardiaque par la disopyramide. Coeur Med Int 7: 455, 1968
Granier J: La disopyramide nel trattamento delle alterazioni ritmiche. Min Med 61: 3718, 1970
Mathur PP: Cardiovascular effects of a newer antiarrhythmic agent, disopyramide phosphate. Am Heart J 84: 764, 1972
Hulting J, Rosenhamer G: Antiarrhythmic and haemodynamic effects of intravenous and oral disopyramide in patients with ventricular arrhythmia. J Int Med Res (Suppl I ), 4: 9, 1976
Mizgala HF, Huvell PR: Acute termination of cardiac arrhythmias with intravenous disopyramide. J Int Med Res (Suppl I ) 4: 82, 1976
Ranney RE, Dean RR, Karim A, Radzialowski FM: Disopyramide phosphate: phar-macokinetic and pharmacologic relationship of a new antiarrhythmic agent. Arch Int Pharmacodyn Ther 191: 162, 1971
Yen BK, Sung P, Scherlag BJ: Effects of disopyramide on electrophysiological and mechanical properties of the heart. J Pharm Sciences 62: 1924, 1973
Edwards IR, Martin JF, Ward JW: The effect of disopyramide on in vivo measurement of monophasic action potential in canine heart muscle. J Intern Med Res (Suppl I ): 4: 26, 1976
Levites R, Anderson GJ: Electrophysiological effects of disopyramide phosphate during experimental myocardial ischemia. Am Heart J 98, 339, 1979
Josephson ME, Caracta AR, Lau S, Gallagher JJ, Damato AN: Electrophysiological evaluation of disopyramide in man. Am Heart J 86: 771, 1973
Befeler B, Castellanos A Jr, Wells DE, Vagueiro MC, Yen BK: Electrophysiological effects of the antiarrhythmic agent disopyramide phosphate. Am J Cardiol 35: 282, 1975
Spurrell RAJ, Thorburn CW, Camm J, Sowton E, Deuchar DC: Effects of disopyramide on electrophysiological properties of specialized conduction system in man and on accessory atrioventricular pathway in Wolff-Parkinson-White syndrome. Br heart J 37: 861, 1975
Marrott PK, Ruttley MSI, Winterbottom JT, Muit JR: A study of the acute electrophysiological and cardiovascular action of disopyramide in man. Europ J Cardiol 4: 303, 1976
Birkhead JS, Vaughan Williams EM: Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods. Br Heart J 39: 657, 1977
Desai JM, Scheinman M, Peters R, O’Young J: Electrophysiological effects of disopyramide in patients with bundle branch block. Circulation 59: 215, 1979
Bigger JF, Bassett AL, Hoffman BF: Electrophysiological effects of diphenylhydantoine in canine Purkinje fibers. Circ Res 22: 221, 1968
Bigger JT, Mandel WJ: Effects of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers. Circ Res 22: 221, 1968
Davis LD, Temte JV: Electrophysiological actions of lidocaine on canine ventricular muscle and Purkinje fibers. Circ Res 24: 639, 1969
Mandel WS, Bigger JT: Effect of lidocaine on sino-atrial node and atrial fibers. Am J Cardiol 25: 113, 1970
Southworth JL, McKusick VA, Peirce EC, Rawson FL Jr: Ventricular fibrillation precipitated by cardiac catheterization. JAMA 143: 717, 1950
Cotoi S, Luca C: Effetti della lidocaina nelle aritmie sopraventricolari. G Ital Cardiol 6: 433, 1976
Hoffman BF, Bigger JT Jr: Antiarrhythmic drugs. In: Drill’s pharmacology in medicine, 4th edn Palma JR. New York: McGraw-Hill, 1971, p 824
Benowits N, Forsyth RP, Melmon KL, Rowland M: Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model. Clin Pharmacol Ther 16: 87, 1974
Sung CY, Truant AP: The physiological disposition of lidocaine and its comparison in some respects with procaine. J Pharmacol Exp Ther 112: 432, 1954
Scott DB, Jerson PJ, Vellani CW, Julian DG: Plasma lignocaine levels after intravenous and intramuscular injection. Lancet 1: 41, 1970
Alboni P: La lidocaina intramuscolare nel trattamento delle aritmie. G Ital Cardiol 1: 581, 1971
Bellet S, Roman L, Kostis JB, Fleischmann D: Intramuscular lidocaine in the therapy of ventricular arrhythmias. Am J Cardiol 27: 291, 1971
Fehmers MCO, Dunning AJ: Intramuscularly and orally administered lidocaine in the treatment of ventricular arrhythmias in acute myocardial infarction. Am J Cardiol 29: 514, 1972
Sarnoff SJ: Plasma levels of lidocaine after intramuscular administration. Am J Cardiol 29: 520, 1972
Rossi P, Lombardi M, Lotto A, Puddu V: La lidocaina per via intramuscolare nella prevenzione delle complicazioni e della mortalità nell’infarto miocardico acuto. Studio a doppio cieco di 246 casi. G Ital Cardiol 6: 220, 1976
Bigger JT Jr, Mandel WJ: Effect of lidocaine on canine Purkinje fibers and at the ventricular muscle-Purkinje fiber junction. J Pharmacol Exp Ther 172: 239, 1970
Bigger JT Jr, Mandel WJ: Effect of lidocaine on transmembrane potentials of ventricular muscle and Purkinje fibers. J Clin Invest 49: 63, 1970
Sasyniuk BI, Kus T: Comparison of the effects of lidocaine on electrophysiological properties of normal Purkinje fibers and those surviving acute myocardial infarction. Fed Proc (Abstr) 33: 476, 1974
El-Sherif N, Scherlag BJ, Lazzara R: Re-entrant ventricular arrhythmias in the late myocardial infarction period. IV. Mechanism of action of lidocaine. Circulation 56: 395, 1977
Kupersmith J, Antam EM, Hoffman BF: In vivo electrophysiological effects of lidocaine in canine acute myocardial infarction. Circ Res 36: 84, 1975
Rosen MR, Merker C, Pippenger CE: Effects of clinically relevant plasma lidocaine concentrations on electrophysiologic properties of canine Purkinje fibers. Circulation 48 (Suppl) IV: 209, 1973
Rosen MR, Hoffman BF, Wit AL: Electrophysiology and pharmacology of cardiac arrhythmias. V. Cardiac antiarrhythmic effects of lidocaine. Am Heart J 89: 526, 1975
Rosen MR, Merker C, Pippenger CE: The effects of lidocaine on the canine ECG and electrophysiologic properties of Purkinje fibers. Am Heart J 91: 191, 1976
Rosen KM, Lau SH, Weiss MB, Damato AN: The effect of lidocaine on atrioventricular and intraventricular conduction in man. Am J Cardiol 25: 1, 1970
Kunkel F, Rowland M, Scheinman MM: The electrophysiological effects of lidocaine in patients with intraventricular conduction defects. Circulation 49: 894, 1974
Bekheit S, Murtagh JG, Fletcher E: Effect of lignocaine on conducting system of human heart. Br Heart J 35: 305, 1973
Gupta PK, Lichstein E, Chadda KD: Lidocaine-induced heart block in patients with bundle branch block. Am J Cardiol 39: 550, 1974
Roos JC, Dunning A: Effects of lidocaine on impulse formation and conduction defects in man. Am Heart J 89: 686, 1975
Josephson ME, Caracta AR, Gallagher JJ, Damato AN: Effects of lidocaine on refractory periods in man. Am Heart J 84: 1778, 1972
Gerstenblith G, Scherlag BJ, Hope RR, Lazzara R: Effect of lidocaine on conduction in the ischemic His-Purkinje system in dog. Am J Cardiol 42: 587, 1978
Harris AS, Kodernot RH: Effects of diphenylhydantoin sodium (Dilantin) sodium and phenobarbital sodium upon ectopic ventricular tachycardia in acute myocardial infarction. Am J Physiol 163: 505, 1950
Leonard WA: The use of diphenylhydantoin (Dilantin) sodium in the treatment of ventricular tachycardia. Arch Inter Med 101: 714, 1958
Mercer EN, Osborn JA: The current status of diphenylhydantoin in heart disease. Ann Inter Med 67: 1084, 1967
Eddy JD, Singh SP: Treatment of cardiac arrhythmias with phenytoin. Br Heart J 4: 270, 1969
Bigger JT Jr, Schmidt DH, Kutt H: Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects. Circulation 38: 363, 1968
Kutt H: Biochemical and genetic factors regulating Dilantin metabolism in man. Ann NY Acad Sci 179: 704, 1971
Maynert EW: The metabolic fate of diphenylhydantoin in the dog, rat and man. J Pharmacol Exp Ther 130: 275, 1960
Bigger JT Jr, Bassett AL, Hoffman BF: Electrophysiological effects of diphenylhydantoin on canine Purkinje fibers. Circ Res 22: 221, 1968
Bassett AL, Bigger JT Jr, Hoffman BF: Prospective action of diphenylhydantoin on canine Purkinje fibers during hypoxia. J Pharmacol Exp Ther 173: 336, 1970
Helfant RH, Scherlag BJ, Damato AN: The electrophysiological properties of diphenylhydantoin sodium as compared to procaine amide in the normal and digitalis intoxicated heart. Circulation 36: 108, 1967
Rosati RA, Alexander JA, Schall SF, Wallace AG: Influence of diphenylhydantoin on electrophysiological properties of the canine heart. Circ Res 21: 757, 1967
Damato AN, Berkowitz WD, Patton RD, Lau SH: The effect of diphenylhydantoin on atrioventricular and intraventricular conduction in man. Am Heart J 79: 51, 1970
Caracta AR, Damato AN, Josephson ME, Riccuittu MA, Gallagher JJ, Lau SH: Electrophysiologic properties of diphenylhydantoin. Circulation 47: 1234, 1973
Bissett JK, De Soyza NDB, Kane JJ, Murphy ML: Improved intraventricular conduction of premature beats after diohenylhydantoin. Am J Cardiol 33: 493, 1974
Helfant RH, Scherlag BJ, Damato AN: Use of diphenylhydantoin sodium to dissociate the effects of procainamide on automaticity and conductions in the normal and arrhythmic heart. Am J Cardiol 20: 280, 1967
Haiat R, Chapelle M, Benaim R: Effect of diphenylhydantoin on intraventricular conduction disturbance: report of a case. J Electrocardiol 5: 197, 1972
Evans GH, Shand DG: Disposition of propranolol. IV. Independent variation in steady state circulating drug concentration and half-life as a result of plasma drug binding in man Clin Pharmacol Ther 14: 494, 1973
Nies AS, Whand DG: Clinical pharmacology of propranolol. Circulation 52: 6, 1975
Shand DG, Nuckolls EM, Oates JA: Plasma propranolol levels in adults, with observations in four children. Clin Pharmacol Ther 11: 112, 1970
Walle T, Gaffney TE: Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites. J Pharmacol Exp Ther 182: 83, 1972
With AL, Hoffman BE, Rosen MR: Electrophysiology and pharmacology of cardiac arrhythmias. IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Part C. Am Heart J 90: 795, 1975
Davis LD, Temte JV: Effects of propranolol on the transmembrane potentials of ventricular muscle and Purkinje fibers in the dog. Circ Res 23: 661, 1968
Coltart DJ, Meldrum SJ: The effect of racemic propranolol, dextropropranolol and racemic practolol on the human and canine cardiac transmembrane action potential. Arch Int Pharmacodyn 192: 188, 1971
Strauss HC, Bigger JT Jr, Hoffman BF: electrophysiological and beta-receptor blocking effects of MJ 1999 om dog and rabbit cardiac tissue. Circ Res 26: 661, 1970
Kumakura S, Somani P: The effects of LB-46, a ß-adrenoceptor blocking drug on isolated normal and ouabain intoxicated Purkinje fibers of the dog. Europ J Pharmacol 25: 335, 1974
Wu CH, Narashashi T: Mechanism of action of propranolol on squid axon membranes. J Pharmacol Exp Ther 184: 155, 1973
Berkowitz WD, Wit AL, Lau SH, Steiner C, Damato AH: Effects of propranolol on cardiac conduction. Circulation 40: 855, 1969
Smithen CS, Balcon R, Sowton E: Use of His potentials to assess changes in atrioventricular conduction produced by a series of beta-adrenergic blocking agents. Br Heart J 33: 955, 1971
Seides SF, Josephson ME, Batsford WP, Weisfogel GM, Lau SH, Damato AN: The electrophysiology of propanolol in man. Am Heart J 88: 733, 1974
Seipel L, Both A, Breithardt G, Gleichmann U, Loogen F: Action of antiarrhythmic drugs on His bundle electrogram and sinus node function. Acta Cardiol, Suppl XVIII, 251, 1974
Dini P, Santini M, Di Mascolo R, Milazzotto F, Jacovella G: Effetti elettrofisiologici del pindololo in pazienti con disturbi della eccito-conduzione. VI Congr. Naz ANMCO Rome: Pozzi, 1975, p 322
Alboni P, Malacarne C, Tomasi AM, Masoni A: Effetti del tolamololo sulla eccitoconduzione nell’uomo. G Ital Cardiol 7: 862, 1977
Di Biase M, Guglielmi R, Scarcia A, Chiddo A, Rizzon P: Electrophysiologic properties of intravenous oxprenolol in man. J Electrocardiol 10: 267, 1977
Rizzon P, Di Biase M, Chiddo A, Mastrangelo D, Sorgente L: Electrophysiologic properties of intravenous metoprolol in man. Br Heart J 40: 650, 1978
Di Biase M, Favale S, Rizzon P: Electrophysiologic properties of intravenous tenormine in man. Europ J Cardiol 9: 333, 1979
Charlier R: Cardiac actions in the dog of a new antagonist of adrenergic excitation which does not produce competitive blockade of adrenoreceptors. Br J Pharmacol 39: 668, 1970
Coumel P, Bouvrain Y: Etude clinique des effets pharmacodynamiques et antiarythmiques de l’amiodarone. J Agrèges 6: 69, 1973
Fauchier JP, Brochier M, Raynaud R: Etude clinique des effets anti-arythmiques ventriculaires de l’amiodarone (orale et injectable). Ann Cardiol Angeiol 22: 427, 1973
Rosenbaum MB, Chiale PA, Halpern MS, Nau GJ, Przybylski J, Levi RJ, Lazzari JO, Elizari MV: Clinical efficacy of Amiodarone as an antiarrhythmic agent. Am J Cardiol 38: 934, 1976
Broekhuysen J, Laurel R, Sion R: Etude comparée du transit et du métabolisme de l’amiodarone chez diverses espèces animales et chez l’homme. Arch Inter Pharmacodyn Thér 177: 340, 1969
Singh BN, Vaughan Williams EM: The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol 39: 657, 1970
Cabasson J, Puech P, Melle JM, Guimond G, Bachy C, Sassine A: Analyse des effets électrophysiologiques de l’amiodarone par l’enregistrement simultane des potentiels d’action monophasiques et du faisceau de His. Arch Mal Coeur 69: 691, 1976
Olsson SB, Brorson L, Varnauskas E: Class 3 antiarrhythmic action in man. Observations from monoplasic action potential recordings and amiodarone treatment. Br Heart J 35: 1255, 1973
Curry PVC: Fundamentals of arrhythmias: modern methods of investigation. In: Cardiac arrythmias. The modern electrophysiological approach, Krikler D, Goodwin JF. London: WB Saunders, 1975, p. 39
Disertori M, Molinis G, Vergara G, Bettini R, Furlanello F: Effetti dell’amiodarone sulla conduzione atrio-ventricolare e ventricolo-atriale nella sindrome di Wolff-Parkinson-White. G. Ital Cardiol 6: 792, 1976
Touboul H, Huerta F, Porte J, Delahaye JP: Bases électrophysiologiques de l’action antiarythmique de l’amiodarone chez l’homme. Arch Mal Coeur 69: 845, 1976
Wellens HJJ, Lie KI, Bar FW, Wesdorp JC, Dohmen HJ, Duren Dr, Durrer D: Effect of amiodarone in the Woll-Parkinson-White syndrome. Am J Cardiol 38: 189, 1976
Waleffe A, Bruninx P, Kulbertus HE: Effects of amiodarone studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventriular tachycardia. J Electrocardiol 11: 253, 1978
Bacaner M: Bretylium tosylate for suppression of induced ventricular fibrillation. Am J Cardiol 17: 528, 1966
Terry G, Vellani CW, Higgins MR, Doig A: Bretylium toxylate in treatment of refractory ventricular arrhythmias complicating myocardial infarction. Br Heart J 32: 21, 1070
Dhurandhar RW, Teasdale SJ, Mahon WA: Bretylium tosylate in the management of refractory ventricular fibrillation. Can Med Ass J 105: 161, 1971
Berstein JG, Koch-Weser J: Effectiveness of bretylium tosylate against refractory ventricular arrhythmias. Circulation 45: 1024, 1972
Wit AL, Steiner C, Damato AM: Electrophysiological effects of bretylium tosylate on single fibers of the canine specialized conduction system and ventricle. J Pharmacol Exp Ther 173: 344, 1970
Bigger JT, Jaffe CC: The effect of bretylium tosylate on the electrophysiological properties of ventricular muscle and Purkinje fibers. Am J Cardiol 27: 82, 1971
Haas, H, Hartfelder G: a-Isopropyl-â-[N-methyl-N-homoveratril)-6-aminopropyl]3,4-dimethoxyphenyl-acetonitril, eine Substanz mit Coronargefässerweiternden Eigenschaften. Arzneimittel Forsch 12: 549, 1962
Schamroth L, Krikler DM, Garrett C: Immediate effects of intravenous verapamil in cardiac arrhythmias. Br Med J 1: 660, 1972
Krikler D: Verapamil in cardiology. Europ J Cardiol 2: 10, 1974
Spurrell RAJ, Krikler M, Sowton E: Concealed bypass of the A-V node in patients with paroxismal supraventricular tachycardia revealed by intracardiac electrical stimulation and intravenous verapamil. Am J Cardiol 33: 590, 1974
Rosen MR, Wit AL, Hoffman BF: Electrophysiology and pharmacology of cardiac arrhythmias. VI. Cardiac effects of Verapamil. Am Heart J 89: 665, 1975
Belz GG, Bender F: Therapie der Herzrhythmusstörungen mit Verapamil. Stuttgart: Gustav Fischer, 1974
Fleckenstein A: Specific inhibitors and promotors of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention or production of myocardial lesions. In: Calcium and the heart, Harris P, Opie LH. New York: Academic Press, 1971, p 135
Kohlhardt M, Baver B, Krause H, Fleckenstein A: New selective inhibitors of the transmembrane Ca conductivity in mammalian myocardial fibers. Experientia 15: 288, 1972
Shigenobu K, Schneider JA, Sperelakis N: Verapamil blockade of slow Na + and Ca++ responses in myocardial cells. J Pharmacol Exp Ther 190: 280, 1974
Rosen MR, Ilvento JP, Gelband H, Merker C: Effects of verapamil on electrophysiologic properties of canine cardiac Purkinje fibers. J Pharmacol Exp Ther 189: 414, 1974
Zipes DP, Besch HR, Watanabe AM: Role of the slow current in cardiac electrophysiology. Circulation 51: 761, 1975
Dershm GH, Han J: Effects of Verapamil on action potentials of Purkinje fibers. J Electrocardiol 13: 67, 1980
El-Sherif N, Lazzara R: Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of Verapamil and D-600 and the role of the slow channel. Circulation 60: 605, 1979
Fazzini PF, Marchi F, Pucci P: Azione antiaritmica del Verapamil nell’infarto miocardico acuto. Considerazioni sul possibile meccanismo d’azione. G Ital Cardiol 7: 940, 1977
Elharrar V, Gaum WE, Zipes DP: Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs. Am J Cardiol 39: 544, 1977
Husaini MH, Kvasnicka J, Rysen L, Holmberg S: Action of Verapamil in sinus node, atrioventricular, and intraventricular conduction. Br Heart J 35: 734, 1973
Rizzon P. Di Biase M, Calabrese P, Brindicci G, Chiddo A: Electrophysiologic evaluation of intravenous Verapamil in man. Europ J Cardiol 6: 179, 1977
Hoffman BF: Effects of digitalis on electrical activity of cardiac membranes. In: Basic and clinical pharmacology of digitalis, Marks BH, Weissler AM. Springfield: Charles C. Thomas, 1972, p 118
Kassebaum DC: Electrophysiological effects of strophantin on the heart. J Pharmacol Exp Ther 140: 329, 1963
Hashimoto K, Moe GK: Transient depolarizations induced by acetylstrophanthidin in specialized tissue of dog atrium and ventricle. Cire Res 32: 618, 1973
Davies LD: Effect of changes in cycle length on diastolic depolarization produced by ouabain in canine Purkinje fibers. Circ Res 32: 206, 1973
Ferrier GR, Saunders JH, Mendez C: A cellular mechanism for the generation of ventricular arrhythmias by acetylstrophanthidin. Circ Res 32: 600, 1973
Hogan PM, Wittenberg SM, Klocke FJ: Relationship of stimulation frequency to automaticity in the canine Purkinje fiber during ouabain administration. Circ Res 32: 377, 1973
Rosen MR, Gelband H, Merker C, Hoffman BF: Mechanisms of digitalis toxicity: effects of ouabain on phase 4 of canine Purkinje fiber transmembrane potentials. Circulation 47: 681, 1973
Damato AN, Lau SH: Clinical value of the electrocardiogram of the conducting system. Progr Cardiovasc Dis 13: 119, 1970
Puech P, Grolleau R: L’enregistrement endocavitaire des potentiels du tissu de conduction. Rev Prat 22: 1207, 1972
Przybyla AC: Effects of digoxine on atrio-ventricular conduction pattern in man. Am J Cardiol 33: 344, 1974
Gomes JA, Dhatt MS, Akhtar M, Carambas CR, Rubenson DS, Damato AN: Effects of digitalis on ventricular myocardial and His-Purkinje refractoriness and reentry in man. Am J Cardiol 42: 931, 1978
Gomes JA, Damato AN, Bobb G, Lau S: The effect of digitalis on refractoriness of the intact canine His-Pukinje system. Circulation 58: 284, 1978
Gaultier M, Fournier E, Efthymiou ML, Freaville JP, Jouannot P, Dentan M: Intoxications digitaliques aiguës (70 observations). Bull Soc Med Hop 119: 247, 1968
Ollagnier J: Digitaliques et conduction cardiaque coeur. Med Int 17: 537, 1978
Akhtar M, Damato AN, Caracta AR, Batsford WP, Josephson ME, Lau SH: Electrophysiologic effects of atropine on atrioventricular conduction studied by His bundle electrogram. Am J Cardiol 33: 333, 1974
Hoffman BF, Singer DH: Appraisal of the effects of catecholamines on cardiac electrical activity. In: New adrenergic blocking drugs: their pharmacological, biochemical and clinical actions, Moran N. Ann NY Acad Sci 139: 914, 1967
Giotti A, Ledda F, Mannaioni PF: Effects of noradrenaline and isoprenaline in combination with a and ß-receptor blocking substances on the action potential of cardiac Purkinje fibers. J Physiol 229: 99, 1973
Wit AL, Hoffman BF, Rosen RR: Electrophysiology and pharmacology of cardiac arrhythmias. IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Part A. Am Heart J 90: 521, 1975
Trautwein W, Schmidt RZ: Zur Membranwirkung des Adrenalin an der Herzmuskelfaser. Pflügers Arch 271: 715, 1960
Cannom DS, Rider A, Stinson EB, Harrison DC: Electrophysiologic studies in the denervated transplanted heart. II. Response to norepinephrine, isoproterenol and propranolol. Am J Cardiol 36: 859, 1975
Vargas G, Akhtar M, Damato AN: Electrophysiologic effects of isoproterenol on cardiac conduction system in man. Am Heart J 90: 25, 1975
Masoni A, Alboni P, Malacarne C, Codeca’ L: Effects of Dobutamine on electrophysiological properties of the specialized conduction system in man. J Electrocardiol 12: 361, 1979
Dhingra RC, Winslow E, Pouget J, Rahimtoola S, Rosen KM: The effect of isoproterenol on atrioventricular and intraventricular conduction. Am Heart J 90: 25, 1975
Masini G, Gherardi C, Dianda R, Cuccu E: Effetti della dopamina sulla conduzione atrio-ventricolare ed intraventricolare. G ltal Cardiol 3: 545, 1973
Kesteloot H, Van Mieghem W, De Geest H: Aprindine (AC 1802). A new antiarrhythmic drug. Acta Cardiol 28: 145, 1973
Fasola AF, Carmichael R: The pharmacology and clinical evaluation of aprindine, a new antiarrhythmic agent. Acta Cardiol (Suppl) 18: 317, 1974
Fasola AF, Noble RJ, Zipes DP: Treatment of recurrent ventricular tachycardia and fibrillation with aprindine. Am J Cardiol 39: 903, 1977
Pouleur H, Chaudron JM, Reyns P: Effects of disopyramide and aprindine on arrhythmias after acute myocardial infarction. Europ J Cardiol 5: 397, 1977
Murphy PJ: Metabolic pathways of aprindine. Acta Cardiol (Suppl) 18: 131, 1976
Delcroix C, Martin L, Van Durme JP, Kesteloot H, Hagemeijer F, Mbuyamba P, Deblecker M: Model for exchange kinetics of aprindine in man after single and multiple doses. Acta Cardiol (Suppl) 18: 177, 1974
Verdonck F, Vereecke J, Vleugels A: Electrophysiological effects of aprindine on isolated heart preparations. Europ J Pharm 26: 338, 1974
Steinberg MI, Greenspan K: Intracellular electrophysiological alterations in canine cardiac conducting tissue induced by aprindine and lignocaine. Cardiovasc Res 10: 236, 1976
Greene HL, Reid PR, Schaeffer AH: Prolongation of cardiac conduction times by intravenous aprindine in man. Am J Cardiol 42: 1002, 1978
Zipes DP, Troup PJ: New antiarrhythmic agents. Amiodarone, Aprindine, Disopyramide, Ethmozim, Mexiletine, Tocainide, Verapamil. Am J Cardiol 41: 1005, 1978
Vergara G, Disertori M, Molinis G, Mama G, Antonini L, Del Favero A, Stefenelli C, Furlanello F: Studio degli effetti elettrofisiologici dell’aprindine nell’uomo con particolare riferimento alla sindrome da preeccitazione ventricolare. G Ital Cardiol 9: 597, 1979
Kesteloot H, Van de Werf F, Marchandise B, Sluyts R: Influence of moxaprindine treatment on ventricular arrhythmias occurring during maximal exercise stress testing. Acta Cardiol 34: 301, 1979
Waleffe A, Mary-Rabine L, Kulbertus HE: Study of moxaprindine with programmed electrical stimulation of the heart in patients with reentrant tachyarrhythmias. Am J Cardiol 45: 640, 1980
Beani L: Profilo farmacologico di un nuovo antiaritmico: la bunaftide. Boll Soc It Card 17: 1279, 1972
Lotto A, Lomanto B, Bossi M: Prime esperienze nell’impiego clinico di un nuovo antiaritmico: la bunaftide. Cardiol Prat 23: 123, 1972
Masini G, Cuccu E, Zanetti L: Sull’impiego della bunaftide nel trattamento ambulatoriale di alcuni disturbi del ritmo cardiaco. Boll Soc It Card 17: 1173, 1972
Rossi P, Carcano G, Rognoni G, Cernigliaro C, Calcaterra G: Correlazione fra concentrazioni plasmatiche ed effetto antiaritmico della bunaftide. G Ital Cardiol 6: 1048, 1976
Ferroni A, Monticelli G: Electrophysiological aspects of the action of bunaphtine on single cardiac muscle fibres. Pharmacol Res 5: 151, 1973
Bonatti V, Finardi A, Cabasson J, Botti G: L’effetto della bunaftide sui potenziali di azione monofasici del miocardio atriale e ventricolare destro nell’uomo. Nota preliminare. G Ital Cardiol 6: 440, 1976
Bonatti V, Finardi A, Cabasson J, Botti G: Studio sul meccanismo d’azione della bunaftide mediante registrazione dei potenziali d’azione monofasici del miocardio nell’uomo. Nota conclusiva. G Ital Cardiol 6: 1378, 1976
Scibilla G, Bonatti V, Pavarani A, Tagliavini S, Botti G: Effetto sul fascio di His di una nuova sostanza antiaritmica, la bunaftide. Cardiol Prat 24: 79, 1973
Grazi S, Romano S, Bonazzi O, Pozzoni L, Cavoretto D, Gardumi L, Sardella F: Effetti di un nuovo antiaritmico, la bunaftide, sulla conduzione intraatriale, atrioventricolare ed intraventricolare dello stimolo. Cardiol Prat 25: 213, 1974
Byrne JE, Gomoll AW: Antiarrhythmic activity of MJ 9067. Fed Proc (Abstr) 32: 812, 1973
Byrne JE, Gomoll AW: Antiarrhythmic properties of MJ 9067 in acute animal models. J Pharmacol Exp Ther 200: 147, 1977
Gibson JK, Somani PF, Bassett A: Effect of MJ 9067 on transmembrane potentials of canine cardiac Purkinje fibers (Abstr). Pharmacology 18: 169, 1976
Sami M, Mason JW, Oh G, Harrison DC: Canine electrophysiology of Encainide, a new antiarrhythmic drug. Am J Cardiol 43: 1149, 1979
Sami M, Mason JW, Peters F, Harrison DC: Clinical electrophysiologic effects of Encainide, a newly developed antiarrhythmic agent. Am J Cardiol 44: 526, 1979
Kaverina NV, Senova DP, Vikhlyayev YI, Ul’yanova OV: Antiarrhythmic properties of ethmozine. Farmako Toksikol 33: 693, 1970
Votchal BY, Lozinskiy LG: Efficacy of a new antiarrhythmic drug, ethmozim. Klin Med (Mosk) 10: 16, 1971
Senova ZP, L’Vov MV: Mechanism of the antiarrhythmic effect of ethmozim Farmakol Toksikol 36: 703, 1973
Morganroth J, Pealman AS, Dunkam WB, Horowitz LN, Josephson ME, Michelson EL: Ethmozim: a new antiarrhythmic agent developed in the USSR. Efficacy and tolerance. Am Heart J 98: 621, 1979
Podrid PJ, Lyakishev A, Lown B, Mazur N: Ethmozim, a new antiarrhythmic drug for suppression of ventricular premature complexes. Circulation 61: 450, 1980
Danilo P, Langman WB, Rosen MR, Hoffman BF: Effects of phenothiazine analog, EN 131, on ventricular arrhythmias in the dog. Europ J Pharmacol 45: 127, 1977
Ruffy R, Rozenshtraukh L, Elharrar V, Zipes DP: Cardiac electrophysiologic properties of ethmozim. Clin Res (Abstr) 25: 557, 1977
Campbell NPS, Kelly JG, Shanks RG, Chaturvedi NC, Strong JE, Partridge JF: Mexiletine (Ko 1173) in the management of ventricular arrhythmias. Lancet 2: 404, 1973
Talbot RG, Nimmo J, Julian DG, Clark RA, Nielson JMM, Prescott LF: Treatment of ventricular arrhythmias with mexiletine (Ko 1173). Lancet 2: 399, 1973
Heger JJ, Nattel S, Rinkenberger RL, Zipes DP: Mexiletine therapy in 15 patients with drug-resistant ventricular tachycardia. Am J Cardiol 45: 627, 1980
Prescott LF, Clements JD, Pottage A: Absorption, distribution and elimination of mexiletine. Postgrad Med J (Suppl) 53: 50, 1977
Weld FM, Bigger JT, Swistel D, Bordiuk J, Lau YH: Electrophysiological effects of mexiletine (Kö 1173) on ovine cardiac Purkinje fibers. (In preparation)
Roos JC, Paalman ACA, Dunning AJ: Electrophysiological effects of mexiletine in man. Br Heart J 38: 1261, 1976
McComish M, Kitson D, Robinson CC, Jewitt DE: Clinical electrophysiological effects of mexiletine. Postgrad Med J 53 (Suppl I): 85, 1977
Beck OA, Kramer KD, Wolff R, Muller A, Hochrein H: Propafenon, ein neues Antiarrhythmikum zur Therapie tachycarder und extrasystolischer Herzrhythmusstörungen. Med Klin 70, 95: 1975
Ador E, Heeger I: Propafenon, ein neues Antiarrhythmikum. Dtsch Med Wschr 101: 1318, 1976
Kock R: Zur Propafenon-wirkung bei ventrikularer Arrhythmie. In: Fortschritte in der Pharmakotherapie von Herzrhythmusstörungen 1, Hochrein H, Hapke Hi, Beck OA. Internationales Propafenon-Symposium. Stuttgart: Gustav Fischer, 1977, p 84
Fazzini PF, Marchi F, Santoro GM, Pucci P, Zambaldi G: Profilo di un nuovo antiaritmico: il proprafenone. Contributo casistico in terapia clinica. (In preparation)
Keller K, Meyer-Estorf G, Beck OA, Hochrein H: Correlation between serum concentration and pharmacological effect of atrioventricular conduction time of the antiarrhythmic drug. Europ J Pharmacol 13: 17, 1978
Bergamann M, Bolte HD: Elektrophysiologische Untersuchungen mit Propafenon in myokardialen Einzelfasern. In: Fortschritte in der Pharmakotherapie von Herzrhythmusstörungen I, Hochrein H, Hapke HJ, Beck OA. Internationales Propafenon-Symposium. Suttgart: Gustav Fischer, 1977, p 84
Seipel L, Both A, Breithardt G, Loogen F: Die Wirkung neuer Antiarrhythmika (Aprindin, Propafenon, Ci 661) auf die intrakardiale Anregungsleitung und die Sinusknotenautomatik beim Menschen. (Personal communication)
McDevitt DG, Nies AS, Wilkinson GR, Smith RF, Woosley RL, Oates JA: Antiar-rhythmic effects of a lidocaine congener, tocainide, 2-amino-2, 6-propionoxylidide in man. Clin Pharmacol Ther 19: 396, 1976
Lewinter MM, Englel RE, Karliner JS: Tocainide therapy for treatment of ventricular arrhythmias: assessment with ambulatory electrocardiographic monitoring and treadmill exercice. Am J Cardiol 45: 1045, 1980
Harrison DC, Meffin PJ, Winkle RA: Clinical pharmacokinetics of antiarrhythmic drugs. Prof Cardiovasc Dis 20: 217, 1977
Gerstenblith G, Spear JF, Moore EN: Electrophysiological effects of a new antiarrhythmic drug. Clin Res 21: 419, 1973
Anderson JL, Mason JW, Winkle RA, Meffin PJ, Fowles RE, Peters F, Harrison DC: Clinical electrophysiologic effects of tocainide. Circulation 57: 685, 1978
Pamintuan JC, Dreifus LS, Watanabe Y: Comparative mechanism of antiarrhythmic agents. Am J Cardiol 26: 512, 1960
Watanabe Y, Dreifuss LS, Likoff W: Electrophysiologic antagonism and synergism of potassium and antiarrhythmic agents. Am J Cardiol 12: 702, 1963
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© 1981 Martinus Nijhoff Publishers, The Hague
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Alboni, P. (1981). Effect of Antiarrhythmic Drugs on Intraventricular Conduction. In: Intraventricular Conduction Disturbances. Developments in Cardiovascular Medicine, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8287-1_13
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