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The Role of Polymer Permeability in the Control of Drug Release

  • Chapter
Polymer Permeability

Abstract

Polymer permeability causes a number of problems in various areas of pharmaceutical interest, such as the loss of drugs or other formulation ingredients by diffusion controlled sorption into plastic containers1–3 or into plastic components of delivery systems,4,5 the uptake of preservatives from cleansing and soaking solutions by soft contact lenses and their subsequent release into the eye6,7 and the release of residual ethylene oxide and its reaction products from plastic devices sterilised by exposure to that gas.8 However, permeability, together with other properties of polymers, form the basis of a number of important applications, such as tablet coatings,9 haemodialysis10 and wound dressings.11 In addition to these applications a considerable amount of research and development has been and continues to be concerned with the use of polymers as agents for controlling the release of drugs from various types of formulated product or dosage form, e.g. tablets, implants, injectables and topically applied adhesive strips. Evidence of the high degree of current interest in the design of such dosage forms and parallel studies in the fields of agriculture and pest control is provided by the number of recent reviews,12–29 books30–34 and symposia35–40 that have been concerned with these subjects.

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  1. School of Pharmacy, Leicester Polytechnic, UK

    John H. Richards

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  1. School of Chemistry, Leicester Polytechnic, UK

    J. Comyn

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© 1985 Chapman & Hall

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Richards, J.H. (1985). The Role of Polymer Permeability in the Control of Drug Release. In: Comyn, J. (eds) Polymer Permeability. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4858-7_6

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