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Progress in Radiopharmacy pp 475–508Cite as

Radionuclides in Drug Formulation Studies

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Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 10))

Abstract

Ariens (1) has defined three separate phases of drug action that relate the dose of a drug to its pharmacological effect. These (in sequence) are the pharmaceutical phase (release of drug from the dosage form), the pharmacokinetic phase (absorption, distribution, metabolism, excretion) and the pharmacodynamic phase (interaction of the drug at the tissue site with the appropriate receptor). One of the important roles of the pharmaceutical scientist engaged in formulation studies is to design a dosage form that performs correctly in relation to these phases and releases the drug in the correct quantity over the appropriate time scale, with the result that the pharmacokinetic profile and, in turn the therapeutic response, are optimal. In some cases the processes of drug release and distribution within the body are not very sophisticated, for example the rapid disintegration of a tablet and the subsequent dissolution of the drug in the stomach or intestine followed by absorption and distribution controlled solely by the physicochemical and metabolic characteristics of the drug. In other situations, more advances drug delivery systems have been designed that can release the drug slowly over an extent period of time, either in a continuous or pulsed manner, or that can introduce some element of tissue selectivity into drug therapy.

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  1. S. S. Davis
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Editors and Affiliations

  1. Department of Nuclear Medicine, Rotterdamsch Radiotherapeutisch Instituut, Rotterdam, The Netherlands

    P. H. Cox

  2. Regional Centre for Radiotherapy Department of Oncology and Nuclear Medicine, Essex County Hospital, Colchester, UK

    S. J. Mather

  3. Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, UK

    C. B. Sampson

  4. Department of Nuclear Medicine, Guy’s Hospital, London, UK

    C. R. Lazarus

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© 1986 Martinus Nijhoff Publishers, Dordrecht

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Davis, S.S. (1986). Radionuclides in Drug Formulation Studies. In: Cox, P.H., Mather, S.J., Sampson, C.B., Lazarus, C.R. (eds) Progress in Radiopharmacy. Developments in Nuclear Medicine, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4297-4_26

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  • DOI: https://doi.org/10.1007/978-94-009-4297-4_26

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