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The implantable artificial pancreas

  • Chapter
International Handbook of Pancreas Transplantation

Part of the book series: Developments in Surgery ((DISU,volume 10))

Abstract

The pathogenesis of long-term complications associated with Insulin Dependent Diabetes Mellitus (IDDM) remains a contentious issue between two schools of thought: either accelerated macroangiopathy, microangiopathy, and neuropathy are genetically determined and independent of biochemical derangements; or they result from metabolic abnormalities. Although this issue is not yet decided, proponents of the ‘metabolic’ theory have gathered impressive clinical evidence [1–4], confirmatory data from animal models [5, 6], and demonstrable histologic changes [7–12] which correlate with metabolic abnormalities [13–18]. Conversely, there are other reports [19–24] either directly opposing or questioning this published evidence. Nevertheless, at present it is a reasonable assumption that long term diabetic abnormalities, with genetic factors play a modifying role.

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  1. J. L. Selam
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Editors and Affiliations

  1. Edouard Herriot Hospital, Dept. of Urology and Transplantation Surgery, University of Lyon, Lyon, France

    J. M. Dubernard

  2. Dept. of Surgery, University of Minnesota, Minneapolis, Minnesota, USA

    D. E. R. Sutherland

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© 1989 Kluwer Academic Publishers

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Selam, J.L. (1989). The implantable artificial pancreas. In: Dubernard, J.M., Sutherland, D.E.R. (eds) International Handbook of Pancreas Transplantation. Developments in Surgery, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1083-6_37

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  • DOI: https://doi.org/10.1007/978-94-009-1083-6_37

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