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Functions of peptidergic nerves

  • Chapter
Dynamic Aspects of Dental Pulp

Abstract

During the two last decades an increasing number of biologically active peptides have been encountered in autonomic and sensory nerves in peripheral tissues. The dental pulp is no exception to this, as reviewed in the previous chapter. The knowledge about the functional roles of neuropeptides is, however, still incomplete. The fact that in many tissues several of the substances are found in nerve terminals in close association to vessels and the finding that they have vasoactive properties has been taken to indicate that they are involved in vasomotor regulation. However, some of the peptides may have other roles, such as in endocrine and exocrine secretion, growth, bone remodelling, nerve regeneration and influences on immune responses, to mention a few. In analogy with the variety of actions that classical neurotransmitters have in different organs, it is not surprising that neuropeptides are associated with many different effects in different target organs. This chapter will focus on certain neuropeptides in the dental pulp and their possible roles in haemodynamic regulation.

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References

  • Brodin, E., Gazelius, B., Lundberg, J. M. and Olgart, L. (1981a) Substance P in trigeminal nerve endings: Occurrence and release. Acta Physiol. Scand., 111, 501–503.

    Article  Google Scholar 

  • Brodin, E., Gazelius, B., Olgart, L. and Nilsson, G. (1981b) Tissue concentration and release of substance P-like immunoreactivity in the dental pulp. Acta Physiol. Scand., 111, 141–149.

    Article  Google Scholar 

  • Brodin, E., Gazelius, B., Panopoulos, P. and Olgart, L. (1983) Morphine inhibits substance P release from peripheral sensory nerve endings. Acta Physiol. Scand., 117, 567–570.

    Article  Google Scholar 

  • Edwall, B. (1987) Experimental studies on blood flozv regulation in oral tissues. Thesis, Stockholm.

    Google Scholar 

  • Edwall, L. (1971) Some effects of sympathetic nerve activation in oral tissues as studied by tracer disappearance. Thesis, Stockholm.

    Google Scholar 

  • Edwall, B., Gazelius, B., Fazekas, A., Theodorsson-Norheim, E. and Lundberg, J. M. (1985) Neuropeptide Y (NPY) and sympathetic control of blood flow in oral mucosa and dental pulp in the cat. Acta Physiol. Scand., 125, 253–264.

    Article  Google Scholar 

  • Edwall, B., Gazelius, B., Berg J.-O., Edwall, L., Hellander, K. and Olgart, L. (1987) Blood flow changes in the dental pulp of the cat and rat measured simultaneously by laser Doppler flowmetry and local 1251 clearance. Acta Physiol. Scand., 131, 81–91.

    Article  Google Scholar 

  • Ekström, J., Ekman, R., Hâkanson, R. et al. (1988) Calcitonin gene-related peptide in rat salivary gland: Neuronal localization, depletion upon nerve stimulation and effects on salivation in relation to substance P. Neuroscience (in press).

    Google Scholar 

  • Gamse, R., Holzer, P. and Lembeck, F. (1980) Decrease of substance P in primary afferent neurons and impairment of neurogenic plasma extravasation by capsaicin. Br. J. Pharmacol., 68, 207–213.

    Google Scholar 

  • Gazelius, B. (1981) Studies on the release and effects of putative mediators of pain in the dental pulp. Thesis, Stockholm.

    Google Scholar 

  • Gazelius, B. and Olgart, L. (1981) Vasodilatation in the dental pulp produced by electrical stimulation of the inferior alveolar nerve in the cat. Acta Physiol. Scand., 108, 181–186.

    Article  Google Scholar 

  • Gazelius, B., Olgart, L., Edwall, L. and Trowbridge, H. O. (1977) Effects of substance P on sensory nerves and blood flow in the feline dental pulp, in Pain in the Trigeminal Region (eds D. Anderson and B. Matthews ), Elsevier, Amsterdam, pp. 95–101.

    Google Scholar 

  • Gazelius, B., Brodin, E. and Olgart, L. (1981a) Depletion of substance P-like immunoreactivity in the cat dental pulp by antidromic nerve stimulation. Acta Physiol. Scand., 111, 319–327.

    Article  Google Scholar 

  • Gazelius, B., Brodin, E., Olgart, L. and Panopoulos, P. (1981b) Evidence that substance P is a mediator of antidromic vasodilatation using somatostatin as a release inhibitor. Acta Physiol. Scand., 113, 155–159.

    Article  Google Scholar 

  • Gazelius, B., Brodin, E., Kahan, T., Panopoulos, P. and Olgart, L. (1983) Local application of capsaicin to a peripheral nerve: Effects on substance P and noradrenaline levels in peripheral nerve endings and vascular responses to nerve stimulation, in Substance P. (eds P. Skrabanek and D. Powell ), Boole Press, Dublin, pp. 241–242.

    Google Scholar 

  • Gazelius, B., Edwall, B., Olgart, L., Lundberg, J. M., Hökfelt, T. and Fisher, J. A. (1987) Vasodilatory effects and coexistence of calcitonin gene-related peptide (CGRP) and substance P in sensory nerves of cat dental pulp. Acta Physiol. Scand., 130, 33 40.

    Google Scholar 

  • Inoki, R., Toyoda, T. and Yamamoto, I. (1973) Elaboration of a bradykinin-like substance in dog’s canine pulp during electrical stimulation and its inhibition by narcotic and non-narcotic analgesics. Naunyn-Schmiedeberg’s Arch. Pharmacol., 279, 387–398.

    Article  Google Scholar 

  • Inoki, R., Matsumoto, K., Kudo, T., Kotani, Y. and Oka, M. (1979) Bradykinin as an algesic (pain producing) substance in the pulp. Naunyn-Schmiedeberg’s Arch. Pharmacol., 306, 29–36.

    Article  Google Scholar 

  • Kim, S. and Dorscher-Kim, J. (1987) Hemodynamic regulation of the dental pulp in a low compliance environment, in Microcirculation: An Update (eds M. Tsuchiya et al.), Elsevier, Amsterdam, pp. 105–106.

    Google Scholar 

  • Kishi, Y. and Takahashi, K. (1987) Changing of vascular architecture of mammalian dental pulp with growth using corrosion resin casts examined under scanning electron microscope, in Microcirculation: An Update (eds M. Tsuchya et al.), Elsevier, Amsterdam, pp. 93–96.

    Google Scholar 

  • Kroeger, D. C. (1968) Possible role of neurohumoral substances in the pulp, in Biology of the Dental Pulp Organ: A Symposium (ed. S. B. Finn ), University of Alabama Press, Birmingham, pp. 333–346.

    Google Scholar 

  • Lembeck, F. and Holtzer, P. (1979) Substance P as a neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. NaunynSchmiedeberg’s Arch. Pharmacol., 310, 175–183.

    Article  Google Scholar 

  • Lembeck, F., Gamse, R., Holzer, P. and Molnar, A. (1980) Substance P and chemosensitive neurones, in Neuropeptides and Neural Transmission (eds A. Marsan and W. Z. Traczyk ), Raven Press, New York, pp. 51–72.

    Google Scholar 

  • Lundberg, J. M., Fried, G., Fahrenkrug, J., Holmstedt, B., Hökfelt, T., Lagercrantz, H., Lundgren, G. and Anggârd, A. (1981a) Subcellular fractionation of cat submandibular gland: Comparative studies on the distribution of acetylcholine and vasoactive intestinal polypeptide (VIP). Neuroscience, 6, 1001–1010.

    Article  Google Scholar 

  • Lundberg, J. M., Änggârd, A. and Fahrenkrug, J. (1981b) Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. Acta Physiol. Scand„ 114, 329–337.

    Article  Google Scholar 

  • Lundberg, J. M., Änggârd, A., Emson, T., Fahrenkrug, J. and Hökfelt, T. (1982c) Vasoactive intestinal polypeptide and cholinergic mechanisms in cat nasal mucosa. Studies on choline acetyltransferase and release of vasoactive intestinal polypeptide. Proc. Natl Acad. Sci. USA, 78, 5255–5259.

    Article  Google Scholar 

  • Lundberg, J. M., Rudehill, A., Sollevi, A., Theodorsson-Norheim, E. and Hamberger, B. (1986) Frequency-and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleen. Neurosci. Lett., 63, 96–100.

    Article  Google Scholar 

  • Lundberg, J. M., Saria, A., Lundblad, L., Änggdrd, A., Martling, C.-R. et al. (1987) Bioactive peptides in capsaicin-sensitive C-fibre afferents of the airways. Functional and pathophysiological implications, in Lung Biology in Health and Disease (eds M. Kaliner and P. Barnes), Dekker, New York (in press).

    Google Scholar 

  • Närhi, M. V. O. (1985) The characteristics of intradental sensory units and their responses to stimulation. J. Dent. Res. (special issue), 64, 564–571.

    Google Scholar 

  • Närhi, M., Virtanen, A., Hirvonen, T. and Huopaniemi, T. (1983) Comparison of electrical thresholds of intradental nerves and jaw-opening reflex in the cat. Acta Physiol. Scand., 119, 399–403.

    Article  Google Scholar 

  • Olgart, L., Gazelius, B., Brodin, E. and Nilsson, G. (1977) Release of substance P-like immunoreactivity from the dental pulp. Acta Physiol. Scand., 101, 510–512.

    Article  Google Scholar 

  • Olgart, L., Edwall, B. and Gazelius, B. (1989) Neurogenic mediators in control of pulpal blood flow. J. Endod., 15, 409–12.

    Article  Google Scholar 

  • Panopoulos, P. (1983) Intradental sensory nerve responses to some factors affecting dentin and pulp. Thesis, Stockholm.

    Google Scholar 

  • Pernow, J., Saria, A. and Lundberg, J. M. (1986) Mechanisms underlying pre-and post-junctional effects of neuropeptide Y in sympathetic vascular control. Acta Physiol. Scand., 126, 239–249.

    Article  Google Scholar 

  • Rosell, S., Olgart, L., Gazelius, B., Panopoulos, P., Folkers, K. and Hörig, J. (1981) Inhibition of antidromic and substance P-induced vasodilatation by a substance P antagonist. Acta Physiol. Scand., 111, 381–382.

    Article  Google Scholar 

  • Tönder, K. H. and Naess, G. (1978) Control of blood flow in the dental pulp in dogs. Acta Physiol. Scand., 104, 13–23.

    Article  Google Scholar 

  • Uddman, R., Alumets, J., Densert, 0., Hâkanson, R. and Sundler, F. (1978) Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall. Acta Otolaryngol., 85, 443–448.

    Google Scholar 

  • Wallin, B. G. (1981) New aspects of sympathetic function in man, in Butterworths International Medical Reviews (eds E. Stählberg and R. R. Young ), Butterworths, London, pp. 145–167.

    Google Scholar 

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  1. L. M. Olgart
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© 1990 Chapman and Hall

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Olgart, L.M. (1990). Functions of peptidergic nerves. In: Dynamic Aspects of Dental Pulp. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0421-7_22

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  • DOI: https://doi.org/10.1007/978-94-009-0421-7_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6675-4

  • Online ISBN: 978-94-009-0421-7

  • eBook Packages: Springer Book Archive

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