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The Role of CD81 in HCV and Plasmodium Infection

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Book cover Tetraspanins

Part of the book series: Proteins and Cell Regulation ((PROR,volume 9))

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Abstract

Hepatitis C and malaria, two of the most prevalent infectious diseases in the world, are caused by Hepatitis C virus (HCV) and Plasmodium parasites, respectively. Both HCV particles and Plasmodium sporozoites, the mosquito-­transmitted stage of the malaria parasite, infect and replicate in the liver. Whereas HCV enters cells by clathrin-mediated endocytosis, Plasmodium sporozoite invasion is a specific active process that relies on the parasite motility machinery. Remarkably, both pathogens critically depend on the host tetraspanin CD81 to enter hepatocytes. In this chapter, we summarize the current knowledge on the role of CD81, tetraspanin-enriched microdomains and CD81-associated partners during HCV and Plasmodium liver infection.

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Abbreviations

AMA-1:

Apical membrane antigen 1

ApoB:

Apolipoprotein B

ApoE:

Apolipoprotein E

CLDN-1:

Claudin-1

CSP:

Circumsporozoite protein

EC1:

First extracellular loop

EEFs:

Exo-erythrocytic forms

ER:

Endoplasmic reticulum

hCD81:

Human CD81

HCV:

Hepatitis C virus

HCVcc:

HCV produced in cell culture

HCVpc:

HCV from primary culture

HCVpp:

HCV pseudoparticles

HCVs:

HCV from infectious serum

HDL:

High-density lipoproteins

HSPGs:

Heparan sulfate proteoglycans

HTLV-1:

Human T-lymphotropic virus 1

HVR1:

Hypervariable region 1

LDL:

Low-density lipoproteins

LDL-R:

Low-density lipoproteins receptor

LEL:

Large extracellular loop

LS:

Liver stages

LVPs:

Lipo-viro-particles

mCD81:

Mouse CD81

MβCD:

Methyl-beta-cyclo-dextrin

NS:

Non structural

PCSK9:

Proprotein convertase subtilisin/kexin type 9

PHH:

Primary human hepatocytes

sE2:

Soluble E2

SR-BI:

Scavenger receptor class B type I

TEM:

Tetraspanin-enriched microdomains

TRAP:

Thrombospondin-related anonymous protein

VLDL:

Very-low-density lipoproteins

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  1. Center for Infection and Immunity of Lille, Inserm U1019 – CNRS UMR8204, Pasteur Institute of Lille, University Lille North of France, 1 rue Calmette, 447, 59021, Lille Cedex, France

    Laurence Cocquerel

  2. INSERM, UMR S 945, Paris, 75013, France

    Olivier Silvie

  3. Université Pierre et Marie Curie-Paris 6, UMR S 945, Paris, 75013, France

    Olivier Silvie

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  1. Laurence Cocquerel
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Correspondence to Laurence Cocquerel .

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    Fedor Berditchevski

  2. INSERM U1004, Av. Paul Vaillant Couturier 14, Villejuif, F-94807, France

    Eric Rubinstein

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Cocquerel, L., Silvie, O. (2013). The Role of CD81 in HCV and Plasmodium Infection. In: Berditchevski, F., Rubinstein, E. (eds) Tetraspanins. Proteins and Cell Regulation, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6070-7_14

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