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Tumor Dormancy, Quiescence, and Senescence, Volume 1 pp 261–268Cite as

Chemotherapy of Malignant Pleural Mesothelioma Induces Both Senescence and Apoptosis

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Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 1))

Abstract

It has recently been appreciated that several mechanisms, including apoptosis, senescence and autophagy control the growth of tumors exposed to cytotoxic chemotherapy. The knowledge of processes involved in the response to chemotherapy is important to understand mechanisms of resistance and identify means to enhance tumor response. Clinical research into this issue is hampered by the need for serial tumor biopsies which is often not feasible. Our current trial for patients with malignant pleural mesothelioma (MPM) includes neoadjuvant chemotherapy followed by surgery rendering it possible to evaluate in situ the effect of chemotherapy. For some patients tissue was available before chemotherapy so that we could investigate apoptosis and accelerated senescence induced by chemotherapy and could determine changes at individual level.

We observed that both apoptosis and senescence to be induced by chemotherapy in malignant pleural mesothelioma. In addition, our results demonstrated that induction in a proportion of patients with MPM of the senescence marker plasminogen-activator inhibitor-1 by neo-adjuvant chemotherapy has potential association with a poor outcome.

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Acknowledgements

This work was supported by grant from Oncosuisse, the Zurich Krebsliga and the Stiftung für angewandte Krebsforschung Zürich.

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Authors and Affiliations

  1. Laboratory of Molecular Oncology, Clinic of Oncology, Zurich University Hospital, Haeldeliweg 4, 8044, Zurich, Switzerland

    Emanuela Felley-Bosco & Rolf A. Stahel

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  1. Emanuela Felley-Bosco
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  2. Rolf A. Stahel
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Correspondence to Emanuela Felley-Bosco .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Felley-Bosco, E., Stahel, R.A. (2013). Chemotherapy of Malignant Pleural Mesothelioma Induces Both Senescence and Apoptosis. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 1. Tumor Dormancy and Cellular Quiescence and Senescence, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5958-9_22

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