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Biological Functions of the Elements

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Essentials of Medical Geology

Abstract

Much discussion has taken place with regard to how to define the essentiality of elements, particularly trace elements. The earliest definition was actually borrowed from protein chemistry. In this definition, an element is essential if:

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Further Reading

  • Abreu IA, Cabelli DE (2010) Superoxide dismutases – a review of the metal-associated mechanistic variations. Biochim Biophys Acta 1804:263–274

    Article  Google Scholar 

  • Andreesen JR, Makdessi K (2008) Tungsten, the surprisingly positively acting heavy metal element for prokaryotes. Ann N Y Acad Sci 1125:215–229

    Article  Google Scholar 

  • Andreini C, Bertini I (2012) A bioinformatics view of zinc enzymes. J Inorg Biochem 111:150–156

    Article  Google Scholar 

  • Andrews SC, Robinson AK, Rodriquez-Quinones F (2003) Bacterial iron homeostasis. FEMS Microbiol Rev 27:215–237

    Article  Google Scholar 

  • Arunan E, Desiraju GR, Klein RA, Sadlej J, Scheiner S, Alkorta I, Clary DC, Crabtree RH, Dannenberg JJ, Hobza PH, Kjaergaard G, Legon AC, Mennucci B, Nesbitt DJ (2011) Definition of the hydrogen bond. Pure Appl Chem 83:1637–1641

    Article  Google Scholar 

  • Aubin JE, Triffitt JT (2002) Mesenchyman stem cells and osteoblast differentiation. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology, 2nd edn. Academic, San Diego, pp 59–81

    Chapter  Google Scholar 

  • Baker HM, Anderson BF, Baker E (2003) Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci U S A 100:3579–3583

    Article  Google Scholar 

  • Banci L, Bertini I, Cantini F, Ciofi-Baffoni S (2010) Cellular copper distribution: a mechanistic systems biology approach. Cell Mol Life Sci 67:2563–2589

    Article  Google Scholar 

  • Barañano DE, Snyder SH (2001) Neural roles for heme oxygenase: contrasts to nitric oxide synthase. Proc Natl Acad Sci U S A 98:10996–11002

    Article  Google Scholar 

  • Barber J (2003) Photosystem II: the engine of life. Q Rev Biophys 36:71–89

    Article  Google Scholar 

  • Barceloux DG, Bond GR, Krenzelok EP, Cooper H, Vale JA (2002) American academy of clinical toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol 40:415–446

    Article  Google Scholar 

  • Bates DM, Popescu CV, Khoroshilova N, Vogt K, Beinert H, Münck E, Kiley PJ (2000) Substitution of leucine 28 with histidine in the Escherichia coli transcription factor FNR results in increased stability of the [4Fe–4S]2+ cluster to oxygen. J Biol Chem 275:6234–6240

    Article  Google Scholar 

  • Beard JL (2001) Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 131:568S–580S

    Google Scholar 

  • Begley TP, Xi J, Kinsland C, Taylor S, MacLafferty F (1999) The enzymology of sulphur activation during thiamine and biotin biosynthesis. Curr Opin Chem Biol 3:623–629

    Article  Google Scholar 

  • Behne D, Kyriakopoulos A (2001) Mammalian selenium-containing proteins. Annu Rev Nutr 21:453–473

    Article  Google Scholar 

  • Beinert H (2000) A tribute to sulphur. Eur J Biochem 267:5657–5664

    Article  Google Scholar 

  • Beinert H, Kennedy MC, Stout CD (1996) Aconitase as iron–sulfur protein, enzyme and iron-regulatory protein. Chem Rev 96:2335–2373

    Article  Google Scholar 

  • Beninga J, Rock KL, Goldberg AL (1998) Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. J Biol Chem 273:18734–18742

    Article  Google Scholar 

  • Berg D, Gerlach M, Youdim MBH, Double KL, Zecca L, Riederer P, Becker G (2001) Brain iron pathways and their relevance to Parkinson’s disease. J Neurochem 79:225–236

    Article  Google Scholar 

  • Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universatility of calcium signalling. Nat Rev Mol Cell Biol 1:11–21

    Article  Google Scholar 

  • Birringer M, Pilawa S, Flohé L (2002) Trends in selenium biochemistry. Nat Prod Rep 19:693–718

    Article  Google Scholar 

  • Brown KM, Arthur JR (2001) Selenium, selenoproteins and human health: a review. Public Health Nutr 4:593–599

    Article  Google Scholar 

  • Burk RF (1973) Effect of dietary selenium level on Se binding to rat plasma proteins. Proc Soc Exp Biol Med 143:719–722

    Google Scholar 

  • Camarakis J, Voskoboinik I, Mercer JF (1999) Molecular mechanisms of copper homeostasis. Biochem Biophys Res Commun 261:225–232

    Article  Google Scholar 

  • Carafoli E, Klee C (1999) Calcium as a cellular regulator. Oxford University Press, Oxford

    Google Scholar 

  • Chausmer AB (1998) Zinc, insulin and diabetes. J Am Coll Nutr 17:109–115

    Google Scholar 

  • Chen CL, Shim MS, Chung J, Yoo HS, Ha JM, Kim JY, Choi J, Zang SL, Hou X, Carlson BA, Hatfield DL, Lee BJ (2006) G-rich, a drosophila selenoprotein, is a Golgi-resident type III membrane. Biochem Biophys Res Commun 348:1296–1301

    Article  Google Scholar 

  • Chen TC, Sakaki T, Yamamoto K, Kittaka A (2012) The roles of cytochrome P450 enzymes in prostate cancer development and treatment. Anticancer Res 32:291–298

    Google Scholar 

  • Cigic B, Pain RH (1999) Location of the binding site for chloride Ion activation of cathepsin C. Eur J Biochem 264:944–951

    Article  Google Scholar 

  • Ciobica A, Padurariu M, Dobrin I, Stefanescu C, Dobrin R (2011) Oxidative stress in schizophrenia – focusing on the main markers. Psychiatr Danub 23:237–245

    Google Scholar 

  • Clark LC, Combs GF Jr, Trumbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL Jr, Park HK, Sanders BB Jr, Smith CL, Taylor JR (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. JAMA 276:1957–1963

    Article  Google Scholar 

  • Coindet JF (1821) Nouvelles recherches sur les effets d’iode, et sur les precautions à suivre dans le traitement du goitre par ce nouveau remède. Ann Chim Phys (Paris) 16:252–266

    Google Scholar 

  • Conklin DS, McMaster JA, Culbertson MR, Kung C (1992) COT1: a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol Cell Biol 12:3678–3688

    Google Scholar 

  • Cousins RJ (1998) A role of zinc in the regulation of gene expression. Proc Nutr Soc 57:307–311

    Article  Google Scholar 

  • Coyle P, Phicox JC, Carey LC, Rofe AM (2002) Metallothionein: the multipurpose protein. Cell Mol Life Sci 59:627–647

    Article  Google Scholar 

  • D’Amico S, Gerday C, Feller G (2000) Structural similarities and evolutionary relationships in chloride-dependent alpha-amylases. Gene 253:95–105

    Article  Google Scholar 

  • Dae-won J, Tae SK, Youn WC, Byeong JL, Ick YK (2002) Selenoprotein W is a glutathione-dependent antioxidant in vivo. FEBS Lett 517:225–228

    Article  Google Scholar 

  • Dardenne M (2002) Zinc and immune function. Eur J Clin Nutr 56:S20–S23

    Article  Google Scholar 

  • Davis SR, Cousins RJ (2000) Metallothionein expression in animals: a physiological perspective on function. J Nutr 130:1085–1088

    Google Scholar 

  • De Feo CJ, Aller SG, Siluvai GS, Blackburn NJ, Unger VM (2009) Three-dimensional structure of the human copper transporter hCTR1. Proc Natl Acad Sci U S A 106:4237–4242

    Article  Google Scholar 

  • Decensi A, Costa A (2000) Recent advances in cancer chemoprevention, with emphasis on breast and colorectal cancer. Eur J Cancer 36:694–709

    Article  Google Scholar 

  • Dennert G, Zwahlen M, Brinkman M, Vinceti M, Zeegers MPA, Horneber M (2012) Selenium for preventing cancer (review). Cochrane Lib 4:1–135

    Google Scholar 

  • Dodson G, Steiner D (1998) The role of assembly in insulin’s biosynthesis. Curr Opin Struct Biol 8:189–194

    Article  Google Scholar 

  • Dreosti IE (2001) Zinc and the gene. Mutat Res 475:161–167

    Article  Google Scholar 

  • Duester G (1998) Alcohol dehydrogenase as a critical mediator of retinoic acid synthesis from vitamin a in the mouse embryo. J Nutr 128:459S–462S

    Google Scholar 

  • Dunn JT, Dunn AD (2001) Update on intrathyroidal iodine metabolism. Thyroid 11:407–414

    Article  Google Scholar 

  • Dupont CL, Neupane K, Shearer J, Palenik B (2008) Diversity, functioning and evolution of genes coding for putative Ni-containing superoxide dismutases. Environ Microbiol 10:1831–1843

    Article  Google Scholar 

  • Eibel JK, Abdallah Z, Ross GM (2010) Zinc-metallothionein: a potential mediator of antioxidant defence mechanisms in response to dopamine-induced stress. Can J Physiol Pharmacol 88:305–312

    Article  Google Scholar 

  • Eitinger T, Mandrand-Berthelot MA (2000) Nickel transport systems in microorganisms. Arch Microbiol 173:1–9

    Article  Google Scholar 

  • Ellis DR, Salt DE (2003) Plants, selenium and human health. Curr Opin Plant Biol 6:273–279

    Article  Google Scholar 

  • Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O’Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME (2008) A dynamic pathway for calcium-independent activation of CaM_KII by methionine oxidation. Cell 133:462–474

    Article  Google Scholar 

  • Falchuk KH (1998) The molecular basis for the role of zinc in developmental biology. Mol Cell Biochem 188:41–48

    Article  Google Scholar 

  • Finazzo C, Harmer J, Jaun B, Duin EC, Mahlert F, Thauer RK, Van Doorslaer S, Schweiger A (2003) Characterization of the MCRred2 form of methyl-coenzyme M reductase: a pulse EPR and ENDOR study. J Biol Inorg Chem 8:586–593

    Google Scholar 

  • Fletcher EL, Clark MJ, Furness JB (2002) Neuronal and glial localization of GABA transporter immunoreactivity in the myenteric plexus. Cell Tissue Res 308:339–346

    Article  Google Scholar 

  • Florian S, Krehl S, Loewinger M, Banning A, Esworthy S, Chu FF, Brigelius-Flohé R (2010) Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice. Free Radic Biol Med 49:1694–1702

    Article  Google Scholar 

  • Fraústo da Silva JJR, Williams RJP (2001) The biological chemistry of the elements: the inorganic chemistry of life, 2nd edn. Oxford University Press, London

    Google Scholar 

  • Frazzon J, Fick JR, Dean DR (2002) Biosynthesis of iron-sulphur clusters is a complex and highly conserved process. Biochem Soc Trans 30:60–685

    Google Scholar 

  • Fridovich I (1995) Superoxide radical and superoxide dismutases. Annu Rev Biochem 64:97–112

    Article  Google Scholar 

  • Fritz H, Kennedy D, Fergusson D, Fernandez R, Cooley K, Seely A, Sagar S, Wong R, Seely D (2011) Selenium and lung cancer: a systematic review and meta analysis. PLoS One 6:1–10

    Google Scholar 

  • Gaggelli E, Berti F, D’Amelio N, Gaggelli N, Valensin G, Bovalini L, Paffetti A, Trabalsini L (2002) Metabolic pathways of carcinogenic chromium. Environ Health Perspect 110(suppl 5):733–738

    Article  Google Scholar 

  • Gaxiola RA, Yuan DS, Klausner RD, Fink GR (1998) The yeast CLC chloride channel functions in cation homeostasis. Proc Natl Acad Sci U S A 95:4046–4050

    Article  Google Scholar 

  • Ghosh M, Grunden AM, Dunn DM, Weiss R, Adams MW (1998) Characterization of native and recombinant forms of an unusual cobalt-dependent proline dipeptidase (prolidase) from the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol 180:402–408

    Google Scholar 

  • Gromer S, Wissing J, Behne D, Ashman K, Schirmer RH, Flohe L, Becker K (1998) A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase. Biochem J 332:591–592

    Google Scholar 

  • Gu QP, Beilstein MA, Barofsky E, Ream W, Whanger PD (1999) Purification, characterization, and glutathione binding to selenoprotein W from monkey muscle. Arch Biochem Biophys 361:25–33

    Article  Google Scholar 

  • Hagen H, Marzenell P, Jentzsch E, Wenz F, Veldwijk MR (2012) Aminoferrocene-based produgs activated by reactive oxygen species. J Med Chem 55:924–934

    Article  Google Scholar 

  • Haile DJ, Rouault TA, Harford JB, Kennedy MC, Blondin GA, Beinert H, Klausner RD (1992) Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron–sulfur cluster results in high-affinity RNA binding. Proc Natl Acad Sci U S A 89:11735–11739

    Article  Google Scholar 

  • Handy RD, Eddy FB, Baines H (2002) Sodium-dependent copper uptake across epithelia: a review of rationale with experimental evidence from gill and intestine. Biochim Biophys Acta 1566:104–115

    Article  Google Scholar 

  • Harris ED (2000) Cellular copper transport and metabolism. Annu Rev Nutr 20:291–310

    Article  Google Scholar 

  • Hartmann GC, Klein AR, Linder M, Thauer RK (1996) Purification, properties and primary structure of H2-forming N5, N10-methylenetetrahydromethanopterin dehydrogenase from methanococcus thermolithotrophicus. Arch Microbiol 165:187–193

    Google Scholar 

  • Hausinger RP (1993) Carbon monoxide dehydrogenase. In: Hausinger RP (ed) The biochemistry of nickel. Plenum Press, New York, pp 107–145

    Google Scholar 

  • Hellman NE, Gitlin JD (2002) Ceruloplasmin metabolism and function. Annu Rev Nutr 22:439–458

    Article  Google Scholar 

  • Hille R (2002) Molybdenum and tungsten in biology. Trends Biochem Sci 27:360–367

    Article  Google Scholar 

  • Hilvo M, Tolvanen M, Clark A, Shen B, Shah GN, Wahed A, Halmi P, Hanninen M, Hamalainen JM, Vihinen M, Sly WS, Parkkila S (2005) Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. Biochem J 392:83–92

    Article  Google Scholar 

  • Holley AK, Dhar SK, St. Clair DK (2010) Manganese superoxide dismutase versus p53: the mitochondrial center. Ann N Y Acad Sci 1201:72–78

    Article  Google Scholar 

  • Holmberg CG, Laurell CB (1948) Investigations in serum copper. II. Isolation of the copper-containing protein and a description of some of its properties. Acta Chem Scand 2:550–556

    Article  Google Scholar 

  • Horibata Y, Harabayashi Y (2007) Identification and characterization of human ethanolaminephosphotransferase1. J Lipid Res 48:503–505

    Article  Google Scholar 

  • Hoshi T, Heinemann S (2001) Regulation of cell function by methionine oxidation and reduction. J Physiol 531:1–11

    Article  Google Scholar 

  • Huffman DL, O’Halloran TV (2001) Function, structure, and mechanism of intracellular copper trafficking proteins. Annu Rev Biochem 70:677–701

    Article  Google Scholar 

  • Iyengar GV, Kollmer WE, Bowen HJM (1978) The elemental composition of human tissues and body fluids: a compilation of values for adults. Verlag Chemie, Weinheim

    Google Scholar 

  • Jaiswal JK (2001) Calcium – how and why? J Biosci 26:357–363

    Article  Google Scholar 

  • John LB, Ward AC (2011) The ikaros gene family: transcriptional regulators of hematopoiesis and immunity. Mol Immunol 48:1272–1278

    Article  Google Scholar 

  • Kappler U, Dahl C (2001) Enzymology and molecular biology of prokaryotic sulfite oxidation. FEMS Microbiol Lett 203:1–9

    Google Scholar 

  • Katagiri T, Takahasi N (2002) Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 8:147–159

    Article  Google Scholar 

  • Kawakami N, Ueki T, Kanamori K, Matsuo K, Gekko K, Michibata H (2009) A novel vanadium reductase, Vanabin2, forms a possible cascade involved in electron transfer. Biochim Biophys Acta 1794:676–679

    Google Scholar 

  • Kayne FJ (1971) Thallium (I) activation of pyruvate kinase. Arch Biochem Biophys 143:232–239

    Article  Google Scholar 

  • Kehres DG, Maguire ME (2002) Structure, properties and regulation of magnesium transport proteins. Biometals 15:261–270

    Article  Google Scholar 

  • Kehres DG, Maguire ME (2003) Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria. FEMS Microbiol Rev 27:263–290

    Article  Google Scholar 

  • Kim JY, Tillison KS, Zhou S, Lee JH, Smas CM (2007a) Differentiation-dependent expression of Adhfe1 in adipogenesis. Arch Biochem Biophys 464:100–111

    Article  Google Scholar 

  • Kim KH, Gao Y, Walder K, Collier GR, Skelton J, Kissebah AH (2007b) SEPS1 Protects RAW264.7 Cells from pharmacological ER stress agent-induced apoptosis. Biochem Biophys Res Commun 354:127–132

    Article  Google Scholar 

  • Kim J-H, Nam Y-P, Jeon S-M, Han H-S, Suk K (2012) Amyloid neurotoxicity is attenuated by metallthionein: dual mechanisms at work. J Neurochem 121:751–762

    Article  Google Scholar 

  • Kletzin A, Adams MWW (1996) Tungsten in biological systems. FEMS Microbiol Rev 18:5–63

    Article  Google Scholar 

  • Kobayashi M, Shimizu S (1999) Cobalt proteins. Eur J Biochem 261:1–9

    Article  Google Scholar 

  • Köhrle J (1999) The trace element selenium and the thyroid gland. Biochimie 81:527–533

    Article  Google Scholar 

  • Köhrle J (2000) The deiodinase family: selenoenzymes regulating thyroid hormone availability and action. Cell Mol Life Sci 57:1853–1863

    Article  Google Scholar 

  • Kossiva L, Gourgiotis ID, Tsentidis C, Anastasiou T, Marmarinos A, Vasilenko H, Sdogou T, Gerogouli H (2012) Serum hepcidin and ferritin to iron ratio in evaluating of bacterial versus viral infections in children. A single center study. Pediatr Infect Dis J 31(8):795–798

    Article  Google Scholar 

  • Kotrebai M, Birringer M, Tyson JF, Block E, Uden PC (2000) Selenium speciation in enriched and natural samples by HPLC-ICP-MS and HPLC-ESI-MS with perfluorinated carboxylic acid Ion-pairing agents. Analyst 125:71–78

    Article  Google Scholar 

  • Kruzel ML, Zimecki M (2002) Lactoferrin and immunologic dissonance: clinical implications. Arch Immunol Ther Exp 50:399–410

    Google Scholar 

  • Kryukov GV, Kuman RA, Koc A, Sun Z, Gladyshev VN (2002) Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A 99:4245–4250

    Article  Google Scholar 

  • Ladomery M, Dellaire G (2002) Multifunctional zinc finger proteins in development and disease. Ann Hum Genet 66:331–342

    Article  Google Scholar 

  • Lau FC, Bagchi M, Sen CK, Bagchi D (2008) Nutrigenomic basis of beneficial effects of chromium(III) on obesity and diabetes. Mol Cell Biochem 317:1–10

    Article  Google Scholar 

  • Lebedeva MA, Eaton JS, Shadel G (2009) Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta 1787:328–334

    Article  Google Scholar 

  • Lebioda L (2000) The honorary enzyme haemoglobin turns out to be a real enzyme. Cell Mol Life Sci 57:1817–1819

    Article  Google Scholar 

  • Leroy J (1926) Necessité du magnesium pour la croissance de la Souris. C R Seances Soc Biol 94:431–433

    Google Scholar 

  • Li YH (2000) A compendium of geochemistry: from solar nebula to the human brain. Princeton University Press, Princeton

    Google Scholar 

  • Li M, Eastman CJ (2012) The changing epidemiology of iodine deficiency. Nat Rev Endocrinol 8(7):434–440

    Article  Google Scholar 

  • Li JY, Li B, Blot WJ, Taylor PR (1993) Preliminary report on the results of nutrition prevention trials of cancer and other common disease among residents in Linxian, China. Chin J Pathol 15:165–181

    Google Scholar 

  • Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ (2006) Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 442:91–95

    Article  Google Scholar 

  • Linder MC, Hazegh-Azam M (1996) Copper biochemistry and molecular biology. Am J Clin Nutr 63:797S–811S

    Google Scholar 

  • Lund PA, Brown NL (1987) Role of the merT and merP gene products of transposon Tn501 in the induction and expression of resistance to mercuric ions. Gene 52:207–214

    Article  Google Scholar 

  • Lyonnet B, Martz F, Martin E (1899) L’emploi Thérapeutique des derives du vanadium. Presse Med 1:191–192

    Google Scholar 

  • Ma K, Adams WW (1999) An unusual oxygen-sensitive, iron- and zinc-containing alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol 181:1163–1170

    Google Scholar 

  • Macomber L, Hausinger RP (2011) Mechanisms of nickel toxicity in microorganisms. Metallomics 3:1153–1162

    Article  Google Scholar 

  • Maggini S, Wenzlaff S, Hornig D (2010) Essential role of vitamin C and zinc in child immunity and health. J Int Med Res 38:386–414

    Google Scholar 

  • Maret W (2000) The function of zinc metallothionein: a link between cellular zinc and redox state. J Nutr 130:1455S–1458S

    Google Scholar 

  • Mason KE (1979) A conspectus of research on copper metabolism and requirements of man. J Nutr 109:1079–2066

    Google Scholar 

  • Matoso CMM, Pombeiro AJL, Fraústo da Silva JJR, Guedes da Silva MFC, Silva JAL, Baptista-Ferreria JL, Pinho-Almeida F (1998) A possible role for amavadine in some amanita fungi. In: Tracey AS, Craus DC (eds) Vanadium compounds – chemistry, biochemistry and therapeutic applications, vol 711, ACS symposium series. American Chemical Society, Washington, DC, pp 186–201

    Chapter  Google Scholar 

  • Mauk MR, Smith A, Mauk AG (2011) An alternative view of the proposed alternative activities of hemopexin. Protein Sci 20:791–805

    Article  Google Scholar 

  • Maumené E (1854) Experiencé pour determiner l’action des fluores sur l’economie animale. C R Acad Sci (Paris) 39:538–539

    Google Scholar 

  • McCall KA, Huang C, Fierke CA (2000) Function and mechanism of zinc metalloenzymes. J Nutr 130:1437S–1446S

    Google Scholar 

  • Mendel RR (1997) Molybdenum cofactor of higher plants: biosynthesis and molecular biology. Planta 203:399–405

    Article  Google Scholar 

  • Mertz W (1998) Review of the scientific basis for establishing the essentiality of trace elements. Biol Trace Elem Res 66:185–191

    Article  Google Scholar 

  • Mertz W, Toepfer EW, Roginiski EE, Polansky MM (1974) Present knowledge of the role of chromium. Fed Proc Fed Am Soc Exp Biol 33:2275–2280

    Google Scholar 

  • Messerschmidt A, Rossi A, Ladenstein R, Huber R, Bolognesi M, Gatti G, Marchesini A, Petruzzelli R, Finazzi-Agro A (1989) X-Ray crystal structure of the blue oxidase ascorbate oxidase from zuccnini. Analysis of the polypeptide fold and a model of the copper sites and ligands. J Mol Biol 206:513–529

    Article  Google Scholar 

  • Michels AJ, Joisher N, Hagen TM (2003) Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes. Arch Biochem Biophys 410:112–120

    Article  Google Scholar 

  • Michibata H, Uyama T, Ueki T, Kanamore K (2002) Vanadocytes: cells hold the Key to resolving the highly selective accumulation and reduction of vanadium in ascidians. Microsc Res Tech 56:421–434

    Article  Google Scholar 

  • Mitchell AC, Peterson L, Reardon CL, Reed SB, Culley DE, Romine MR, Geesey G (2012) Role of outer membrane C-type cytochromes MtrC and OmcA in shewanella oneidensis MR-1 cell production, accumulation, and detachment during respiration on hematite. Geobiology 10(4):355–370

    Article  Google Scholar 

  • Mobley HLT, Island MD, Hausinger RP (1995) Molecular biology of microbial ureases. Microbiol Rev 59:451–480

    Google Scholar 

  • Moon TE, Levine N, Cartmel B, Bangert JL, Rodney S, Dong Q, Peng YM, Alberts DS (1997) Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest skin cancer prevention study group. Cancer Epidemiol Biomarkers Prev 6:949–956

    Google Scholar 

  • Moxon AL (1937) Akali disease, or selenium poisoning, Bulletin 331. South Dakota Agricultural Experimental Station, Brookings

    Google Scholar 

  • Mühlenhoff U, Molik S, Godoy JR, Uzarska MA, Richter N, Seubert A, Zhang Y, Stubbe J, Pierrel F, Herrero E, Horst Lillig C, Lill R (2010) Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab 12:373–385

    Article  Google Scholar 

  • Nelson AA, Fitzhugh OG, Calvery HO (1943) Liver tumors following cirrhosis caused by selenium in rats. Cancer Res 3:230–236

    Google Scholar 

  • Nishino T, Okamoto K (2000) The role of the [2Fe–S] cluster centers in xanthine oxidoreductase. J Inorg Biochem 82:43–49

    Article  Google Scholar 

  • Noblanc A, Kocer A, Chabory E, Vernet P, Saez F, Cadet R, Conrad M, Drevet JR (2011) Glutathione peroxidases at work on epidymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability. J Androl 32:641–650

    Article  Google Scholar 

  • Okamoto S, Eltis LD (2011) The biological occurrence and trafficking of cobalt. Metallomics 3:963–970

    Article  Google Scholar 

  • Ortiz de Montellano PR, De Voss JJ (2002) Oxidizing species in the mechanism of cytochrome P450. Nat Prod Rep 19:477–493

    Article  Google Scholar 

  • Osaki S, Johnson DA, Frieden E (1971) The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxoidase 1. J Biol Chem 246:3018–3023

    Google Scholar 

  • Panee J, Stoytcheva ZR, Liu W, Berry MJ (2007) Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that Up-regulates genes involved in glutathione synthesis and phase II detoxification. J Biol Chem 282:23759–23765

    Article  Google Scholar 

  • Pappas AC, Zoidis E, Surai PF, Zervas G (2008) Seleoproteins and maternal nutrition. Comp Biochem Physiol B Biochem Mol Biol 151:361–372

    Article  Google Scholar 

  • Peña MMO, Lee J, Thiele DJ (1999) A delicate balance: homeostatic control of copper uptake and distribution. J Nutr 129:1251–1260

    Google Scholar 

  • Persson Moschos M (2000) Selenoprotein P. Cell Mol Life Sci 57:1836–1845

    Article  Google Scholar 

  • Prasad AS (1995) Zinc: an overview. Nutrition 11:93–99

    Google Scholar 

  • Purcarea C, Hervé G, Ladjimi MM, Cunin R (1997) Aspartate transcarbamylase from the deep-Sea hyperthermophilic archaeon Pyrococcus abyssi: genetic, organisation, structure, and expression in Escherichia coli. J Bacteriol 179:4143–4157

    Google Scholar 

  • Putney JW, McKay RR (1999) Capacitive calcium entry channels. Bioassays 21:38–46

    Article  Google Scholar 

  • Ragsdale SW (1998) Nickel biochemistry. Curr Opin Chem Biol 2:208–215

    Article  Google Scholar 

  • Rahman SH, Maeder ML, Joung JK, Cathomen T (2011) Zinc-finger nucleases for somatic gene therapy: The next frontier. Hum Gene Ther 22:925–933

    Google Scholar 

  • Ramirez-Silva L, Ferreira ST, Nowak T, Tuena de Gomez-Puyou M, Gomez-Puyou A (2001) Dimethylsulfoxide promotes K+ -independent activity of pyruvate kinase and the acquisition of the active catalytic conformation. Eur J Biochem 268:3267–3274

    Article  Google Scholar 

  • Rayman M (2012) Selenium and human health. Lancet 379:1256–1268

    Article  Google Scholar 

  • Reeves MA, Hoffmann PR (2009) The human selenoproteome: recent insights into functions and regulation. Cell Mol Life Sci 66:2457–2478

    Article  Google Scholar 

  • Richardson DR, Lane DJ, Becker EM, Whitnall M, Rahmanto YS, Sheftel AD, Ponka P (2010) Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci U S A 107:10775–10782

    Article  Google Scholar 

  • Romani AMP, Maguire ME (2002) Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells. Biometals 15:271–283

    Article  Google Scholar 

  • Romão MJ (2009) Molybdenum and tungsten enzymes: a crystallographic and mechanistic overview. Dalton Trans 21:4053–4068

    Article  Google Scholar 

  • Roy R, Adams MWW (2002) Characterization of a fourth tungsten-containing enzyme from the hyperthermofilic archaeon Pyrococcus furiosus. J Bacteriol 184:6952–6956

    Article  Google Scholar 

  • Rutter GA (2010) Think zinc. New roles for zinc in the control of insulin secretion. Islets 2:49–50

    Article  Google Scholar 

  • Sager TN, Thomsen C, Valsborg JS, Laursen H, Hansen AJ (1999) Astroglia contain a specific transport mechanism for N-acetyl-l-aspartate. J Neurochem 73:807–811

    Article  Google Scholar 

  • Saito Y, Takahashi K (2000) Selenoprotein P: its structure and functions. J Health Sci 44:409–413

    Article  Google Scholar 

  • Sakurai H (2002) A new concept: the use of vanadium complexes in the treatment of diabetes mellitus. Chem Rec 2:237–248

    Article  Google Scholar 

  • Sakurai T, Kataoka K (2007) Structure and function of type I copper in multicopper oxidases. Cell Mol Life Sci 64:2642–2656

    Article  Google Scholar 

  • Sanchez R, Zhou M-M (2011) The PHD finger: a versatile epigenome reader. Trends Biochem Sci 36:364–372

    Google Scholar 

  • Schipper HM (1999) Glial HO-1 expression, iron deposition and oxidative stress in neurodegenerative disease. Neurotox Res 1:57–70

    Article  Google Scholar 

  • Schmitt C, Strazielle N, Richaud P, Bouron A, Ghersi-Egea J-F (2011) Active transport at the blood-CSF barrier contributes to manganese influx into the brain. J Neurochem 117:747–756

    Google Scholar 

  • Schrauzer GN (2000) Selenmethionine: a review of its nutritional significance, metabolism, and toxicity. J Nutr 130:1653–1656

    Google Scholar 

  • Schrauzer GN, Surai PF (2009) Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality o selenium, dedicated to the memory of Klaus Schwarz (1914–1978) on the occasion of the thirtieth anniversary of his death. Crit Rev Biotechnol 29:2–9

    Article  Google Scholar 

  • Schwartz K, Foltz CM (1957) Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J Am Chem Soc 79:3292–3293

    Article  Google Scholar 

  • Schweizer U, Dehina N, Schomburg L (2011) Disorders of selenium metabolism and selenoprotein function. Curr Opin Pediatr 23:429–435

    Article  Google Scholar 

  • Ségurel L, Leffler EM, Przeworski M (2011) The case of the fickle fingers: How the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans. PLoS Biol 9:e1001211. doi:10.1371/journal.pbio.1001211

    Article  Google Scholar 

  • Shamberger RJ, Frost DV (1969) Possible protective effect of selenium against human cancer. Can Med Assoc J 100:682

    Google Scholar 

  • Shen DHY, Kloos RT, Mazzaferri EL, Jhiang SM (2001) Sodium iodide symporter in health and disease. Thyroid 11:415–425

    Article  Google Scholar 

  • Siddique T, Ajroud-Driss S (2011) Familial amyotrophic lateral sclerosis, a historical perspective. Acta Myol 30:117–120

    Google Scholar 

  • Sorrentino V, Rizzuto R (2001) Molecular genetics of Ca2+ stores and intracellular Ca2+ signalling. Trends Pharmacol Sci 22:459–464

    Article  Google Scholar 

  • Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL (2002) Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8:514–517

    Article  Google Scholar 

  • Squires JE, Berry MJ (2008) Eukaryotic selenoprotein synthesis: mechanistic insight incorporating new factors and new functions for old factors. IUBMB Life 60:232–235

    Article  Google Scholar 

  • Sreedhara A, Cowan JA (2002) Structural and catalytic roles for divalent magnesium in nucleic acid biochemistry. Biometals 15:211–223

    Article  Google Scholar 

  • Stanely JS, Mock DM, Griffin JB, Zempleni J (2002) Biotin uptake into human peripheral blood mononuclear cells increases early in the cell cycle, increasing carboxylate activities. J Nutr 132:1854–1859

    Google Scholar 

  • Sterling D, Reithmeier RAF, Casey JR (2001) Carbonic anhydrase: in the Driver’s seat for bicarbonate transport. J Pancreas (Online) 2:165–170

    Google Scholar 

  • Sträter N, Sun L, Kantrowitz ER, Lipscomb WN (1999) A bicarbonate ion as a general base in the mechanisms of peptide hydrolysis by dizinc leucine aminopeptidase. Proc Natl Acad Sci U S A 96:11151–11155

    Article  Google Scholar 

  • Sun X, Kang YJ (2002) Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity. Exp Biol Med 227:652–657

    Google Scholar 

  • Supuran CT, Scozzofava A (2007) Carbonic anhydrases as targets for medicinal chemistry. Bioorg Med Chem 15:4336–4350

    Article  Google Scholar 

  • Tamarit J, Cabiscol E, Aguilar J, Ros J (1997) Differential inactivation of alcohol dehydrogenase isoenzymes in Zymomonas mobilis by oxygen. J Bacteriol 179:1102–1104

    Google Scholar 

  • Tolosano E, Fagoonee S, Morello N, Vinchi F, Fiorito V (2010) Heme scavenging and the other facets of hemopexin. Antioxid Redox Signal 12:305–320

    Article  Google Scholar 

  • Torsdottir G, Kristinsson J, Snaedal J, Sveinbjörnsdottir S, Gudmundsson G, Hreidarsson S, Jóhannesson T (2010) Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: a short review. J Neurol Sci 299:51–54

    Article  Google Scholar 

  • Trinder D, Macey DJ, Olynyk JK (2000) The new iron age. Int J Mol Med 6:607–612

    Google Scholar 

  • Ueki T, Uyama Y, Yamamoto K, Kanamori K, Michibata H (2000) Exclusive expression of transketolase in vanadocytes of the vanadium-rich ascidian, Ascidia syneiensis samea. Biochim Biophys Acta 1494:83–90

    Article  Google Scholar 

  • Ueki T, Furuno N, Michibata H (2011) A novel vanadium transporter of the Nramp family expressed at the vacuole of vanadium-accumulating cells of the ascidian Ascidia sydneiensis samea. Biochim Biophys Acta 1810:457–464

    Article  Google Scholar 

  • Väänänen K, Zhao H (2001) Osteoclast function. In: Bilezikan JP, Raisz LG, Rodan GA (eds) Principles of bone biology, 2nd edn. Academic, San Diego, pp 127–139

    Google Scholar 

  • Vasilyev VB (2010) Interactions of ceruloplasmin with other proteins participating in inflammation. Biochem Soc Trans 38:947–951

    Article  Google Scholar 

  • Venkatchalam K, van Rossum DB, Patterson RL, Ma HT, Gill DL (2002) The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol 4:E263–E272

    Article  Google Scholar 

  • Vincent JB (2000) The biochemistry of chromium. J Nutr 130:715–718

    Google Scholar 

  • Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ (1999) Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 21:195–199

    Article  Google Scholar 

  • Wang J, Pantopoulos K (2011) Regulation of cellular iron metabolism. Biochem J 434:365–381

    Article  Google Scholar 

  • Watt RK, Ludden PW (1999) Nickel-binding proteins. Cell Mol Life Sci 56:604–625

    Article  Google Scholar 

  • West AK, Hidalgo J, Eddins D, Levin ED, Aschner M (2008) Metallothionein in the central nervous system: roles in protection, regeneration and cognition. Neurotoxicology 29:489–503

    Article  Google Scholar 

  • Whanger PD (2000) Selenoprotein W: a review. Cell Mol Life Sci 57:1846–1852

    Article  Google Scholar 

  • Whittaker JW (2010) Metal uptake by manganese superoxide dismutase. Biochim Biophys Acta 1804:298–307

    Article  Google Scholar 

  • Wilks A (2002) Heme oxygenase: evolution, structure, and mechanism. Antioxid Redox Signal 4:603–614

    Article  Google Scholar 

  • Williams RJP (2012) Zinc in evolution. J Inorg Biochem 111:104–109

    Article  Google Scholar 

  • Williamson A, Conian B, Hillier W, Wydrzynski T (2011) The evolution of photosystem II: insights into the past and future. Photosynth Res 107:71–86

    Article  Google Scholar 

  • Yamamoto A, Wada O, Ono T (1987) Isolation of a biologically active Low-molecular-mass chromium compound from rabbit liver. Eur J Biochem 165:627–631

    Article  Google Scholar 

  • Yang Y, Zhou HM (2001) Effect of zinc ions on conformational stability of yeast alcohol dehydrogenase. Biochemistry (Moscow) 66:47–54

    Article  Google Scholar 

  • Yocum CF, Pecoraro VL (1999) Recent advances in the understanding of the biological chemistry of manganese. Curr Opin Chem Biol 3:182–187

    Article  Google Scholar 

  • Youn HD, Kim EJ, Roe JH, Hah YC, Kang SO (1996) A novel nickel-containing superoxide dismutase from Streptomyces spp. Biochem J 318:889–896

    Google Scholar 

  • Yu SY, Zhu YJ, Li WG, Huang QS, Zhi-Huang C, Zhang QN, Hou C (1991) A preliminary report of the intervention trials of liver cancer in high risk populations with nutritional supplementation in China. Biol Trace Elem Res 29:289–294

    Article  Google Scholar 

  • Yu SY, Zhu YJ, Li WG (1997) Protective role of selenium against hepatitis B virus and primary liver cancer in qidong. Biol Trace Elem Res 56:117–124

    Article  Google Scholar 

  • Yusuf M, Fariduddin Q, Hayat S, Ahmad A (2011) Nickel: an overview of uptake, essentiality and toxicity in plants. Bull Environ Contam Toxicol 86:1–17

    Article  Google Scholar 

  • Zinchuk VX, Kobayashi T, Garcia del Saz E, Seguchi H (1997) Biochemical properties and cytochemical localization of ouabain-insensitive, potassium-dependent p-nitrophenylphosphatase activity in rat atrial myocytes. J Histochem Cytochem 45:177–187

    Article  Google Scholar 

  • Zoroddu MA, Schinocca L, Jankowska-Kowalik T, Koslowski H, Salnikow K, Costa M (2002) Molecular mechanisms in nickel carcinogenesis: modelling Ni(II) binding site in histone 4. Environ Health Perspect 101(suppl 5):719–723

    Article  Google Scholar 

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  1. Biomedical Radiation Sciences, Rudbeck Laboratory, Research in Metal Biology, Uppsala University, Uppsala, Sweden

    Ulf Lindh

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    Olle Selinus

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Lindh, U. (2013). Biological Functions of the Elements. In: Selinus, O. (eds) Essentials of Medical Geology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4375-5_7

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