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Nature and Nurture: Impacts on Mouse Phenotypes and Translational Research

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Mouse as a Model Organism

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Abstract

While genome projects continue to provide crucial information about the structure of genomes and their genes, functional genomics (or functional genetics) initiatives strive to understand the function of genomes and their genes. Identification of a protein gene product and determination of its function as a receptor, ligand or enzyme is a proximal goal. Understanding the role of the gene and its product, in the context of a living organism, in its environment is the ultimate goal of functional genomics initiatives. Thus, functional genomics efforts in genetically engineered animals aim to produce and characterize phenotype(s) that clearly result from the intended genetic manipulation(s) and help to elucidate gene function(s). However, phenotypes reflect genetic influences other than the intended genetic manipulations, as well as experiential and environmental influences including infectious agents. Potential impacts of extra-experimental variables must be considered when interpreting phenotype data.

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    Cory Brayton

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    Cord Brakebusch

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    Taina Pihlajaniemi

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Brayton, C. (2011). Nature and Nurture: Impacts on Mouse Phenotypes and Translational Research. In: Brakebusch, C., Pihlajaniemi, T. (eds) Mouse as a Model Organism. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0750-4_3

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