Abstract
Computational modeling has become an important tool for understanding trabecular bone mechanics. Models provide a means to investigate the individual and combined effects of changes in trabecular architecture, density, and material properties on overall trabecular bone mechanics. In experimental studies, specimen-specific models derived from high-resolution micro-CT scans provide a means to interpret the mechanical testing data at both macroscopic and tissue levels in order to calculate multi-scale material properties. More recently, micro-CT-based finite element modeling has been applied to the detailed investigation of the biomechanical effects of therapeutic treatments, and studies are now using such techniques to address the micro-mechanics of whole-bone behavior. Advances in computational power and solution algorithms have made trabecular bone modeling practical in almost any laboratory. Improvements in imaging technology, the spread of high-speed computing systems, and new computational algorithms will drive continued growth of this technique for the foreseeable future. In addition to its current role as a tool to study basic science and micro-mechanics, this technique may ultimately find clinical usage in diagnosis of disease and assessment of treatments.
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The publication was made possible through the support of the National Institutes of Health AR52008 (GLN) and AR49828, AR43784 (TMK), and the US ARMY Medical Research and Materiel Command PR054672 (GLN).
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Niebur, G.L., Keaveny, T.M. (2010). Computational Modeling of Trabecular Bone Mechanics. In: De, S., Guilak, F., Mofrad R. K., M. (eds) Computational Modeling in Biomechanics. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3575-2_9
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DOI: https://doi.org/10.1007/978-90-481-3575-2_9
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