Abstract
In the previous chapters, we analyzed the most relevant aspects related to peritoneal surface malignancy (PSM) classification and treatment by integrated cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS plus HIPEC). Many of the issues dealt with in previous chapters are common to various forms of PSM; others are more specific to single pathological forms. Recent experience has provided greater clarity for the role of CRS plus HIPEC, albeit partial and nondefinitive, but has also emphasized problems requiring solutions for greater reliability and effectiveness of the combined procedure and to dispel doubts and criticisms regarding its application. The main focus of ongoing studies and of this chapter is on both general and specific issues of HIPEC and its application in specific forms of PSM.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Jacquet P, Sugarbaker PH (1996) Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. Cancer Treat Res 82:359–374
Fagotti A, Ferexidina D, Fanfani F et al (2006) A laparoscopy-based score to predict surgical outcome in patients with advanced ovarian carcinoma: a pilot study. Ann Surg Oncol 13:1156–1161
Yan TD, Deraco M, Elias D et al (2011) Peritoneal Surface Oncology Group. A novel tumournode-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database. Cancer 117:1855–1863
Vergote I, Marquette S, Amant F et al (2005) Port-site metastases after open laparoscopy: a study in 173 patients with advanced ovarian carcinoma. Int J Gynecol Cancer 15:776–779
Thomas F, Ferron G, Gesson-Paute A et al (2008) Increased tissue diffusion of oxaliplatin during laparoscopically assisted versus open heated intraoperative intraperitoneal chemotherapy (HIPEC). Ann Surg Oncol 15:3623–3624
Jacquet P, Stuart OA, Chang D, Sugarbaker PH (1996) Effects of intra-abdominal pressure on pharmacokinetics and tissue distribution of doxorubicin after intraperitoneal administration. Anticancer Drugs 7:596–603
Tempfer CB, Celik I, Solass W et al (2014) Activity of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with cisplatin and doxorubicin in women with recurrent, platinumresistant ovarian cancer: preliminary clinical experience. Gynecol Oncol 132:307–311
Hauck ML, Zalutsky MR (2005) Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia. Int J Hyperthermia 21:1–11
Hauck ML, Zalutsky MR (2005) Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: Application of the thermal equivalency equation. Int J Hyperthermia 21:13–27
Kinuya S, Yokoyama K, Hiramatsu T et al (2000) Optimal timing of administration of hyperthermia in combined radioimmunotherapy. Cancer Biother Radiopharm 15:373–379
Kinuya S, Yokoyama K, Michigishi T, Tonami N (2004) Optimization of radioimmunotherapy interactions with hyperthermia. Int J Hyperthermia 20:190–200
Kong G, Dewhirst MW (1999) Hyperthermia and liposomes. Int J Hyperthermia 15:345–370
Lindner LH, Eichhorn ME, Eibl H et al (2004) Novel temperature-sensitive liposomes with prolonged circulation time. Clin Cancer Res 10:2168–2178
Votanopoulos KI, Shen P, Stewart JH 4th, Levine EA 2012) Current status and future directions in appendiceal cancer with peritoneal dissemination. Surg Oncol Clin N Am 21:599–609
Chua TC, Moran BJ, Sugarbaker PH (2012) Early and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol 30:2449–2456
Elias D, Honoré C, Dumont F et al (2011) Results of systematic second-look surgery plus HIPEC in asymptomatic patients presenting a high risk of developing colorectal peritoneal carcinomatosis. Ann Surg 254:289–293
Sammartino P, Sibio S, Biacchi D et al (2012) Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients: Preliminary Results of Surgery plus Prophylactic HIPEC. Gastroenterol Res Pract 2012:141585
Noura S, Ohue M, Shingai T (2011) Effects of intraperitoneal chemotherapy with mitomycin C on the prevention of peritoneal recurrence in colorectal cancer patients with positive peritoneal lavage cytology findings. Ann Surg Oncol 18:396–404
Goéré D, Gras-Chaput N, Aupérin A et al (2014) Treatment of gastric peritoneal carcinomato-sis by combining complete surgical resection of lesions and intraperitoneal immunotherapy using catumaxomab. BMC Cancer 14:148
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Italia
About this chapter
Cite this chapter
Di Giorgio, A. (2015). Main Topics of Discussion and New Trends. In: Di Giorgio, A., Pinto, E. (eds) Treatment of Peritoneal Surface Malignancies. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-5711-1_24
Download citation
DOI: https://doi.org/10.1007/978-88-470-5711-1_24
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-5710-4
Online ISBN: 978-88-470-5711-1
eBook Packages: MedicineMedicine (R0)