Abstract
The differentiation of skeletal muscle is an early and crucial step in the development of vertebrates since it provides the embryo with motility in the early stages.Skeletal myogenesis begins shortly after gastrulation but persists, at least in mammals, until the end of postnatal growth, and the potential for myogenesis continues for the entire life span of the animal [1]. Local signalling commits mesodermal cells to a myogenic fate, and shortly afterwards they begin to synthesise contractile proteins that accumulate in the cytoplasm and self-assemble into sarcomeres. Motility is dependent upon shortening of the sarcomeres, paracrystalline structures that are specialised for transforming chemical energy into movement. The advantage of accumulating millions of sarcomeres within a single cytoplasm has led to multinucleation, a different strategy from the coupling of single cells adopted by the heart. Within the highly structured cytoplasm of the multinucleated muscle fibre mitosis is no longer possible, and when experimentally induced by oncogenes it leads to disruption of the spindle and death (mitotic catastrophe). As a consequence, growth of the muscle fibre during fetal and postnatal development depends upon the addition of single cells, which must be instructed on when to divide and when to differentiate, by fusing either with pre-existing fibres or among themselves to generate a new fibre. It is therefore obvious that diversification of myogenic cell fate is as crucial as their commitment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hauschka SD (1994) The embryonic origin of skeletal muscle. In: The scientific basis of myology. Academic Press, pp 3–72
Christ B, Ordhal CP (1994) Early stages of chick somite development. Anat Embryol 191:381–396
Cossu G, Tajbakhsh S, Buckingham M (1996) Myogenic specification in mammals. Trends Genet 12:218–223
Cossu G, Kelly R, Tajbakhsh S et al (1996) Activation of different myogenic pathways: Myf5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm. Development 122:429–437
Tajbakhsh S, Rocancourt D, Cossu G, Buckingham M (1997) Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf5 act upstream of MyoD. Cell 89:127–138
Braun T, Rudnicki MA, Arnold HH, Jaenisch R (1992) Targeted inactivation of the muscle regulatory gene Myf5 results in abnormal rib development and perinatal death. Cell 71:369–382
Kablar B, Krastel K, Ying C et al (1997) MyoD and Myf5 differentially regulate the development of limb versus trunk skeletal muscle. Development 124:4729–4738
Tajbakhsh S, Buckingham ME (1994) Mouse limb muscle is determined in the absence of the earhest myogenic factor Myf5. Proc Natl Acad Sei USA 91:747–751
Bober E, Franz T, Arnold HH et al (1994) Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120:603–612
Bladt F, Riethmacher D, Isenmann S et al (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376:768–771
Pourquié O, Fan CM, Coltey M et al (1996) Lateral and axial signals involved in avian somite patterning: a role for BMP4. Cell 84:461–471
Fan C, Tessier-Lavigne M (1994) Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79:1175–1186
Borycki AG, Brunk B, Tajbakhsh S et al (1999) Sonic hedgehog control epaxial muscle deteminao Myf5 activation. Development 126:4053–4063
Münsterberg AE, Kitajewski J, Bumcroft DA et al (1995) Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev 9:2911–2922
Tajbakhsh S, Borello U, Vivarelli E et al (1998) Differential activation of Myf5 and MyoD by different Wnts in expiants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5. Development 125:4155–4162
Murtaugh LC, Chyung JH, Lassar AB (1999) Sonic hedgehog promotes somitic chon-drogenesis by altering the cellular response to BMP signaling. Genes Dev 15:225–237
Hirsinger E, Duprez D, Jouve C et al (1997) Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning. Development 124:4605–4614
Marcelle C, Stark MR, Bronner-Fraser M (1997) Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite. Development 124:3955–3963
Banhot P, Brink M, Samos CH et al (1996) A new member of the frizzled family from Drosophila functions as a wingless receptor. Nature 382:225–230
Wodarz A, Nusse R (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59–88
Dierick H, Bejsovec A (1999) Cellular mechanisms of wingless/Wnt signal transduction. Curr Top Dev Biol 43:153–190
Kengaku M, Capdevila J, Rodriguez-Esteban C et al (1998) WNT3a regulates AER formation and utilizes an intracellular signaling pathway distinct from the dorso-ventral signal WNT7a during chick limb morphogenesis. Science 280:1274–1277
Leyns L, Bouwmeester T, Kim S-H et al (1997) Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88:747–756
Wang S, Krinks M, Lin K et al (1997) Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 88:757–766
Borello U, Coletta M, Tajbakhsh S et al (1999) Trans-placental delivery of the Wnt antagonist Frzbl inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development 126:4247–4255
Ikeya M, Takada S (1998) Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome. Development 125:4969–4976
Teillet M-A, Watanabe Y, Jeffs P et al (1998) Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages. Development 125:2019–2030
Duprez D, Four nier-Thibault C, Douarin N. le (1998) Sonic hedgehog induces proliferation of committed skeletal muscle cells in the chick limb. Development 125:495–505
Tajbakhsh S, Cossu G (1997) Establishing myogenic identity during somitogenesis. Curr Opin Genet Dev 7:634–641
Kelly AM, Zachs S (1969) The histogenesis of rat intercostal muscle. J Cell Biol 42:154–169
Baylies MK, Bate M, Ruiz Gomez M (1998) Myogenesis: a view from Drosophila. Cell 93:921–927
McGrew M J, Pourquié O (1998) Somitogenesis: segmenting a vertebrate. Curr Opin Genet Dev 8:487–493
Wilson-Rawls J, Molkentin JD, Black BL, Olson EN (1999) Activated Notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol 4:2853–2862
Nofziger D, Miyamoto A, Lyons KM, Weinmaster G (1999) Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development 126:1689–1702
Buffmger N, Stockdale PB (1994) Myogenic specification in somites: induction by axial structures. Development 120:1443–1452
Kalcheim C, Neufeld G (1990) Expression of basic fibroblast growth factor in the nervous system of early avian embryos. Development 109:203–215
Marcelle C, Wolf J, Bonner-Fraser M (1995) The in vivo expression of the FGF receptor FREK mRNA in avian myoblasts suggests a role in muscle growth and differentiation. Dev Biol 172:100–114
Cusella de Angelis MG, Molinari S, Ledonne A et al (1994) Differential response of embryonic and fetal myoblasts to TGFß: a possible regulatory mechanism of skeletal muscle histogenesis. Development 120:925–933
Zappelli F, Willems D, Osada S et al (1996) The inhibition of differentiation caused by TGFß in fetal myoblasts is dependant upon selective expression of PKCO: A possible molecular basis for myoblast diversification during limb histogenesis. Dev Biol 180:156–164
Bischoff R (1994) The satellite cell and muscle regeneration, In: Engel AG, Franzini-Armstrong C (eds) Myology, 2nd edn. McGraw-Hill, New York, pp 97–133
Miller JB, Schaefer L, Dominov JA (1999) Seeking muscle stem cells. Curr Top Dev Biol 43:191–219
Seale P, Rudnicki MA (2000) A new look at the origin, function, and “stem-cell” status of muscle satellite cells. Dev Biol 218:115–124
Cossu G, Molinaro M (1987) Cell heterogeneity in the myogenic lineage. Curr Top Dev Biol 23:185–208
Armand O, Boutineau AM, Mauger A et al (1983) Origin of satellite cells in avian skeletal muscles. Arch Anat Microsc 72:163–181
Grounds MD, Garrett KL, Lai MC et al (1992) Identification of skeletal muscle precursor cells in vivo by use of MyoDl and myogenin probes. Cell Tissue Res 267:99–104
Tajbakhsh S, Vivarelli G, Cusella de AngeHs G et al (1994) A population of myogenic cells derived from the mouse neural tube. Neuron 13:813–821
Cossu G (1997) Unorthodox myogenesis: possible developmental significance and implications for tissue histogenesis and regeneration. Histol Histopathol 12:755–760
Ferrari G, Cusella de Angelis MG, Coletta M et al (1998) Skeletal muscle regeneration by bone marrow derived myogenic progenitors. Science 279:1528–1530
De Angelis L, Berghella L, Coletta M et al (1999) Skeletal myogenic progenitors originating from embryonic dorsal aorta co-express endothelial and myogenic markersand contribute to post-natal muscle growth and regeneration. J Cell Biol 147:869–878
Katagiri T, Yamaguchi A, Komaki M et al (1994) Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:1755–1766
Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–74
Kaul A, Köster M, Neahus H, Braun T (2000) Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Cell 102:17–19
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Italia
About this chapter
Cite this chapter
Cossu, G. (2002). Ontogeny of Skeletal Muscle Cells. In: Vincent, A., Martino, G. (eds) Autoantibodies in Neurological Diseases. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2097-9_6
Download citation
DOI: https://doi.org/10.1007/978-88-470-2097-9_6
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2163-1
Online ISBN: 978-88-470-2097-9
eBook Packages: Springer Book Archive