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Cachexia and Wasting: A Modern Approach pp 603–617Cite as

Pharmaco-Nutritional Supports for the Treatment of Cancer Cachexia

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Abstract

Cancer cachexia is a major symptom burden for patients with cancer.Cachexia occurs in up to one half of all patients diagnosed with cancer [1] and is more frequent in patients with lung and upper-gastrointestinal cancer.Cancer cachexia results from the interaction of the host and the tumour. However, the nature of this interaction is incompletely understood [2] [5], including the dynamics of the host response (activation of the systemic inflammatory response, metabolic, immune and neuroendocrine changes) and those tumour characteristics or tumour-derived products that influence expression of the syndrome (e.g. proteolysis-inducing factor [PIF]). The relative importance of individual mediators and pathways in different patients or tumour types is unclear, as is the reason why individuals with apparently similar tumours should show considerable variation in their tendency to develop cachexia.As ability to discriminate the relative importance in vivo of different mediators improves, so too should the ability to develop appropriately targeted therapy.

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Authors and Affiliations

  1. Department of Clinical and Surgical Sciences (Surgery), The University of Edinburgh, Royal Infirmary, Edinburgh, UK

    Max Dahele & Kenneth C. H. Fearon

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  1. Max Dahele
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  2. Kenneth C. H. Fearon
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Editor information

Editors and Affiliations

  1. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Giovanni Mantovani

  2. Department of Clinical Cardiology, Imperial College, NHLI, London, UK

    Stefan D. Anker

  3. Department of Cardiology Charité, Applied Cachexia Research, Campus Virchow-Klinikum, Berlin, Germany

    Stefan D. Anker

  4. Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Akio Inui

  5. GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, St. Louis, MO, USA

    John E. Morley

  6. Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy

    Filippo Rossi Fanelli

  7. Department of Infectious Diseases, IRCCS S.Matteo Polyclinic, University of Pavia, Pavia, Italy

    Daniele Scevola

  8. Bone Marrow and Blood Stem Cell Transplantation Program, Center for Lymphoma and Myeloma, New York Presbyterian Hospital/Weill Medical Center, New York, NY, USA

    Michael W. Schuster

  9. Department of Medicine-Geriatrics, University of New York at Stony Brook VAMC, Northport, NY, USA

    Shing-Shing Yeh

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Dahele, M., Fearon, K.C.H. (2006). Pharmaco-Nutritional Supports for the Treatment of Cancer Cachexia. In: Mantovani, G., et al. Cachexia and Wasting: A Modern Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-0552-5_58

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  • DOI: https://doi.org/10.1007/978-88-470-0552-5_58

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