Skip to main content

Side-Effects and Potential Complications

  • Chapter
Hand Transplantation

Abstract

Since the first hand transplantation carried out in September 1998, there has been a great deal of discussion concerning the potential risks inducted by the immunosuppressive therapy for the patients transplanted, as they need lifelong immunosuppression. This discussion has been particularly emotional, as composite allograft transplantations (CAT) are not considered as life saving whereas immunosuppressive therapy can expose the recipients to serious side-effects and life-threatening complications. Transplantation is routinely indicated and accepted for non-life-threatening situations, such as dialysis-dependent renal failure and poorly controlled diabetes, because it allows a significant improvement in patient’s quality of life. Consequently, the above rationale might be applied to hand transplantation when functional recovery and improvement in quality of life are demonstrated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baumeister S, Kleist C, Dohler B et al (2004) Risks of allogeneic hand transplantation. Microsurgery 24:98–103

    Article  PubMed  Google Scholar 

  2. Frezza EE, Fung JJ, van Thiel DH (1999) Non-lymphoid cancer after liver transplantation. Hepatogastroenterology 44:1172–1181

    Google Scholar 

  3. Jain AB, Yee LD, Nalesnik MA et al (1999) Comparative incidence of de novo nonlymphoid malignancies after liver transplantation under tacrolimus using surveillance epidemiologic end result data. Transplantation 66:1193–1200

    Article  Google Scholar 

  4. Kinlen LJ, Sheil AG, Peto J, Doll R (1979) Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs. Br Med J 2:1461–1466

    PubMed  CAS  Google Scholar 

  5. Opelz G, Henderson R (1993) Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 342:1514–1516

    Article  PubMed  CAS  Google Scholar 

  6. Penn I (1996) Posttransplantation de novo tumors in liver allograft recipients. Liver Transpl Surg 2:52–59

    Article  PubMed  CAS  Google Scholar 

  7. Johnson C, Ahsan N, Gonwa T et al (2000) Randomized trial of tacrolimus (Prograf) in combination with azathioprine or mycophenolate mofetil versus cyclosporine (Neoral) with mycophenolate mofetil after cadaveric kidney transplantation. Transplantation 69:834–841

    Article  PubMed  CAS  Google Scholar 

  8. Miller J (1999) Tacrolimus and mycophenolate mofetil in renal transplant recipients: one year results of a multicenter, randomized dose ranging trial. FK506/MMF Dose-Ranging Kidney Transplant Study Group. Transplant Proc 31:276–277

    Article  PubMed  CAS  Google Scholar 

  9. Pirsch JD, Miller J, Deierhoi MH et al (1997) A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. Transplantation 63:977–983

    Article  PubMed  CAS  Google Scholar 

  10. Shapiro R, Jordan ML, Scantlebury VP et al (1995) A prospective randomized trial of FK506-based immunosuppression after renal transplantation. Transplantation 59(4):485–490

    Article  PubMed  CAS  Google Scholar 

  11. van Hooff JP, Christiaans MH, van Duijnhoven EM (2005) Tacrolimus and posttransplant diabetes mellitus in renal transplantation. Transplantation 79:1465–1469

    Article  PubMed  Google Scholar 

  12. Lanzetta M, Petruzzo P, Margreiter R et al (2005) The international registry on hand and composite tissue transplantation. Transplantation 79:1210–1214

    Article  PubMed  Google Scholar 

  13. Porter R, Crombie AL, Gardner PS, Uldall RP (1972) Incidence of ocular complications in patients undergoing renal transplantation. Br Med J 3:133–136

    Article  PubMed  CAS  Google Scholar 

  14. Mathew TH (1995) A blinded, long-term, randomized multicenter study of mycophenolate mofetil in cadaveric renal transplantation: results at three years. Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. Transplantation 65:1450–1454

    Article  Google Scholar 

  15. European Mycophenolate Mofetil Cooperative Study Group (1995) Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345:1321–1325

    Google Scholar 

  16. Fung JJ, Alessiani M, Abu-Elmagd K et al (1991) Adverse effects associated with the use of FK 506. Transplant Proc 23:3105–3108

    PubMed  CAS  Google Scholar 

  17. McCauley J, Takaya S, Fung J et al (1991) The question of FK 506 nephrotoxicity after liver transplantation. Transplant Proc 23:1444–1447

    PubMed  CAS  Google Scholar 

  18. Porayko MK, Textor SC, Krom RA et al (1994) Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. Mayo Clin Proc 69:105–111

    PubMed  CAS  Google Scholar 

  19. Eidelman, BH, Abu-Elmagd K, Wilson J et al (1991) Neurologic complications of FK 506. Transplant Proc 23:3175–178

    PubMed  CAS  Google Scholar 

  20. Sollinger, HW (1995) Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group. Transplantation 60:225–232

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Italia

About this chapter

Cite this chapter

Badet, L., Petruzzo, P., Lefrançois, N., Morelon, E., Martin, X., Dubernard, JM. (2007). Side-Effects and Potential Complications. In: Lanzetta, M., Dubernard, JM., Petruzzo, P. (eds) Hand Transplantation. Springer, Milano. https://doi.org/10.1007/978-88-470-0374-3_28

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-0374-3_28

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0373-6

  • Online ISBN: 978-88-470-0374-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics