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Hypersensitivity Reactions to Nanomedicines: Causative Factors and Optimization of Design Parameters

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Allergy Frontiers: Future Perspectives

Part of the book series: Allergy Frontiers ((ALLERGY,volume 6))

Abstract

Administration of clinically approved nanomedicines often induces non-IgE-mediated hypersdensitivity reactions in some patients. Current research strongly suggests that complement activation may be a contributing, but not a rate limiting factor in eliciting hypersensitivity reactions to nanomedicines in sensitive individuals. The molecular basis of complement activation by nanomedicines is complex and depends on nanomedicine structure and dose. These issues are discussed in relation to liposomal, micellar and polymeric nanomedicines as well as current structural design strategies to circumvent nanomedicine- mediated complement activation.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitestparken 2, Copenhagen Ø, DK2100, Denmark

    S. Moein Moghimi

  2. Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, BN2 4GJ, UK

    Islam Hamad

Authors
  1. S. Moein Moghimi
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  2. Islam Hamad
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Correspondence to S. Moein Moghimi .

Editor information

Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. University of Southampton Southampton General Hospital, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Children's Mercy Hospitals and Clinics UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Moghimi, S.M., Hamad, I. (2010). Hypersensitivity Reactions to Nanomedicines: Causative Factors and Optimization of Design Parameters. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Future Perspectives. Allergy Frontiers, vol 6. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99365-0_14

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  • DOI: https://doi.org/10.1007/978-4-431-99365-0_14

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-99364-3

  • Online ISBN: 978-4-431-99365-0

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