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Malignant Hyperthermia pp 173–182Cite as

Malignant Hyperthermia in Dogs

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Abstract

Our knowledge and understanding of the pharmacogenetic disease malignant hyperthermia (MH) has been significantly advanced through investigations of the porcine animal model. The distinction between “trigger” and “safe” anesthetics for MH-susceptible (MHS) human patients was originally based on the results of testing these drugs in the MHS pig [1,2]. The efficacy of dantrolene sodium for treating and preventing MH was discovered by Harrison [3] via experiments with MH pigs. Subsequent to its discovery in pigs, MHS was reported to occur in other species including the dog [4], cat [5], and horse [6]. Because MH in man represents a spectrum of susceptibility [7] and is genetically heterogenous [8], thorough investigations of MH among different animal species may provide important genetic and epigenetic information that will further advance our understanding of MH in man. In this chapter, I attempt to document the current state of knowledge regarding MH in dogs, focusing on the interesting genetic and phenotypic differences between MH in dogs and in pigs and how understanding the basis for these differences may have an impact on our understanding of MH in man.

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Author information

Authors and Affiliations

  1. Department of Anesthesia, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, 25157-1009, USA

    Thomas E. Nelson

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  1. Thomas E. Nelson
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Editor information

Editors and Affiliations

  1. Chugoku Rosai General Hospital, Hiroshima University, 737-01, Kure, Hiroshima, Japan

    Michio Morio M.D., Ph.D. (Professor Emeritus, Director General) (Professor Emeritus, Director General)

  2. The First Department of Anesthesiology, Toho University School of Medicine, Ohta-ku, Tokyo, 143, Japan

    Hirosato Kikuchi M.D., Ph.D. (Chairman and Professor) (Chairman and Professor)

  3. Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, 734, Japan

    Osafumi Yuge M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 1996 Springer-Verlag Tokyo

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Nelson, T.E. (1996). Malignant Hyperthermia in Dogs. In: Morio, M., Kikuchi, H., Yuge, O. (eds) Malignant Hyperthermia. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68346-9_23

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  • DOI: https://doi.org/10.1007/978-4-431-68346-9_23

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68348-3

  • Online ISBN: 978-4-431-68346-9

  • eBook Packages: Springer Book Archive

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