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Multiple Mechanisms of Cancer Prevention by Phytochemicals: Interaction Between Cellular Proliferation and Endogenous Mutagens

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Food Factors for Cancer Prevention

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Summary

The development of a neoplastic cell involves multiple genetic changes in various key genes, including tumor suppressor genes, oncogenes, or DNA repair genes. Increasingly, it is recognized that these genetic changes may be the result of mutations caused through the synergistic interaction between cellular proliferation and the endogenous generation of oxidative radicals, including nitrogen oxides and various oxygen radicals. Numerous phytochemicals such as the tocopherols, carotenoids, Flavonoids, monoterpenes, and ascorbate, among others, have been shown to prevent or delay the development of tumor cells in cell culture and in animal models, while epidemiologic evidence suggests that increased consumption of fruits and vegetables and their associated phytochemicals is correlated with decreased cancer incidence. In vitro cell transformation models offer unique insights into not only the mechanisms of action for various dietary phytochemicals, but the process of carcinogenesis itself.

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Author information

Authors and Affiliations

  1. Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI, 96813, USA

    Robert V. Cooney, Lawrence J. Mordan & Adrian Franke

Authors
  1. Robert V. Cooney
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  2. Lawrence J. Mordan
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  3. Adrian Franke
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Editor information

Editors and Affiliations

  1. Department of Food Science and Technology Faculty of Agriculture, Kyoto University, Oiwake-cho, Kitashirakawa, Kakyo-ku, Kyoto, 606-01, Japan

    Hajime Ohigashi Ph.D. (Professor) (Professor)

  2. Department of Applied Biological Sciences Faculty of Agriculture, Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi, 464-01, Japan

    Toshihiko Osawa Ph.D. (Professor) (Professor)

  3. Lipid Science Laboratory, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305, Japan

    Junji Terao Ph.D. (Head) (Head)

  4. Nutrition and Epidemiology, Department of Agriculture, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156, Japan

    Shaw Watanabe M.D. (Professor) (Professor)

  5. First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan

    Toshikazu Yoshikawa M.D. (Associate Professor) (Associate Professor)

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© 1997 Springer Japan

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Cooney, R.V., Mordan, L.J., Franke, A. (1997). Multiple Mechanisms of Cancer Prevention by Phytochemicals: Interaction Between Cellular Proliferation and Endogenous Mutagens. In: Ohigashi, H., Osawa, T., Terao, J., Watanabe, S., Yoshikawa, T. (eds) Food Factors for Cancer Prevention. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67017-9_5

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  • DOI: https://doi.org/10.1007/978-4-431-67017-9_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67019-3

  • Online ISBN: 978-4-431-67017-9

  • eBook Packages: Springer Book Archive

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