Skip to main content
SpringerLink
Log in

Temperature Sensitive Polymers for Delivery of Macromolecular Drugs

  • Conference paper
Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Abstract

Significant progress has been made for the last decade in the research of drug delivery systems. For the sustained action, to maximize efficiency and minimize side effects of drugs, novel polymeric carriers or devices have been introduced. Intelligent drug delivery systems can defined as a novel drug delivery which shows drug release based on metabolite concentration or regulated or modulated via external stimuli. In this paper, macromolecular drug delivery by using thermosensitive polymers is reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Sminoff LA, and Kim SW in Pulsed and Self-Regulated Drug Delivery, ed. bv J. Kost CRC Press, Boca Raton, FL 1990 p.187.

    Google Scholar 

  2. Okano T, Bae YH, and Kim SW, in Pulsed and Self-Regulated Drug Delivery, ed. bv J. Kost CRC Press, Boca Raton, FL 1990, p. 17.

    Google Scholar 

  3. Okano T, Yui N, Yokoyama M, and Yoshida R, Advance in Polymeric Systems for Drug Delivery, Japanese Technology Reviews Gordon and Breach Science, publisher, Vol. 4 (1) (1994).

    Google Scholar 

  4. Bronsted H, Ph.D. Thesis, University of Utah, (1991)

    Google Scholar 

  5. Peppas NA, and Klier J, J. Control. Rel., 16:203 (1991).

    Article  Google Scholar 

  6. Dong LC, and Hoffman AS, J. Control. Rel., 15:141 (1991).

    Article  Google Scholar 

  7. Siegel RA, Falamarzian M, Firestone BA, and Moxley BC, J. Control., Rel.,8:179 (1988).

    Article  Google Scholar 

  8. Eisenberg SR, and Grodzinsky AJ, J. Memb. Sci., 19:173 (1984).

    Article  Google Scholar 

  9. Osada Y. Adv. Polv. Sci., 82:1 (1987).

    Article  Google Scholar 

  10. Yuk SH, Cho SH, and Lee HB, Pharm. Res. 9:955 (1992).

    Article  Google Scholar 

  11. Kwon IC, Bae YH, and Kim SW, J. Control. Rel., 17:149 (1991).

    Article  Google Scholar 

  12. Kwon IC, Bae YH, Kim SW. Nature. 354:291 (1991)

    Article  Google Scholar 

  13. Kwon IC, Bae YH, and Kim SW, J. Contr. Rel. 30:155 (1994).

    Article  Google Scholar 

  14. Hoffman AS, Afrassiaki A, and Dong LC. J. Control. Rel. 4:213 (1988).

    Article  Google Scholar 

  15. Bae YH, Okano T, Hsu R, and Kim SW, Makromol. Chem. Rapid. Comm. 8:481 (1987).

    Article  Google Scholar 

  16. Dong LC, and Hoffman AS, J. Control.. Rel., 13:21 (1990).

    Article  Google Scholar 

  17. Bae YH, Okano T, and Kim SW. J. Polv. Sci., Polv. Phys. 28:923 (1990).

    Article  Google Scholar 

  18. Gutowska A, Bae YH, Feijen J, and Kim SW, J. Contr. Rel., 95 (1992).

    Google Scholar 

  19. Feil H, Bae YH, Fiejen J, Kim SW, Makromolekular Chemie. 14:465 (1993).

    Article  Google Scholar 

  20. Feil H, Bae YH, Feijen J, and Kim SW, Macromolecules. 25:5528 (1992).

    Article  Google Scholar 

  21. Feil H, Bae YH, Feijen J, Kim SW, Macromolecules. 26:2496 (1993).

    Article  Google Scholar 

  22. Feil H, Bae YH, Feien J, and Kim SW, J. Membrane Sci., 64:283 (1991).

    Article  Google Scholar 

  23. Gehrke SH, Andrews GP, and Cussler EL, Chem. Eng. Sci., 41:2153 (1986).

    Article  Google Scholar 

  24. Palasis M, and Gehrke SH, J. Control. Rel., 18:1 (1992).

    Article  Google Scholar 

  25. Yamada N, Okano T, Sakai H, Karikusa F, Sawasaki Y, and Sakurai Y, Makromol. Chem. Rapid. Comm..,11:571 (1990).

    Article  Google Scholar 

  26. Okano T, Bae YH, Jacobs H, and Kim SW, J. Control. Rel., 11:255 (1990).

    Article  Google Scholar 

  27. Bae YH, Okano T, and Kim SW, Pharmaceutical Research 8:624 (1991).

    Article  Google Scholar 

  28. Gutowska A, Bae YH, Jacobs H, Feijen J, Kim SW, J. Biomed. Mater. Res. (in press)

    Google Scholar 

  29. Gutowska A, Bae YH, Jacobs H, Feijen J, Kim SW, J. Biomed. Mater. Res. (in press)

    Google Scholar 

  30. Kim YH, Bae YH, and Kim SW, J. Control. Rel. 28:143 (1994).

    Article  Google Scholar 

  31. Serre A, Baudys M, and Kim SW, Pharm. Res., (submitted)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD, University of Utah, Salt Lake City, Utah, 84112, USA

    Sung Wan Kim

Authors
  1. Sung Wan Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Chemistry, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    Naoya Ogata Ph.D. (Professor) (Professor)

  2. Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 84112, USA

    Sung Wan Kim Ph.D. (Professor and Director) (Professor and Director)

  3. Department of Chemical Technology and Institute of Biomedical Technology, University of Twente, P.O. Box 217, 7500 AD, Enschede, The Netherlands

    Jan Feijen Ph.D. (Professor) (Professor)

  4. Institute of Biomedical Engineering, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan

    Teruo Okano Ph.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Tokyo

About this paper

Cite this paper

Kim, S.W. (1996). Temperature Sensitive Polymers for Delivery of Macromolecular Drugs. In: Ogata, N., Kim, S.W., Feijen, J., Okano, T. (eds) Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65883-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-65883-2_25

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65885-6

  • Online ISBN: 978-4-431-65883-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation