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Non-small Cell Lung Cancer

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Intensity-Modulated Radiation Therapy

Abstract

In this review of the use of intensity-modulated radiation therapy (IMRT) for treating locally advanced non-small cell lung cancer, topics discussed include aspects of treatment simulation, planning, and delivery and dose constraints and dosimetric findings used to predict treatment-related toxicity. Studies of toxicity arising from inadvertent radiation exposure of the normal lung, esophagus, and heart are described. Numerous treatment plan comparisons have been undertaken to demonstrate the putative dosimetric advantages of IMRT over previous techniques; results from these studies and clinical trials with analyses of survival outcomes and toxicity after IMRT versus other radiation therapy techniques are reviewed and discussed.

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Acknowledgments

Supported in part by Cancer Center Support (Core) Grant CA016672 from the US National Cancer Institute to the University of Texas MD Anderson Cancer Center.

Conflict of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Unit 1150, 1840 Old Spanish Trail, Houston, TX, 77054-1901, USA

    Quynh-Nhu Nguyen M.D., Ritsuko Komaki M.D., Daniel R. Gomez M.D. & Zhongxing Liao M.D.

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  1. Quynh-Nhu Nguyen M.D.
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  2. Ritsuko Komaki M.D.
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  3. Daniel R. Gomez M.D.
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  4. Zhongxing Liao M.D.
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Corresponding author

Correspondence to Quynh-Nhu Nguyen M.D. .

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Editors and Affiliations

  1. Department of Radiation Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan

    Yasumasa Nishimura

  2. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Ritsuko Komaki

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Nguyen, QN., Komaki, R., Gomez, D.R., Liao, Z. (2015). Non-small Cell Lung Cancer. In: Nishimura, Y., Komaki, R. (eds) Intensity-Modulated Radiation Therapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55486-8_12

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  • DOI: https://doi.org/10.1007/978-4-431-55486-8_12

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55485-1

  • Online ISBN: 978-4-431-55486-8

  • eBook Packages: MedicineMedicine (R0)

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